Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fuller MA et al. | Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity. | 2001 | Arch. Biochem. Biophys. | pmid:11361131 |
Kamphuis MM et al. | Fat-specific satiety in humans for fat high in linoleic acid vs fat high in oleic acid. | 2001 | Eur J Clin Nutr | pmid:11423927 |
Chakrabarti KB et al. | Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane). | 2001 | Eur. J. Cancer | pmid:11435077 |
Banni S et al. | Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | 2001 | Nutr Cancer | pmid:12094634 |
OlguÃn EJ et al. | The effect of low light flux and nitrogen deficiency on the chemical composition of Spirulina sp. (Arthrospira) grown on digested pig waste. | 2001 | Bioresour. Technol. | pmid:11211071 |
Hounsom L et al. | Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. | 2001 | Diabetologia | pmid:11357471 |
Goffman FD and Galletti S | Gamma-linolenic acid and tocopherol contents in the seed oil of 47 accessions from several Ribes species. | 2001 | J. Agric. Food Chem. | pmid:11170598 |
Conti E et al. | gamma-Linolenic acid production by solid-state fermentation of Mucorales strains on cereals. | 2001 | Bioresour. Technol. | pmid:11198184 |
Agatha G et al. | Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. | 2001 | Cancer Lett. | pmid:11597788 |
Wollheim FA | [Meager support for herbal therapy of rheumatoid arthritis]. | 2001 | Lakartidningen | pmid:11699249 |
Kast RE | Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. | 2001 | Int. Immunopharmacol. | pmid:11710548 |
Ide T et al. | Dietary mold oil rich in gamma linolenic acid increases insulin-dependent glucose utilization in isolated rat adipocytes. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11567903 |
Kaku S et al. | Dietary gamma-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728173 |
Colquhoun A and Schumacher RI | gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells. | 2001 | Biochim. Biophys. Acta | pmid:11731331 |
Birch AE et al. | Antioxidant properties of evening primrose seed extracts. | 2001 | J. Agric. Food Chem. | pmid:11559161 |
Demmelmair H et al. | Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants. | 2001 | Lipids | pmid:11485158 |
Guil-Guerrero JL et al. | Occurrence and characterization of oils rich in gamma-linolenic acid (III): the taxonomical value of the fatty acids in Echium (Boraginaceae). | 2001 | Phytochemistry | pmid:11524120 |
Ford I et al. | The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. | 2001 | Metab. Clin. Exp. | pmid:11474472 |
Tsimaratos M et al. | Gamma-linolenic acid restores renal medullary thick ascending limb Na(+),K(+)-ATPase activity in diabetic rats. | 2001 | J. Nutr. | pmid:11739860 |
Thies F et al. | Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. | 2001 | Lipids | pmid:11795850 |
Kaku S et al. | Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302164 |
Fan YY et al. | Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. | 2001 | J. Nutr. | pmid:11385052 |
Nwankwo JO | Repression of cellular anaplerosis as the hypothesized mechanism of gamma-linolenic acid-induced toxicity to tumor cells. | 2001 | Med. Hypotheses | pmid:11388772 |
Furse RK et al. | Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes. | 2001 | J. Immunol. | pmid:11418687 |
Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
Yogo Y and Fujishima S | [Nutritional support for ARDS]. | 2001 | Nippon Rinsho | pmid:11439576 |
Frenoux JM et al. | A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. | 2001 | J. Nutr. | pmid:11208936 |
Berry JA | Benign breast pain. New approaches manage this common condition more effectively. | 2001 | Adv Nurse Pract | pmid:12400335 |
Cunnane SC et al. | NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478372 |
Nwankwo JO and Robbins ME | Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418018 |
Borenshtein D et al. | Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate. | 2001 Jan-Feb | Diabetes Metab. Res. Rev. | pmid:11241890 |
Zavodnik LB et al. | [Effect of gamma-linolenic acid on microsomal oxidation in the rat liver following gamma-irradiation]. | 2001 Jul-Aug | Eksp Klin Farmakol | pmid:11589114 |
OtleÅŸ S and Pire R | Fatty acid composition of Chlorella and Spirulina microalgae species. | 2001 Nov-Dec | J AOAC Int | pmid:11767135 |
Keegan A et al. | Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment. | 2001 Sep-Oct | Diabetes Metab. Res. Rev. | pmid:11747143 |
SimoncÃkova P et al. | Comparison of the extrapancreatic action of gamma-linolenic acid and n-3 PUFAs in the high fat diet-induced insulin resistance [corrected]. | 2002 | Endocr Regul | pmid:12466014 |
