gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Pain D010146 64 associated lipids
Neuroblastoma D009447 66 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Nausea D009325 7 associated lipids
Mucocele D009078 1 associated lipids
Melanoma D008545 69 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Na-Ranong S et al. Substrate specificity and preference of Delta6-desaturase of Mucor rouxii. 2005 FEBS Lett. pmid:15862319
Zhang Q et al. Identification and characterization of a novel Delta6-fatty acid desaturase gene from Rhizopus arrhizus. 2004 FEBS Lett. pmid:14706830
Miura Y et al. Production of gamma-linolenic acid from the marine green alga Chlorella sp. NKG 042401. 1993 FEMS Microbiol. Lett. pmid:8386122
Kankaanpää PE et al. The influence of polyunsaturated fatty acids on probiotic growth and adhesion. 2001 FEMS Microbiol. Lett. pmid:11164299
Kristofíková L et al. Selection of Rhizopus strains for L(+)-lactic acid and gamma-linolenic acid production. 1991 Folia Microbiol. (Praha) pmid:1668279
Tso P et al. Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days. 2012 Food Chem. Toxicol. pmid:22265940
Bala KV et al. Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linolenic acid. 1993 Food Chem. Toxicol. pmid:8390392
Kanbur M et al. The effects of evening primrose oil on lipid peroxidation induced by subacute aflatoxin exposure in mice. 2011 Food Chem. Toxicol. pmid:21600263
al-Shabanah OA Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. 1997 Food Chem. Toxicol. pmid:9350221
Küpper C [Premenstrual syndrome: does gamma-linolenic acid help?]. 1997 Fortschr. Med. pmid:9173016
Preuss M et al. Role of antioxidant enzyme expression in the selective cytotoxic response of glioma cells to gamma-linolenic acid supplementation. 2000 Free Radic. Biol. Med. pmid:10832077
Hatanaka E et al. Systematic study on ROS production induced by oleic, linoleic, and gamma-linolenic acids in human and rat neutrophils. 2006 Free Radic. Biol. Med. pmid:16962937
Ramanathan R et al. Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. 1994 Free Radic. Biol. Med. pmid:8299995
Yu Q et al. LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenase-catalysed peroxidation of gamma-linolenic acid. 2008 Free Radic. Res. pmid:18484409
Bard JM et al. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. 1997 Fundam Clin Pharmacol pmid:9107561
Khunyoshyeng S et al. Differential expression of desaturases and changes in fatty acid composition during sporangiospore germination and development in Mucor rouxii. 2002 Fungal Genet. Biol. pmid:12223185
Bordoni A et al. [Treatment of premenstrual syndrome with essential fatty acids (evening primrose oil)]. 1987 G Clin Med pmid:3609594
Frati-Munari AC and Ariza-Andraca CR [Treatment of diabetic neuropathy]. 1998 Jan-Feb Gac Med Mex pmid:9658700
Viau S et al. Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. 2009 Graefes Arch. Clin. Exp. Ophthalmol. pmid:19415319
Macrì A et al. Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. 2003 Graefes Arch. Clin. Exp. Ophthalmol. pmid:12768289
Viau S et al. Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells. 2012 Graefes Arch. Clin. Exp. Ophthalmol. pmid:21894532
Jenkins AP et al. Effects of bolus doses of fat on small intestinal structure and on release of gastrin, cholecystokinin, peptide tyrosine-tyrosine, and enteroglucagon. 1992 Gut pmid:1541417
Jenkins AP and Thompson RP Effect of dietary fat on the distribution of mucosal mass and cell proliferation along the small intestine. 1992 Gut pmid:1541418
Melnik B and Plewig G [A new concept of the etiopathogenesis and prevention of atopic dermatitis]. 1989 Hautarzt pmid:2558092
Melnik B and Plewig G [External treatment of atopic eczema with gamma-linolenic acid?]. 1993 Hautarzt pmid:8407331
Cohen SM et al. Therapeutic use of selected herbs. 2000 Holist Nurs Pract pmid:12119629
Vogelzang JL Fat facts and fallacies. 2003 Home Healthc Nurse pmid:14614382
Ramrath S et al. Stimulation of cardiac glucose transport by thioctic acid and insulin. 1999 Horm. Metab. Res. pmid:10668913
Chaintreuil J et al. Effects of dietary gamma-linolenate supplementation on serum lipids and platelet function in insulin-dependent diabetic patients. 1984 Hum Nutr Clin Nutr pmid:6323358
St Louis C et al. Antihypertensive effect of gamma-linolenic acid in spontaneously hypertensive rats. 1992 Hypertension pmid:1310479
Purasiri P et al. Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. 1997 Immunology pmid:9415022
