Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
de Bravo MG et al. | [Effect of dietary supplementation with gamma-linolenic acid on the growth of a human lung carcinoma implanted in nude mice]. | 1995 | Medicina (B Aires) | pmid:8731577 |
Barar J et al. | Barrier functionality and transport machineries of human ECV304 cells. | 2010 | Med. Sci. Monit. | pmid:20037486 |
Das UN | Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. | 2007 | Med. Sci. Monit. | pmid:17599036 |
Khoo SK et al. | Evening primrose oil and treatment of premenstrual syndrome. | 1990 | Med. J. Aust. | pmid:2201888 |
Horrobin DF | Evening primrose oil and premenstrual syndrome. | 1990 | Med. J. Aust. | pmid:2233440 |
Menendez JA et al. | Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. | 2005 | Med. Hypotheses | pmid:15607568 |
Schrek R | An animal model for intractable chronic lymphocytic leukemia. | 1990 | Med. Hypotheses | pmid:1963468 |
Horrobin DF | A biochemical basis for alcoholism and alcohol-induced damage including the fetal alcohol syndrome and cirrhosis: interference with essential fatty acid and prostaglandin metabolism. | 1980 | Med. Hypotheses | pmid:6253773 |
Horrobin DF | Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjogren's syndrome. | 1984 | Med. Hypotheses | pmid:6088955 |
Puri BK | The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparations. | 2004 | Med. Hypotheses | pmid:14729014 |
McCarty MF | Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. | 1996 | Med. Hypotheses | pmid:8692033 |
Booyens J et al. | The use of drugs for the inhibition of prostaglandin or leukotriene synthesis from arachidonic acid is theoretically hazardous. | 1985 | Med. Hypotheses | pmid:2995775 |
Bégin ME and Das UN | A deficiency in dietary gamma-linolenic and/or eicosapentaenoic acids may determine individual susceptibility to AIDS. | 1986 | Med. Hypotheses | pmid:3014282 |
Nwankwo JO | Repression of cellular anaplerosis as the hypothesized mechanism of gamma-linolenic acid-induced toxicity to tumor cells. | 2001 | Med. Hypotheses | pmid:11388772 |
Booyens J and Katzeff IE | Cancer: a simple metabolic disease? | 1983 | Med. Hypotheses | pmid:6321917 |
McCarty MF and Rubin EJ | Rationales for micronutrient supplementation in diabetes. | 1984 | Med. Hypotheses | pmid:6325854 |
Ring J and Kleinheinz A | [Evening primrose oil in neurodermatitis?]. | 1991 | Med Monatsschr Pharm | pmid:1943974 |
Schöpf E et al. | [Gamma-linolenic acid in atopic patients?]. | 1996 | Med Monatsschr Pharm | pmid:8684312 |
Ferrando J | [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions]. | 1986 | Med Cutan Ibero Lat Am | pmid:3528709 |
Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
Oguogho A et al. | Prostaglandin synthesis in human lymphatics from precursor fatty acids. | 2000 | Lymphology | pmid:10897472 |
Faragó N et al. | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes. | 2011 | Lipids Health Dis | pmid:21961478 |
Jubie S et al. | Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line. | 2013 | Lipids Health Dis | pmid:23537396 |
Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
Miyake JA et al. | Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. | 2009 | Lipids Health Dis | pmid:19292920 |
Scheim DE | Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. | 2009 | Lipids Health Dis | pmid:20003514 |
Dawczynski C et al. | Incorporation of n-3 PUFA and γ-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis--a randomized controlled human intervention trial. | 2011 | Lipids Health Dis | pmid:21816071 |
Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
Bégin ME and Ells G | Levels of thiobarbituric acid reactive substances and the cytocidal potential of gammalinolenic and docosahexaenoic acids on ZR-75-1 and CV-1 cells. | 1992 | Lipids | pmid:1315901 |
Senanayake SP and Shahidi F | Positional distribution of FA in TAG of enzymatically modified borage and evening primrose oils. | 2002 | Lipids | pmid:12371752 |
Turon F et al. | A direct method for regiospecific analysis of TAG using alpha-MAG. | 2002 | Lipids | pmid:12371754 |
Ziboh VA et al. | gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. | 1997 | Lipids | pmid:9252965 |
Delmonte P et al. | Synthesis and isolation of trans-7,cis-9 octadecadienoic acid and other CLA isomers by base conjugation of partially hydrogenated gamma-linolenic acid. | 2003 | Lipids | pmid:12880116 |
Gibson RA et al. | Gamma linolenic acid (GLA) content of encapsulated evening primrose oil products. | 1992 | Lipids | pmid:1318991 |
