Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kitz R et al. | Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. | 2006 | Pediatr Allergy Immunol | pmid:16618360 |
Chen YC et al. | Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. | 2006 | Am. J. Kidney Dis. | pmid:16797388 |
Miles EA et al. | Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16820286 |
Hongsthong A et al. | Revealing the complementation of ferredoxin by cytochrome b (5) in the Spirulina- (6)-desaturation reaction by N-terminal fusion and co-expression of the fungal-cytochrome b (5) domain and Spirulina- (6)-acyl-lipid desaturase. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16575563 |
Das UN | Re: Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. | 2006 | J. Natl. Cancer Inst. | pmid:16705127 |
Puri BK | Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). | 2007 | J. Clin. Pathol. | pmid:16935966 |
Noli C et al. | Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. | 2007 | Vet. J. | pmid:16495095 |
Dasgupta S and Bhattacharyya DK | Dietary effect of gamma-linolenic acid on the lipid profile of rat fed erucic acid rich oil. | 2007 | J Oleo Sci | pmid:17938547 |
Sýkora J et al. | High-performance liquid chromatography with nuclear magnetic resonance detection--A method for quantification of alpha- and gamma-linolenic acids in their mixtures with free fatty acids. | 2007 | J Chromatogr A | pmid:17157864 |
Martin TA et al. | Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid. | 2007 | J. Cell. Biochem. | pmid:17243118 |
Matta JA et al. | TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. | 2007 | J. Physiol. (Lond.) | pmid:17038422 |
Pitel S et al. | At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. | 2007 | J. Nutr. | pmid:17237313 |
Christie A et al. | Effectiveness of nonpharmacological and nonsurgical interventions for patients with rheumatoid arthritis: an overview of systematic reviews. | 2007 | Phys Ther | pmid:17906290 |
Dobryniewski J et al. | [The gamma-linolenic acid (GLA)--the therapeutic value]. | 2007 | Prz. Lek. | pmid:17892041 |
Theilla M et al. | A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study. | 2007 | Clin Nutr | pmid:17933438 |
Garaiova I et al. | A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. | 2007 | Nutr J | pmid:17254329 |
Das UN | Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. | 2007 | Med. Sci. Monit. | pmid:17599036 |
Schirmer MA and Phinney SD | Gamma-linolenate reduces weight regain in formerly obese humans. | 2007 | J. Nutr. | pmid:17513402 |
Curtis L | High-quality enteral nutrition essential for reducing morbidity and mortality in acute care patients. | 2007 | Crit. Care Med. | pmid:17421112 |
Ortiz-Leyba C and Garnacho-Montero J | Saving lives in severe sepsis with the help of enteral nutrition. | 2007 | Crit. Care Med. | pmid:17421113 |
Kanehara S et al. | Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. | 2007 | J. Dermatol. | pmid:18078406 |
Vrinten P et al. | Production of polyunsaturated fatty acids in transgenic plants. | 2007 | Biotechnol. Genet. Eng. Rev. | pmid:18059637 |
Villamor E et al. | Long-chain n-6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding. | 2007 | Am. J. Clin. Nutr. | pmid:17823433 |
Stolyhwo A and Mol J | Changes in the content of gamma-linolenic C18:3 (n-6) and stearidonic C18:4 (n-3) acids in developing seeds of viper's bugloss Echium vulgare L. | 2007 | Acta Biochim. Pol. | pmid:18066400 |
Saied GM et al. | Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females. | 2007 | Tanzan Health Res Bull | pmid:18087899 |
Poulsen RC et al. | Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. | 2007 | Calcif. Tissue Int. | pmid:18008020 |
Lindmark L and Clough P | A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia. | 2007 | J Med Food | pmid:18158838 |
Guo SX et al. | [Influence of methyl esterification on the ultraviolet absorption of gamma-linolenic acid]. | 2007 | Zhong Yao Cai | pmid:18236761 |
Puri BK | The safety of evening primrose oil in epilepsy. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17764919 |
Pinna A et al. | Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. | 2007 | Cornea | pmid:17413949 |
Lu H et al. | [Cloning and expression of a delta6-fatty acid desaturase gene from Rhizopus stolonifer in Saccharomyces cervisiae]. | 2007 | Wei Sheng Wu Xue Bao | pmid:17436625 |
Cho HS et al. | Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation. | 2007 | Photodermatol Photoimmunol Photomed | pmid:17803593 |
Kanehara S et al. | Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children. | 2007 Sep-Oct | Eur J Dermatol | pmid:17673396 |
Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Clément M et al. | Purification and identification of bovine cheese whey fatty acids exhibiting in vitro antifungal activity. | 2008 | J. Dairy Sci. | pmid:18565910 |
