gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
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Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bordoni A et al. | Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. | 1997 | Biochim. Biophys. Acta | pmid:9366250 |
| Larsen LN et al. | Polyunsaturated thia- and oxa-fatty acids: incorporation into cell-lipids and their effects on arachidonic acid- and eicosanoid synthesis. | 1997 | Biochim. Biophys. Acta | pmid:9366251 |
| Ziboh VA et al. | gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. | 1997 | Lipids | pmid:9252965 |
| De La Cruz JP et al. | Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. | 1997 | Thromb. Res. | pmid:9253809 |
| Küpper C | [Premenstrual syndrome: does gamma-linolenic acid help?]. | 1997 | Fortschr. Med. | pmid:9173016 |
| Vassilopoulos D et al. | Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. | 1997 | Clin. Immunol. Immunopathol. | pmid:9175912 |
| Manninen P and Laakso P | Capillary supercritical fluid chromatography--atmospheric pressure chemical ionization mass spectrometry of gamma- and alpha-linolenic acid containing triacylglycerols in berry oils. | 1997 | Lipids | pmid:9270973 |
| Fan YY et al. | Dietary gamma-linolenic acid enhances mouse macrophage-derived prostaglandin E1 which inhibits vascular smooth muscle cell proliferation. | 1997 | J. Nutr. | pmid:9278557 |
| Jiang WG et al. | Gamma linolenic acid regulates expression of maspin and the motility of cancer cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299418 |
| Mancuso P et al. | Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats. | 1997 | Crit. Care Med. | pmid:9233748 |
| Johnson MM et al. | Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. | 1997 | J. Nutr. | pmid:9237935 |
| Harbige LS et al. | Protective mechanisms by omega-6 lipids in experimental autoimmune encephalomyelitis (EAE) are associated with cytokines and eicosanoids. | 1997 | Biochem. Soc. Trans. | pmid:9191387 |
| Fisher BA and Harbige LS | Effect of omega-6 lipid-rich borage oil feeding on immune function in healthy volunteers. | 1997 | Biochem. Soc. Trans. | pmid:9191388 |
| Jiang WG et al. | Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150377 |
| Biernat J and Grajeta H | Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 1. Blood serum and liver lipids. | 1997 | Nahrung | pmid:9113670 |
| Grajeta H and Biernat J | Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 2. Blood serum and liver fatty acids. | 1997 | Nahrung | pmid:9113671 |
| Utsunomiya T | Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. | 1997 | Br J Surg | pmid:9117334 |
| Mancuso P et al. | Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. | 1997 | Crit. Care Med. | pmid:9118672 |
| Vartak S et al. | Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. | 1997 | Lipids | pmid:9076665 |
| Bard JM et al. | A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. | 1997 | Fundam Clin Pharmacol | pmid:9107561 |
| Fang C et al. | Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051726 |
| Liang T and Liao S | Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase. | 1997 | J. Invest. Dermatol. | pmid:9242500 |
| McGahon B et al. | The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. | 1997 | Neuroscience | pmid:9300396 |
| Rossetti RG et al. | Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. | 1997 | J. Leukoc. Biol. | pmid:9335312 |
| Horrobin DF | Essential fatty acids in the management of impaired nerve function in diabetes. | 1997 | Diabetes | pmid:9285506 |
| Quoc KP and Dubacq JP | Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. | 1997 | Biochim. Biophys. Acta | pmid:9219908 |
| Purasiri P et al. | Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. | 1997 | Immunology | pmid:9415022 |
| de Antueno R et al. | In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas. | 1997 | Br. J. Cancer | pmid:9192987 |
| Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
| Mpanju O et al. | Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. | 1997 | Antivir. Ther. (Lond.) | pmid:11322262 |
| Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
| Steinbrunn BS et al. | Mastalgia. Tailoring treatment to type of breast pain. | 1997 | Postgrad Med | pmid:9385340 |
| Tocher DR et al. | Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. | 1997 | Lipids | pmid:9438233 |
| Fearon KC et al. | An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. | 1996 Mar-Apr | Anticancer Res. | pmid:8687143 |
