Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bordoni A et al. | Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. | 1997 | Biochim. Biophys. Acta | pmid:9366250 |
Larsen LN et al. | Polyunsaturated thia- and oxa-fatty acids: incorporation into cell-lipids and their effects on arachidonic acid- and eicosanoid synthesis. | 1997 | Biochim. Biophys. Acta | pmid:9366251 |
Ziboh VA et al. | gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. | 1997 | Lipids | pmid:9252965 |
De La Cruz JP et al. | Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. | 1997 | Thromb. Res. | pmid:9253809 |
Küpper C | [Premenstrual syndrome: does gamma-linolenic acid help?]. | 1997 | Fortschr. Med. | pmid:9173016 |
Vassilopoulos D et al. | Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. | 1997 | Clin. Immunol. Immunopathol. | pmid:9175912 |
Manninen P and Laakso P | Capillary supercritical fluid chromatography--atmospheric pressure chemical ionization mass spectrometry of gamma- and alpha-linolenic acid containing triacylglycerols in berry oils. | 1997 | Lipids | pmid:9270973 |
Fan YY et al. | Dietary gamma-linolenic acid enhances mouse macrophage-derived prostaglandin E1 which inhibits vascular smooth muscle cell proliferation. | 1997 | J. Nutr. | pmid:9278557 |
Jiang WG et al. | Gamma linolenic acid regulates expression of maspin and the motility of cancer cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299418 |
Mancuso P et al. | Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats. | 1997 | Crit. Care Med. | pmid:9233748 |
Johnson MM et al. | Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. | 1997 | J. Nutr. | pmid:9237935 |
Harbige LS et al. | Protective mechanisms by omega-6 lipids in experimental autoimmune encephalomyelitis (EAE) are associated with cytokines and eicosanoids. | 1997 | Biochem. Soc. Trans. | pmid:9191387 |
Fisher BA and Harbige LS | Effect of omega-6 lipid-rich borage oil feeding on immune function in healthy volunteers. | 1997 | Biochem. Soc. Trans. | pmid:9191388 |
Grajeta H and Biernat J | Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 2. Blood serum and liver fatty acids. | 1997 | Nahrung | pmid:9113671 |
Utsunomiya T | Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. | 1997 | Br J Surg | pmid:9117334 |
Mancuso P et al. | Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. | 1997 | Crit. Care Med. | pmid:9118672 |
Vartak S et al. | Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. | 1997 | Lipids | pmid:9076665 |
Bard JM et al. | A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. | 1997 | Fundam Clin Pharmacol | pmid:9107561 |
Fang C et al. | Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051726 |
Liang T and Liao S | Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase. | 1997 | J. Invest. Dermatol. | pmid:9242500 |
McGahon B et al. | The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. | 1997 | Neuroscience | pmid:9300396 |
Rossetti RG et al. | Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. | 1997 | J. Leukoc. Biol. | pmid:9335312 |
Horrobin DF | Essential fatty acids in the management of impaired nerve function in diabetes. | 1997 | Diabetes | pmid:9285506 |
Quoc KP and Dubacq JP | Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. | 1997 | Biochim. Biophys. Acta | pmid:9219908 |
Purasiri P et al. | Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. | 1997 | Immunology | pmid:9415022 |
de Antueno R et al. | In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas. | 1997 | Br. J. Cancer | pmid:9192987 |
Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
Mpanju O et al. | Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. | 1997 | Antivir. Ther. (Lond.) | pmid:11322262 |
Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
Steinbrunn BS et al. | Mastalgia. Tailoring treatment to type of breast pain. | 1997 | Postgrad Med | pmid:9385340 |
Tocher DR et al. | Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. | 1997 | Lipids | pmid:9438233 |
Morris GM et al. | Modulation of the cell kinetics of pig skin by the topical application of evening primrose oil or Lioxasol. | 1997 Aug-Sep | Cell Prolif. | pmid:9501921 |
Borrek S et al. | [Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study]. | 1997 May-Jun | Klin Padiatr | pmid:9244815 |
