gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Psoriasis D011565 47 associated lipids
Alcoholism D000437 27 associated lipids
Bacteriuria D001437 7 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Kavanagh T et al. Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15041032
Del Castillo ML et al. Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. 2004 J. Agric. Food Chem. pmid:14969555
Menendez JA et al. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. 2004 Int. J. Cancer pmid:15027132
van Gool CJ et al. Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. 2004 Br. J. Dermatol. pmid:15099370
Leaver HA et al. Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15062847
Miles EA et al. The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120716
Das UN From bench to the clinic: gamma-linolenic acid therapy of human gliomas. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120717
Gallagher S Omega 3 oils and pregnancy. 2004 Midwifery Today Int Midwife pmid:15124319
Karia C et al. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. 2004 Int J Pharm pmid:15129999
Menendez JA et al. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. 2004 Int. J. Oncol. pmid:15138577
Shotton HR et al. Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil. 2004 Auton Neurosci pmid:15109939
Fewtrell MS et al. Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. 2004 J. Pediatr. pmid:15069395
Radomska A Antioxidant properties of captopril in vitro. 2003 May-Jun Acta Pol Pharm pmid:14556487
Nelson JL et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants on antioxidant status in patients with acute respiratory distress syndrome. 2003 Mar-Apr JPEN J Parenter Enteral Nutr pmid:12665164
Giamarellos-Bourboulis EJ et al. Lipid peroxidation by Pseudomonas aeruginosa in the pathogenesis of nosocomial sepsis. 2003 Jan-Mar J Postgrad Med pmid:12865564
Halat KM and Dennehy CE Botanicals and dietary supplements in diabetic peripheral neuropathy. 2003 Jan-Feb J Am Board Fam Pract pmid:12583650
Harris NM et al. Epirubicin and meglumine gamma-linolenic acid: a logical choice of combination therapy for patients with superficial bladder carcinoma. 2003 Cancer pmid:12491507
Pham H et al. Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells. 2003 Cancer Lett. pmid:12445673
Shotton HR et al. The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. 2003 Diabetes pmid:12502507
Delmonte P et al. Synthesis and isolation of trans-7,cis-9 octadecadienoic acid and other CLA isomers by base conjugation of partially hydrogenated gamma-linolenic acid. 2003 Lipids pmid:12880116
Surette ME et al. Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects. 2003 Clin Ther pmid:12852710
Surette ME et al. Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo-controlled, parallel-group, prospective trial. 2003 Clin Ther pmid:12852711
Whitehouse PA et al. Synergistic activity of gamma-linolenic acid and cytotoxic drugs against pancreatic adenocarcinoma cell lines. 2003 Pancreatology pmid:14526145
Song C et al. Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. 2003 J. Lipid Res. pmid:12837849
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Li MC et al. [Expression of Mortierella isabellina delta6-fatty acid desaturase gene in gamma-linolenic acid production in transgenic tobacco]. 2003 Sheng Wu Gong Cheng Xue Bao pmid:15966318
Vogelzang JL Fat facts and fallacies. 2003 Home Healthc Nurse pmid:14614382
Koletzko B et al. Fatty acid profiles, antioxidant status, and growth of preterm infants fed diets without or with long-chain polyunsaturated fatty acids. A randomized clinical trial. 2003 Eur J Nutr pmid:14569405
Arimura T et al. Caspase-independent apoptosis induced by evening primrose extract in Ehrlich ascites tumor cells. 2003 Cancer Lett. pmid:14580681
Barabino S et al. Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. 2003 Cornea pmid:12605039
Djoussé L et al. Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:14668270
Williams HC Evening primrose oil for atopic dermatitis. 2003 BMJ pmid:14670851
Takwale A et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. 2003 BMJ pmid:14670885
Macrì A et al. Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. 2003 Graefes Arch. Clin. Exp. Ophthalmol. pmid:12768289