Leskinen H et al. | Regioisomeric structure determination of alpha- and gamma-linolenoyldilinoleoylglycerol in blackcurrant seed oil by silver ion high-performance liquid chromatography and mass spectrometry. | 2008 | Anal. Chem. | pmid:18578547 |
Guo JP and Xue H | [Prepared evening primrose oil microspheres by spray drying]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18589773 |
Fakas S et al. | Gamma-linolenic acid production by Cunninghamella echinulata growing on complex organic nitrogen sources. | 2008 | Bioresour. Technol. | pmid:18609766 |
Yu Q et al. | LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenase-catalysed peroxidation of gamma-linolenic acid. | 2008 | Free Radic. Res. | pmid:18484409 |
Thumfart J et al. | Magnesium stimulates renal phosphate reabsorption. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18701629 |
Bloom P | Atopic dermatitis: the quest for the silver bullet. | 2008 | Vet. J. | pmid:18554562 |
Adam O | [Ankylosing Spondylitis and convenient nutrition]. | 2008 | Wien Med Wochenschr | pmid:18560957 |
Wedig KE and Whitsett JA | Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. | 2008 | J. Pediatr. | pmid:18154917 |
Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
Shi LM et al. | [Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260318 |
Nandakumar M and Tan MW | Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. | 2008 | PLoS Genet. | pmid:19023415 |
Won J et al. | Stability analysis of zinc oxide-nanoencapsulated conjugated linoleic acid and gamma-linolenic acid. | 2008 | J. Food Sci. | pmid:19019122 |
Geppert J et al. | Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. | 2008 | Br. J. Nutr. | pmid:17678567 |
Rühl R et al. | Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. | 2008 | Br. J. Nutr. | pmid:18005485 |
Chilton FH et al. | Mechanisms by which botanical lipids affect inflammatory disorders. | 2008 | Am. J. Clin. Nutr. | pmid:18258646 |
Surette ME et al. | The impact of a medical food containing gammalinolenic and eicosapentaenoic acids on asthma management and the quality of life of adult asthma patients. | 2008 | Curr Med Res Opin | pmid:18194593 |
Cui PH et al. | Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. | 2008 | Chem. Phys. Lipids | pmid:18339314 |
Wu CC et al. | Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. | 2008 | Asia Pac J Clin Nutr | pmid:18296341 |
Jeennor S et al. | Evaluation of inoculum performance for enhancing gamma-linolenic acid production from Mucor rouxii. | 2008 | Lett. Appl. Microbiol. | pmid:18298455 |
Puch F et al. | Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. | 2008 | Exp. Dermatol. | pmid:18318715 |
Vinggaard AM et al. | Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008 | Chem. Res. Toxicol. | pmid:18324785 |
Song C et al. | Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. | 2008 | J. Nutr. | pmid:18424607 |
Choi GG et al. | Enhanced biomass and gamma-linolenic acid production of mutant strain Arthrospira platensis. | 2008 | J. Microbiol. Biotechnol. | pmid:18388474 |
Prociuk MA et al. | Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. | 2008 | Can. J. Physiol. Pharmacol. | pmid:18418423 |
Funtikova NS and Mysiakina IS | [Effects of conditions for obtaining sporangiospores of the inoculum on the morphology and productivity of the fungus Mucor circinelloides var. lusitanicus 12 M, a producer of gamma-linolenic acid]. | 2008 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:18924414 |
Mysiakina IS and Funtikova NS | [Activity of NAD-dependent isocitrate dehydrogenase, isocitrate lyase, and malate dehydrogenase in Mucor circinelloides var. lusitanicus INMI under different modes of nitrogen supply]. | 2008 Jul-Aug | Mikrobiologiia | pmid:18825970 |
Mysiakina IS and Funtikova NS | [Metabolic characteristics and lipid composition of yeastlike cells and mycelium of Mucor circinelloides var. lusitanicus INMI grown at a high glucose content in the medium]. | 2008 Jul-Aug | Mikrobiologiia | pmid:18825971 |
Pontes-Arruda A et al. | The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974237 |
Preiser JC | Nutrition therapy for acute respiratory distress syndrome. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974251 |
Dickerson RN | Modified EN support for patients with acute respiratory distress syndrome. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974252 |
Senapati S et al. | Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. | 2008 Sep-Oct | Indian J Dermatol Venereol Leprol | pmid:19052401 |
Ahmed SU et al. | Application of response surface method for studying the role of dissolved oxygen and agitation speed on gamma-linolenic acid production. | 2009 | Appl. Biochem. Biotechnol. | pmid:18480973 |
