Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pakala R et al. | Eicosapentaenoic acid and docosahexaenoic acid selectively attenuate U46619-induced smooth muscle cell proliferation. | 1999 | Lipids | pmid:10574655 |
Ward GR et al. | Effects of gamma-linolenic acid and docosahexaenoic acid in formulae on brain fatty acid composition in artificially reared rats. | 1999 | Lipids | pmid:10580333 |
Joubert AM et al. | Comparative study of the effects of polyunsaturated fatty acids and their metabolites on cell growth and tyrosine kinase activity in oesophageal carcinoma cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582657 |
Bell HS et al. | Effects of N-6 essential fatty acids on glioma invasion and growth: experimental studies with glioma spheroids in collagen gels. | 1999 | J. Neurosurg. | pmid:10584845 |
Cai J et al. | Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10319914 |
Ihara-Watanabe M et al. | Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10327618 |
Giamarellos-Bourboulis EJ et al. | In vitro interactions of gamma-linolenic acid and arachidonic acid with ceftazidime on multiresistant Pseudomonas aeruginosa. | 1999 | Lipids | pmid:10419130 |
Hrelia S et al. | Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397404 |
Pakala R et al. | Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397410 |
Woltil HA et al. | Does supplementation of formula with evening primrose and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts? | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359022 |
DeLuca P et al. | Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo. | 1999 | J. Investig. Med. | pmid:10361385 |
Ilc K et al. | Cytotoxic effects of two gamma linoleic salts (lithium gammalinolenate or meglumine gammalinolenate) alone or associated with a nitrosourea: an experimental study on human glioblastoma cell lines. | 1999 | Anticancer Drugs | pmid:10378677 |
Tsevegsüren N et al. | Occurrence of gamma-linolenic acid in compositae: a study of Youngia tenuicaulis seed oil. | 1999 | Lipids | pmid:10380126 |
Wolf LA and Laster SM | Characterization of arachidonic acid-induced apoptosis. | 1999 | Cell Biochem. Biophys. | pmid:10403056 |
Cai J et al. | Inhibition of the expression of VE-cadherin/catenin complex by gamma linolenic acid in human vascular endothelial cells, and its impact on angiogenesis. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10222244 |
Leaver HA et al. | Dynamics of reactive oxygen intermediate production in human glioma: n-6 essential fatty acid effects. | 1999 | Eur. J. Clin. Invest. | pmid:10202379 |
Tamimi NA et al. | Role of gamma-linolenic acid in uraemic pruritus. | 1999 | Nephron | pmid:10516500 |
Wu D et al. | Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. | 1999 | Am. J. Clin. Nutr. | pmid:10500023 |
Peterson LD et al. | Dose-dependent effects of dietary gamma-linolenic acid on rat spleen lymphocyte functions. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10477037 |
Haag M et al. | Polyunsaturated fatty acids inhibit Mg2+ -ATPase in basolateral membranes from rat enterocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10477038 |
Huang YS et al. | Cloning of delta12- and delta6-desaturases from Mortierella alpina and recombinant production of gamma-linolenic acid in Saccharomyces cerevisiae. | 1999 | Lipids | pmid:10478922 |
Gadek JE et al. | Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. | 1999 | Crit. Care Med. | pmid:10470743 |
Passorn S et al. | Heterologous expression of Mucor rouxii delta(12)-desaturase gene in Saccharomyces cerevisiae. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10486251 |
Patel J and Tomlinson DR | Nerve conduction impairment in experimental diabetes-proximodistal gradient of severity. | 1999 | Muscle Nerve | pmid:10487907 |
Palombo JD et al. | Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats. | 1999 | Crit. Care Med. | pmid:10507617 |
Senanayake SP and Shahidi F | Enzyme-assisted acidolysis of borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils: incorporation of omega-3 polyunsaturated fatty acids. | 1999 | J. Agric. Food Chem. | pmid:10552616 |
Gehring W et al. | Effect of topically applied evening primrose oil on epidermal barrier function in atopic dermatitis as a function of vehicle. | 1999 | Arzneimittelforschung | pmid:10442214 |
Cheung KL | Management of cyclical mastalgia in oriental women: pioneer experience of using gamolenic acid (Efamast) in Asia. | 1999 | Aust N Z J Surg | pmid:10442919 |
De La Cruz JP et al. | Antioxidant potential of evening primrose oil administration in hyperlipemic rabbits. | 1999 | Life Sci. | pmid:10462081 |
