Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Guenther L and Wexler D | Efamol in the treatment of atopic dermatitis. | 1987 | J. Am. Acad. Dermatol. | pmid:3680673 |
Ziboh VA and Chapkin RS | Biologic significance of polyunsaturated fatty acids in the skin. | 1987 | Arch Dermatol | pmid:3688908 |
Singh NK et al. | Essential fatty acids and cancer with particular reference to Hodgkin's disease. | 1987 | J Assoc Physicians India | pmid:3693269 |
Das UN et al. | Beneficial effect of essential fatty acids in cirrhosis of the liver. | 1987 | J Assoc Physicians India | pmid:3693270 |
Levy RJ and Lian JB | gamma-Carboxyglutamate excretion and warfarin therapy. | 1979 | Clin. Pharmacol. Ther. | pmid:373941 |
Sugano M et al. | Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. | 1986 | Ann. Nutr. Metab. | pmid:3752928 |
Puolakka J et al. | Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors. | 1985 | J Reprod Med | pmid:3839018 |
Wright S | Atopic dermatitis and essential fatty acids: a biochemical basis for atopy? | 1985 | Acta Derm Venereol Suppl (Stockh) | pmid:3890448 |
Bamford JT et al. | Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids). | 1985 | J. Am. Acad. Dermatol. | pmid:3908514 |
Kumar S et al. | Prediction of response to endocrine therapy in pronounced cyclical mastalgia using dynamic tests of prolactin release. | 1985 | Clin. Endocrinol. (Oxf) | pmid:3938354 |
Soma M et al. | The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. | 1985 | Can. J. Physiol. Pharmacol. | pmid:4005704 |
Webb J and McCredie M | Primary Sjögren's syndrome treated with Efamol/efavit. A double-blind cross-over investigation. | 1985 | Rheumatol. Int. | pmid:4048763 |
Belch JJ et al. | Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. | 1985 | Thromb. Haemost. | pmid:4082084 |
Strong AM et al. | The effect of oral linoleic acid and gamma-linolenic acid (Efamol [G]). | 1985 Nov-Dec | Br J Clin Pract | pmid:4092010 |
Horrobin DF | Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjogren's syndrome. | 1984 | Med. Hypotheses | pmid:6088955 |
Mertin J | Omega-6 and omega-3 polyunsaturates and the immune system. | 1984 | Br J Clin Pract Suppl | pmid:6091715 |
Leonard BE | Possible relationships between thiamine, carnitine, polyunsaturated fatty acids and the neurotoxicity of alcohol. | 1984 | Alcohol Alcohol. | pmid:6093831 |
Traitler H et al. | Characterization of gamma-linolenic acid in Ribes seed. | 1984 | Lipids | pmid:6098796 |
Monnier L | [Influence of metabolic and nutritional balance on platelet function in insulin-dependent diabetes]. | 1984 | Journ Annu Diabetol Hotel Dieu | pmid:6100381 |
Lovell CR et al. | Treatment of atopic eczema with evening primrose oil. | 1981 | Lancet | pmid:6109930 |
Wright S and Burton JL | Oral evening-primrose-seed oil improves atopic eczema. | 1982 | Lancet | pmid:6128449 |
Chalmers RJ and Shuster S | Evening primrose seed oil in ichthyosis vulgaris. | 1983 | Lancet | pmid:6130264 |
Horrobin DF | A biochemical basis for alcoholism and alcohol-induced damage including the fetal alcohol syndrome and cirrhosis: interference with essential fatty acid and prostaglandin metabolism. | 1980 | Med. Hypotheses | pmid:6253773 |
Darcet P et al. | [Study of the metabolism of fatty acids and total plasma lipids, and platelet aggregation of a population of elderly men using a diet enriched in gamma-linolenic acid]. | 1980 | Ann Nutr Aliment | pmid:6254419 |
Beitz J et al. | Influence of linseed oil diet on the pattern of serum phospholipids in man. | 1981 | Acta Biol. Med. Ger. | pmid:6277115 |
