Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Chen YC et al. | Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. | 2006 | Am. J. Kidney Dis. | pmid:16797388 |
Milner LS et al. | Synergistic effects of fish oil diet and dimethylthiourea in acute adriamycin nephrosis. | 1994 | Am. J. Med. Sci. | pmid:7977444 |
Blommers J et al. | Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. | 2002 | Am. J. Obstet. Gynecol. | pmid:12439536 |
Cameron NE and Cotter MA | Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats. | 1996 | Am. J. Physiol. | pmid:8843740 |
Beno DW et al. | Gamma-linolenic acid suppression of hepatic Ito cell mitogenesis: post-PDGF receptor prostaglandin-independent mechanism. | 1993 | Am. J. Physiol. | pmid:7694498 |
Murray MJ et al. | Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. | 1995 | Am. J. Physiol. | pmid:8594921 |
Peth JA et al. | Effects of a unique conjugate of alpha-lipoic acid and gamma-linolenic acid on insulin action in obese Zucker rats. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10666147 |
Hou X et al. | 2,3-Dinor-5,6-dihydro-15-F(2t)-isoprostane: a bioactive prostanoid metabolite. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11448840 |
Thumfart J et al. | Magnesium stimulates renal phosphate reabsorption. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18701629 |
Hirano A et al. | Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. | 2003 | Anal Sci | pmid:12608744 |
Leskinen H et al. | Regioisomeric structure determination of alpha- and gamma-linolenoyldilinoleoylglycerol in blackcurrant seed oil by silver ion high-performance liquid chromatography and mass spectrometry. | 2008 | Anal. Chem. | pmid:18578547 |
Smyk B et al. | Steady-state and time-resolved fluorescence studies of stripped Borage oil. | 2009 | Anal. Chim. Acta | pmid:19523559 |
Gilani S et al. | Chick embryonic development following exposure to ethanol, gamma-linolenic and linolenic acids. | 1991 | Anat Anz | pmid:1666823 |
Taweechaisupapong S et al. | Evening primrose oil effects on osteoclasts during tooth movement. | 2005 | Angle Orthod | pmid:15898373 |
Stenius-Aarniala B et al. | Evening primose oil and fish oil are ineffective as supplementary treatment of bronchial asthma. | 1989 | Ann Allergy | pmid:2735560 |
Darcet P et al. | [Study of the metabolism of fatty acids and total plasma lipids, and platelet aggregation of a population of elderly men using a diet enriched in gamma-linolenic acid]. | 1980 | Ann Nutr Aliment | pmid:6254419 |
Hauben M | Comment: evening primrose oil in the treatment of rheumatoid arthritis--proper application of statistical analysis. | 1994 Jul-Aug | Ann Pharmacother | pmid:7832860 |
Joe LA and Hart LL | Evening primrose oil in rheumatoid arthritis. | 1993 | Ann Pharmacother | pmid:8305783 |
Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Spector SL and Surette ME | Diet and asthma: has the role of dietary lipids been overlooked in the management of asthma? | 2003 | Ann. Allergy Asthma Immunol. | pmid:12722956 |
Auberger J et al. | Topical evening primrose oil for reduction of bortezomib-induced skin reactions. | 2013 | Ann. Hematol. | pmid:23262668 |
Platzbecker U et al. | Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil. | 2010 | Ann. Hematol. | pmid:19714330 |
Phinney S | Potential risk of prolonged gamma-linolenic acid use. | 1994 | Ann. Intern. Med. | pmid:8135457 |
Leventhal LJ et al. | Treatment of rheumatoid arthritis with gammalinolenic acid. | 1993 | Ann. Intern. Med. | pmid:8214997 |
Mansel RE et al. | A randomized trial of dietary intervention with essential fatty acids in patients with categorized cysts. | 1990 | Ann. N. Y. Acad. Sci. | pmid:2192634 |
Ergan F et al. | Lipase specificity against some fatty acids? | 1992 | Ann. N. Y. Acad. Sci. | pmid:1335712 |
