gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Premenstrual Syndrome D011293 7 associated lipids
Bacteriuria D001437 7 associated lipids
Raynaud Disease D011928 7 associated lipids
Kidney Calculi D007669 7 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Dysmenorrhea D004412 9 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
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Authors Title Published Journal PubMed Link
Willemaers V et al. [Atopic dermatitis]. 1998 Rev Med Liege pmid:9564223
Hørby Jørgensen M et al. Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. 1998 J. Pediatr. Gastroenterol. Nutr. pmid:9552137
Solomon LZ et al. Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. 1998 Urol. Res. pmid:9537690
Kis M et al. Light-induced expression of fatty acid desaturase genes. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9539715
Cameron NE et al. Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. 1998 Diabetologia pmid:9562342
Engler MM and Engler MB Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758202
van Rooyen J et al. Diet can manipulate the metabolism of EPA and GLA in erythrocyte membrane and plasma. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758205
Jiang WG et al. gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. 1998 Int. J. Oncol. pmid:9683802
Villalobos MA et al. Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. 1998 Thromb. Haemost. pmid:9798993
Eynard AR et al. Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin and desmoglein in human squamous cell carcinoma in vitro. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:10102382
Tanaka T et al. Methylene-interrupted double bond in polyunsaturated fatty acid is an essential structure for metabolism by the fatty acid chain elongation system of rat liver. 1998 Biochim. Biophys. Acta pmid:9748638
de Vries JE [Painful breasts]. 1998 Ned Tijdschr Geneeskd pmid:9749309
Ravichandran D et al. Effect of lithium gamma-linolenate on the growth of experimental human pancreatic carcinoma. 1998 Br J Surg pmid:9752859
Brouwer DA et al. Gamma-linolenic acid does not augment long-chain polyunsaturated fatty acid omega-3 status. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888208
Fan YY and Chapkin RS Importance of dietary gamma-linolenic acid in human health and nutrition. 1998 J. Nutr. pmid:9732298
Dirks J et al. Cytokine levels affected by gamma-linolenic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849654
Seegers JC et al. Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849656
Leng GC et al. Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. 1998 Clin Nutr pmid:10205349
Hounsom L et al. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. 1998 Diabetologia pmid:9686927
Kahler CP and Du Plooy WJ Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654407
Solomon LZ et al. Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? 1998 Br J Urol pmid:9698674
Vartak S et al. Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. 1998 Br. J. Cancer pmid:9635836
McGahon B et al. Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study. 1998 Exp. Gerontol. pmid:9639170
Solomon LZ et al. Intravesical chemotherapy with gamma linolenic acid becomes a realistic prospect in serum-free applications: in vitro cytotoxicity and systemic absorption studies. 1998 J. Urol. pmid:9817384
Marra F et al. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. 1998 J. Hepatol. pmid:9566835
Chen Q et al. Analysis of the acyl-CoAs that accumulate during the peroxisomal beta-oxidation of arachidonic acid and 6,9,12-octadecatrienoic acid. 1998 Arch. Biochem. Biophys. pmid:9448727
Jiang WG et al. The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. 1998 Br. J. Cancer pmid:9514051
Ramesh G and Das UN Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. 1998 Cancer Lett. pmid:9489490
Jiang WG et al. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. 1998 Biochem. Biophys. Res. Commun. pmid:9514943
Gu JY et al. Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. 1998 Biosci. Biotechnol. Biochem. pmid:9836427
Kairemo KJ et al. The effect of lithium gamma-linolenate therapy of pancreatic cancer on perfusion in liver and pancreatic tissues. 1998 Pancreas pmid:9436871
Frati-Munari AC and Ariza-Andraca CR [Treatment of diabetic neuropathy]. 1998 Jan-Feb Gac Med Mex pmid:9658700
Oakley OR et al. The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro. 1998 Jan-Jun Rom J Physiol pmid:11000861
Burnard SL et al. Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat. 1998 Mar-Apr J. Diabetes Complicat. pmid:9559483
Anderson KM et al. Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. 1998 Mar-Apr Anticancer Res. pmid:9615721
Joubert AM et al. Comparative study of the effects of polyunsaturated fatty acids and their metabolites on cell growth and tyrosine kinase activity in oesophageal carcinoma cells. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10582657
Bell HS et al. Effects of N-6 essential fatty acids on glioma invasion and growth: experimental studies with glioma spheroids in collagen gels. 1999 J. Neurosurg. pmid:10584845
Srinivas CV et al. Safflower petals: a source of gamma linolenic acid. 1999 Plant Foods Hum Nutr pmid:10646633
Hornych A et al. Effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandins in old subjects. 1999 Br J Clin Pharmacol pmid:10651470
Fan YY et al. Modulation of atherogenesis by dietary gamma-linolenic acid. 1999 Adv. Exp. Med. Biol. pmid:10667372
Vartak S et al. The selective cytotoxicity of gamma-linolenic acid (GLA) is associated with increased oxidative stress. 1999 Adv. Exp. Med. Biol. pmid:10667373
Robbins M et al. gamma-linolenic acid (GLA)-mediated cytotoxicity in human prostate cancer cells. 1999 Adv. Exp. Med. Biol. pmid:10667374
Harris JE et al. Five-lipoxygenase inhibitors reduce Panc-1 survival: synergism of MK886 with gamma linolenic acid. 1999 Adv. Exp. Med. Biol. pmid:10667375
Ramrath S et al. Stimulation of cardiac glucose transport by thioctic acid and insulin. 1999 Horm. Metab. Res. pmid:10668913
Motaung E et al. Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10670696
Davies CL et al. Effect of gamma-linolenic acid on cellular uptake of structurally related anthracyclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines. 1999 Eur. J. Cancer pmid:10673983
Likhodii SS and Cunnane SC Uptake of 13C-tracer arachidonate and gamma-linolenate by the brain and liver of the suckling rat observed using 13C-NMR. 1999 J. Neurochem. pmid:10349866
Yoshimoto-Furuie K et al. Effects of oral supplementation with evening primrose oil for six weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients. 1999 Nephron pmid:9933750
Murakami K et al. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. 1999 Biochem. Biophys. Res. Commun. pmid:10403814
Pirich C et al. Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. 1999 Thromb. Res. pmid:10588465