Leaver HA et al. |
Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology. |
2002 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12445487
|
Vaddadi KS |
Use of gamma-linolenic acid in the treatment of schizophrenia and tardive dyskinesia. |
1992 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:1321448
|
Horrobin DF |
The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism. |
1992 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:1321449
|
Mengeaud V et al. |
Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. |
1992 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:1337209
|
Vang K and Ziboh VA |
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. |
2005 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15850718
|
Jiang WG et al. |
Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. |
2000 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10780877
|
Fokkema MR et al. |
Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. |
2000 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:11090255
|
Dines KC et al. |
Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. |
1996 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:8931113
|
Fang C et al. |
Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. |
1997 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9051726
|
de Kock M et al. |
The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. |
1996 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9014218
|
Cleland LG et al. |
The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids. |
1990 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:2169063
|
Miller MA and Morgan RJ |
Eicosanoids, erections and erectile dysfunction. |
1994 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:7938091
|
Miles EA et al. |
Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16820286
|
Engler MM and Engler MB |
Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. |
1998 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9758202
|
van Rooyen J et al. |
Diet can manipulate the metabolism of EPA and GLA in erythrocyte membrane and plasma. |
1998 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9758205
|
Dirks J et al. |
Cytokine levels affected by gamma-linolenic acid. |
1998 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9849654
|
Seegers JC et al. |
Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. |
1998 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9849656
|
Morphake P et al. |
Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats. |
1994 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:8146206
|
Cai J et al. |
Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid. |
1999 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10319914
|
Singer P et al. |
N-6 and N-3 PUFA in liver lipids, thromboxane formation and blood pressure from SHR during diets supplemented with evening primrose, sunflowerseed or fish oil. |
1990 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:2336450
|
Hrelia S et al. |
Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture. |
1999 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10397404
|
Pakala R et al. |
Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. |
1999 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10397410
|
Singer P et al. |
Blood pressure and serum lipids from SHR after diets supplemented with evening primrose, sunflowerseed or fish oil. |
1990 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:2399267
|
Engler MM |
Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. |
1993 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:8259378
|
Kavanagh K et al. |
Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. |
2013 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:23664597
|
Kahler CP and Du Plooy WJ |
Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. |
1998 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9654407
|
Leaver HA et al. |
Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15062847
|
Miles EA et al. |
The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15120716
|
Peterson LD et al. |
Dose-dependent effects of dietary gamma-linolenic acid on rat spleen lymphocyte functions. |
1999 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10477037
|
Haag M et al. |
Polyunsaturated fatty acids inhibit Mg2+ -ATPase in basolateral membranes from rat enterocytes. |
1999 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10477038
|
Ebden P et al. |
A study of evening primrose seed oil in atopic asthma. |
1989 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:2717651
|
Huang YS et al. |
The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. |