Senapati S et al. Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. 2008 Sep-Oct Indian J Dermatol Venereol Leprol pmid:19052401
Chang CS et al. Gamma-linolenic acid inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. 2010 Inflammation pmid:19842026
Martens-Lobenhoffer J and Meyer FP Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). 1998 Int J Clin Pharmacol Ther pmid:9707349
Viikari J and Lehtonen A Effect of primrose oil on serum lipids and blood pressure in hyperlipidemic subjects. 1986 Int J Clin Pharmacol Ther Toxicol pmid:3028968
Ribeiro P et al. Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. 2012 Int J Food Sci Nutr pmid:21707451
Ranieri M et al. The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. 2009 Jul-Sep Int J Immunopathol Pharmacol pmid:19887043
Wilson JH et al. The effect of very low energy diets on the fatty acid composition of serum lipids. 1989 Int J Obes pmid:2613428
Haslett C et al. A double-blind evaluation of evening primrose oil as an antiobesity agent. 1983 Int J Obes pmid:6360923
Heard CM et al. Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. 2005 Int J Pharm pmid:16115741
Karia C et al. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. 2004 Int J Pharm pmid:15129999
Redden PR et al. Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. 1999 Int J Pharm pmid:10370185
Harrison RA et al. Who and how many people are taking herbal supplements? A survey of 21,923 adults. 2004 Int J Vitam Nutr Res pmid:15296076
Martínez-Augustin O et al. Bioactive anti-obesity food components. 2012 Int J Vitam Nutr Res pmid:23258394
Kast RE Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. 2001 Int. Immunopharmacol. pmid:11710548
Dib A and Carreau JP Effects of gamma-linolenic acid supplementation on lipogenesis regulation in pregnant zinc-deficient rat and fetus. 1986 Int. J. Biochem. pmid:3026865
Menendez JA et al. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. 2004 Int. J. Cancer pmid:15027132
Kenny FS et al. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. 2000 Int. J. Cancer pmid:10699943
Pham H et al. Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. 2004 Int. J. Cancer pmid:15197770
Kenny FS et al. Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts. 2001 Int. J. Cancer pmid:11291069
Jiang WG et al. gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. 1998 Int. J. Oncol. pmid:9683802
Menendez JA et al. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. 2004 Int. J. Oncol. pmid:15138577
Rahbeeni F et al. The effect of evening primrose oil on the radiation response and blood flow of mouse normal and tumour tissue. 2000 Int. J. Radiat. Biol. pmid:10902742
Hopewell JW et al. Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. 1994 Int. J. Radiat. Oncol. Biol. Phys. pmid:7961020
Aragona P et al. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients. 2005 Invest. Ophthalmol. Vis. Sci. pmid:16303936
Prencipe M et al. Naudicelle and platelet reactivity in TIA patients. 1982 Ital J Neurol Sci pmid:7166485
Halat KM and Dennehy CE Botanicals and dietary supplements in diabetic peripheral neuropathy. 2003 Jan-Feb J Am Board Fam Pract pmid:12583650
Horner NK and Lampe JW Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. 2000 J Am Diet Assoc pmid:11103660
McCollum JR FDA alert on evening primrose oil. 1989 J Am Diet Assoc pmid:2542387
OtleÅŸ S and Pire R Fatty acid composition of Chlorella and Spirulina microalgae species. 2001 Nov-Dec J AOAC Int pmid:11767135
Singh NK et al. Essential fatty acids and cancer with particular reference to Hodgkin's disease. 1987 J Assoc Physicians India pmid:3693269
Das UN et al. Beneficial effect of essential fatty acids in cirrhosis of the liver. 1987 J Assoc Physicians India pmid:3693270
Giamarellos-Bourboulis EJ et al. Do Escherichia coli susceptibilities to various antibiotics decrease in the presence of polyunsaturated fatty acids? A preliminary report. 1994 J Chemother pmid:8071677
Arnold LE et al. Does zinc moderate essential fatty acid and amphetamine treatment of attention-deficit/hyperactivity disorder? 2000 J Child Adolesc Psychopharmacol pmid:10933121
Sýkora J et al. High-performance liquid chromatography with nuclear magnetic resonance detection--A method for quantification of alpha- and gamma-linolenic acids in their mixtures with free fatty acids. 2007 J Chromatogr A pmid:17157864
Lísa M et al. Comparison of various types of stationary phases in non-aqueous reversed-phase high-performance liquid chromatography-mass spectrometry of glycerolipids in blackcurrant oil and its enzymatic hydrolysis mixture. 2009 J Chromatogr A pmid:19837411
