gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alcoholism D000437 27 associated lipids
Arteriosclerosis D001161 86 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Back Pain D001416 5 associated lipids
Bacteriuria D001437 7 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Dysmenorrhea D004412 9 associated lipids
Ecchymosis D004438 3 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Fallopian Tube Neoplasms D005185 1 associated lipids
Fatigue D005221 10 associated lipids
Fibrocystic Breast Disease D005348 1 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Gastritis D005756 27 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Glioma D005910 112 associated lipids
Hand Dermatoses D006229 5 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperplasia D006965 34 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Intermittent Claudication D007383 6 associated lipids
Kidney Calculi D007669 7 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Leukemia P388 D007941 43 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Melanoma D008545 69 associated lipids
Mucocele D009078 1 associated lipids
Nausea D009325 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Puri BK Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). 2007 J. Clin. Pathol. pmid:16935966
Noli C et al. Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. 2007 Vet. J. pmid:16495095
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Christie A et al. Effectiveness of nonpharmacological and nonsurgical interventions for patients with rheumatoid arthritis: an overview of systematic reviews. 2007 Phys Ther pmid:17906290
Dobryniewski J et al. [The gamma-linolenic acid (GLA)--the therapeutic value]. 2007 Prz. Lek. pmid:17892041
Theilla M et al. A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study. 2007 Clin Nutr pmid:17933438
Garaiova I et al. A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. 2007 Nutr J pmid:17254329
Das UN Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. 2007 Med. Sci. Monit. pmid:17599036
Schirmer MA and Phinney SD Gamma-linolenate reduces weight regain in formerly obese humans. 2007 J. Nutr. pmid:17513402
Curtis L High-quality enteral nutrition essential for reducing morbidity and mortality in acute care patients. 2007 Crit. Care Med. pmid:17421112
Ortiz-Leyba C and Garnacho-Montero J Saving lives in severe sepsis with the help of enteral nutrition. 2007 Crit. Care Med. pmid:17421113
Kanehara S et al. Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. 2007 J. Dermatol. pmid:18078406
Vrinten P et al. Production of polyunsaturated fatty acids in transgenic plants. 2007 Biotechnol. Genet. Eng. Rev. pmid:18059637
Stolyhwo A and Mol J Changes in the content of gamma-linolenic C18:3 (n-6) and stearidonic C18:4 (n-3) acids in developing seeds of viper's bugloss Echium vulgare L. 2007 Acta Biochim. Pol. pmid:18066400
Saied GM et al. Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females. 2007 Tanzan Health Res Bull pmid:18087899
Pinna A et al. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. 2007 Cornea pmid:17413949
Guil-Guerrero JL et al. Gamma-linolenic acid from Cape Verdian Boraginaceae. 2006 Nat. Prod. Res. pmid:16286301
Umeda-Sawada R et al. Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats. 2006 Biosci. Biotechnol. Biochem. pmid:16960355
Kim J et al. Comparative effect of gromwell (Lithospermum erythrorhizon) extract and borage oil on reversing epidermal hyperproliferation in guinea pigs. 2006 Biosci. Biotechnol. Biochem. pmid:16960390
Hatanaka E et al. Systematic study on ROS production induced by oleic, linoleic, and gamma-linolenic acids in human and rat neutrophils. 2006 Free Radic. Biol. Med. pmid:16962937
Pontes-Arruda A et al. Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. 2006 Crit. Care Med. pmid:16850002
Fakas S et al. Lipids of Cunninghamella echinulata with emphasis to gamma-linolenic acid distribution among lipid classes. 2006 Appl. Microbiol. Biotechnol. pmid:16850299
Kong X et al. Induction of apoptosis in K562/ADM cells by gamma-linolenic acid involves lipid peroxidation and activation of caspase-3. 2006 Chem. Biol. Interact. pmid:16857180
Pham H et al. Dietary gamma-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE(2) and 5S-HETE. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16567086
Singer P et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. 2006 Crit. Care Med. pmid:16484911
Das UN and Rao KP Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16488586
