gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Osteosarcoma D012516 50 associated lipids
Salivary Gland Diseases D012466 1 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Raynaud Disease D011928 7 associated lipids
Psoriasis D011565 47 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Premenstrual Syndrome D011293 7 associated lipids
Pityriasis D010915 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Oakley OR et al. The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro. 1998 Jan-Jun Rom J Physiol pmid:11000861
de Kock M et al. Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells. 1992 S. Afr. Med. J. pmid:1315459
Leary WP et al. Some effects of gamma-linolenic acid on cultured human oesophageal carcinoma cells. 1982 S. Afr. Med. J. pmid:6291175
Dippenaar N et al. The reversibility of cancer: evidence that malignancy in human hepatoma cells is gamma-linolenic acid deficiency-dependent. 1982 S. Afr. Med. J. pmid:6291176
van der Merwe CF The reversibility of cancer. 1983 S. Afr. Med. J. pmid:6298954
Botha JH et al. Parenteral gamma-linolenic acid administration in nude mice bearing a range of human tumour xenografts. 1983 S. Afr. Med. J. pmid:6304925
Van der Merwe CF The reversibility of cancer. 1984 S. Afr. Med. J. pmid:6320476
Booyens J and Koenig L The effect of dietary supplementation with gamma-linolenic acid on the growth of induced tumours in rats. 1984 S. Afr. Med. J. pmid:6324397
van der Merwe CF The reversibility of cancer. 1984 S. Afr. Med. J. pmid:6326340
Hansen TM et al. Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. 1983 Scand. J. Rheumatol. pmid:6304871
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Oxholm P et al. Patients with primary Sjögren's syndrome treated for two months with evening primrose oil. 1986 Scand. J. Rheumatol. pmid:3529370
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Horrobin DF Essential fatty acid and prostaglandin metabolism in Sjögren's syndrome, systemic sclerosis and rheumatoid arthritis. 1986 Scand. J. Rheumatol. Suppl. pmid:3296151
Simmons DA et al. Significance of tissue myo-inositol concentrations in metabolic regulation in nerve. 1982 Science pmid:6285474
Saad N et al. Optimization of aeration and agitation rate for lipid and gamma linolenic acid production by Cunninghamella bainieri 2A1 in submerged fermentation using response surface methodology. 2014 ScientificWorldJournal pmid:25610901
Rothman D et al. Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. 1995 Semin. Arthritis Rheum. pmid:8578315
Li MC et al. [Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:16108486
Zhang Q et al. [Progress on molecular biology of delta6-fatty acid desaturases]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:15971598
Li MC et al. [Expression of Mortierella isabellina delta6-fatty acid desaturase gene in gamma-linolenic acid production in transgenic tobacco]. 2003 Sheng Wu Gong Cheng Xue Bao pmid:15966318
Larsson-Backström C et al. Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. 1995 Shock pmid:7552772
Yoon S et al. The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. 2002 Jan-Feb Skin Pharmacol. Appl. Skin Physiol. pmid:11803254
Mohajeri S and Newman SA Review of evidence for dietary influences on atopic dermatitis. 2014 Jul-Aug Skin Therapy Lett. pmid:25188523
Qureshi S and Sultan N Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. 2005 Surgeon pmid:15789786
Saied GM et al. Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females. 2007 Tanzan Health Res Bull pmid:18087899
Paccalin J et al. [Changes in the higher derivatives of linoleic acid in cirrhotics treated with gamma-linolenic acid]. 1983 May-Jun Therapie pmid:6310813
Villalobos MA et al. Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. 1998 Thromb. Haemost. pmid:9798993
Belch JJ et al. Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. 1985 Thromb. Haemost. pmid:4082084
De La Cruz JP et al. Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. 1997 Thromb. Res. pmid:9253809
Nakahara T et al. Inhibitory effects of mold oil including gamma-linolenate on platelet thrombus formation in mesenteric microvessels of the rat. 1990 Thromb. Res. pmid:2156348
Pirich C et al. Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. 1999 Thromb. Res. pmid:10588465
Takahashi R et al. Effect of different ratios of dietary N-6 and N-3 fatty acids on fatty acid composition, prostaglandin formation and platelet aggregation in the rat. 1987 Thromb. Res. pmid:3660347
Akahane N et al. Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature. 1995 Thromb. Res. pmid:7660360
Kietzmann M [Pharmacotherapeutic use of antipruritic drugs in skin diseases]. 1995 Tierarztl Prax pmid:7545832
Kong X et al. Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. 2009 Toxicol In Vitro pmid:19268700
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
Nykiforuk CL et al. High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds. 2012 Transgenic Res. pmid:21853296
Lindskov R and Petersen CS [Oral gamma-linoleic acid (Epogam) in the treatment of atopic dermatitis]. 1995 Ugeskr. Laeg. pmid:7483071
Omran OM Histopathological study of evening primrose oil effects on experimental diabetic neuropathy. 2012 Ultrastruct Pathol pmid:22574767
Schumacher MC et al. A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens. 2013 Urol. Oncol. pmid:21414816
Solomon LZ et al. Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. 1998 Urol. Res. pmid:9537690
Simán CM et al. Failure of short-term gamma-linolenic acid treatment to reduce urinary calcium loss of diabetic rats. 2000 Urol. Res. pmid:10850637
Tulloch I et al. Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. 1994 Urol. Res. pmid:7871634
du Toit PJ et al. Pyelonephritis: renal urokinase activity in rats on essential fatty acid diets. 1994 Urol. Res. pmid:7992455
Burgess NA et al. Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. 1995 Urol. Res. pmid:8533210
Crook TJ et al. The effects of meglumine gamma linolenic acid (MeGLA) on an organ culture model of superficial bladder cancer. 2002 Urol. Res. pmid:11942327
Gueck T et al. Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. 2004 Vet. Dermatol. pmid:15500483
Saevik BK et al. A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. 2004 Vet. Dermatol. pmid:15214949
Noli C et al. Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. 2007 Vet. J. pmid:16495095
Bloom P Atopic dermatitis: the quest for the silver bullet. 2008 Vet. J. pmid:18554562