| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Gain | D015430 | 101 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hyperplasia | D006965 | 34 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leaver HA et al. | Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445487 |
| Vaddadi KS | Use of gamma-linolenic acid in the treatment of schizophrenia and tardive dyskinesia. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1321448 |
| Horrobin DF | The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1321449 |
| Mengeaud V et al. | Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1337209 |
| Efstathopoulos N et al. | N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850717 |
| Vang K and Ziboh VA | 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850718 |
| Jiang WG et al. | Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780877 |
| Jiang WG et al. | Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150377 |
| Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
| Dines KC et al. | Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931113 |
| Fang C et al. | Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051726 |
| de Kock M et al. | The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014218 |
| Cleland LG et al. | The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2169063 |
| van der Merwe CF et al. | The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2169638 |
| Miller MA and Morgan RJ | Eicosanoids, erections and erectile dysfunction. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938091 |
| Miles EA et al. | Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16820286 |
| Horrobin DF et al. | The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: choice of an appropriate placebo for clinical studies on primrose oil. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1871175 |
| Motaung E et al. | Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670696 |
| Arisaka M et al. | Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1871184 |
| Hrelia S et al. | Kinetic analysis of delta-6-desaturation in liver microsomes: influence of gamma-linoleic acid dietary supplementation to young and old rats. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808628 |
| Engler MM and Engler MB | Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758202 |
| van Rooyen J et al. | Diet can manipulate the metabolism of EPA and GLA in erythrocyte membrane and plasma. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758205 |
| Laivuori H et al. | Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248275 |
| Stevens EJ et al. | Prostacyclin release in experimental diabetes: effects of evening primrose oil. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248277 |
| Dirks J et al. | Cytokine levels affected by gamma-linolenic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849654 |
| Seegers JC et al. | Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849656 |
| Morphake P et al. | Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146206 |
| Cai J et al. | Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10319914 |
| Hrelia S et al. | Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397404 |
| Pakala R et al. | Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397410 |
| Engler MM | Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8259378 |
| Botha JH et al. | The role of prostaglandins in the inhibition of cultured carcinoma cell growth produced by gamma-linolenic acid. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2541450 |
| Giamarellos-Bourboulis EJ et al. | In vitro activity of polyunsaturated fatty acids on Pseudomonas aeruginosa: relationship to lipid peroxidation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654401 |
| Kavanagh K et al. | Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23664597 |
| Kahler CP and Du Plooy WJ | Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654407 |
| Leaver HA et al. | Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15062847 |
| Moodley J and Norman RJ | Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2608693 |
| Peterson LD et al. | Dose-dependent effects of dietary gamma-linolenic acid on rat spleen lymphocyte functions. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10477037 |
| Haag M et al. | Polyunsaturated fatty acids inhibit Mg2+ -ATPase in basolateral membranes from rat enterocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10477038 |
| Ebden P et al. | A study of evening primrose seed oil in atopic asthma. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2717651 |
| Huang YS et al. | The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2717652 |
| Bell JG et al. | Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577782 |
| Sangeetha P et al. | Free radical generation in human leukocytes by CIS-unsaturated fatty acids is a calmodulin dependent process. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2160083 |
| Bunce OR and Abou-El-Ela SH | Eicosanoid synthesis and ornithine decarboxylase activity in mammary tumors of rats fed varying levels and types of N-3 and/or N-6 fatty acids. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2177199 |
| Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
| Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
| Mohan IK and Das UN | Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765977 |
| Leaver HA et al. | Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12051954 |
| Rosenstein ED et al. | Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591005 |
| Watkins G et al. | Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15763439 |