| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Nausea | D009325 | 7 associated lipids |
| Mucocele | D009078 | 1 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Viau S et al. | Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. | 2009 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:19415319 |
| Macrì A et al. | Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. | 2003 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:12768289 |
| Viau S et al. | Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells. | 2012 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:21894532 |
| Frati-Munari AC and Ariza-Andraca CR | [Treatment of diabetic neuropathy]. | 1998 Jan-Feb | Gac Med Mex | pmid:9658700 |
| Bordoni A et al. | [Treatment of premenstrual syndrome with essential fatty acids (evening primrose oil)]. | 1987 | G Clin Med | pmid:3609594 |
| Khunyoshyeng S et al. | Differential expression of desaturases and changes in fatty acid composition during sporangiospore germination and development in Mucor rouxii. | 2002 | Fungal Genet. Biol. | pmid:12223185 |
| Bard JM et al. | A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. | 1997 | Fundam Clin Pharmacol | pmid:9107561 |
| Yu Q et al. | LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenase-catalysed peroxidation of gamma-linolenic acid. | 2008 | Free Radic. Res. | pmid:18484409 |
| Preuss M et al. | Role of antioxidant enzyme expression in the selective cytotoxic response of glioma cells to gamma-linolenic acid supplementation. | 2000 | Free Radic. Biol. Med. | pmid:10832077 |
| Hatanaka E et al. | Systematic study on ROS production induced by oleic, linoleic, and gamma-linolenic acids in human and rat neutrophils. | 2006 | Free Radic. Biol. Med. | pmid:16962937 |
| Ramanathan R et al. | Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. | 1994 | Free Radic. Biol. Med. | pmid:8299995 |
| Küpper C | [Premenstrual syndrome: does gamma-linolenic acid help?]. | 1997 | Fortschr. Med. | pmid:9173016 |
| Tso P et al. | Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days. | 2012 | Food Chem. Toxicol. | pmid:22265940 |
| Bala KV et al. | Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linolenic acid. | 1993 | Food Chem. Toxicol. | pmid:8390392 |
| Kanbur M et al. | The effects of evening primrose oil on lipid peroxidation induced by subacute aflatoxin exposure in mice. | 2011 | Food Chem. Toxicol. | pmid:21600263 |
| al-Shabanah OA | Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. | 1997 | Food Chem. Toxicol. | pmid:9350221 |
| KristofÃková L et al. | Selection of Rhizopus strains for L(+)-lactic acid and gamma-linolenic acid production. | 1991 | Folia Microbiol. (Praha) | pmid:1668279 |
| Miura Y et al. | Production of gamma-linolenic acid from the marine green alga Chlorella sp. NKG 042401. | 1993 | FEMS Microbiol. Lett. | pmid:8386122 |
| Kankaanpää PE et al. | The influence of polyunsaturated fatty acids on probiotic growth and adhesion. | 2001 | FEMS Microbiol. Lett. | pmid:11164299 |
| Na-Ranong S et al. | Substrate specificity and preference of Delta6-desaturase of Mucor rouxii. | 2005 | FEBS Lett. | pmid:15862319 |
| Kinchington D et al. | Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. | 1993 | FEBS Lett. | pmid:8396048 |
| Zhang Q et al. | Identification and characterization of a novel Delta6-fatty acid desaturase gene from Rhizopus arrhizus. | 2004 | FEBS Lett. | pmid:14706830 |
| Karikó K et al. | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. | 1995 | FEBS Lett. | pmid:7890029 |
| Devi MA and Das NP | Antiproliferative effect of polyunsaturated fatty acids and interleukin-2 on normal and abnormal human lymphocytes. | 1994 | Experientia | pmid:8194587 |
| Oon BB et al. | A diet enriched in essential fatty acids protects against the loss of lymphocytes which occurs in rats suffering from streptozotocin-induced diabetes. | 1992 | Exp. Physiol. | pmid:1543584 |
| McGahon B et al. | Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study. | 1998 | Exp. Gerontol. | pmid:9639170 |
| Puch F et al. | Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. | 2008 | Exp. Dermatol. | pmid:18318715 |
| Sadi AM et al. | Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. | 1996 | Exp. Anim. | pmid:8689581 |
| Harris NM et al. | Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study. | 2002 | Eur. Urol. | pmid:12121728 |
| Field EJ and Joyce G | Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids. | 1983 | Eur. Neurol. | pmid:6301844 |
| Dines CD et al. | Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin. | 1995 | Eur. J. Pharmacol. | pmid:8521914 |
| Sergeant S et al. | Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes. | 2016 | Eur. J. Pharmacol. | pmid:27083549 |