Manninen P and Laakso P | Capillary supercritical fluid chromatography--atmospheric pressure chemical ionization mass spectrometry of gamma- and alpha-linolenic acid containing triacylglycerols in berry oils. | 1997 | Lipids | pmid:9270973 |
Pakala R et al. | Eicosapentaenoic acid and docosahexaenoic acid selectively attenuate U46619-induced smooth muscle cell proliferation. | 1999 | Lipids | pmid:10574655 |
Ward GR et al. | Effects of gamma-linolenic acid and docosahexaenoic acid in formulae on brain fatty acid composition in artificially reared rats. | 1999 | Lipids | pmid:10580333 |
Raederstorff D and Moser U | Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats. | 1992 | Lipids | pmid:1336802 |
Palombo JD et al. | Comparison of growth and fatty acid metabolism in rats fed diets containing equal levels of gamma-linolenic acid from high gamma-linolenic acid canola oil or borage oil. | 2000 | Lipids | pmid:11026618 |
Vartak S et al. | Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. | 1997 | Lipids | pmid:9076665 |
Traitler H et al. | Characterization of gamma-linolenic acid in Ribes seed. | 1984 | Lipids | pmid:6098796 |
Abou-el-Ela SH et al. | Eicosanoid synthesis in 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats fed primrose oil, menhaden oil or corn oil diet. | 1988 | Lipids | pmid:3143882 |
Hirschberg Y et al. | The response to endotoxin in guinea pigs after intravenous black currant seed oil. | 1990 | Lipids | pmid:2170795 |
Giamarellos-Bourboulis EJ et al. | In vitro interactions of gamma-linolenic acid and arachidonic acid with ceftazidime on multiresistant Pseudomonas aeruginosa. | 1999 | Lipids | pmid:10419130 |
Tsevegsüren N et al. | Occurrence of gamma-linolenic acid in compositae: a study of Youngia tenuicaulis seed oil. | 1999 | Lipids | pmid:10380126 |
Hennessy AA et al. | The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. | 2012 | Lipids | pmid:22160449 |
Kumamoto T and Ide T | Comparative effects of alpha- and gamma-linolenic acids on rat liver fatty acid oxidation. | 1998 | Lipids | pmid:9688166 |
Huang YS et al. | Cloning of delta12- and delta6-desaturases from Mortierella alpina and recombinant production of gamma-linolenic acid in Saccharomyces cerevisiae. | 1999 | Lipids | pmid:10478922 |
Trevizan L et al. | Maintenance of arachidonic acid and evidence of Δ5 desaturation in cats fed γ-linolenic and linoleic acid enriched diets. | 2012 | Lipids | pmid:22249937 |
Schnebelen C et al. | Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. | 2009 | Lipids | pmid:19242743 |
Schäfer L and Kragballe K | Supplementation with evening primrose oil in atopic dermatitis: effect on fatty acids in neutrophils and epidermis. | 1991 | Lipids | pmid:1943500 |
Cronholm T et al. | Influence of dietary fats on pancreatic phospholipids of chronically ethanol-treated rats. | 1988 | Lipids | pmid:2846981 |
Demmelmair H et al. | Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants. | 2001 | Lipids | pmid:11485158 |
Mills DE et al. | Gamma linolenic acid attenuates cardiovascular responses to stress in borderline hypertensive rats. | 1985 | Lipids | pmid:2995750 |
Thies F et al. | Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. | 2001 | Lipids | pmid:11795850 |
el-Ela SH et al. | Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12-dimethylbenz(a)anthracene. | 1987 | Lipids | pmid:3131611 |
GarcÃa-Maroto F et al. | Cloning and molecular characterization of the delta6-desaturase from two echium plant species: production of GLA by heterologous expression in yeast and tobacco. | 2002 | Lipids | pmid:12030323 |
Barcelli UO et al. | A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats. | 1988 | Lipids | pmid:3237005 |
Manninen P et al. | Separation of gamma- and alpha-linolenic acid containing triacylglycerols by capillary supercritical fluid chromatography. | 1995 | Lipids | pmid:7564922 |
Wainwright PE et al. | Effects of high-gamma-linolenic acid canola oil compared with borage oil on reproduction, growth, and brain and behavioral development in mice. | 2003 | Lipids | pmid:12733750 |
Barre DE and Holub BJ | The effect of borage oil consumption on the composition of individual phospholipids in human platelets. | 1992 | Lipids | pmid:1328794 |
Takeno S et al. | Molecular evidence that the rate-limiting step for the biosynthesis of arachidonic acid in Mortierella alpina is at the level of an elongase. | 2005 | Lipids | pmid:15825827 |
Tocher DR et al. | Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. | 1997 | Lipids | pmid:9438233 |
