gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Gastritis D005756 27 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Kidney Calculi D007669 7 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Del Castillo ML et al. Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. 2004 J. Agric. Food Chem. pmid:14969555
Knorr R and Hamburger M Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil. 2004 J. Agric. Food Chem. pmid:15161190
Liu JW et al. Effect of long-term dietary supplementation of high-gamma-linolenic canola oil versus borage oil on growth, hematology, serum biochemistry, and N-6 fatty acid metabolism in rats. 2004 J. Agric. Food Chem. pmid:15186123
Qin F et al. Composition of transgenic soybean seeds with higher γ-linolenic acid content is equivalent to that of conventional control. 2012 J. Agric. Food Chem. pmid:22324875
Alhazzaa R et al. Up-regulated desaturase and elongase gene expression promoted accumulation of polyunsaturated fatty acid (PUFA) but not long-chain PUFA in Lates calcarifer, a tropical euryhaline fish, fed a stearidonic acid- and γ-linoleic acid-enriched diet. 2011 J. Agric. Food Chem. pmid:21707030
Goffman FD and Galletti S Gamma-linolenic acid and tocopherol contents in the seed oil of 47 accessions from several Ribes species. 2001 J. Agric. Food Chem. pmid:11170598
Birch AE et al. Antioxidant properties of evening primrose seed extracts. 2001 J. Agric. Food Chem. pmid:11559161
Senanayake SP and Shahidi F Structured lipids via lipase-catalyzed incorporation of eicosapentaenoic acid into borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils. 2002 J. Agric. Food Chem. pmid:11804516
Teichert SA and Akoh CC Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. 2011 J. Agric. Food Chem. pmid:22097918
Skogh M Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids) 1986 J. Am. Acad. Dermatol. pmid:3013957
Melnik B and Plewig G Atopic dermatitis and disturbances of essential fatty acid and prostaglandin E metabolism. 1991 J. Am. Acad. Dermatol. pmid:1666398
Melnik BC and Plewig G Is the origin of atopy linked to deficient conversion of omega-6-fatty acids to prostaglandin E1? 1989 J. Am. Acad. Dermatol. pmid:2550526
Hanifin JM Diet, nutrition, and allergy in atopic dermatitis. 1983 J. Am. Acad. Dermatol. pmid:6863636
Guenther L and Wexler D Efamol in the treatment of atopic dermatitis. 1987 J. Am. Acad. Dermatol. pmid:3680673
Bamford JT et al. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids). 1985 J. Am. Acad. Dermatol. pmid:3908514
Ingram AJ et al. Dietary alteration of dihomogamma-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. The Nutrition & Kidney Disease Research Group. 1996 J. Am. Soc. Nephrol. pmid:8829117
Giamarellos-Bourboulis EJ et al. In-vitro inhibitory activity of gamma-linolenic acid on Escherichia coli strains and its influence on their susceptibilities to various antimicrobial agents. 1995 J. Antimicrob. Chemother. pmid:8522462
Papanikolaou S et al. Repression of reserve lipid turnover in Cunninghamella echinulata and Mortierella isabellina cultivated in multiple-limited media. 2004 J. Appl. Microbiol. pmid:15357737
Zikou E et al. Evaluating glucose and xylose as cosubstrates for lipid accumulation and γ-linolenic acid biosynthesis of Thamnidium elegans. 2013 J. Appl. Microbiol. pmid:23279437
Laho T et al. Effects of prefermented cereal-derived substrates (ground barley and rye bran) enriched with fungal γ-linolenic acid on rumen fermentation parameters and lipid metabolism in vitro. 2011 J. Appl. Microbiol. pmid:21672096
Wencelová M et al. Substrates enriched by the fungus Cunninghamella echinulata: an in vitro study of nutrient composition, sheep rumen fermentation and lipid metabolism. 2014 J. Appl. Microbiol. pmid:24995934
Kishino S et al. Microbial production of conjugated gamma-linolenic acid from gamma-linolenic acid by Lactobacillus plantarum AKU 1009a. 2010 J. Appl. Microbiol. pmid:19919619