Bodak A et al. | [Comparative study of light and electron microscopic aspects of myocardial lesions induced in the rat by oils with several amounts of gamma-linolenic acid (author's transl)]. | 1982 | Pathol. Biol. | pmid:6278382 |
Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
Huang YS et al. | Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). | 1982 | Atherosclerosis | pmid:6279122 |
Simmons DA et al. | Significance of tissue myo-inositol concentrations in metabolic regulation in nerve. | 1982 | Science | pmid:6285474 |
Varma PK and Persaud TV | Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. | 1982 | Prostaglandins Leukot Med | pmid:6287501 |
Leary WP et al. | Some effects of gamma-linolenic acid on cultured human oesophageal carcinoma cells. | 1982 | S. Afr. Med. J. | pmid:6291175 |
Dippenaar N et al. | The reversibility of cancer: evidence that malignancy in human hepatoma cells is gamma-linolenic acid deficiency-dependent. | 1982 | S. Afr. Med. J. | pmid:6291176 |
Renaud S et al. | Comparative beneficial effects on platelet functions and atherosclerosis of dietary linoleic and gamma-linolenic acids in the rabbit. | 1982 | Atherosclerosis | pmid:6297517 |
van der Merwe CF | The reversibility of cancer. | 1983 | S. Afr. Med. J. | pmid:6298954 |
Field EJ and Joyce G | Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids. | 1983 | Eur. Neurol. | pmid:6301844 |
Hansen TM et al. | Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. | 1983 | Scand. J. Rheumatol. | pmid:6304871 |
Botha JH et al. | Parenteral gamma-linolenic acid administration in nude mice bearing a range of human tumour xenografts. | 1983 | S. Afr. Med. J. | pmid:6304925 |
Paccalin J et al. | [Changes in the higher derivatives of linoleic acid in cirrhotics treated with gamma-linolenic acid]. | 1983 May-Jun | Therapie | pmid:6310813 |
Kirstein D et al. | Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. | 1983 | Br. J. Nutr. | pmid:6315055 |
Kemp P and Lander DJ | The hydrogenation of gamma-linolenic acid by pure cultures of two rumen bacteria. | 1983 | Biochem. J. | pmid:6318740 |
Hamberg M | Omega 6-oxygenation of 6, 9, 12-octadecatrienoic acid in human platelets. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6318765 |
Van der Merwe CF | The reversibility of cancer. | 1984 | S. Afr. Med. J. | pmid:6320476 |
Booyens J and Katzeff IE | Cancer: a simple metabolic disease? | 1983 | Med. Hypotheses | pmid:6321917 |
Hamberg M | Isotope effects in enzymatic and non-enzymatic oxygenation of 6,9,12-octadecatrienoic acid. | 1984 | Biochim. Biophys. Acta | pmid:6322853 |
Chaintreuil J et al. | Effects of dietary gamma-linolenate supplementation on serum lipids and platelet function in insulin-dependent diabetic patients. | 1984 | Hum Nutr Clin Nutr | pmid:6323358 |
Mills DE and Ward R | Attenuation of psychosocial stress-induced hypertension by gamma-linolenic acid (GLA) administration in rats. | 1984 | Proc. Soc. Exp. Biol. Med. | pmid:6324224 |
Booyens J and Koenig L | The effect of dietary supplementation with gamma-linolenic acid on the growth of induced tumours in rats. | 1984 | S. Afr. Med. J. | pmid:6324397 |
Paccalin J et al. | [Rediscovery of an oleaginous plant: Oenothera biennis. The importance of gamma-linolenic acid in nutrition]. | 1983 | Bull. Acad. Natl. Med. | pmid:6324965 |
McCarty MF and Rubin EJ | Rationales for micronutrient supplementation in diabetes. | 1984 | Med. Hypotheses | pmid:6325854 |
van der Merwe CF | The reversibility of cancer. | 1984 | S. Afr. Med. J. | pmid:6326340 |