Martin TA et al. Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. 2006 J. Cell. Biochem. pmid:16514648
Pacht ER Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come. 2006 Crit. Care Med. pmid:16921322
Arab K et al. Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. 2006 Br. J. Nutr. pmid:17092368
Das UN Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives. 2006 Curr Pharm Biotechnol pmid:17168663
Morse NL and Clough PM A meta-analysis of randomized, placebo-controlled clinical trials of Efamol evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries? 2006 Curr Pharm Biotechnol pmid:17168667
Kapoor R and Huang YS Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. 2006 Curr Pharm Biotechnol pmid:17168669
DeMichele SJ et al. A nutritional strategy to improve oxygenation and decrease morbidity in patients who have acute respiratory distress syndrome. 2006 Respir Care Clin N Am pmid:17150431
Kim JJ et al. Properties of cholesterol-reduced butter made with beta-cyclodextrin and added evening primrose oil and phytosterols. 2006 J. Dairy Sci. pmid:17106080
Gasperino J and Kvetan V Acute lung injury and nutritional support. 2006 Crit. Care Med. pmid:16550085
Yu Z et al. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. 2006 J. Pharmacol. Exp. Ther. pmid:16421287
Tocher DR et al. Effect of diets enriched in Delta6 desaturated fatty acids (18:3n-6 and 18:4n-3), on growth, fatty acid composition and highly unsaturated fatty acid synthesis in two populations of Arctic charr (Salvelinus alpinus L.). 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16630735
Kitz R et al. Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. 2006 Pediatr Allergy Immunol pmid:16618360
Chen YC et al. Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. 2006 Am. J. Kidney Dis. pmid:16797388
Miles EA et al. Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820286
Hongsthong A et al. Revealing the complementation of ferredoxin by cytochrome b (5) in the Spirulina- (6)-desaturation reaction by N-terminal fusion and co-expression of the fungal-cytochrome b (5) domain and Spirulina- (6)-acyl-lipid desaturase. 2006 Appl. Microbiol. Biotechnol. pmid:16575563
Das UN Re: Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2006 J. Natl. Cancer Inst. pmid:16705127
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
Verhoeven MO et al. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. 2005 Jul-Aug Menopause pmid:16037756
Goyal A and Mansel RE A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. 2005 Jan-Feb Breast J pmid:15647077
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15810447
Menendez JA et al. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. 2005 Med. Hypotheses pmid:15607568
Vahedi K et al. A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients. 2005 Br. J. Nutr. pmid:16351767
Menendez JA et al. Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2005 J. Natl. Cancer Inst. pmid:16264182
Heard CM et al. Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. 2005 Int J Pharm pmid:16115741
Efstathopoulos N et al. N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850717
Oikawa D et al. Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. 2005 Br. J. Nutr. pmid:16115363
Vang K and Ziboh VA 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850718
Taweechaisupapong S et al. Evening primrose oil effects on osteoclasts during tooth movement. 2005 Angle Orthod pmid:15898373
Na-Ranong S et al. Substrate specificity and preference of Delta6-desaturase of Mucor rouxii. 2005 FEBS Lett. pmid:15862319
Cerolini S et al. Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels. 2005 Br. Poult. Sci. pmid:15957443
Hao YL et al. Cloning of delta6-desaturase from Mucor circinelloides and its high expression in Saccharomyces cerevisiae. 2005 Yi Chuan Xue Bao pmid:15931792
Tahvonen RL et al. Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. 2005 J. Nutr. Biochem. pmid:15936647
Seidel A et al. The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. 2005 J Vet Med A Physiol Pathol Clin Med pmid:15943605
Cury-Boaventura MF and Curi R Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. 2005 Clin. Sci. pmid:15563273
Hirasawa A et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. 2005 Nat. Med. pmid:15619630
Aragona P et al. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients. 2005 Invest. Ophthalmol. Vis. Sci. pmid:16303936