| Leaver HA et al. | Dynamics of reactive oxygen intermediate production in human glioma: n-6 essential fatty acid effects. | 1999 | Eur. J. Clin. Invest. | pmid:10202379 |
| Chakrabarti KB et al. | Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane). | 2001 | Eur. J. Cancer | pmid:11435077 |
| Ravichandran D et al. | Effect of 1-(gamma)linolenyl-3-eicosapentaenoyl propane diol on the growth of human pancreatic carcinoma in vitro and in vivo. | 2000 | Eur. J. Cancer | pmid:10708945 |
| Davies CL et al. | Effect of gamma-linolenic acid on cellular uptake of structurally related anthracyclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines. | 1999 | Eur. J. Cancer | pmid:10673983 |
| Ravichandran D et al. | Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. | 1998 | Eur. J. Cancer | pmid:9624256 |
| Menéndez JA et al. | Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. | 2001 | Eur. J. Cancer | pmid:11239764 |
| Izumi T et al. | Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. | 1991 | Eur. J. Biochem. | pmid:1662607 |
| Di Geronimo G et al. | Treatment of carpal tunnel syndrome with alpha-lipoic acid. | 2009 Mar-Apr | Eur Rev Med Pharmacol Sci | pmid:19499849 |
| Manosroi A et al. | Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction. | 2012 | Eur J Pharm Biopharm | pmid:22490981 |
| Koletzko B et al. | Fatty acid profiles, antioxidant status, and growth of preterm infants fed diets without or with long-chain polyunsaturated fatty acids. A randomized clinical trial. | 2003 | Eur J Nutr | pmid:14569405 |
| Hoppu U et al. | Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines. | 2012 | Eur J Nutr | pmid:21626296 |
| Enzenbach C et al. | Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men. | 2011 | Eur J Nutr | pmid:21301856 |
| Kanehara S et al. | Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children. | 2007 Sep-Oct | Eur J Dermatol | pmid:17673396 |
| Kamphuis MM et al. | Fat-specific satiety in humans for fat high in linoleic acid vs fat high in oleic acid. | 2001 | Eur J Clin Nutr | pmid:11423927 |
| Thijs C et al. | Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation. | 2000 | Eur J Clin Nutr | pmid:10713746 |
| Remans PH et al. | Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. | 2004 | Eur J Clin Nutr | pmid:15164103 |
| Reilly JD et al. | Effect of a supplementary dietary evening primrose oil mixture on hoof growth, hoof growth rate and hoof lipid fractions in horses: a controlled and blinded trial. | 1998 | Equine Vet J Suppl | pmid:9932095 |
| Reinikainen M et al. | The toxicities of a polyunsaturated fatty acid and a microcystin to Daphnia magna. | 2001 | Environ. Toxicol. | pmid:11594032 |
| Bruder ED et al. | Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. | 2004 | Endocrinology | pmid:15271879 |
| Schwartz Z et al. | Arachidonic acid directly mediates the rapid effects of 24,25-dihydroxyvitamin D3 via protein kinase C and indirectly through prostaglandin production in resting zone chondrocytes. | 1999 | Endocrinology | pmid:10385391 |
| SimoncÃkova P et al. | Comparison of the extrapancreatic action of gamma-linolenic acid and n-3 PUFAs in the high fat diet-induced insulin resistance [corrected]. | 2002 | Endocr Regul | pmid:12466014 |
| Zavodnik LB et al. | [Effect of gamma-linolenic acid on microsomal oxidation in the rat liver following gamma-irradiation]. | 2001 Jul-Aug | Eksp Klin Farmakol | pmid:11589114 |
| Biagi PL et al. | The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. | 1994 | Drugs Exp Clin Res | pmid:7924900 |
| Biagi PL et al. | A long-term study on the use of evening primrose oil (Efamol) in atopic children. | 1988 | Drugs Exp Clin Res | pmid:3048952 |
| Bordoni A et al. | Evening primrose oil (Efamol) in the treatment of children with atopic eczema. | 1988 | Drugs Exp Clin Res | pmid:3048953 |
| Cyclical breast pain--what works and what doesn't. | 1992 | Drug Ther Bull | pmid:1425218 | |
| Gamolenic acid in atopic eczema: Epogam. | 1990 | Drug Ther Bull | pmid:2131219 | |
| Recently introduced products. | 1991 | Drug Ther Bull | pmid:1935601 | |
| Wade AE et al. | Effect of 7,12-dimethylbenz(a)anthracene administration on hepatic drug metabolizing enzymes in female rats fed corn, primrose, and menhaden oils. | 1988 | Drug Nutr Interact | pmid:3149238 |
| Duffy O et al. | Effects of an oil enriched in gamma linolenic acid on locomotor activity and behaviour in the Morris Maze, following in utero ethanol exposure in rats. | 1992 | Drug Alcohol Depend | pmid:1317288 |
| Duffy O et al. | Attenuation of the effects of chronic ethanol administration in the brain lipid content of the developing rat by an oil enriched in gamma linolenic acid. | 1992 | Drug Alcohol Depend | pmid:1330473 |
| Huang YS et al. | Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats. | 1987 | Digestion | pmid:3030865 |