Itoh S et al. Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. 2010 J Clin Biochem Nutr pmid:20664735
Patel GK and Logan RA Golden nail pigmentation. 2002 J Dermatolog Treat pmid:12006139
Julu PO Essential fatty acids prevent slowed nerve conduction in streptozotocin diabetic rats. 1988 Oct-Dec J Diabet Complications pmid:2853165
Park SO et al. Gamma-linolenic acid egg production enriched with hemp seed oil and evening primrose oil in diet of laying hens. 2014 J Environ Biol pmid:25004746
Montserrat-de la Paz S et al. Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages. 2014 J Ethnopharmacol pmid:24239848
Labruzzo BA et al. Which complementary therapies can help patients with PMS? 2009 J Fam Pract pmid:19874736
Seibel MM Treating hot flushes without hormone replacement therapy. 2003 J Fam Pract pmid:12681090
Deferne JL and Leeds AR Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. 1996 J Hum Hypertens pmid:8895037
Cohen DA et al. Impact of two pulmonary enteral formulations on nutritional indices and outcomes. 2013 J Hum Nutr Diet pmid:23189938
Julu PO et al. Endogenous cyclo-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats. 1996 J Lipid Mediat Cell Signal pmid:8925193
Julu PO Latency of neuroactivity and optimum period of treatment with evening primrose oil in diabetic rats. 1996 J Lipid Mediat Cell Signal pmid:8925199
Zaniewska A et al. The activity of lysosomal exoglycosidases in serum of alcohol-dependent men supplemented with borage oil enriched with vitamin E. 2009 J Med Food pmid:19735195
Lindmark L and Clough P A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia. 2007 J Med Food pmid:18158838
Samuels R et al. Hypocholesterolemic effect of spirulina in patients with hyperlipidemic nephrotic syndrome. 2002 J Med Food pmid:12487756
Al-Khamees WA et al. Status epilepticus associated with borage oil ingestion. 2011 J Med Toxicol pmid:21387119
Chan LW et al. Microencapsulation of oils using sodium alginate. 2000 Nov-Dec J Microencapsul pmid:11063422
Dove D and Johnson P Oral evening primrose oil: its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women. 1999 May-Jun J Nurse Midwifery pmid:10380450
Ormerod LD et al. Eicosanoid modulation and epithelial wound healing kinetics of the alkali-burned cornea. 1992 J Ocul Pharmacol pmid:1328428
Dasgupta S and Bhattacharyya DK Dietary effect of gamma-linolenic acid on the lipid profile of rat fed erucic acid rich oil. 2007 J Oleo Sci pmid:17938547
Kawamura A et al. Dietary supplementation of gamma-linolenic acid improves skin parameters in subjects with dry skin and mild atopic dermatitis. 2011 J Oleo Sci pmid:22123240
Ruiz-Rodriguez A et al. Recent trends in the advanced analysis of bioactive fatty acids. 2010 J Pharm Biomed Anal pmid:19525080
Giamarellos-Bourboulis EJ et al. Lipid peroxidation by Pseudomonas aeruginosa in the pathogenesis of nosocomial sepsis. 2003 Jan-Mar J Postgrad Med pmid:12865564
Sutton GC 'Too tired to go to the support group': a health needs assessment of myalgic encephalomyelitis. 1996 J Public Health Med pmid:8887847
Wright S Atopic eczema. 1991 J R Coll Physicians Lond pmid:1920221
Gateley CA et al. Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. 1992 J R Soc Med pmid:1548647
Horrobin DF The role of essential fatty acids and prostaglandins in the premenstrual syndrome. 1983 J Reprod Med pmid:6350579
Puolakka J et al. Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors. 1985 J Reprod Med pmid:3839018
Campbell EM et al. Premenstrual symptoms in general practice patients. Prevalence and treatment. 1997 J Reprod Med pmid:9350019
Williams JH The use of gamma linolenic acid, linoleic acid and natural vitamin E for the treatment of multicentric lymphoma in two dogs. 1988 J S Afr Vet Assoc pmid:2848946
Ghoreishi SM et al. Separation of γ-linolenic and other polyunsaturated fatty acids from Boraginaceae via supercritical CO2. 2011 J Sep Sci pmid:21246730
Krestnikova N et al. JNK implication in adipocyte-like cell death induced by chemotherapeutic drug cisplatin. 2015 J Toxicol Sci pmid:25560393
Seidel A et al. The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. 2005 J Vet Med A Physiol Pathol Clin Med pmid:15943605
Del Castillo ML et al. Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. 2004 J. Agric. Food Chem. pmid:14969555
Hamburger M et al. Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities. 2002 J. Agric. Food Chem. pmid:12236675