gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Scleroderma, Systemic D012595 16 associated lipids
Raynaud Disease D011928 7 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Dysmenorrhea D004412 9 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Synovitis D013585 15 associated lipids
Arthritis, Psoriatic D015535 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Insulin Resistance D007333 99 associated lipids
Fatigue D005221 10 associated lipids
Nausea D009325 7 associated lipids
Critical Illness D016638 13 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Acute Lung Injury D055371 33 associated lipids
Intermittent Claudication D007383 6 associated lipids
Fibrocystic Breast Disease D005348 1 associated lipids
Tietze's Syndrome D013991 1 associated lipids
Pityriasis D010915 3 associated lipids
Xerostomia D014987 6 associated lipids
Fallopian Tube Neoplasms D005185 1 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Scurvy D012614 2 associated lipids
Hand Dermatoses D006229 5 associated lipids
Mucocele D009078 1 associated lipids
Salivary Gland Diseases D012466 1 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Back Pain D001416 5 associated lipids
Urolithiasis D052878 1 associated lipids
Mastocytoma D034801 3 associated lipids
Ecchymosis D004438 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Bordoni A et al. Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. 1997 Biochim. Biophys. Acta pmid:9366250
Larsen LN et al. Polyunsaturated thia- and oxa-fatty acids: incorporation into cell-lipids and their effects on arachidonic acid- and eicosanoid synthesis. 1997 Biochim. Biophys. Acta pmid:9366251
Johnson MM et al. Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. 1997 J. Nutr. pmid:9237935
Harbige LS et al. Protective mechanisms by omega-6 lipids in experimental autoimmune encephalomyelitis (EAE) are associated with cytokines and eicosanoids. 1997 Biochem. Soc. Trans. pmid:9191387
Fisher BA and Harbige LS Effect of omega-6 lipid-rich borage oil feeding on immune function in healthy volunteers. 1997 Biochem. Soc. Trans. pmid:9191388
Kokura S et al. Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. 1997 Cancer Res. pmid:9187121
Magnusson G et al. Plasma and tissue levels of lipids, fatty acids and plasma carnitine in neonates receiving a new fat emulsion. 1997 Acta Paediatr. pmid:9202801
Garland HO et al. Dietary essential fatty acid supplementation, urinary calcium excretion and reproductive performance in the diabetic pregnant rat. 1997 J. Endocrinol. pmid:9203989
Murray MJ and Zhang T The incorporation of dietary n-3 polyunsaturated fatty acids into porcine platelet phospholipids and their effects on platelet thromboxane A2 release. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089803
Wagner W and Nootbaar-Wagner U Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. 1997 Cephalalgia pmid:9137851
Jiang WG et al. Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150377
Biernat J and Grajeta H Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 1. Blood serum and liver lipids. 1997 Nahrung pmid:9113670
Grajeta H and Biernat J Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 2. Blood serum and liver fatty acids. 1997 Nahrung pmid:9113671
Utsunomiya T Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1997 Br J Surg pmid:9117334
Mancuso P et al. Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. 1997 Crit. Care Med. pmid:9118672
Vartak S et al. Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. 1997 Lipids pmid:9076665
Bard JM et al. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. 1997 Fundam Clin Pharmacol pmid:9107561
Fang C et al. Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9051726
McGahon B et al. The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. 1997 Neuroscience pmid:9300396
Horrobin DF Essential fatty acids in the management of impaired nerve function in diabetes. 1997 Diabetes pmid:9285506
Quoc KP and Dubacq JP Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. 1997 Biochim. Biophys. Acta pmid:9219908
Purasiri P et al. Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. 1997 Immunology pmid:9415022
de Antueno R et al. In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas. 1997 Br. J. Cancer pmid:9192987
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Mpanju O et al. Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. 1997 Antivir. Ther. (Lond.) pmid:11322262
Griffiths G et al. Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. 1997 Prostate pmid:9108883
Pohl CH et al. The production of gamma-linolenic acid by selected members of the Dikaryomycota grown on different carbon sources. 1997 Antonie Van Leeuwenhoek pmid:9403104
Jiang WG et al. Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids. 1997 Clin. Exp. Metastasis pmid:9344043
Campbell EM et al. Premenstrual symptoms in general practice patients. Prevalence and treatment. 1997 J Reprod Med pmid:9350019
al-Shabanah OA Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. 1997 Food Chem. Toxicol. pmid:9350221
Bíró K et al. Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. 1997 Brain Res. Bull. pmid:9323440
Steinbrunn BS et al. Mastalgia. Tailoring treatment to type of breast pain. 1997 Postgrad Med pmid:9385340
Tocher DR et al. Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. 1997 Lipids pmid:9438233
Fearon KC et al. An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. 1996 Mar-Apr Anticancer Res. pmid:8687143
Papanikolaou N et al. Effects of OKY-046 and nifedipine in cyclosporine-induced renal dysfunction in rats. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8951993
Matsuo N et al. Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8951990
Glen AI et al. Membrane fatty acids, niacin flushing and clinical parameters. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888117
Cameron NE and Cotter MA Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. 1996 Diabetologia pmid:8877288
Awad AB et al. The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. 1996 Cancer Lett. pmid:8950205
Huang Z et al. Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. 1996 Biochemistry pmid:8619991
Leaver HA et al. Arachidonic acid activation of monocyte and neutrophil reactive oxygen in lung cancer patients undergoing pulmonary resection. 1996 Biologicals pmid:9088546
Wainwright PE et al. Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior. 1996 Pharmacol. Biochem. Behav. pmid:8801587
Quoc KP and Pascaud M Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. 1996 Ann. Nutr. Metab. pmid:8773734
Hrelia S et al. gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid composition. 1996 Biochem. Biophys. Res. Commun. pmid:8753781
Fan YY et al. Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro. 1996 J. Nutr. pmid:8814195
Omawari N et al. Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. 1996 Br. J. Pharmacol. pmid:8733594
Sherrington EJ et al. The effect of dietary lipid manipulation on the uptake of [3H]-triolein by tissues of the rat. 1996 Biochem. Soc. Trans. pmid:8736833
Grant D et al. The antioxidant activity of heparins. 1996 Biochem. Soc. Trans. pmid:8736852
Stainforth JM et al. Clinical aspects of the use of gamma linolenic acid in systemic sclerosis. 1996 Acta Derm. Venereol. pmid:8740271
Chilton-Lopez ME et al. Metabolism of gammalinolenic acid in human neutrophils. 1996 J. Immunol. pmid:8609415