Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yadav S et al. | Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features. | 2017 | J. Physiol. Biochem. | pmid:27878518 |
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Khattab HAH et al. | EFFICIENCY OF BORAGE SEEDS OIL AGAINST GAMMA IRRADIATION-INDUCED HEPATOTOXICITY IN MALE RATS: POSSIBLE ANTIOXIDANT ACTIVITY. | 2017 | Afr J Tradit Complement Altern Med | pmid:28638880 |
Veselinovic M et al. | Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. | 2017 | Nutrients | pmid:28346333 |
Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
Sergeant S et al. | Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes. | 2016 | Eur. J. Pharmacol. | pmid:27083549 |
Maldonado-Menetti Jdos S et al. | Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction. | 2016 | Acta Cir Bras | pmid:27050790 |
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Li R et al. | Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. | 2015 | J. Food Sci. | pmid:26408984 |
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GarcÃa de Acilu M et al. | The Role of Omega-3 Polyunsaturated Fatty Acids in the Treatment of Patients with Acute Respiratory Distress Syndrome: A Clinical Review. | 2015 | Biomed Res Int | pmid:26339627 |
Białek M and Rutkowska J | [The importance of γ-linolenic acid in the prevention and treatment]. | 2015 | Postepy Hig Med Dosw (Online) | pmid:26270516 |
Li C et al. | Enteral Immunomodulatory Diet (Omega-3 Fatty Acid, γ-Linolenic Acid and Antioxidant Supplementation) for Acute Lung Injury and Acute Respiratory Distress Syndrome: An Updated Systematic Review and Meta-Analysis. | 2015 | Nutrients | pmid:26184293 |
Tang X et al. | Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. | 2015 | PLoS ONE | pmid:26046932 |
Shewale SV et al. | Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver. | 2015 | J. Lipid Res. | pmid:25921305 |
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Mohajeri S and Newman SA | Review of evidence for dietary influences on atopic dermatitis. | 2014 Jul-Aug | Skin Therapy Lett. | pmid:25188523 |
Sukrutha SK and Janakiraman S | Harnessing indigenous plant seed oil for the production of bio-fuel by an oleaginous fungus, Cunninghamella blakesleeana- JSK2, isolated from tropical soil. | 2014 | Appl. Biochem. Biotechnol. | pmid:24142351 |
Park SO et al. | Gamma-linolenic acid egg production enriched with hemp seed oil and evening primrose oil in diet of laying hens. | 2014 | J Environ Biol | pmid:25004746 |
Simon D et al. | Gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis. | 2014 | Adv Ther | pmid:24435467 |
Miyake JA et al. | Novel ruthenium - gamma-linolenic acid complex inhibits C6 rat glioma cell proliferation in vitro and in the orthotopic C6 model in vivo after osmotic pump infusion. | 2014 | Anticancer Res. | pmid:24692725 |
Bellou S et al. | The olive mill wastewater as substrate for single cell oil production by Zygomycetes. | 2014 | J. Biotechnol. | pmid:24316440 |
Montserrat-de la Paz S et al. | Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages. | 2014 | J Ethnopharmacol | pmid:24239848 |
Kim SH et al. | Functional characterization of polyunsaturated fatty acid delta 6-desaturase and elongase genes from the black seabream (Acanthopagrus schlegelii). | 2014 | Cell Biochem. Biophys. | pmid:24052399 |
Saad N et al. | Optimization of aeration and agitation rate for lipid and gamma linolenic acid production by Cunninghamella bainieri 2A1 in submerged fermentation using response surface methodology. | 2014 | ScientificWorldJournal | pmid:25610901 |
Gautam M et al. | Importance of fatty acid compositions in patients with peripheral arterial disease. | 2014 | PLoS ONE | pmid:25191963 |
Ganjali Dashti M et al. | Repeated batch fermentation biotechnology for the biosynthesis of lipid and gamma-linolenic acid by Cunninghamella bainieri 2A1. | 2014 | Biomed Res Int | pmid:25147817 |
Wencelová M et al. | Substrates enriched by the fungus Cunninghamella echinulata: an in vitro study of nutrient composition, sheep rumen fermentation and lipid metabolism. | 2014 | J. Appl. Microbiol. | pmid:24995934 |
Zhu Y and Zhang BB | Molecular cloning and functional characterization of a Δ6-fatty acid desaturase gene from Rhizopus oryzae. | 2013 | J. Basic Microbiol. | pmid:22961300 |
Saha SS and Ghosh M | Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. | 2013 | Nutrition | pmid:23422533 |
Tasset-Cuevas I et al. | Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies. | 2013 | PLoS ONE | pmid:23460824 |
Klempova T et al. | Biosynthesis of gamma-linolenic acid and beta-carotene by Zygomycetes fungi. | 2013 | Biotechnol J | pmid:23625863 |
Kmietowicz Z | Evening primrose oil and borage oil do not help eczema symptoms, finds Cochrane review. | 2013 | BMJ | pmid:23628953 |