| Whitaker DK et al. | Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. | 1996 | Dermatology (Basel) | pmid:8884146 |
| Sutton GC | 'Too tired to go to the support group': a health needs assessment of myalgic encephalomyelitis. | 1996 | J Public Health Med | pmid:8887847 |
| Cameron NE and Cotter MA | Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats. | 1996 | Am. J. Physiol. | pmid:8843740 |
| Williams WV et al. | Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes. | 1996 | Pathobiology | pmid:8856792 |
| Deferne JL and Leeds AR | Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. | 1996 | J Hum Hypertens | pmid:8895037 |
| Papanikolaou N et al. | Effects of OKY-046 and nifedipine in cyclosporine-induced renal dysfunction in rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951993 |
| Dines KC et al. | Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931113 |
| Matsuo N et al. | Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951990 |
| Zurier RB et al. | gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. | 1996 | Arthritis Rheum. | pmid:8912502 |
| Wigmore SJ et al. | The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. | 1996 | Nutrition | pmid:8850216 |
| Jenkins AP et al. | Essential fatty acid supplementation in chronic hepatitis B. | 1996 | Aliment. Pharmacol. Ther. | pmid:8853774 |
| de Kock M et al. | The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014218 |
| Hederos CA and Berg A | Epogam evening primrose oil treatment in atopic dermatitis and asthma. | 1996 | Arch. Dis. Child. | pmid:9014601 |
| Ingram AJ et al. | Dietary alteration of dihomogamma-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. The Nutrition & Kidney Disease Research Group. | 1996 | J. Am. Soc. Nephrol. | pmid:8829117 |
| Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
| Cameron NE and Cotter MA | Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. | 1996 | Diabetologia | pmid:8877288 |
| Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
| Reddy AS and Thomas TL | Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid production in transgenic plants. | 1996 | Nat. Biotechnol. | pmid:9630958 |
| Sadi AM et al. | Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. | 1996 | Exp. Anim. | pmid:8689581 |
| Huang Z et al. | Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. | 1996 | Biochemistry | pmid:8619991 |
| Cameron NE et al. | Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. | 1996 | Diabetologia | pmid:8635669 |
| Leaver HA et al. | Arachidonic acid activation of monocyte and neutrophil reactive oxygen in lung cancer patients undergoing pulmonary resection. | 1996 | Biologicals | pmid:9088546 |
| Chilton SA | Cognitive behaviour therapy for the chronic fatigue syndrome. Evening primrose oil and magnesium have been shown to be effective. | 1996 | BMJ | pmid:8616424 |
| Cantrill RC et al. | Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. | 1996 | Cancer Lett. | pmid:8620439 |
| Wainwright PE et al. | Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior. | 1996 | Pharmacol. Biochem. Behav. | pmid:8801587 |
| Quoc KP and Pascaud M | Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. | 1996 | Ann. Nutr. Metab. | pmid:8773734 |
| Hrelia S et al. | gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid composition. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753781 |
| Fan YY et al. | Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro. | 1996 | J. Nutr. | pmid:8814195 |
| Omawari N et al. | Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. | 1996 | Br. J. Pharmacol. | pmid:8733594 |
| Sherrington EJ et al. | The effect of dietary lipid manipulation on the uptake of [3H]-triolein by tissues of the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736833 |
| Grant D et al. | The antioxidant activity of heparins. | 1996 | Biochem. Soc. Trans. | pmid:8736852 |
| Stainforth JM et al. | Clinical aspects of the use of gamma linolenic acid in systemic sclerosis. | 1996 | Acta Derm. Venereol. | pmid:8740271 |
| Budeiri D et al. | Is evening primrose oil of value in the treatment of premenstrual syndrome? | 1996 | Control Clin Trials | pmid:8721802 |
| Each of the following has been shown to be effective for cyclical breast pain. | 1996 | Can Fam Physician | pmid:8704485 | |
| Schöpf E et al. | [Gamma-linolenic acid in atopic patients?]. | 1996 | Med Monatsschr Pharm | pmid:8684312 |