| Vinik AI et al. | Diabetic neuropathies. | 2000 | Diabetologia | pmid:10990072 |
| Cameron NE et al. | Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. | 1998 | Diabetologia | pmid:9562342 |
| Dines KC et al. | Contrasting effects of treatment with omega-3 and omega-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. | 1993 | Diabetologia | pmid:8270127 |
| Cameron NE and Cotter MA | Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. | 1996 | Diabetologia | pmid:8877288 |
| Hounsom L et al. | Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. | 2001 | Diabetologia | pmid:11357471 |
| Stevens EJ et al. | Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. | 1993 | Diabetologia | pmid:8314443 |
| Hounsom L et al. | A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. | 1998 | Diabetologia | pmid:9686927 |
| Tomlinson DR et al. | Essential fatty acid treatment--effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats. | 1989 | Diabetologia | pmid:2477293 |
| Karasu C et al. | Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids. | 1995 | Diabetologia | pmid:7713308 |
| Cameron NE et al. | Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. | 1996 | Diabetologia | pmid:8635669 |
| van Doormaal JJ et al. | Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, alpha-tocopherol levels, and erythropoiesis in normal and type 1 (insulin-dependent) diabetic men. | 1988 | Diabetologia | pmid:3065111 |
| Borenshtein D et al. | Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate. | 2001 Jan-Feb | Diabetes Metab. Res. Rev. | pmid:11241890 |
| Keegan A et al. | Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment. | 2001 Sep-Oct | Diabetes Metab. Res. Rev. | pmid:11747143 |
| Keen H et al. | Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. | 1993 | Diabetes Care | pmid:8380765 |
| Shotton HR et al. | The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. | 2003 | Diabetes | pmid:12502507 |
| Horrobin DF | Essential fatty acids in the management of impaired nerve function in diabetes. | 1997 | Diabetes | pmid:9285506 |
| Cameron NE et al. | Essential fatty acid diet supplementation. Effects on peripheral nerve and skeletal muscle function and capillarization in streptozocin-induced diabetic rats. | 1991 | Diabetes | pmid:2022301 |
| Jamal GA | The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. | 1994 | Diabet. Med. | pmid:8200197 |
| Jamal GA and Carmichael H | The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. | 1990 | Diabet. Med. | pmid:2159860 |
| Whitaker DK et al. | Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. | 1996 | Dermatology (Basel) | pmid:8884146 |
| Worm M and Henz BM | Novel unconventional therapeutic approaches to atopic eczema. | 2000 | Dermatology (Basel) | pmid:11096188 |
| Mayo TT et al. | Comparative study on bruise reduction treatments after bruise induction using the pulsed dye laser. | 2013 | Dermatol Surg | pmid:23899131 |
| Mettang T | Uremic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578082 |
| Goldfien A | Premenstrual syndrome. | 1994 | Curr Ther Endocrinol Metab | pmid:7704719 |
| Das UN | Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives. | 2006 | Curr Pharm Biotechnol | pmid:17168663 |
| Morse NL and Clough PM | A meta-analysis of randomized, placebo-controlled clinical trials of Efamol evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries? | 2006 | Curr Pharm Biotechnol | pmid:17168667 |
| Kapoor R and Huang YS | Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. | 2006 | Curr Pharm Biotechnol | pmid:17168669 |
| Lindemann J et al. | Clinical study of the effects on asthma-related QOL and asthma management of a medical food in adult asthma patients. | 2009 | Curr Med Res Opin | pmid:19811112 |
| Surette ME et al. | The impact of a medical food containing gammalinolenic and eicosapentaenoic acids on asthma management and the quality of life of adult asthma patients. | 2008 | Curr Med Res Opin | pmid:18194593 |
| Mancuso P et al. | Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats. | 1997 | Crit. Care Med. | pmid:9233748 |
| Pontes-Arruda A et al. | Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. | 2006 | Crit. Care Med. | pmid:16850002 |
| Singer P et al. | Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. | 2006 | Crit. Care Med. | pmid:16484911 |
| Pacht ER | Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come. | 2006 | Crit. Care Med. | pmid:16921322 |
| Palombo JD et al. | Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats. | 1999 | Crit. Care Med. | pmid:10507617 |
| Ortiz-Leyba C and Garnacho-Montero J | Saving lives in severe sepsis with the help of enteral nutrition. | 2007 | Crit. Care Med. | pmid:17421113 |
| Pacht ER et al. | Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. | 2003 | Crit. Care Med. | pmid:12576957 |