Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Vahedi K et al. | A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients. | 2005 | Br. J. Nutr. | pmid:16351767 |
Oikawa D et al. | Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. | 2005 | Br. J. Nutr. | pmid:16115363 |
Huang YS et al. | Effects of repeated gestation and lactation on milk n-6 fatty acid composition in rats fed on a diet rich in 18:2n-6 or 18:3n-6. | 1992 | Br. J. Nutr. | pmid:1445816 |
Arab K et al. | Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. | 2006 | Br. J. Nutr. | pmid:17092368 |
Dodge JA et al. | Paradoxical effects of essential fatty acid supplementation on lipid profiles and sweat electrolytes in cystic fibrosis. | 1990 | Br. J. Nutr. | pmid:2185826 |
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Miles EA et al. | The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. | 2004 | Br. J. Nutr. | pmid:15182393 |
Safarinejad MR et al. | Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. | 2013 | Br. J. Nutr. | pmid:23199523 |
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Daneshmand R et al. | Associations of estimated Δ-5-desaturase and Δ-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2017 | Br. J. Nutr. | pmid:28382895 |
Harbige LS et al. | Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. | 1995 | Br. J. Nutr. | pmid:8541276 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Leigh-Firbank EC et al. | Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. | 2002 | Br. J. Nutr. | pmid:12010583 |
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Lockett MJ and Tomlinson DR | The effects of dietary treatment with essential fatty acids on sciatic nerve conduction and activity of the Na+/K+ pump in streptozotocin-diabetic rats. | 1992 | Br. J. Pharmacol. | pmid:1313726 |
Cameron NE et al. | The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. | 1993 | Br. J. Pharmacol. | pmid:8401950 |
Omawari N et al. | Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. | 1996 | Br. J. Pharmacol. | pmid:8733594 |
Veale DJ et al. | A double-blind placebo controlled trial of Efamol Marine on skin and joint symptoms of psoriatic arthritis. | 1994 | Br. J. Rheumatol. | pmid:7921757 |
Leventhal LJ et al. | Treatment of rheumatoid arthritis with blackcurrant seed oil. | 1994 | Br. J. Rheumatol. | pmid:8081671 |
Brzeski M et al. | Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. | 1991 | Br. J. Rheumatol. | pmid:1913008 |
Gateley CA and Mansel RE | Management of the painful and nodular breast. | 1991 | Br. Med. Bull. | pmid:1834299 |
Cerolini S et al. | Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels. | 2005 | Br. Poult. Sci. | pmid:15957443 |
Murai A et al. | Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. | 1995 | Br. Poult. Sci. | pmid:8746984 |
BÃró K et al. | Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. | 1997 | Brain Res. Bull. | pmid:9323440 |
Hornych A et al. | The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. | 2002 | Bratisl Lek Listy | pmid:12190041 |
Crowe DL and Chandraratna RA | A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. | 2004 | Breast Cancer Res. | pmid:15318936 |
Menéndez JA et al. | Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. | 2002 | Breast Cancer Res. Treat. | pmid:12058962 |
Chajès V et al. | Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E. | 1995 | Breast Cancer Res. Treat. | pmid:7579484 |
Goyal A and Mansel RE | A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. | 2005 Jan-Feb | Breast J | pmid:15647077 |
Sharma N et al. | Mastalgia cured! Randomized trial comparing centchroman to evening primrose oil. | 2012 | Breast J | pmid:22892074 |
Paccalin J et al. | [Rediscovery of an oleaginous plant: Oenothera biennis. The importance of gamma-linolenic acid in nutrition]. | 1983 | Bull. Acad. Natl. Med. | pmid:6324965 |
Girault C et al. | Effect of dietary gamma-linolenic acid on specific activities of delta 6 desaturation in obese Zucker rats. | 1992 | C. R. Seances Soc. Biol. Fil. | pmid:1337306 |
Poulsen RC et al. | Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. | 2007 | Calcif. Tissue Int. | pmid:18008020 |
Leyton E | Disagreeing on how to treat CFS patients. | 1993 | Can Fam Physician | pmid:8347205 |
Each of the following has been shown to be effective for cyclical breast pain. | 1996 | Can Fam Physician | pmid:8704485 | |
Soma M et al. | The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. | 1985 | Can. J. Physiol. Pharmacol. | pmid:4005704 |
Prociuk MA et al. | Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. | 2008 | Can. J. Physiol. Pharmacol. | pmid:18418423 |
Harris NM et al. | Epirubicin and meglumine gamma-linolenic acid: a logical choice of combination therapy for patients with superficial bladder carcinoma. | 2003 | Cancer | pmid:12491507 |
González CA et al. | Borage consumption as a possible gastric cancer protective factor. | 1993 Mar-Apr | Cancer Epidemiol. Biomarkers Prev. | pmid:8385521 |
Pham H et al. | Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells. | 2003 | Cancer Lett. | pmid:12445673 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Arimura T et al. | Caspase-independent apoptosis induced by evening primrose extract in Ehrlich ascites tumor cells. | 2003 | Cancer Lett. | pmid:14580681 |
Ito Y et al. | Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. | 2001 | Cancer Lett. | pmid:11165751 |
Agatha G et al. | Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. | 2001 | Cancer Lett. | pmid:11597788 |
Cantrill RC et al. | Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture. | 1993 | Cancer Lett. | pmid:8402582 |
Ells GW et al. | Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. | 1996 | Cancer Lett. | pmid:8556710 |
Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
Das UN | Tumoricidal action of cis-unsaturated fatty acids and their relationship to free radicals and lipid peroxidation. | 1991 | Cancer Lett. | pmid:1850658 |
Das UN et al. | Local application of gamma-linolenic acid in the treatment of human gliomas. | 1995 | Cancer Lett. | pmid:7634242 |