Schwartz Z et al. | Arachidonic acid directly mediates the rapid effects of 24,25-dihydroxyvitamin D3 via protein kinase C and indirectly through prostaglandin production in resting zone chondrocytes. | 1999 | Endocrinology | pmid:10385391 |
Henz BM et al. | Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. | 1999 | Br. J. Dermatol. | pmid:10233322 |
Likhodii SS and Cunnane SC | Uptake of 13C-tracer arachidonate and gamma-linolenate by the brain and liver of the suckling rat observed using 13C-NMR. | 1999 | J. Neurochem. | pmid:10349866 |
Khamaisi M et al. | Metabolic effects of gamma-linolenic acid-alpha-lipoic acid conjugate in streptozotocin diabetic rats. | 1999 | Antioxid. Redox Signal. | pmid:11233149 |
Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Redden PR et al. | Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. | 1999 | Int J Pharm | pmid:10370185 |
Burnard SL et al. | Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat. | 1998 Mar-Apr | J. Diabetes Complicat. | pmid:9559483 |
Anderson KM et al. | Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. | 1998 Mar-Apr | Anticancer Res. | pmid:9615721 |
Oakley OR et al. | The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro. | 1998 Jan-Jun | Rom J Physiol | pmid:11000861 |
Frati-Munari AC and Ariza-Andraca CR | [Treatment of diabetic neuropathy]. | 1998 Jan-Feb | Gac Med Mex | pmid:9658700 |
Willemaers V et al. | [Atopic dermatitis]. | 1998 | Rev Med Liege | pmid:9564223 |
Hørby Jørgensen M et al. | Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9552137 |
Solomon LZ et al. | Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. | 1998 | Urol. Res. | pmid:9537690 |
Kis M et al. | Light-induced expression of fatty acid desaturase genes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539715 |
Cameron NE et al. | Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. | 1998 | Diabetologia | pmid:9562342 |
Engler MM and Engler MB | Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758202 |
van Rooyen J et al. | Diet can manipulate the metabolism of EPA and GLA in erythrocyte membrane and plasma. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758205 |
Jiang WG et al. | gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. | 1998 | Int. J. Oncol. | pmid:9683802 |
Villalobos MA et al. | Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. | 1998 | Thromb. Haemost. | pmid:9798993 |
Eynard AR et al. | Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin and desmoglein in human squamous cell carcinoma in vitro. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10102382 |
Tanaka T et al. | Methylene-interrupted double bond in polyunsaturated fatty acid is an essential structure for metabolism by the fatty acid chain elongation system of rat liver. | 1998 | Biochim. Biophys. Acta | pmid:9748638 |
de Vries JE | [Painful breasts]. | 1998 | Ned Tijdschr Geneeskd | pmid:9749309 |
Ravichandran D et al. | Effect of lithium gamma-linolenate on the growth of experimental human pancreatic carcinoma. | 1998 | Br J Surg | pmid:9752859 |
Brouwer DA et al. | Gamma-linolenic acid does not augment long-chain polyunsaturated fatty acid omega-3 status. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9888208 |
Fan YY and Chapkin RS | Importance of dietary gamma-linolenic acid in human health and nutrition. | 1998 | J. Nutr. | pmid:9732298 |
Dirks J et al. | Cytokine levels affected by gamma-linolenic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849654 |
Seegers JC et al. | Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849656 |
Leng GC et al. | Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. | 1998 | Clin Nutr | pmid:10205349 |
Hounsom L et al. | A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. | 1998 | Diabetologia | pmid:9686927 |
Kumamoto T and Ide T | Comparative effects of alpha- and gamma-linolenic acids on rat liver fatty acid oxidation. | 1998 | Lipids | pmid:9688166 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
Ravichandran D et al. | Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. | 1998 | Eur. J. Cancer | pmid:9624256 |
Sanderson P and Calder PC | Dietary fish oil appears to prevent the activation of phospholipase C-gamma in lymphocytes. | 1998 | Biochim. Biophys. Acta | pmid:9630688 |
Martens-Lobenhoffer J and Meyer FP | Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). | 1998 | Int J Clin Pharmacol Ther | pmid:9707349 |
Johnson SR | Premenstrual syndrome therapy. | 1998 | Clin Obstet Gynecol | pmid:9646973 |
Engler MM et al. | Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. | 1998 | Proc. Soc. Exp. Biol. Med. | pmid:9648942 |