Manku MS et al. | Essential fatty acids in the plasma phospholipids of patients with atopic eczema. | 1984 | Br. J. Dermatol. | pmid:6329254 |
Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
Hoffman P and Förster W | Effects of sunflowerseed oil, linseed oil, evening primrose oil and hydrogenated palm kernel oil on hypertension development in spontaneously hypertensive rats. | 1983 | Prostaglandins Leukot Med | pmid:6348801 |
Horrobin DF | The role of essential fatty acids and prostaglandins in the premenstrual syndrome. | 1983 | J Reprod Med | pmid:6350579 |
Haslett C et al. | A double-blind evaluation of evening primrose oil as an antiobesity agent. | 1983 | Int J Obes | pmid:6360923 |
Manthorpe R et al. | Primary Sjögren's syndrome treated with Efamol/Efavit. A double-blind cross-over investigation. | 1984 | Rheumatol. Int. | pmid:6385206 |
Olsson AG et al. | [Ineffectiveness of Naudicelle in intermittent claudication]. | 1984 | Lakartidningen | pmid:6394928 |
Weighill VE and Buglass D | Weight change and psychological state in obese women. | 1984 | Appetite | pmid:6517571 |
Phillips JS | Oil of the evening primrose. | 1984 | N. Z. Med. J. | pmid:6589527 |
Hanifin JM | Diet, nutrition, and allergy in atopic dermatitis. | 1983 | J. Am. Acad. Dermatol. | pmid:6863636 |
Kábrt J et al. | [Serum lipid concentration in familial hyperlipoproteinemia type IV. Treatment with vitamin C and unsaturated fatty acids]. | 1983 | Cas. Lek. Cesk. | pmid:6871949 |
Kábrt J et al. | [Serum lipid concentrations in familial hyperlipoproteinaemia type IIa. Treatment with unsaturated fatty acids and vitamin C (author's transl)]. | 1982 | Cas. Lek. Cesk. | pmid:7093988 |
Prencipe M et al. | Naudicelle and platelet reactivity in TIA patients. | 1982 | Ital J Neurol Sci | pmid:7166485 |
Karmali RA et al. | Prostaglandins and essential fatty acids in regulation of autoimmunity and development of antibodies to DNA in NZB x NZW F1 mice. | 1981 | Prog. Lipid Res. | pmid:7342118 |
Kunkel SL et al. | Suppression of chronic inflammation by evening primrose oil. | 1981 | Prog. Lipid Res. | pmid:7342138 |
Lindskov R and Petersen CS | [Oral gamma-linoleic acid (Epogam) in the treatment of atopic dermatitis]. | 1995 | Ugeskr. Laeg. | pmid:7483071 |
Hrelia S et al. | Essential fatty acid metabolism in cultured rat cardiomyocytes in response to either N-6 or N-3 fatty acid supplementation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488075 |
Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
Kietzmann M | [Pharmacotherapeutic use of antipruritic drugs in skin diseases]. | 1995 | Tierarztl Prax | pmid:7545832 |
Larsson-Backström C et al. | Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. | 1995 | Shock | pmid:7552772 |
Rossetti RG et al. | Differential regulation of human T lymphocyte protein kinase C activity by unsaturated fatty acids. | 1995 | Clin. Immunol. Immunopathol. | pmid:7554442 |
Manninen P et al. | Separation of gamma- and alpha-linolenic acid containing triacylglycerols by capillary supercritical fluid chromatography. | 1995 | Lipids | pmid:7564922 |
Chajès V et al. | Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E. | 1995 | Breast Cancer Res. Treat. | pmid:7579484 |
Jiang WG et al. | Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). | 1995 | Cancer Res. | pmid:7585549 |
Claassen N et al. | Supplemented gamma-linolenic acid and eicosapentaenoic acid influence bone status in young male rats: effects on free urinary collagen crosslinks, total urinary hydroxyproline, and bone calcium content. | 1995 | Bone | pmid:7626328 |