Kavanagh K et al. | Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23664597 |
Jacobs BR et al. | Nutritional immunomodulation in critically ill children with acute lung injury: feasibility and impact on circulating biomarkers. | 2013 | Pediatr Crit Care Med | pmid:23295853 |
Safarinejad MR et al. | Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. | 2013 | Br. J. Nutr. | pmid:23199523 |
Zikou E et al. | Evaluating glucose and xylose as cosubstrates for lipid accumulation and γ-linolenic acid biosynthesis of Thamnidium elegans. | 2013 | J. Appl. Microbiol. | pmid:23279437 |
Auberger J et al. | Topical evening primrose oil for reduction of bortezomib-induced skin reactions. | 2013 | Ann. Hematol. | pmid:23262668 |
Cohen DA et al. | Impact of two pulmonary enteral formulations on nutritional indices and outcomes. | 2013 | J Hum Nutr Diet | pmid:23189938 |
Jubie S et al. | Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line. | 2013 | Lipids Health Dis | pmid:23537396 |
ÄŒertÃk M et al. | Simultaneous enrichment of cereals with polyunsaturated fatty acids and pigments by fungal solid state fermentations. | 2013 | J. Biotechnol. | pmid:23583333 |
Gerhardt LC et al. | Tribological investigation of a functional medical textile with lubricating drug-delivery finishing. | 2013 | Colloids Surf B Biointerfaces | pmid:23524083 |
Lopes C et al. | Functional textiles for atopic dermatitis: a systematic review and meta-analysis. | 2013 | Pediatr Allergy Immunol | pmid:23980847 |
Mayo TT et al. | Comparative study on bruise reduction treatments after bruise induction using the pulsed dye laser. | 2013 | Dermatol Surg | pmid:23899131 |
Kim SH et al. | Isolation and functional characterization of a delta 6-desaturase gene from the pike eel (Muraenesox cinereus). | 2013 | J. Microbiol. | pmid:24097133 |
Yabuki C et al. | A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1. | 2013 | PLoS ONE | pmid:24130766 |
Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
Rezapour-Firouzi S et al. | Erythrocyte membrane fatty acids in multiple sclerosis patients and hot-nature dietary intervention with co-supplemented hemp-seed and evening-primrose oils. | 2013 | Afr J Tradit Complement Altern Med | pmid:24311880 |
Bamford JT et al. | Oral evening primrose oil and borage oil for eczema. | 2013 | Cochrane Database Syst Rev | pmid:23633319 |
Yan Y et al. | Survey of the total fatty acid and triacylglycerol composition and content of 30 duckweed species and cloning of a Δ6-desaturase responsible for the production of γ-linolenic and stearidonic acids in Lemna gibba. | 2013 | BMC Plant Biol. | pmid:24308551 |
Schumacher MC et al. | A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens. | 2013 | Urol. Oncol. | pmid:21414816 |
Das UN | n-3 fatty acids, γ-linolenic acid, and antioxidants in sepsis. | 2013 | Crit Care | pmid:23597172 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Fu J et al. | Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits. | 2012 | J. Food Sci. | pmid:22747885 |
Szachowicz-Petelska B et al. | Protective effect of blackcurrant on liver cell membrane of rats intoxicated with ethanol. | 2012 | J. Membr. Biol. | pmid:22527605 |
Lopez HL | Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. | 2012 | PM R | pmid:22632694 |
Omran OM | Histopathological study of evening primrose oil effects on experimental diabetic neuropathy. | 2012 | Ultrastruct Pathol | pmid:22574767 |
Norris S et al. | FPIN's Clinical Inquiries. Complementary and alternative therapies for atopic dermatitis. | 2012 | Am Fam Physician | pmid:22534392 |
Tso P et al. | Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days. | 2012 | Food Chem. Toxicol. | pmid:22265940 |
Qin F et al. | Composition of transgenic soybean seeds with higher γ-linolenic acid content is equivalent to that of conventional control. | 2012 | J. Agric. Food Chem. | pmid:22324875 |
Mütze U et al. | Metabolomics of dietary fatty acid restriction in patients with phenylketonuria. | 2012 | PLoS ONE | pmid:22912778 |
Kim SH et al. | Isolation and functional characterization of polyunsaturated fatty acid elongase (AsELOVL5) gene from black seabream (Acanthopagrus schlegelii). | 2012 | Biotechnol. Lett. | pmid:22198347 |
Hennessy AA et al. | The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. | 2012 | Lipids | pmid:22160449 |
Felbinger TW et al. | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235078 |
Bistrian BR | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235079 |
König K et al. | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235080 |
Řezanka T et al. | Regioisomer separation and identification of triacylglycerols containing vaccenic and oleic acids, and α- and γ-linolenic acids, in thermophilic cyanobacteria Mastigocladus laminosus and Tolypothrix sp. | 2012 | Phytochemistry | pmid:22445652 |