Zhu Y and Zhang BB Molecular cloning and functional characterization of a Δ6-fatty acid desaturase gene from Rhizopus oryzae. 2013 J. Basic Microbiol. pmid:22961300
Muriana FJ et al. Fatty acid composition and properties of the liver microsomal membrane of rats fed diets enriched with cholesterol. 1992 J. Biochem. pmid:1491012
Gimeno RE et al. Characterization of a heart-specific fatty acid transport protein. 2003 J. Biol. Chem. pmid:12556534
Burke A et al. Specific analysis in plasma and urine of 2,3-dinor-5, 6-dihydro-isoprostane F(2alpha)-III, a metabolite of isoprostane F(2alpha)-III and an oxidation product of gamma-linolenic acid. 2000 J. Biol. Chem. pmid:10644705
Weaver KL et al. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. 2009 J. Biol. Chem. pmid:19359242
Kawashima Y et al. Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. 1990 J. Biol. Chem. pmid:2160962
MEAD JF and HOWTON DR Metabolism of essential fatty acids. VII. Conversion of gamma-linolenic acid to arachidonic acid. 1957 J. Biol. Chem. pmid:13502321
Čertík M et al. Simultaneous enrichment of cereals with polyunsaturated fatty acids and pigments by fungal solid state fermentations. 2013 J. Biotechnol. pmid:23583333
Bellou S et al. The olive mill wastewater as substrate for single cell oil production by Zygomycetes. 2014 J. Biotechnol. pmid:24316440
Zaitone SA et al. Effect of evening primrose oil and ω-3 polyunsaturated fatty acids on the cardiovascular risk of celecoxib in rats. 2011 J. Cardiovasc. Pharmacol. pmid:21499116
Martin TA et al. Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. 2006 J. Cell. Biochem. pmid:16514648
Martin TA et al. Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid. 2007 J. Cell. Biochem. pmid:17243118
Roemen TH et al. Quantitative assessment of gamma-linolenic acid in human blood and plasma with capillary gas chromatography. 1990 J. Chromatogr. pmid:2166745
Furse RK et al. Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. 2002 J. Clin. Immunol. pmid:11998897
Puri BK Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). 2007 J. Clin. Pathol. pmid:16935966
Kim JJ et al. Properties of cholesterol-reduced butter made with beta-cyclodextrin and added evening primrose oil and phytosterols. 2006 J. Dairy Sci. pmid:17106080
Clément M et al. Purification and identification of bovine cheese whey fatty acids exhibiting in vitro antifungal activity. 2008 J. Dairy Sci. pmid:18565910
Kanehara S et al. Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. 2007 J. Dermatol. pmid:18078406
Burnard SL et al. Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat. 1998 Mar-Apr J. Diabetes Complicat. pmid:9559483
Garland HO et al. Dietary essential fatty acid supplementation, urinary calcium excretion and reproductive performance in the diabetic pregnant rat. 1997 J. Endocrinol. pmid:9203989
Cheng Z et al. Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes. 2004 J. Endocrinol. pmid:15283685
Braddock R et al. gamma-Linoleic acid and ascorbic acid ameliorate the effects of experimental diabetes on electrolyte and bone homeostasis in pregnant rats. 2002 J. Endocrinol. pmid:12010635
Ramandi NF et al. Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. 2011 Nov-Dec J. Food Sci. pmid:22416687
Fu J et al. Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits. 2012 J. Food Sci. pmid:22747885
Li R et al. Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. 2015 J. Food Sci. pmid:26408984
Won J et al. Stability analysis of zinc oxide-nanoencapsulated conjugated linoleic acid and gamma-linolenic acid. 2008 J. Food Sci. pmid:19019122
Marra F et al. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. 1998 J. Hepatol. pmid:9566835
Engler MM et al. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. 1992 J. Hypertens. pmid:1335001