Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Vinik AI et al. | Diabetic neuropathies. | 2000 | Diabetologia | pmid:10990072 |
Dines KC et al. | Contrasting effects of treatment with omega-3 and omega-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. | 1993 | Diabetologia | pmid:8270127 |
Stevens EJ et al. | Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. | 1993 | Diabetologia | pmid:8314443 |
Hounsom L et al. | A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. | 1998 | Diabetologia | pmid:9686927 |
Karasu C et al. | Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids. | 1995 | Diabetologia | pmid:7713308 |
Cameron NE et al. | Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. | 1996 | Diabetologia | pmid:8635669 |
van Doormaal JJ et al. | Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, alpha-tocopherol levels, and erythropoiesis in normal and type 1 (insulin-dependent) diabetic men. | 1988 | Diabetologia | pmid:3065111 |
Huang YS et al. | Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats. | 1987 | Digestion | pmid:3030865 |
Duffy O et al. | Effects of an oil enriched in gamma linolenic acid on locomotor activity and behaviour in the Morris Maze, following in utero ethanol exposure in rats. | 1992 | Drug Alcohol Depend | pmid:1317288 |
Duffy O et al. | Attenuation of the effects of chronic ethanol administration in the brain lipid content of the developing rat by an oil enriched in gamma linolenic acid. | 1992 | Drug Alcohol Depend | pmid:1330473 |
Wade AE et al. | Effect of 7,12-dimethylbenz(a)anthracene administration on hepatic drug metabolizing enzymes in female rats fed corn, primrose, and menhaden oils. | 1988 | Drug Nutr Interact | pmid:3149238 |
Cyclical breast pain--what works and what doesn't. | 1992 | Drug Ther Bull | pmid:1425218 | |
Gamolenic acid in atopic eczema: Epogam. | 1990 | Drug Ther Bull | pmid:2131219 | |
Recently introduced products. | 1991 | Drug Ther Bull | pmid:1935601 | |
Biagi PL et al. | The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. | 1994 | Drugs Exp Clin Res | pmid:7924900 |
Biagi PL et al. | A long-term study on the use of evening primrose oil (Efamol) in atopic children. | 1988 | Drugs Exp Clin Res | pmid:3048952 |
Bordoni A et al. | Evening primrose oil (Efamol) in the treatment of children with atopic eczema. | 1988 | Drugs Exp Clin Res | pmid:3048953 |
Zavodnik LB et al. | [Effect of gamma-linolenic acid on microsomal oxidation in the rat liver following gamma-irradiation]. | 2001 Jul-Aug | Eksp Klin Farmakol | pmid:11589114 |
SimoncÃkova P et al. | Comparison of the extrapancreatic action of gamma-linolenic acid and n-3 PUFAs in the high fat diet-induced insulin resistance [corrected]. | 2002 | Endocr Regul | pmid:12466014 |
Bruder ED et al. | Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. | 2004 | Endocrinology | pmid:15271879 |
Schwartz Z et al. | Arachidonic acid directly mediates the rapid effects of 24,25-dihydroxyvitamin D3 via protein kinase C and indirectly through prostaglandin production in resting zone chondrocytes. | 1999 | Endocrinology | pmid:10385391 |
Reinikainen M et al. | The toxicities of a polyunsaturated fatty acid and a microcystin to Daphnia magna. | 2001 | Environ. Toxicol. | pmid:11594032 |
Reilly JD et al. | Effect of a supplementary dietary evening primrose oil mixture on hoof growth, hoof growth rate and hoof lipid fractions in horses: a controlled and blinded trial. | 1998 | Equine Vet J Suppl | pmid:9932095 |
Kamphuis MM et al. | Fat-specific satiety in humans for fat high in linoleic acid vs fat high in oleic acid. | 2001 | Eur J Clin Nutr | pmid:11423927 |
Thijs C et al. | Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation. | 2000 | Eur J Clin Nutr | pmid:10713746 |
Remans PH et al. | Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. | 2004 | Eur J Clin Nutr | pmid:15164103 |
Kanehara S et al. | Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children. | 2007 Sep-Oct | Eur J Dermatol | pmid:17673396 |
Koletzko B et al. | Fatty acid profiles, antioxidant status, and growth of preterm infants fed diets without or with long-chain polyunsaturated fatty acids. A randomized clinical trial. | 2003 | Eur J Nutr | pmid:14569405 |
Hoppu U et al. | Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines. | 2012 | Eur J Nutr | pmid:21626296 |
Enzenbach C et al. | Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men. | 2011 | Eur J Nutr | pmid:21301856 |
Manosroi A et al. | Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction. | 2012 | Eur J Pharm Biopharm | pmid:22490981 |
Di Geronimo G et al. | Treatment of carpal tunnel syndrome with alpha-lipoic acid. | 2009 Mar-Apr | Eur Rev Med Pharmacol Sci | pmid:19499849 |
Izumi T et al. | Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. | 1991 | Eur. J. Biochem. | pmid:1662607 |
Chakrabarti KB et al. | Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane). | 2001 | Eur. J. Cancer | pmid:11435077 |
Ravichandran D et al. | Effect of 1-(gamma)linolenyl-3-eicosapentaenoyl propane diol on the growth of human pancreatic carcinoma in vitro and in vivo. | 2000 | Eur. J. Cancer | pmid:10708945 |
Davies CL et al. | Effect of gamma-linolenic acid on cellular uptake of structurally related anthracyclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines. | 1999 | Eur. J. Cancer | pmid:10673983 |
Ravichandran D et al. | Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. | 1998 | Eur. J. Cancer | pmid:9624256 |
Menéndez JA et al. | Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. | 2001 | Eur. J. Cancer | pmid:11239764 |
Leaver HA et al. | Dynamics of reactive oxygen intermediate production in human glioma: n-6 essential fatty acid effects. | 1999 | Eur. J. Clin. Invest. | pmid:10202379 |
Dines CD et al. | Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin. | 1995 | Eur. J. Pharmacol. | pmid:8521914 |
Sergeant S et al. | Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes. | 2016 | Eur. J. Pharmacol. | pmid:27083549 |
Field EJ and Joyce G | Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids. | 1983 | Eur. Neurol. | pmid:6301844 |
Harris NM et al. | Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study. | 2002 | Eur. Urol. | pmid:12121728 |
Sadi AM et al. | Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. | 1996 | Exp. Anim. | pmid:8689581 |
Puch F et al. | Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. | 2008 | Exp. Dermatol. | pmid:18318715 |
McGahon B et al. | Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study. | 1998 | Exp. Gerontol. | pmid:9639170 |
Oon BB et al. | A diet enriched in essential fatty acids protects against the loss of lymphocytes which occurs in rats suffering from streptozotocin-induced diabetes. | 1992 | Exp. Physiol. | pmid:1543584 |
Devi MA and Das NP | Antiproliferative effect of polyunsaturated fatty acids and interleukin-2 on normal and abnormal human lymphocytes. | 1994 | Experientia | pmid:8194587 |
Kinchington D et al. | Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. | 1993 | FEBS Lett. | pmid:8396048 |
Zhang Q et al. | Identification and characterization of a novel Delta6-fatty acid desaturase gene from Rhizopus arrhizus. | 2004 | FEBS Lett. | pmid:14706830 |