Lukivskaya OY et al. | Reversal of experimental ethanol-induced liver steatosis by borage oil. | 2012 | Phytother Res | pmid:22359349 |
Sharma N et al. | Mastalgia cured! Randomized trial comparing centchroman to evening primrose oil. | 2012 | Breast J | pmid:22892074 |
MartÃnez-Augustin O et al. | Bioactive anti-obesity food components. | 2012 | Int J Vitam Nutr Res | pmid:23258394 |
Yamanaka K et al. | A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. | 2012 | PLoS ONE | pmid:23056190 |
Hoppu U et al. | Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines. | 2012 | Eur J Nutr | pmid:21626296 |
Ribeiro P et al. | Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. | 2012 | Int J Food Sci Nutr | pmid:21707451 |
Trevizan L et al. | Maintenance of arachidonic acid and evidence of Δ5 desaturation in cats fed γ-linolenic and linoleic acid enriched diets. | 2012 | Lipids | pmid:22249937 |
Schott CK and Huang DT | ω-3 fatty acids, γ-linolenic acid, and antioxidants: immunomodulators or inert dietary supplements? | 2012 | Crit Care | pmid:23176247 |
Machado FR et al. | INTERSEPT study: we still need more clarity. | 2012 | Crit Care | pmid:22410246 |
Manosroi A et al. | Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction. | 2012 | Eur J Pharm Biopharm | pmid:22490981 |
Nykiforuk CL et al. | High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds. | 2012 | Transgenic Res. | pmid:21853296 |
Viau S et al. | Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells. | 2012 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:21894532 |
Ramandi NF et al. | Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. | 2011 Nov-Dec | J. Food Sci. | pmid:22416687 |
Meyer BJ and Kolanu N | Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health. | 2011 Nov-Dec | Nutrition | pmid:21658909 |
Cook DJ and Heyland DK | Pharmaconutrition in acute lung injury. | 2011 | JAMA | pmid:21976612 |
Rice TW et al. | Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. | 2011 | JAMA | pmid:21976613 |
Faragó N et al. | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes. | 2011 | Lipids Health Dis | pmid:21961478 |
Vaquerizo Alonso C et al. | Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus SEMICYUC-SENPE: hyperglycemia and diabetes mellitus. | 2011 | Nutr Hosp | pmid:22411519 |
Macfarlane GJ et al. | Evidence for the efficacy of complementary and alternative medicines in the management of rheumatoid arthritis: a systematic review. | 2011 | Rheumatology (Oxford) | pmid:21652584 |
Alhazzaa R et al. | Up-regulated desaturase and elongase gene expression promoted accumulation of polyunsaturated fatty acid (PUFA) but not long-chain PUFA in Lates calcarifer, a tropical euryhaline fish, fed a stearidonic acid- and γ-linoleic acid-enriched diet. | 2011 | J. Agric. Food Chem. | pmid:21707030 |
Wiedemann HP | Fish oil is not the fix for acute lung injury. | 2011 | Crit. Care Med. | pmid:21685749 |
Liu J et al. | Δ6-Desaturase from Mortierella alpina: cDNA cloning, expression, and phylogenetic analysis. | 2011 | Biotechnol. Lett. | pmid:21691840 |
Wang P et al. | Production of γ-linolenic acid using a novel heterologous expression system in the oleaginous yeast Lipomyces kononenkoae. | 2011 | Biotechnol. Lett. | pmid:21681556 |
Laho T et al. | Effects of prefermented cereal-derived substrates (ground barley and rye bran) enriched with fungal γ-linolenic acid on rumen fermentation parameters and lipid metabolism in vitro. | 2011 | J. Appl. Microbiol. | pmid:21672096 |
Pontes-Arruda A et al. | Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study. | 2011 | Crit Care | pmid:21658240 |
Wan X et al. | Molecular cloning and expression analysis of a delta 6-fatty acid desaturase gene from Rhizopus stolonifer strain YF6 which can accumulate high levels of gamma-linolenic acid. | 2011 | J. Microbiol. | pmid:21369993 |
Al-Khamees WA et al. | Status epilepticus associated with borage oil ingestion. | 2011 | J Med Toxicol | pmid:21387119 |
Cameron M et al. | Herbal therapy for treating rheumatoid arthritis. | 2011 | Cochrane Database Syst Rev | pmid:21328257 |
Teichert SA and Akoh CC | Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. | 2011 | J. Agric. Food Chem. | pmid:22097918 |
Machado FR | Fish oil and sepsis: we still need more trials. | 2011 | Crit Care | pmid:22112369 |
Kawamura A et al. | Dietary supplementation of gamma-linolenic acid improves skin parameters in subjects with dry skin and mild atopic dermatitis. | 2011 | J Oleo Sci | pmid:22123240 |
Dawczynski C et al. | Incorporation of n-3 PUFA and γ-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis--a randomized controlled human intervention trial. | 2011 | Lipids Health Dis | pmid:21816071 |