Leaver HA et al. | Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445487 |
Blommers J et al. | Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. | 2002 | Am. J. Obstet. Gynecol. | pmid:12439536 |
Senanayake SP and Shahidi F | Positional distribution of FA in TAG of enzymatically modified borage and evening primrose oils. | 2002 | Lipids | pmid:12371752 |
Turon F et al. | A direct method for regiospecific analysis of TAG using alpha-MAG. | 2002 | Lipids | pmid:12371754 |
Dyer O | Doctor accused of giving false information to drug trial. | 2002 | BMJ | pmid:12269314 |
Tso P et al. | Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. | 2002 | J. Nutr. | pmid:11823581 |
Deng X et al. | Regulation of the rat SREBP-1c promoter in primary rat hepatocytes. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779162 |
Senanayake SP and Shahidi F | Structured lipids via lipase-catalyzed incorporation of eicosapentaenoic acid into borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils. | 2002 | J. Agric. Food Chem. | pmid:11804516 |
Jack AM et al. | Effects of diabetes and evening primrose oil treatment on responses of aorta, corpus cavernosum and mesenteric vasculature in rats. | 2002 | Life Sci. | pmid:12175702 |
Harris NM et al. | Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study. | 2002 | Eur. Urol. | pmid:12121728 |
Hornych A et al. | The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. | 2002 | Bratisl Lek Listy | pmid:12190041 |
Theander E et al. | Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome. | 2002 | Scand. J. Rheumatol. | pmid:12109650 |
Furse RK et al. | Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. | 2002 | J. Clin. Immunol. | pmid:11998897 |
Gema H et al. | Production of gamma-linolenic acid by Cunninghamella echinulata cultivated on glucose and orange peel. | 2002 | Appl. Microbiol. Biotechnol. | pmid:11935180 |
Hong H et al. | High-level production of gamma-linolenic acid in Brassica juncea using a delta6 desaturase from Pythium irregulare. | 2002 | Plant Physiol. | pmid:12011365 |
Patel GK and Logan RA | Golden nail pigmentation. | 2002 | J Dermatolog Treat | pmid:12006139 |
Leigh-Firbank EC et al. | Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. | 2002 | Br. J. Nutr. | pmid:12010583 |
Braddock R et al. | gamma-Linoleic acid and ascorbic acid ameliorate the effects of experimental diabetes on electrolyte and bone homeostasis in pregnant rats. | 2002 | J. Endocrinol. | pmid:12010635 |
Crook TJ et al. | The effects of meglumine gamma linolenic acid (MeGLA) on an organ culture model of superficial bladder cancer. | 2002 | Urol. Res. | pmid:11942327 |
GarcÃa-Maroto F et al. | Cloning and molecular characterization of the delta6-desaturase from two echium plant species: production of GLA by heterologous expression in yeast and tobacco. | 2002 | Lipids | pmid:12030323 |
Colquhoun A | Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour. | 2002 | Biochim. Biophys. Acta | pmid:12069851 |
Menéndez JA et al. | Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. | 2002 | Breast Cancer Res. Treat. | pmid:12058962 |
Cook D et al. | Modification of fatty acid composition in tomato (Lycopersicon esculentum) by expression of a borage delta6-desaturase. | 2002 | Mol. Biotechnol. | pmid:12059112 |
Leaver HA et al. | Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12051954 |
Chung S et al. | Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. | 2002 | J. Nutr. | pmid:12368400 |
Gillis RC et al. | Eicosapentaenoic acid and gamma-linolenic acid induce apoptosis in HL-60 cells. | 2002 | J. Surg. Res. | pmid:12384078 |
Pérez Y et al. | Measurement by nuclear magnetic resonance diffusion of the dimensions of the mobile lipid compartment in C6 cells. | 2002 | Cancer Res. | pmid:12384523 |
Ernst E | Ayurvedic medicines. | 2002 | Pharmacoepidemiol Drug Saf | pmid:12426929 |
Uesaka Y | [Prevention and treatment of diabetic neuropathy]. | 2002 | Nippon Rinsho | pmid:12430238 |
Hamburger M et al. | Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities. | 2002 | J. Agric. Food Chem. | pmid:12236675 |
Khunyoshyeng S et al. | Differential expression of desaturases and changes in fatty acid composition during sporangiospore germination and development in Mucor rouxii. | 2002 | Fungal Genet. Biol. | pmid:12223185 |
Whelan J et al. | Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect. | 2002 | Adv. Exp. Med. Biol. | pmid:12664643 |
Pham H and Ziboh VA | 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:12589947 |