1989 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:2717652
|
Bell JG et al. |
Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. |
1995 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:8577782
|
Agostoni C et al. |
Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. |
2001 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:11237478
|
Hrelia S et al. |
Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. |
2001 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:11334548
|
Leaver HA et al. |
Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. |
2002 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12051954
|
Rosenstein ED et al. |
Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis. |
2003 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12591005
|
Watkins G et al. |
Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. |
2005 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15763439
|
Griffiths G et al. |
Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. |
1997 |
Prostate |
pmid:9108883
|
Dobryniewski J et al. |
[The gamma-linolenic acid (GLA)--the therapeutic value]. |
2007 |
Prz. Lek. |
pmid:17892041
|
Vaddadi KS et al. |
A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. |
1989 |
Psychiatry Res |
pmid:2565585
|
Hindo J et al. |
Evidence of the formation of different hydroperoxides in irradiated gamma-linolenate solutions: effect of micelle formation. |
2000 |
Radiat. Res. |
pmid:10629620
|
Castellanos P et al. |
Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. |
2010 |
Reprod. Toxicol. |
pmid:20096347
|
DeMichele SJ et al. |
A nutritional strategy to improve oxygenation and decrease morbidity in patients who have acute respiratory distress syndrome. |
2006 |
Respir Care Clin N Am |
pmid:17150431
|
Willemaers V et al. |
[Atopic dermatitis]. |
1998 |
Rev Med Liege |
pmid:9564223
|
Manthorpe R et al. |
Primary Sjögren's syndrome treated with Efamol/Efavit. A double-blind cross-over investigation. |
1984 |
Rheumatol. Int. |
pmid:6385206
|
Webb J and McCredie M |
Primary Sjögren's syndrome treated with Efamol/efavit. A double-blind cross-over investigation. |
1985 |
Rheumatol. Int. |
pmid:4048763
|
Macfarlane GJ et al. |
Evidence for the efficacy of complementary and alternative medicines in the management of rheumatoid arthritis: a systematic review. |
2011 |
Rheumatology (Oxford) |
pmid:21652584
|
Soeken KL et al. |
Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. |
2003 |
Rheumatology (Oxford) |
pmid:12709541
|
Szczesna M |
[Therapeutic assessment of the evening primrose]. |
1993 |
Rocz Panstw Zakl Hig |
pmid:8016534
|
Oakley OR et al. |
The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro. |
1998 Jan-Jun |
Rom J Physiol |
pmid:11000861
|
de Kock M et al. |
Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells. |
1992 |
S. Afr. Med. J. |
pmid:1315459
|
Leary WP et al. |
Some effects of gamma-linolenic acid on cultured human oesophageal carcinoma cells. |
1982 |
S. Afr. Med. J. |
pmid:6291175
|
Dippenaar N et al. |
The reversibility of cancer: evidence that malignancy in human hepatoma cells is gamma-linolenic acid deficiency-dependent. |
1982 |
S. Afr. Med. J. |
pmid:6291176
|
van der Merwe CF |
The reversibility of cancer. |
1983 |
S. Afr. Med. J. |
pmid:6298954
|
Botha JH et al. |
Parenteral gamma-linolenic acid administration in nude mice bearing a range of human tumour xenografts. |
1983 |
S. Afr. Med. J. |
pmid:6304925
|
Van der Merwe CF |
The reversibility of cancer. |
1984 |
S. Afr. Med. J. |
pmid:6320476
|
Booyens J and Koenig L |
The effect of dietary supplementation with gamma-linolenic acid on the growth of induced tumours in rats. |
1984 |
S. Afr. Med. J. |
pmid:6324397
|
van der Merwe CF |
The reversibility of cancer. |
1984 |
S. Afr. Med. J. |
pmid:6326340
|
Hansen TM et al. |
Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. |
1983 |
Scand. J. Rheumatol. |
pmid:6304871
|
Theander E et al. |
Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome. |
2002 |
Scand. J. Rheumatol. |
pmid:12109650
|
Oxholm P et al. |
Patients with primary Sjögren's syndrome treated for two months with evening primrose oil. |
1986 |
Scand. J. Rheumatol. |
pmid:3529370
|
Manthorpe R and Prause JU |
Treatment of Sjögren's syndrome: an overview. |
1986 |
Scand. J. Rheumatol. Suppl. |
pmid:3296150
|
Horrobin DF |
Essential fatty acid and prostaglandin metabolism in Sjögren's syndrome, systemic sclerosis and rheumatoid arthritis. |
1986 |
Scand. J. Rheumatol. Suppl. |
pmid:3296151
|
Simmons DA et al. |
Significance of tissue myo-inositol concentrations in metabolic regulation in nerve. |
1982 |
Science |
pmid:6285474
|
Saad N et al. |