Palombo JD et al. | Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168366 |
Tollesson A et al. | Malassezia furfur in infantile seborrheic dermatitis. | 1997 Nov-Dec | Pediatr Dermatol | pmid:9436835 |
Kairemo KJ et al. | Effects of lithium gammalinolenate on the perfusion of liver and pancreatic tissues in pancreatic cancer. | 1997 Sep-Oct | Anticancer Res. | pmid:9427770 |
Andreassi M et al. | Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. | 1997 Sep-Oct | J. Int. Med. Res. | pmid:9364289 |
Willemaers V et al. | [Atopic dermatitis]. | 1998 | Rev Med Liege | pmid:9564223 |
Hørby Jørgensen M et al. | Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9552137 |
Solomon LZ et al. | Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. | 1998 | Urol. Res. | pmid:9537690 |
Kis M et al. | Light-induced expression of fatty acid desaturase genes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539715 |
Cameron NE et al. | Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. | 1998 | Diabetologia | pmid:9562342 |
Engler MM and Engler MB | Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758202 |
van Rooyen J et al. | Diet can manipulate the metabolism of EPA and GLA in erythrocyte membrane and plasma. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758205 |
Jiang WG et al. | gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. | 1998 | Int. J. Oncol. | pmid:9683802 |
Villalobos MA et al. | Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. | 1998 | Thromb. Haemost. | pmid:9798993 |
Eynard AR et al. | Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin and desmoglein in human squamous cell carcinoma in vitro. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10102382 |
Tanaka T et al. | Methylene-interrupted double bond in polyunsaturated fatty acid is an essential structure for metabolism by the fatty acid chain elongation system of rat liver. | 1998 | Biochim. Biophys. Acta | pmid:9748638 |
de Vries JE | [Painful breasts]. | 1998 | Ned Tijdschr Geneeskd | pmid:9749309 |
Ravichandran D et al. | Effect of lithium gamma-linolenate on the growth of experimental human pancreatic carcinoma. | 1998 | Br J Surg | pmid:9752859 |
Brouwer DA et al. | Gamma-linolenic acid does not augment long-chain polyunsaturated fatty acid omega-3 status. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9888208 |
Fan YY and Chapkin RS | Importance of dietary gamma-linolenic acid in human health and nutrition. | 1998 | J. Nutr. | pmid:9732298 |
Dirks J et al. | Cytokine levels affected by gamma-linolenic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849654 |
Seegers JC et al. | Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849656 |
Leng GC et al. | Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. | 1998 | Clin Nutr | pmid:10205349 |
Hounsom L et al. | A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. | 1998 | Diabetologia | pmid:9686927 |
Kumamoto T and Ide T | Comparative effects of alpha- and gamma-linolenic acids on rat liver fatty acid oxidation. | 1998 | Lipids | pmid:9688166 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
Ravichandran D et al. | Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. | 1998 | Eur. J. Cancer | pmid:9624256 |
Sanderson P and Calder PC | Dietary fish oil appears to prevent the activation of phospholipase C-gamma in lymphocytes. | 1998 | Biochim. Biophys. Acta | pmid:9630688 |
Martens-Lobenhoffer J and Meyer FP | Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). | 1998 | Int J Clin Pharmacol Ther | pmid:9707349 |
Johnson SR | Premenstrual syndrome therapy. | 1998 | Clin Obstet Gynecol | pmid:9646973 |
Engler MM et al. | Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. | 1998 | Proc. Soc. Exp. Biol. Med. | pmid:9648942 |
Giamarellos-Bourboulis EJ et al. | In vitro activity of polyunsaturated fatty acids on Pseudomonas aeruginosa: relationship to lipid peroxidation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654401 |
Kahler CP and Du Plooy WJ | Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654407 |
Solomon LZ et al. | Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? | 1998 | Br J Urol | pmid:9698674 |
Vartak S et al. | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. | 1998 | Br. J. Cancer | pmid:9635836 |
McGahon B et al. | Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study. | 1998 | Exp. Gerontol. | pmid:9639170 |