Jelińska M et al. Effects of dietary linseed, evening primrose or fish oils on fatty acid and prostaglandin E2 contents in the rat livers and 7,12-dimethylbenz[a]anthracene-induced tumours. 2003 Biochim. Biophys. Acta pmid:12697300
van Gool CJ et al. Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis--a randomized controlled trial in infants at high familial risk. 2003 Am. J. Clin. Nutr. pmid:12663296
Spector SL and Surette ME Diet and asthma: has the role of dietary lipids been overlooked in the management of asthma? 2003 Ann. Allergy Asthma Immunol. pmid:12722956
Vecera R et al. Antioxidant status, lipoprotein profile and liver lipids in rats fed on high-cholesterol diet containing currant oil rich in n-3 and n-6 polyunsaturated fatty acids. 2003 Physiol Res pmid:12678660
Seibel MM Treating hot flushes without hormone replacement therapy. 2003 J Fam Pract pmid:12681090
Wainwright PE et al. Effects of high-gamma-linolenic acid canola oil compared with borage oil on reproduction, growth, and brain and behavioral development in mice. 2003 Lipids pmid:12733750
Soeken KL et al. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. 2003 Rheumatology (Oxford) pmid:12709541
Duttaroy AK et al. Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538089
Pacht ER et al. Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. 2003 Crit. Care Med. pmid:12576957
Xian M et al. Production of gamma-linolenic acid by disrupted mycelia of Mortierella isabellina. 2003 Lett. Appl. Microbiol. pmid:12581380
Rosenstein ED et al. Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591005
Usami M et al. Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation. 2003 Nutrition pmid:12591548
Hirano A et al. Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. 2003 Anal Sci pmid:12608744
Shimizu S and Nakano M Structural characterization of triacylglycerol in several oils containing gamma-linolenic acid. 2003 Biosci. Biotechnol. Biochem. pmid:12619674
Funtikova NS et al. [Synthesis of biologically active lipids by fungus Mucor lusitanicus 306D grown on media with various composition]. 2002 Nov-Dec Prikl. Biokhim. Mikrobiol. pmid:12449793
Das UN Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. 2002 Jul-Aug Nutrition pmid:12093450
Yoon S et al. The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. 2002 Jan-Feb Skin Pharmacol. Appl. Skin Physiol. pmid:11803254
Simoncíkova P et al. Comparison of the extrapancreatic action of gamma-linolenic acid and n-3 PUFAs in the high fat diet-induced insulin resistance [corrected]. 2002 Endocr Regul pmid:12466014
Leaver HA et al. Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12445487
Blommers J et al. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. 2002 Am. J. Obstet. Gynecol. pmid:12439536
Senanayake SP and Shahidi F Positional distribution of FA in TAG of enzymatically modified borage and evening primrose oils. 2002 Lipids pmid:12371752
Turon F et al. A direct method for regiospecific analysis of TAG using alpha-MAG. 2002 Lipids pmid:12371754
Dyer O Doctor accused of giving false information to drug trial. 2002 BMJ pmid:12269314
Tso P et al. Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. 2002 J. Nutr. pmid:11823581
Deng X et al. Regulation of the rat SREBP-1c promoter in primary rat hepatocytes. 2002 Biochem. Biophys. Res. Commun. pmid:11779162
Senanayake SP and Shahidi F Structured lipids via lipase-catalyzed incorporation of eicosapentaenoic acid into borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils. 2002 J. Agric. Food Chem. pmid:11804516
Jack AM et al. Effects of diabetes and evening primrose oil treatment on responses of aorta, corpus cavernosum and mesenteric vasculature in rats. 2002 Life Sci. pmid:12175702
Harris NM et al. Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study. 2002 Eur. Urol. pmid:12121728
Hornych A et al. The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. 2002 Bratisl Lek Listy pmid:12190041
Theander E et al. Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome. 2002 Scand. J. Rheumatol. pmid:12109650
Furse RK et al. Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. 2002 J. Clin. Immunol. pmid:11998897
Gema H et al. Production of gamma-linolenic acid by Cunninghamella echinulata cultivated on glucose and orange peel. 2002 Appl. Microbiol. Biotechnol. pmid:11935180