Giamarellos-Bourboulis EJ et al. | In vitro activity of polyunsaturated fatty acids on Pseudomonas aeruginosa: relationship to lipid peroxidation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654401 |
Kahler CP and Du Plooy WJ | Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654407 |
Solomon LZ et al. | Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? | 1998 | Br J Urol | pmid:9698674 |
Vartak S et al. | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. | 1998 | Br. J. Cancer | pmid:9635836 |
McGahon B et al. | Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study. | 1998 | Exp. Gerontol. | pmid:9639170 |
Reilly JD et al. | Effect of a supplementary dietary evening primrose oil mixture on hoof growth, hoof growth rate and hoof lipid fractions in horses: a controlled and blinded trial. | 1998 | Equine Vet J Suppl | pmid:9932095 |
Kruger MC et al. | Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. | 1998 | Aging (Milano) | pmid:9932142 |
Ramesh G and Das UN | Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844986 |
Kuruvilla R et al. | Evening primrose oil treatment corrects reduced conduction velocity but not depletion of arachidonic acid in nerve from streptozotocin-induced diabetic rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844993 |
Schellhammer PF | Intravesical chemotherapy with gamma linolenic acid becomes a reality. | 1998 | J. Urol. | pmid:9817299 |
Solomon LZ et al. | Intravesical chemotherapy with gamma linolenic acid becomes a realistic prospect in serum-free applications: in vitro cytotoxicity and systemic absorption studies. | 1998 | J. Urol. | pmid:9817384 |
Marra F et al. | Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. | 1998 | J. Hepatol. | pmid:9566835 |
Chen Q et al. | Analysis of the acyl-CoAs that accumulate during the peroxisomal beta-oxidation of arachidonic acid and 6,9,12-octadecatrienoic acid. | 1998 | Arch. Biochem. Biophys. | pmid:9448727 |
Jiang WG et al. | The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. | 1998 | Br. J. Cancer | pmid:9514051 |
Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
Jiang WG et al. | Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514943 |
Gu JY et al. | Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9836427 |
Kairemo KJ et al. | The effect of lithium gamma-linolenate therapy of pancreatic cancer on perfusion in liver and pancreatic tissues. | 1998 | Pancreas | pmid:9436871 |
Kairemo KJ et al. | Effects of lithium gammalinolenate on the perfusion of liver and pancreatic tissues in pancreatic cancer. | 1997 Sep-Oct | Anticancer Res. | pmid:9427770 |
Andreassi M et al. | Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. | 1997 Sep-Oct | J. Int. Med. Res. | pmid:9364289 |
Tollesson A et al. | Malassezia furfur in infantile seborrheic dermatitis. | 1997 Nov-Dec | Pediatr Dermatol | pmid:9436835 |
Borrek S et al. | [Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study]. | 1997 May-Jun | Klin Padiatr | pmid:9244815 |
Palombo JD et al. | Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168366 |
Morris GM et al. | Modulation of the cell kinetics of pig skin by the topical application of evening primrose oil or Lioxasol. | 1997 Aug-Sep | Cell Prolif. | pmid:9501921 |
Bordoni A et al. | Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. | 1997 | Biochim. Biophys. Acta | pmid:9366250 |
Larsen LN et al. | Polyunsaturated thia- and oxa-fatty acids: incorporation into cell-lipids and their effects on arachidonic acid- and eicosanoid synthesis. | 1997 | Biochim. Biophys. Acta | pmid:9366251 |
Kokura S et al. | Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. | 1997 | Cancer Res. | pmid:9187121 |
Magnusson G et al. | Plasma and tissue levels of lipids, fatty acids and plasma carnitine in neonates receiving a new fat emulsion. | 1997 | Acta Paediatr. | pmid:9202801 |
Garland HO et al. | Dietary essential fatty acid supplementation, urinary calcium excretion and reproductive performance in the diabetic pregnant rat. | 1997 | J. Endocrinol. | pmid:9203989 |
Murray MJ and Zhang T | The incorporation of dietary n-3 polyunsaturated fatty acids into porcine platelet phospholipids and their effects on platelet thromboxane A2 release. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089803 |
Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
Pohl CH et al. | The production of gamma-linolenic acid by selected members of the Dikaryomycota grown on different carbon sources. | 1997 | Antonie Van Leeuwenhoek | pmid:9403104 |
Jiang WG et al. | Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids. | 1997 | Clin. Exp. Metastasis | pmid:9344043 |
Campbell EM et al. | Premenstrual symptoms in general practice patients. Prevalence and treatment. | 1997 | J Reprod Med | pmid:9350019 |