Liu QY and Tan BK | Effects of cis-unsaturated fatty acids on doxorubicin sensitivity in P388/DOX resistant and P388 parental cell lines. | 2000 | Life Sci. | pmid:10954054 |
De La Cruz JP et al. | Antioxidant potential of evening primrose oil administration in hyperlipemic rabbits. | 1999 | Life Sci. | pmid:10462081 |
Jack AM et al. | Effects of diabetes and evening primrose oil treatment on responses of aorta, corpus cavernosum and mesenteric vasculature in rats. | 2002 | Life Sci. | pmid:12175702 |
Mainou-Fowler T et al. | Gamma-linolenic acid induces apoptosis in B-chronic lymphocytic leukaemia cells in vitro. | 2001 | Leuk. Lymphoma | pmid:11426562 |
Jangbua P et al. | Gamma-linolenic acid production of Mucor rouxii by solid-state fermentation using agricultural by-products. | 2009 | Lett. Appl. Microbiol. | pmid:19453951 |
Serrano I et al. | Ethanol-induced dimorphism and lipid composition changes in Mucor fragilis CCMI 142. | 2001 | Lett. Appl. Microbiol. | pmid:11442823 |
Jeennor S et al. | Evaluation of inoculum performance for enhancing gamma-linolenic acid production from Mucor rouxii. | 2008 | Lett. Appl. Microbiol. | pmid:18298455 |
Xian M et al. | Production of gamma-linolenic acid by disrupted mycelia of Mortierella isabellina. | 2003 | Lett. Appl. Microbiol. | pmid:12581380 |
Patnayak S and Sree A | Screening of bacterial associates of marine sponges for single cell oil and PUFA. | 2005 | Lett. Appl. Microbiol. | pmid:15836739 |
Wright S and Burton JL | Oral evening-primrose-seed oil improves atopic eczema. | 1982 | Lancet | pmid:6128449 |
Sharpe GR and Farr PM | Evening primrose oil and eczema. | 1990 | Lancet | pmid:1969047 |
Horrobin DF and Stewart C | Evening primrose oil in atopic eczema. | 1990 | Lancet | pmid:1969596 |
Sharpe GR and Farr PM | Evening primrose oil and eczema. | 1990 | Lancet | pmid:1971352 |
Horrobin DF and Stewart C | Evening primrose oil and atopic eczema. | 1990 | Lancet | pmid:1973228 |
Berth-Jones J et al. | Evening primrose oil and atopic eczema. | 1995 | Lancet | pmid:7861894 |
Horrobin DF and Morse PF | Evening primrose oil and atopic eczema. | 1995 | Lancet | pmid:7823743 |
Berth-Jones J and Graham-Brown RA | Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8099640 |
Shield MJ et al. | Essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8101623 |
Jamal GA et al. | Gamma-linolenic acid in diabetic neuropathy. | 1986 | Lancet | pmid:2871365 |
Pye JK et al. | Clinical experience of drug treatments for mastalgia. | 1985 | Lancet | pmid:2862523 |
Chalmers RJ and Shuster S | Evening primrose seed oil in ichthyosis vulgaris. | 1983 | Lancet | pmid:6130264 |
Lovell CR et al. | Treatment of atopic eczema with evening primrose oil. | 1981 | Lancet | pmid:6109930 |
Wollheim FA | [Meager support for herbal therapy of rheumatoid arthritis]. | 2001 | Lakartidningen | pmid:11699249 |
Olsson AG et al. | [Ineffectiveness of Naudicelle in intermittent claudication]. | 1984 | Lakartidningen | pmid:6394928 |
Borrek S et al. | [Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study]. | 1997 May-Jun | Klin Padiatr | pmid:9244815 |
Scholey JW and Mills DE | Dietary fatty acids and the glomerular hemodynamic response to cyclosporine in borderline hypertensive rats. | 1995 | Kidney Int. | pmid:7723248 |
Mettang T and Kremer AE | Uremic pruritus. | 2015 | Kidney Int. | pmid:24402092 |
Gillis RC et al. | Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells. | 2004 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:15449569 |
Pontes-Arruda A et al. | The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974237 |
Preiser JC | Nutrition therapy for acute respiratory distress syndrome. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974251 |
Dickerson RN | Modified EN support for patients with acute respiratory distress syndrome. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974252 |
Ferrie S | Re: The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. | 2010 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:20631393 |
Palombo JD et al. | Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168366 |
Nelson JL et al. | Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants on antioxidant status in patients with acute respiratory distress syndrome. | 2003 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:12665164 |
Monnier L | [Influence of metabolic and nutritional balance on platelet function in insulin-dependent diabetes]. | 1984 | Journ Annu Diabetol Hotel Dieu | pmid:6100381 |
Cook DJ and Heyland DK | Pharmaconutrition in acute lung injury. | 2011 | JAMA | pmid:21976612 |