Hong H et al. High-level production of gamma-linolenic acid in Brassica juncea using a delta6 desaturase from Pythium irregulare. 2002 Plant Physiol. pmid:12011365
Patel GK and Logan RA Golden nail pigmentation. 2002 J Dermatolog Treat pmid:12006139
Leigh-Firbank EC et al. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. 2002 Br. J. Nutr. pmid:12010583
Braddock R et al. gamma-Linoleic acid and ascorbic acid ameliorate the effects of experimental diabetes on electrolyte and bone homeostasis in pregnant rats. 2002 J. Endocrinol. pmid:12010635
Crook TJ et al. The effects of meglumine gamma linolenic acid (MeGLA) on an organ culture model of superficial bladder cancer. 2002 Urol. Res. pmid:11942327
García-Maroto F et al. Cloning and molecular characterization of the delta6-desaturase from two echium plant species: production of GLA by heterologous expression in yeast and tobacco. 2002 Lipids pmid:12030323
Colquhoun A Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour. 2002 Biochim. Biophys. Acta pmid:12069851
Menéndez JA et al. Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. 2002 Breast Cancer Res. Treat. pmid:12058962
Cook D et al. Modification of fatty acid composition in tomato (Lycopersicon esculentum) by expression of a borage delta6-desaturase. 2002 Mol. Biotechnol. pmid:12059112
Leaver HA et al. Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12051954
Chung S et al. Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. 2002 J. Nutr. pmid:12368400
Gillis RC et al. Eicosapentaenoic acid and gamma-linolenic acid induce apoptosis in HL-60 cells. 2002 J. Surg. Res. pmid:12384078
Pérez Y et al. Measurement by nuclear magnetic resonance diffusion of the dimensions of the mobile lipid compartment in C6 cells. 2002 Cancer Res. pmid:12384523
Ernst E Ayurvedic medicines. 2002 Pharmacoepidemiol Drug Saf pmid:12426929
Uesaka Y [Prevention and treatment of diabetic neuropathy]. 2002 Nippon Rinsho pmid:12430238
Hamburger M et al. Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities. 2002 J. Agric. Food Chem. pmid:12236675
Khunyoshyeng S et al. Differential expression of desaturases and changes in fatty acid composition during sporangiospore germination and development in Mucor rouxii. 2002 Fungal Genet. Biol. pmid:12223185
Whelan J et al. Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect. 2002 Adv. Exp. Med. Biol. pmid:12664643
Pham H and Ziboh VA 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids. 2002 J. Steroid Biochem. Mol. Biol. pmid:12589947
Das UN Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. 2002 Nutrition pmid:12297217
Samuels R et al. Hypocholesterolemic effect of spirulina in patients with hyperlipidemic nephrotic syndrome. 2002 J Med Food pmid:12487756
Keegan A et al. Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment. 2001 Sep-Oct Diabetes Metab. Res. Rev. pmid:11747143
OtleÅŸ S and Pire R Fatty acid composition of Chlorella and Spirulina microalgae species. 2001 Nov-Dec J AOAC Int pmid:11767135
Zavodnik LB et al. [Effect of gamma-linolenic acid on microsomal oxidation in the rat liver following gamma-irradiation]. 2001 Jul-Aug Eksp Klin Farmakol pmid:11589114
Borenshtein D et al. Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate. 2001 Jan-Feb Diabetes Metab. Res. Rev. pmid:11241890
Nwankwo JO and Robbins ME Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418018
Cunnane SC et al. NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain. 2001 Apr-Jun J. Mol. Neurosci. pmid:11478372
Hounsom L et al. Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. 2001 Diabetologia pmid:11357471
Kast RE Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. 2001 Int. Immunopharmacol. pmid:11710548
Ide T et al. Dietary mold oil rich in gamma linolenic acid increases insulin-dependent glucose utilization in isolated rat adipocytes. 2001 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11567903
Kaku S et al. Dietary gamma-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728173
Furse RK et al. Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes. 2001 J. Immunol. pmid:11418687
Thies F et al. Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. 2001 J. Nutr. pmid:11435508
Yogo Y and Fujishima S [Nutritional support for ARDS]. 2001 Nippon Rinsho pmid:11439576