| Jiang WG et al. | Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. | 1996 | Br J Surg | pmid:8689213 |
| McCarty MF | Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. | 1996 | Med. Hypotheses | pmid:8692033 |
| Ells GW et al. | Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. | 1996 | Cancer Lett. | pmid:8556710 |
| Palombo JD et al. | Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. | 1996 | Am. J. Clin. Nutr. | pmid:8561062 |
| Chilton-Lopez ME et al. | Metabolism of gammalinolenic acid in human neutrophils. | 1996 | J. Immunol. | pmid:8609415 |
| Redden PR et al. | Comparison of the grignard deacylation TLC and HPLC methods and high resolution 13C-NMR for the sn-2 positional analysis of triacylglycerols containing gamma-linolenic acid. | 1996 | Chem. Phys. Lipids | pmid:8907238 |
| Julu PO et al. | Endogenous cyclo-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925193 |
| Julu PO | Latency of neuroactivity and optimum period of treatment with evening primrose oil in diabetic rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925199 |
| Sasaki S et al. | Effects of gamma-linolenic and eicosapentaenoic acids on blood pressure in SHR. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072404 |
| Berth-Jones J et al. | Evening primrose oil and atopic eczema. | 1995 | Lancet | pmid:7861894 |
| Morris GM et al. | Trophic effects of essential fatty acids on pig skin. | 1995 | Cell Prolif. | pmid:7893841 |
| Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
| Scholey JW and Mills DE | Dietary fatty acids and the glomerular hemodynamic response to cyclosporine in borderline hypertensive rats. | 1995 | Kidney Int. | pmid:7723248 |
| Fan YY et al. | Dietary gamma-linolenic acid modulates macrophage-vascular smooth muscle cell interactions. Evidence for a macrophage-derived soluble factor that downregulates DNA synthesis in smooth muscle cells. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670954 |
| Sherrington EJ et al. | The effect of dietary lipid manipulation on macrophage cell surface molecule expression. | 1995 | Biochem. Soc. Trans. | pmid:7672298 |
| Karasu C et al. | Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids. | 1995 | Diabetologia | pmid:7713308 |
| Dines KC et al. | Comparison of the effects of evening primrose oil and triglycerides containing gamma-linolenic acid on nerve conduction and blood flow in diabetic rats. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7714803 |
| Murray MJ et al. | Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. | 1995 | Am. J. Physiol. | pmid:8594921 |
| Bell JG et al. | Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577782 |
| Rothman D et al. | Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. | 1995 | Semin. Arthritis Rheum. | pmid:8578315 |
| Dines CD et al. | Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin. | 1995 | Eur. J. Pharmacol. | pmid:8521914 |
| Koba K et al. | Distribution of plasma phosphatidylcholine molecular species in rabbits fed fish oil is modulated by dietary n-6 fatty acids. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8821127 |
| Leichsenring M et al. | (n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. | 1995 | Pediatr Allergy Immunol | pmid:8822394 |
| Meehan E et al. | Influence of an n-6 polyunsaturated fatty acid-enriched diet on the development of tolerance during chronic ethanol administration in rats. | 1995 | Alcohol. Clin. Exp. Res. | pmid:8749808 |
| de Bravo MG et al. | [Effect of dietary supplementation with gamma-linolenic acid on the growth of a human lung carcinoma implanted in nude mice]. | 1995 | Medicina (B Aires) | pmid:8731577 |
| Giamarellos-Bourboulis EJ et al. | In-vitro inhibitory activity of gamma-linolenic acid on Escherichia coli strains and its influence on their susceptibilities to various antimicrobial agents. | 1995 | J. Antimicrob. Chemother. | pmid:8522462 |
| Burgess NA et al. | Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. | 1995 | Urol. Res. | pmid:8533210 |
| Harbige LS et al. | Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. | 1995 | Br. J. Nutr. | pmid:8541276 |
| Sture GH and Lloyd DH | Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. | 1995 | Vet. Rec. | pmid:8553525 |
| Cartwright-Shamoon JM et al. | A complex biochemical modulation of intestinal ion transport in rats fed on high-fat diets. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7884616 |
| Karikó K et al. | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. | 1995 | FEBS Lett. | pmid:7890029 |