| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Kidney Calculi | D007669 | 7 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu FX et al. | [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15810447 |
| Menendez JA et al. | Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. | 2005 | Med. Hypotheses | pmid:15607568 |
| Vahedi K et al. | A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients. | 2005 | Br. J. Nutr. | pmid:16351767 |
| Menendez JA et al. | Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. | 2005 | J. Natl. Cancer Inst. | pmid:16264182 |
| Heard CM et al. | Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. | 2005 | Int J Pharm | pmid:16115741 |
| Efstathopoulos N et al. | N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850717 |
| Oikawa D et al. | Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. | 2005 | Br. J. Nutr. | pmid:16115363 |
| Vang K and Ziboh VA | 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850718 |
| Hao YL et al. | Cloning of delta6-desaturase from Mucor circinelloides and its high expression in Saccharomyces cerevisiae. | 2005 | Yi Chuan Xue Bao | pmid:15931792 |
| Tahvonen RL et al. | Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. | 2005 | J. Nutr. Biochem. | pmid:15936647 |
| Seidel A et al. | The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. | 2005 | J Vet Med A Physiol Pathol Clin Med | pmid:15943605 |
| Cury-Boaventura MF and Curi R | Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. | 2005 | Clin. Sci. | pmid:15563273 |
| Hirasawa A et al. | Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | 2005 | Nat. Med. | pmid:15619630 |
| Aragona P et al. | Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16303936 |
| Watkins G et al. | Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15763439 |
| Qureshi S and Sultan N | Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. | 2005 | Surgeon | pmid:15789786 |
| Patnayak S and Sree A | Screening of bacterial associates of marine sponges for single cell oil and PUFA. | 2005 | Lett. Appl. Microbiol. | pmid:15836739 |
| Gillis RC et al. | Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells. | 2004 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:15449569 |
| Torres CF et al. | Lipase-catalyzed ethanolysis of borage oil: a kinetic study. | 2004 May-Jun | Biotechnol. Prog. | pmid:15176879 |
| Kavanagh T et al. | Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041032 |
| Del Castillo ML et al. | Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. | 2004 | J. Agric. Food Chem. | pmid:14969555 |
| Menendez JA et al. | Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. | 2004 | Int. J. Cancer | pmid:15027132 |
| Nakanishi T et al. | Gamma-linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice. | 2004 | Nutrition | pmid:15043857 |
| Plowman PN | Re: Packer RJ. Effects of radiotherapy on the brain. Med Pediatr Oncol 2003;41:448-449. | 2004 | Pediatr Blood Cancer | pmid:15049029 |
| Gamma-linolenic acid (GLA). Monograph. | 2004 | Altern Med Rev | pmid:15005646 | |
| Zhang Q et al. | [Progress on molecular biology of delta6-fatty acid desaturases]. | 2004 | Sheng Wu Gong Cheng Xue Bao | pmid:15971598 |
| Cheng Z et al. | Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes. | 2004 | J. Endocrinol. | pmid:15283685 |
| Knorr R and Hamburger M | Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil. | 2004 | J. Agric. Food Chem. | pmid:15161190 |
| Javadi M et al. | The effect of six different C18 fatty acids on body fat and energy metabolism in mice. | 2004 | Br. J. Nutr. | pmid:15469642 |
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| Bruder ED et al. | Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. | 2004 | Endocrinology | pmid:15271879 |
| Pham H et al. | Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. | 2004 | Int. J. Cancer | pmid:15197770 |
| Johnston GA et al. | The use of dietary manipulation by parents of children with atopic dermatitis. | 2004 | Br. J. Dermatol. | pmid:15214908 |
| Saevik BK et al. | A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. | 2004 | Vet. Dermatol. | pmid:15214949 |
| Ziboh VA et al. | Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma. | 2004 | Clin. Dev. Immunol. | pmid:15154607 |
| Agombar A et al. | An aqueous formulation of gamma-linolenic acid with anti-proliferative action on human pancreatic cancer cell lines. | 2004 | Anticancer Drugs | pmid:15075672 |
| Dokholyan RS et al. | A trial of omega-3 fatty acids for prevention of hypertension. | 2004 | Am. J. Cardiol. | pmid:15081453 |
| van Gool CJ et al. | Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. | 2004 | Br. J. Dermatol. | pmid:15099370 |
| Leaver HA et al. | Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15062847 |
| Miles EA et al. | The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15120716 |
| Das UN | From bench to the clinic: gamma-linolenic acid therapy of human gliomas. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15120717 |
| Gallagher S | Omega 3 oils and pregnancy. | 2004 | Midwifery Today Int Midwife | pmid:15124319 |
| Karia C et al. | Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. | 2004 | Int J Pharm | pmid:15129999 |
| Menendez JA et al. | Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. | 2004 | Int. J. Oncol. | pmid:15138577 |
| Shotton HR et al. | Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil. | 2004 | Auton Neurosci | pmid:15109939 |
| Fewtrell MS et al. | Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. | 2004 | J. Pediatr. | pmid:15069395 |
| Puri BK | The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparations. | 2004 | Med. Hypotheses | pmid:14729014 |
| Zhang Q et al. | Identification and characterization of a novel Delta6-fatty acid desaturase gene from Rhizopus arrhizus. | 2004 | FEBS Lett. | pmid:14706830 |
| de La Puerta Vázquez R et al. | Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. | 2004 | Metab. Clin. Exp. | pmid:14681843 |
| Menendez JA et al. | Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. | 2004 | Oncol. Rep. | pmid:15138562 |