Dib A and Carreau JP | Effects of gamma-linolenic acid supplementation on pregnant rats fed a zinc-deficient diet. | 1987 | Ann. Nutr. Metab. | pmid:2821872 |
Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
Christophe A et al. | Effect of administration of gamma-linolenic acid on the fatty acid composition of serum phospholipids and cholesteryl esters in patients with cystic fibrosis. | 1994 | Ann. Nutr. Metab. | pmid:8185286 |
Quoc KP and Pascaud M | Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. | 1996 | Ann. Nutr. Metab. | pmid:8773734 |
Pascaud M and Strouve-Vallet C | Desaturation of 14C linoleic acid by the rat fetus. | 1985 | Ann. Nutr. Metab. | pmid:2983600 |
Barre DE | Potential of evening primrose, borage, black currant, and fungal oils in human health. | 2001 | Ann. Nutr. Metab. | pmid:11359029 |
Sugano M et al. | Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. | 1986 | Ann. Nutr. Metab. | pmid:3752928 |
Jäntti J et al. | Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. | 1989 | Ann. Rheum. Dis. | pmid:2649022 |
Horrobin DF | Effects of evening primrose oil in rheumatoid arthritis. | 1989 | Ann. Rheum. Dis. | pmid:2688567 |
Belch JJ et al. | Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. | 1988 | Ann. Rheum. Dis. | pmid:2833184 |
Godfrey DG et al. | Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation. | 1986 | Ann. Rheum. Dis. | pmid:3492970 |
Darlington LG | Do diets rich in polyunsaturated fatty acids affect disease activity in rheumatoid arthritis? | 1988 | Ann. Rheum. Dis. | pmid:3281607 |
Ilc K et al. | Cytotoxic effects of two gamma linoleic salts (lithium gammalinolenate or meglumine gammalinolenate) alone or associated with a nitrosourea: an experimental study on human glioblastoma cell lines. | 1999 | Anticancer Drugs | pmid:10378677 |
Agombar A et al. | An aqueous formulation of gamma-linolenic acid with anti-proliferative action on human pancreatic cancer cell lines. | 2004 | Anticancer Drugs | pmid:15075672 |
Takeda S et al. | Lipid peroxidation in human breast cancer cells in response to gamma-linolenic acid and iron. | 1992 Mar-Apr | Anticancer Res. | pmid:1316091 |
Cantrill RC et al. | The effect of n-6 fatty acids on normal and v-Ki ras transformed NIH-3T3 cells. | 1992 Nov-Dec | Anticancer Res. | pmid:1338278 |
Ikushima S et al. | Gamma linolenic acid alters the cytotoxic activity of anticancer drugs on cultured human neuroblastoma cells. | 1990 Jul-Aug | Anticancer Res. | pmid:2166461 |
Anderson KM et al. | Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. | 1998 Mar-Apr | Anticancer Res. | pmid:9615721 |
Bégin ME et al. | Differential sensitivity of tumorigenic and genetically related non-tumorigenic cells to cytotoxic polyunsaturated fatty acids. | 1989 Jul-Aug | Anticancer Res. | pmid:2554786 |
De Antueno R et al. | Tissue distribution and metabolism of gamma-linolenoyl-3-eicosapentaenoyl propane diol enterally or intravenously administered to mice bearing human pancreatic carcinomas. | 1999 May-Jun | Anticancer Res. | pmid:10470146 |
Miyake JA et al. | Novel ruthenium - gamma-linolenic acid complex inhibits C6 rat glioma cell proliferation in vitro and in the orthotopic C6 model in vivo after osmotic pump infusion. | 2014 | Anticancer Res. | pmid:24692725 |
Sircar S et al. | Transformation renders MDR cells more sensitive to polyunsaturated fatty acids. | 1990 Nov-Dec | Anticancer Res. | pmid:2178327 |
Fearon KC et al. | An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. | 1996 Mar-Apr | Anticancer Res. | pmid:8687143 |
Kairemo KJ et al. | Effects of lithium gammalinolenate on the perfusion of liver and pancreatic tissues in pancreatic cancer. | 1997 Sep-Oct | Anticancer Res. | pmid:9427770 |