gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Gastritis D005756 27 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Kidney Calculi D007669 7 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15810447
Menendez JA et al. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. 2005 Med. Hypotheses pmid:15607568
Menendez JA et al. Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2005 J. Natl. Cancer Inst. pmid:16264182
Heard CM et al. Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. 2005 Int J Pharm pmid:16115741
Efstathopoulos N et al. N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850717
Vang K and Ziboh VA 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850718
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Tahvonen RL et al. Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. 2005 J. Nutr. Biochem. pmid:15936647
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Watkins G et al. Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15763439
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Kavanagh T et al. Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15041032
Del Castillo ML et al. Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. 2004 J. Agric. Food Chem. pmid:14969555
Menendez JA et al. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. 2004 Int. J. Cancer pmid:15027132
Nakanishi T et al. Gamma-linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice. 2004 Nutrition pmid:15043857
Plowman PN Re: Packer RJ. Effects of radiotherapy on the brain. Med Pediatr Oncol 2003;41:448-449. 2004 Pediatr Blood Cancer pmid:15049029
Gamma-linolenic acid (GLA). Monograph. 2004 Altern Med Rev pmid:15005646
Li MC et al. [Heteologous expression of Mortierella isabellina delta6 -fatty acid desaturase gene in soybean]. 2004 Yi Chuan Xue Bao pmid:15481543
Gueck T et al. Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. 2004 Vet. Dermatol. pmid:15500483
Ho S et al. In-vitro transcutaneous delivery of tamoxifen and gamma-linolenic acid from borage oil containing ethanol and 1,8-cineole. 2004 J. Pharm. Pharmacol. pmid:15525441
Li MC et al. [Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:16108486
Zhang Q et al. [Progress on molecular biology of delta6-fatty acid desaturases]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:15971598
Knorr R and Hamburger M Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil. 2004 J. Agric. Food Chem. pmid:15161190
Remans PH et al. Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. 2004 Eur J Clin Nutr pmid:15164103
Javadi M et al. The effect of six different C18 fatty acids on body fat and energy metabolism in mice. 2004 Br. J. Nutr. pmid:15469642
Miles EA et al. The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. 2004 Br. J. Nutr. pmid:15182393
Liu JW et al. Effect of long-term dietary supplementation of high-gamma-linolenic canola oil versus borage oil on growth, hematology, serum biochemistry, and N-6 fatty acid metabolism in rats. 2004 J. Agric. Food Chem. pmid:15186123
Das UN Occlusion of infusion vessels on gamma-linolenic acid infusion. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643176
Papanikolaou S et al. Repression of reserve lipid turnover in Cunninghamella echinulata and Mortierella isabellina cultivated in multiple-limited media. 2004 J. Appl. Microbiol. pmid:15357737
Papanikolaou S et al. Single cell oil (SCO) production by Mortierella isabellina grown on high-sugar content media. 2004 Bioresour. Technol. pmid:15288271
Harrison RA et al. Who and how many people are taking herbal supplements? A survey of 21,923 adults. 2004 Int J Vitam Nutr Res pmid:15296076
Crowe DL and Chandraratna RA A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. 2004 Breast Cancer Res. pmid:15318936
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Bruder ED et al. Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. 2004 Endocrinology pmid:15271879
Pham H et al. Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. 2004 Int. J. Cancer pmid:15197770
Karia C et al. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. 2004 Int J Pharm pmid:15129999
Menendez JA et al. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. 2004 Int. J. Oncol. pmid:15138577
Shotton HR et al. Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil. 2004 Auton Neurosci pmid:15109939
Fewtrell MS et al. Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. 2004 J. Pediatr. pmid:15069395
Puri BK The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparations. 2004 Med. Hypotheses pmid:14729014
Zhang Q et al. Identification and characterization of a novel Delta6-fatty acid desaturase gene from Rhizopus arrhizus. 2004 FEBS Lett. pmid:14706830
de La Puerta Vázquez R et al. Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. 2004 Metab. Clin. Exp. pmid:14681843