Reilly JD et al. | Effect of a supplementary dietary evening primrose oil mixture on hoof growth, hoof growth rate and hoof lipid fractions in horses: a controlled and blinded trial. | 1998 | Equine Vet J Suppl | pmid:9932095 |
Kruger MC et al. | Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. | 1998 | Aging (Milano) | pmid:9932142 |
Ramesh G and Das UN | Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844986 |
Kuruvilla R et al. | Evening primrose oil treatment corrects reduced conduction velocity but not depletion of arachidonic acid in nerve from streptozotocin-induced diabetic rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844993 |
Schellhammer PF | Intravesical chemotherapy with gamma linolenic acid becomes a reality. | 1998 | J. Urol. | pmid:9817299 |
Solomon LZ et al. | Intravesical chemotherapy with gamma linolenic acid becomes a realistic prospect in serum-free applications: in vitro cytotoxicity and systemic absorption studies. | 1998 | J. Urol. | pmid:9817384 |
Marra F et al. | Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. | 1998 | J. Hepatol. | pmid:9566835 |
Chen Q et al. | Analysis of the acyl-CoAs that accumulate during the peroxisomal beta-oxidation of arachidonic acid and 6,9,12-octadecatrienoic acid. | 1998 | Arch. Biochem. Biophys. | pmid:9448727 |
Jiang WG et al. | The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. | 1998 | Br. J. Cancer | pmid:9514051 |
Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
Jiang WG et al. | Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514943 |
Gu JY et al. | Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9836427 |
Kairemo KJ et al. | The effect of lithium gamma-linolenate therapy of pancreatic cancer on perfusion in liver and pancreatic tissues. | 1998 | Pancreas | pmid:9436871 |
Frati-Munari AC and Ariza-Andraca CR | [Treatment of diabetic neuropathy]. | 1998 Jan-Feb | Gac Med Mex | pmid:9658700 |
Oakley OR et al. | The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro. | 1998 Jan-Jun | Rom J Physiol | pmid:11000861 |
Burnard SL et al. | Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat. | 1998 Mar-Apr | J. Diabetes Complicat. | pmid:9559483 |
Anderson KM et al. | Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. | 1998 Mar-Apr | Anticancer Res. | pmid:9615721 |
Srinivas CV et al. | Safflower petals: a source of gamma linolenic acid. | 1999 | Plant Foods Hum Nutr | pmid:10646633 |
Hornych A et al. | Effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandins in old subjects. | 1999 | Br J Clin Pharmacol | pmid:10651470 |
Fan YY et al. | Modulation of atherogenesis by dietary gamma-linolenic acid. | 1999 | Adv. Exp. Med. Biol. | pmid:10667372 |
Vartak S et al. | The selective cytotoxicity of gamma-linolenic acid (GLA) is associated with increased oxidative stress. | 1999 | Adv. Exp. Med. Biol. | pmid:10667373 |
Robbins M et al. | gamma-linolenic acid (GLA)-mediated cytotoxicity in human prostate cancer cells. | 1999 | Adv. Exp. Med. Biol. | pmid:10667374 |
Harris JE et al. | Five-lipoxygenase inhibitors reduce Panc-1 survival: synergism of MK886 with gamma linolenic acid. | 1999 | Adv. Exp. Med. Biol. | pmid:10667375 |
Ramrath S et al. | Stimulation of cardiac glucose transport by thioctic acid and insulin. | 1999 | Horm. Metab. Res. | pmid:10668913 |
Motaung E et al. | Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670696 |
Davies CL et al. | Effect of gamma-linolenic acid on cellular uptake of structurally related anthracyclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines. | 1999 | Eur. J. Cancer | pmid:10673983 |
Warren G et al. | The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. | 1999 | Acta Neurol. Scand. | pmid:10071170 |
Muñoz SE et al. | Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. | 1999 | Nutrition | pmid:10198915 |
Tamimi NA et al. | Role of gamma-linolenic acid in uraemic pruritus. | 1999 | Nephron | pmid:10516500 |
Yoshimoto-Furuie K et al. | Effects of oral supplementation with evening primrose oil for six weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients. | 1999 | Nephron | pmid:9933750 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Redden PR et al. | Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. | 1999 | Int J Pharm | pmid:10370185 |