De Spirt S et al. | Intervention with flaxseed and borage oil supplements modulates skin condition in women. | 2009 | Br. J. Nutr. | pmid:18761778 |
Kong X et al. | Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. | 2009 | Toxicol In Vitro | pmid:19268700 |
Schnebelen C et al. | Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. | 2009 | Lipids | pmid:19242743 |
Miyake JA et al. | Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. | 2009 | Lipids Health Dis | pmid:19292920 |
Ge H et al. | Gamma-linolenic acid induces apoptosis and lipid peroxidation in human chronic myelogenous leukemia K562 cells. | 2009 | Cell Biol. Int. | pmid:19356705 |
Weaver KL et al. | Effect of dietary fatty acids on inflammatory gene expression in healthy humans. | 2009 | J. Biol. Chem. | pmid:19359242 |
Zaniewska A et al. | The activity of lysosomal exoglycosidases in serum of alcohol-dependent men supplemented with borage oil enriched with vitamin E. | 2009 | J Med Food | pmid:19735195 |
Lu H et al. | Identification and characterization of a novel delta6-fatty acid desaturase gene from Rhizopus nigricans. | 2009 | Mol. Biol. Rep. | pmid:19152021 |
Schnebelen C et al. | Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation. | 2009 | Ophthalmic Res. | pmid:19451735 |
Jangbua P et al. | Gamma-linolenic acid production of Mucor rouxii by solid-state fermentation using agricultural by-products. | 2009 | Lett. Appl. Microbiol. | pmid:19453951 |
Smyk B et al. | Steady-state and time-resolved fluorescence studies of stripped Borage oil. | 2009 | Anal. Chim. Acta | pmid:19523559 |
Fakas S et al. | Fatty acid composition in lipid fractions lengthwise the mycelium of Mortierella isabellina and lipid production by solid state fermentation. | 2009 | Bioresour. Technol. | pmid:19574039 |
Viau S et al. | Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. | 2009 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:19415319 |
Wan X et al. | Production of gamma-linolenic acid in Pichia pastoris by Expression of a delta-6 desaturase gene from Cunninghamella echinulata. | 2009 | J. Microbiol. Biotechnol. | pmid:19884765 |
LÃsa M et al. | Comparison of various types of stationary phases in non-aqueous reversed-phase high-performance liquid chromatography-mass spectrometry of glycerolipids in blackcurrant oil and its enzymatic hydrolysis mixture. | 2009 | J Chromatogr A | pmid:19837411 |
Cameron M et al. | Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 2: Rheumatoid arthritis. | 2009 | Phytother Res | pmid:19941324 |
Rodgers A et al. | Evening primrose oil supplementation increases citraturia and decreases other urinary risk factors for calcium oxalate urolithiasis. | 2009 | J. Urol. | pmid:19846138 |
Scheim DE | Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. | 2009 | Lipids Health Dis | pmid:20003514 |
Lindemann J et al. | Clinical study of the effects on asthma-related QOL and asthma management of a medical food in adult asthma patients. | 2009 | Curr Med Res Opin | pmid:19811112 |
Riaz A et al. | Assessment of anticoagulant effect of evening primrose oil. | 2009 | Pak J Pharm Sci | pmid:19783511 |
Labruzzo BA et al. | Which complementary therapies can help patients with PMS? | 2009 | J Fam Pract | pmid:19874736 |
Ranieri M et al. | The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. | 2009 Jul-Sep | Int J Immunopathol Pharmacol | pmid:19887043 |
Di Geronimo G et al. | Treatment of carpal tunnel syndrome with alpha-lipoic acid. | 2009 Mar-Apr | Eur Rev Med Pharmacol Sci | pmid:19499849 |
Tsai NP et al. | Activation of testicular orphan receptor 4 by fatty acids. | 2009 Nov-Dec | Biochim. Biophys. Acta | pmid:19800043 |
Habermann N et al. | Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. | 2009 Sep-Oct | Biofactors | pmid:19798733 |
Castellanos P et al. | Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. | 2010 | Reprod. Toxicol. | pmid:20096347 |
Barar J et al. | Barrier functionality and transport machineries of human ECV304 cells. | 2010 | Med. Sci. Monit. | pmid:20037486 |
Itoh S et al. | Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. | 2010 | J Clin Biochem Nutr | pmid:20664735 |
Huang CB et al. | Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. | 2010 | Arch. Oral Biol. | pmid:20541177 |
Pruthi S et al. | Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. | 2010 | Altern Med Rev | pmid:20359269 |
Chang CS et al. | Gamma-linolenic acid inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. | 2010 | Inflammation | pmid:19842026 |
Ribeiro G et al. | The novel ruthenium-gamma-linolenic complex [Ru(2)(aGLA)(4)Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitro. | 2010 | Cell Biochem. Funct. | pmid:19927275 |
Kishino S et al. | Microbial production of conjugated gamma-linolenic acid from gamma-linolenic acid by Lactobacillus plantarum AKU 1009a. | 2010 | J. Appl. Microbiol. | pmid:19919619 |