Das UN et al. | Local application of gamma-linolenic acid in the treatment of human gliomas. | 1995 | Cancer Lett. | pmid:7634242 |
Akahane N et al. | Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature. | 1995 | Thromb. Res. | pmid:7660360 |
Fan YY et al. | Dietary gamma-linolenic acid modulates macrophage-vascular smooth muscle cell interactions. Evidence for a macrophage-derived soluble factor that downregulates DNA synthesis in smooth muscle cells. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670954 |
Sherrington EJ et al. | The effect of dietary lipid manipulation on macrophage cell surface molecule expression. | 1995 | Biochem. Soc. Trans. | pmid:7672298 |
Beno DW et al. | Gamma-linolenic acid suppression of hepatic Ito cell mitogenesis: post-PDGF receptor prostaglandin-independent mechanism. | 1993 | Am. J. Physiol. | pmid:7694498 |
Goldfien A | Premenstrual syndrome. | 1994 | Curr Ther Endocrinol Metab | pmid:7704719 |
Jiang WG et al. | Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. | 1995 | Br. J. Cancer | pmid:7710939 |
Karasu C et al. | Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids. | 1995 | Diabetologia | pmid:7713308 |
Dines KC et al. | Comparison of the effects of evening primrose oil and triglycerides containing gamma-linolenic acid on nerve conduction and blood flow in diabetic rats. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7714803 |
Scholey JW and Mills DE | Dietary fatty acids and the glomerular hemodynamic response to cyclosporine in borderline hypertensive rats. | 1995 | Kidney Int. | pmid:7723248 |
Tate GA and Zurier RB | Suppression of monosodium urate crystal-induced inflammation by black currant seed oil. | 1994 | Agents Actions | pmid:7741038 |
Darlington LG and Ramsey NW | Review of dietary therapy for rheumatoid arthritis. | 1994 | Compr Ther | pmid:7805365 |
BeLieu RM | Mastodynia. | 1994 | Obstet. Gynecol. Clin. North Am. | pmid:7816407 |
Berth-Jones J and Graham-Brown RA | Evening primrose oil. Does not show promise in atopic dermatitis. | 1994 | BMJ | pmid:7819863 |
Horrobin DF and Morse PF | Evening primrose oil and atopic eczema. | 1995 | Lancet | pmid:7823743 |
Araya J and Cagalj A | [Exclusion of alpha-linolenic acid from diets for rats during several generations. I. Effect on reproduction and postnatal growth]. | 1993 | Arch Latinoam Nutr | pmid:7826185 |
Hauben M | Comment: evening primrose oil in the treatment of rheumatoid arthritis--proper application of statistical analysis. | 1994 Jul-Aug | Ann Pharmacother | pmid:7832860 |
Guivernau M et al. | Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846101 |
McCaul JA and Lamey PJ | Multiple oral mucoceles treated with gamma-linolenic acid: report of a case. | 1994 | Br J Oral Maxillofac Surg | pmid:7849001 |
Falconer JS et al. | Polyunsaturated fatty acids in the treatment of weight-losing patients with pancreatic cancer. | 1994 | World Rev Nutr Diet | pmid:7856240 |
Berth-Jones J et al. | Evening primrose oil and atopic eczema. | 1995 | Lancet | pmid:7861894 |
Tulloch I et al. | Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. | 1994 | Urol. Res. | pmid:7871634 |
Purasiri P et al. | Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. | 1994 | Clin. Sci. | pmid:7874864 |
Cartwright-Shamoon JM et al. | A complex biochemical modulation of intestinal ion transport in rats fed on high-fat diets. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7884616 |
Cameron NE and Cotter MA | Effects of evening primrose oil treatment on sciatic nerve blood flow and endoneurial oxygen tension in streptozotocin-diabetic rats. | 1994 | Acta Diabetol | pmid:7888693 |