Das UN | Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. | 2002 | Nutrition | pmid:12297217 |
Samuels R et al. | Hypocholesterolemic effect of spirulina in patients with hyperlipidemic nephrotic syndrome. | 2002 | J Med Food | pmid:12487756 |
Yoon S et al. | The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. | 2002 Jan-Feb | Skin Pharmacol. Appl. Skin Physiol. | pmid:11803254 |
Das UN | Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. | 2002 Jul-Aug | Nutrition | pmid:12093450 |
Funtikova NS et al. | [Synthesis of biologically active lipids by fungus Mucor lusitanicus 306D grown on media with various composition]. | 2002 Nov-Dec | Prikl. Biokhim. Mikrobiol. | pmid:12449793 |
Harris NM et al. | Epirubicin and meglumine gamma-linolenic acid: a logical choice of combination therapy for patients with superficial bladder carcinoma. | 2003 | Cancer | pmid:12491507 |
Pham H et al. | Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells. | 2003 | Cancer Lett. | pmid:12445673 |
Shotton HR et al. | The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. | 2003 | Diabetes | pmid:12502507 |
Delmonte P et al. | Synthesis and isolation of trans-7,cis-9 octadecadienoic acid and other CLA isomers by base conjugation of partially hydrogenated gamma-linolenic acid. | 2003 | Lipids | pmid:12880116 |
Surette ME et al. | Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects. | 2003 | Clin Ther | pmid:12852710 |
Surette ME et al. | Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo-controlled, parallel-group, prospective trial. | 2003 | Clin Ther | pmid:12852711 |
Whitehouse PA et al. | Synergistic activity of gamma-linolenic acid and cytotoxic drugs against pancreatic adenocarcinoma cell lines. | 2003 | Pancreatology | pmid:14526145 |
Song C et al. | Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. | 2003 | J. Lipid Res. | pmid:12837849 |
Gimeno RE et al. | Characterization of a heart-specific fatty acid transport protein. | 2003 | J. Biol. Chem. | pmid:12556534 |
Vogelzang JL | Fat facts and fallacies. | 2003 | Home Healthc Nurse | pmid:14614382 |
Koletzko B et al. | Fatty acid profiles, antioxidant status, and growth of preterm infants fed diets without or with long-chain polyunsaturated fatty acids. A randomized clinical trial. | 2003 | Eur J Nutr | pmid:14569405 |
Arimura T et al. | Caspase-independent apoptosis induced by evening primrose extract in Ehrlich ascites tumor cells. | 2003 | Cancer Lett. | pmid:14580681 |
Barabino S et al. | Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. | 2003 | Cornea | pmid:12605039 |
Djoussé L et al. | Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:14668270 |
Williams HC | Evening primrose oil for atopic dermatitis. | 2003 | BMJ | pmid:14670851 |
Takwale A et al. | Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. | 2003 | BMJ | pmid:14670885 |
Macrì A et al. | Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. | 2003 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:12768289 |
Jelińska M et al. | Effects of dietary linseed, evening primrose or fish oils on fatty acid and prostaglandin E2 contents in the rat livers and 7,12-dimethylbenz[a]anthracene-induced tumours. | 2003 | Biochim. Biophys. Acta | pmid:12697300 |
van Gool CJ et al. | Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis--a randomized controlled trial in infants at high familial risk. | 2003 | Am. J. Clin. Nutr. | pmid:12663296 |
Spector SL and Surette ME | Diet and asthma: has the role of dietary lipids been overlooked in the management of asthma? | 2003 | Ann. Allergy Asthma Immunol. | pmid:12722956 |
Vecera R et al. | Antioxidant status, lipoprotein profile and liver lipids in rats fed on high-cholesterol diet containing currant oil rich in n-3 and n-6 polyunsaturated fatty acids. | 2003 | Physiol Res | pmid:12678660 |
Seibel MM | Treating hot flushes without hormone replacement therapy. | 2003 | J Fam Pract | pmid:12681090 |
Wainwright PE et al. | Effects of high-gamma-linolenic acid canola oil compared with borage oil on reproduction, growth, and brain and behavioral development in mice. | 2003 | Lipids | pmid:12733750 |
Soeken KL et al. | Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. | 2003 | Rheumatology (Oxford) | pmid:12709541 |
Duttaroy AK et al. | Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538089 |
Pacht ER et al. | Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. | 2003 | Crit. Care Med. | pmid:12576957 |
Xian M et al. | Production of gamma-linolenic acid by disrupted mycelia of Mortierella isabellina. | 2003 | Lett. Appl. Microbiol. | pmid:12581380 |