Takeno S et al. Molecular evidence that the rate-limiting step for the biosynthesis of arachidonic acid in Mortierella alpina is at the level of an elongase. 2005 Lipids pmid:15825827
Hrastinger A et al. Is there clinical evidence supporting the use of botanical dietary supplements in children? 2005 J. Pediatr. pmid:15756210
Watkins G et al. Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15763439
Qureshi S and Sultan N Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. 2005 Surgeon pmid:15789786
Patnayak S and Sree A Screening of bacterial associates of marine sponges for single cell oil and PUFA. 2005 Lett. Appl. Microbiol. pmid:15836739
Gillis RC et al. Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells. 2004 Sep-Oct JPEN J Parenter Enteral Nutr pmid:15449569
Torres CF et al. Lipase-catalyzed ethanolysis of borage oil: a kinetic study. 2004 May-Jun Biotechnol. Prog. pmid:15176879
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Li MC et al. [Heteologous expression of Mortierella isabellina delta6 -fatty acid desaturase gene in soybean]. 2004 Yi Chuan Xue Bao pmid:15481543
Gueck T et al. Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. 2004 Vet. Dermatol. pmid:15500483
Ho S et al. In-vitro transcutaneous delivery of tamoxifen and gamma-linolenic acid from borage oil containing ethanol and 1,8-cineole. 2004 J. Pharm. Pharmacol. pmid:15525441
Li MC et al. [Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:16108486
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Cheng Z et al. Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes. 2004 J. Endocrinol. pmid:15283685
Remans PH et al. Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. 2004 Eur J Clin Nutr pmid:15164103
Miles EA et al. The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. 2004 Br. J. Nutr. pmid:15182393
Liu JW et al. Effect of long-term dietary supplementation of high-gamma-linolenic canola oil versus borage oil on growth, hematology, serum biochemistry, and N-6 fatty acid metabolism in rats. 2004 J. Agric. Food Chem. pmid:15186123
Das UN Occlusion of infusion vessels on gamma-linolenic acid infusion. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643176
Papanikolaou S et al. Repression of reserve lipid turnover in Cunninghamella echinulata and Mortierella isabellina cultivated in multiple-limited media. 2004 J. Appl. Microbiol. pmid:15357737
Papanikolaou S et al. Single cell oil (SCO) production by Mortierella isabellina grown on high-sugar content media. 2004 Bioresour. Technol. pmid:15288271
Harrison RA et al. Who and how many people are taking herbal supplements? A survey of 21,923 adults. 2004 Int J Vitam Nutr Res pmid:15296076
Crowe DL and Chandraratna RA A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. 2004 Breast Cancer Res. pmid:15318936
Hirawa N and Umemura S [Prostaglandin/bradykinin]. 2004 Nippon Rinsho pmid:15250292
Bruder ED et al. Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. 2004 Endocrinology pmid:15271879
Pham H et al. Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. 2004 Int. J. Cancer pmid:15197770
Johnston GA et al. The use of dietary manipulation by parents of children with atopic dermatitis. 2004 Br. J. Dermatol. pmid:15214908
Saevik BK et al. A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. 2004 Vet. Dermatol. pmid:15214949
Ziboh VA et al. Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma. 2004 Clin. Dev. Immunol. pmid:15154607
Agombar A et al. An aqueous formulation of gamma-linolenic acid with anti-proliferative action on human pancreatic cancer cell lines. 2004 Anticancer Drugs pmid:15075672
Dokholyan RS et al. A trial of omega-3 fatty acids for prevention of hypertension. 2004 Am. J. Cardiol. pmid:15081453
van Gool CJ et al. Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. 2004 Br. J. Dermatol. pmid:15099370
Leaver HA et al. Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15062847
Miles EA et al. The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120716
Das UN From bench to the clinic: gamma-linolenic acid therapy of human gliomas. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120717
Gallagher S Omega 3 oils and pregnancy. 2004 Midwifery Today Int Midwife pmid:15124319
Karia C et al. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. 2004 Int J Pharm pmid:15129999
de La Puerta Vázquez R et al. Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. 2004 Metab. Clin. Exp. pmid:14681843
Menendez JA et al. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. 2004 Oncol. Rep. pmid:15138562