Optimization of aeration and agitation rate for lipid and gamma linolenic acid production by Cunninghamella bainieri 2A1 in submerged fermentation using response surface methodology. |
2014 |
ScientificWorldJournal |
pmid:25610901
|
Rothman D et al. |
Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. |
1995 |
Semin. Arthritis Rheum. |
pmid:8578315
|
Li MC et al. |
[Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]. |
2004 |
Sheng Wu Gong Cheng Xue Bao |
pmid:16108486
|
Zhang Q et al. |
[Progress on molecular biology of delta6-fatty acid desaturases]. |
2004 |
Sheng Wu Gong Cheng Xue Bao |
pmid:15971598
|
Li MC et al. |
[Expression of Mortierella isabellina delta6-fatty acid desaturase gene in gamma-linolenic acid production in transgenic tobacco]. |
2003 |
Sheng Wu Gong Cheng Xue Bao |
pmid:15966318
|
Larsson-Backström C et al. |
Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. |
1995 |
Shock |
pmid:7552772
|
Yoon S et al. |
The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. |
2002 Jan-Feb |
Skin Pharmacol. Appl. Skin Physiol. |
pmid:11803254
|
Mohajeri S and Newman SA |
Review of evidence for dietary influences on atopic dermatitis. |
2014 Jul-Aug |
Skin Therapy Lett. |
pmid:25188523
|
Qureshi S and Sultan N |
Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. |
2005 |
Surgeon |
pmid:15789786
|
Saied GM et al. |
Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females. |
2007 |
Tanzan Health Res Bull |
pmid:18087899
|
Paccalin J et al. |
[Changes in the higher derivatives of linoleic acid in cirrhotics treated with gamma-linolenic acid]. |
1983 May-Jun |
Therapie |
pmid:6310813
|
Villalobos MA et al. |
Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. |
1998 |
Thromb. Haemost. |
pmid:9798993
|
Belch JJ et al. |
Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. |
1985 |
Thromb. Haemost. |
pmid:4082084
|
De La Cruz JP et al. |
Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. |
1997 |
Thromb. Res. |
pmid:9253809
|
Nakahara T et al. |
Inhibitory effects of mold oil including gamma-linolenate on platelet thrombus formation in mesenteric microvessels of the rat. |
1990 |
Thromb. Res. |
pmid:2156348
|
Pirich C et al. |
Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. |
1999 |
Thromb. Res. |
pmid:10588465
|
Takahashi R et al. |
Effect of different ratios of dietary N-6 and N-3 fatty acids on fatty acid composition, prostaglandin formation and platelet aggregation in the rat. |
1987 |
Thromb. Res. |
pmid:3660347
|
Akahane N et al. |
Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature. |
1995 |
Thromb. Res. |
pmid:7660360
|
Kietzmann M |
[Pharmacotherapeutic use of antipruritic drugs in skin diseases]. |
1995 |
Tierarztl Prax |
pmid:7545832
|
Kong X et al. |
Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. |
2009 |
Toxicol In Vitro |
pmid:19268700
|
Azevedo-Martins AK et al. |
Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. |
2006 |
Toxicol In Vitro |
pmid:16644178
|
Nykiforuk CL et al. |
High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds. |
2012 |
Transgenic Res. |
pmid:21853296
|
Lindskov R and Petersen CS |
[Oral gamma-linoleic acid (Epogam) in the treatment of atopic dermatitis]. |
1995 |
Ugeskr. Laeg. |
pmid:7483071
|
Omran OM |
Histopathological study of evening primrose oil effects on experimental diabetic neuropathy. |
2012 |
Ultrastruct Pathol |
pmid:22574767
|
Schumacher MC et al. |
A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens. |
2013 |
Urol. Oncol. |
pmid:21414816
|
Solomon LZ et al. |
Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. |
1998 |
Urol. Res. |
pmid:9537690
|
Simán CM et al. |
Failure of short-term gamma-linolenic acid treatment to reduce urinary calcium loss of diabetic rats. |
2000 |
Urol. Res. |
pmid:10850637
|
Tulloch I et al. |
Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. |
1994 |
Urol. Res. |
pmid:7871634
|
du Toit PJ et al. |
Pyelonephritis: renal urokinase activity in rats on essential fatty acid diets. |
1994 |
Urol. Res. |
pmid:7992455
|
Burgess NA et al. |
Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. |
1995 |
Urol. Res. |
pmid:8533210
|
Crook TJ et al. |
The effects of meglumine gamma linolenic acid (MeGLA) on an organ culture model of superficial bladder cancer. |
2002 |
Urol. Res. |
pmid:11942327
|
Gueck T et al. |
Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. |
2004 |
Vet. Dermatol. |
pmid:15500483
|
Saevik BK et al. |
A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. |
2004 |
Vet. Dermatol. |
pmid:15214949
|
Noli C et al. |
Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. |
2007 |
Vet. J. |
pmid:16495095
|
Bloom P |
Atopic dermatitis: the quest for the silver bullet. |
2008 |
Vet. J. |
pmid:18554562
|