Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Jiang WG et al. | Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). | 1995 | Cancer Res. | pmid:7585549 |
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Pham H et al. | Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells. | 2003 | Cancer Lett. | pmid:12445673 |
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Cantrill RC et al. | Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. | 1996 | Cancer Lett. | pmid:8620439 |
Ito Y et al. | Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. | 2001 | Cancer Lett. | pmid:11165751 |
Agatha G et al. | Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. | 2001 | Cancer Lett. | pmid:11597788 |
Cantrill RC et al. | Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture. | 1993 | Cancer Lett. | pmid:8402582 |
Ells GW et al. | Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. | 1996 | Cancer Lett. | pmid:8556710 |
Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
Das UN | Tumoricidal action of cis-unsaturated fatty acids and their relationship to free radicals and lipid peroxidation. | 1991 | Cancer Lett. | pmid:1850658 |
Das UN et al. | Local application of gamma-linolenic acid in the treatment of human gliomas. | 1995 | Cancer Lett. | pmid:7634242 |
González CA et al. | Borage consumption as a possible gastric cancer protective factor. | 1993 Mar-Apr | Cancer Epidemiol. Biomarkers Prev. | pmid:8385521 |
Harris NM et al. | Epirubicin and meglumine gamma-linolenic acid: a logical choice of combination therapy for patients with superficial bladder carcinoma. | 2003 | Cancer | pmid:12491507 |
Soma M et al. | The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. | 1985 | Can. J. Physiol. Pharmacol. | pmid:4005704 |
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Leyton E | Disagreeing on how to treat CFS patients. | 1993 | Can Fam Physician | pmid:8347205 |
Each of the following has been shown to be effective for cyclical breast pain. | 1996 | Can Fam Physician | pmid:8704485 | |
Poulsen RC et al. | Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. | 2007 | Calcif. Tissue Int. | pmid:18008020 |
Girault C et al. | Effect of dietary gamma-linolenic acid on specific activities of delta 6 desaturation in obese Zucker rats. | 1992 | C. R. Seances Soc. Biol. Fil. | pmid:1337306 |
Paccalin J et al. | [Rediscovery of an oleaginous plant: Oenothera biennis. The importance of gamma-linolenic acid in nutrition]. | 1983 | Bull. Acad. Natl. Med. | pmid:6324965 |
Goyal A and Mansel RE | A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. | 2005 Jan-Feb | Breast J | pmid:15647077 |
Sharma N et al. | Mastalgia cured! Randomized trial comparing centchroman to evening primrose oil. | 2012 | Breast J | pmid:22892074 |
Menéndez JA et al. | Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. | 2002 | Breast Cancer Res. Treat. | pmid:12058962 |
Chajès V et al. | Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E. | 1995 | Breast Cancer Res. Treat. | pmid:7579484 |
Crowe DL and Chandraratna RA | A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. | 2004 | Breast Cancer Res. | pmid:15318936 |
Hornych A et al. | The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. | 2002 | Bratisl Lek Listy | pmid:12190041 |
BÃró K et al. | Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. | 1997 | Brain Res. Bull. | pmid:9323440 |
Cerolini S et al. | Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels. | 2005 | Br. Poult. Sci. | pmid:15957443 |
Murai A et al. | Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. | 1995 | Br. Poult. Sci. | pmid:8746984 |
Gateley CA and Mansel RE | Management of the painful and nodular breast. | 1991 | Br. Med. Bull. | pmid:1834299 |