| MeSH term | MeSH ID | Detail |
|---|---|---|
| Multiple Sclerosis, Relapsing-Remitting | D020529 | 7 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Fatigue | D005221 | 10 associated lipids |
| Nausea | D009325 | 7 associated lipids |
| Critical Illness | D016638 | 13 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Intermittent Claudication | D007383 | 6 associated lipids |
| Fibrocystic Breast Disease | D005348 | 1 associated lipids |
| Tietze's Syndrome | D013991 | 1 associated lipids |
| Pityriasis | D010915 | 3 associated lipids |
| Xerostomia | D014987 | 6 associated lipids |
| Fallopian Tube Neoplasms | D005185 | 1 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Scurvy | D012614 | 2 associated lipids |
| Hand Dermatoses | D006229 | 5 associated lipids |
| Mucocele | D009078 | 1 associated lipids |
| Salivary Gland Diseases | D012466 | 1 associated lipids |
| Gastritis, Atrophic | D005757 | 4 associated lipids |
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mengeaud V et al. | Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1337209 |
| Girault C et al. | Effect of dietary gamma-linolenic acid on specific activities of delta 6 desaturation in obese Zucker rats. | 1992 | C. R. Seances Soc. Biol. Fil. | pmid:1337306 |
| Cantrill RC et al. | The effect of n-6 fatty acids on normal and v-Ki ras transformed NIH-3T3 cells. | 1992 Nov-Dec | Anticancer Res. | pmid:1338278 |
| Furuse M et al. | Effect of gamma-linolenic acid on lipid metabolism in laying hens. | 1992 | Comp Biochem Physiol A Comp Physiol | pmid:1347726 |
| MEAD JF and HOWTON DR | Metabolism of essential fatty acids. VII. Conversion of gamma-linolenic acid to arachidonic acid. | 1957 | J. Biol. Chem. | pmid:13502321 |
| Cyclical breast pain--what works and what doesn't. | 1992 | Drug Ther Bull | pmid:1425218 | |
| SHAW R | THE OCCURRENCE OF GAMMA-LINOLENIC ACID IN FUNGI. | 1965 | Biochim. Biophys. Acta | pmid:14320219 |
| Huang YS et al. | Effects of repeated gestation and lactation on milk n-6 fatty acid composition in rats fed on a diet rich in 18:2n-6 or 18:3n-6. | 1992 | Br. J. Nutr. | pmid:1445816 |
| Whitehouse PA et al. | Synergistic activity of gamma-linolenic acid and cytotoxic drugs against pancreatic adenocarcinoma cell lines. | 2003 | Pancreatology | pmid:14526145 |
| Radomska A | Antioxidant properties of captopril in vitro. | 2003 May-Jun | Acta Pol Pharm | pmid:14556487 |
| Koletzko B et al. | Fatty acid profiles, antioxidant status, and growth of preterm infants fed diets without or with long-chain polyunsaturated fatty acids. A randomized clinical trial. | 2003 | Eur J Nutr | pmid:14569405 |
| Arimura T et al. | Caspase-independent apoptosis induced by evening primrose extract in Ehrlich ascites tumor cells. | 2003 | Cancer Lett. | pmid:14580681 |
| Vogelzang JL | Fat facts and fallacies. | 2003 | Home Healthc Nurse | pmid:14614382 |
| Das UN | Occlusion of infusion vessels on gamma-linolenic acid infusion. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643176 |
| Djoussé L et al. | Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:14668270 |
| Williams HC | Evening primrose oil for atopic dermatitis. | 2003 | BMJ | pmid:14670851 |
| Takwale A et al. | Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. | 2003 | BMJ | pmid:14670885 |
| de La Puerta Vázquez R et al. | Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. | 2004 | Metab. Clin. Exp. | pmid:14681843 |
| Zhang Q et al. | Identification and characterization of a novel Delta6-fatty acid desaturase gene from Rhizopus arrhizus. | 2004 | FEBS Lett. | pmid:14706830 |
| Puri BK | The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparations. | 2004 | Med. Hypotheses | pmid:14729014 |
| Arundel BL | Evening primrose oil and epilepsy. | 1992 | Vet. Rec. | pmid:1475904 |
| Bond R and Lloyd DH | A double-blind comparison of olive oil and a combination of evening primrose oil and fish oil in the management of canine atopy. | 1992 | Vet. Rec. | pmid:1481346 |
| Muriana FJ et al. | Fatty acid composition and properties of the liver microsomal membrane of rats fed diets enriched with cholesterol. | 1992 | J. Biochem. | pmid:1491012 |
| Del Castillo ML et al. | Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. | 2004 | J. Agric. Food Chem. | pmid:14969555 |
| Gamma-linolenic acid (GLA). Monograph. | 2004 | Altern Med Rev | pmid:15005646 | |
| Howie A et al. | The influence of dietary essential fatty acids on uterine C20 and C22 fatty acid composition. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1502249 |
| Menendez JA et al. | Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. | 2004 | Int. J. Cancer | pmid:15027132 |
| Kavanagh T et al. | Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041032 |
| Nakanishi T et al. | Gamma-linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice. | 2004 | Nutrition | pmid:15043857 |
| Plowman PN | Re: Packer RJ. Effects of radiotherapy on the brain. Med Pediatr Oncol 2003;41:448-449. | 2004 | Pediatr Blood Cancer | pmid:15049029 |
| Leaver HA et al. | Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15062847 |
| Fewtrell MS et al. | Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. | 2004 | J. Pediatr. | pmid:15069395 |
| Agombar A et al. | An aqueous formulation of gamma-linolenic acid with anti-proliferative action on human pancreatic cancer cell lines. | 2004 | Anticancer Drugs | pmid:15075672 |
| Dokholyan RS et al. | A trial of omega-3 fatty acids for prevention of hypertension. | 2004 | Am. J. Cardiol. | pmid:15081453 |
| van Gool CJ et al. | Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. | 2004 | Br. J. Dermatol. | pmid:15099370 |
| Shotton HR et al. | Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil. | 2004 | Auton Neurosci | pmid:15109939 |
| Miles EA et al. | The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15120716 |
| Das UN | From bench to the clinic: gamma-linolenic acid therapy of human gliomas. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15120717 |
| Gallagher S | Omega 3 oils and pregnancy. | 2004 | Midwifery Today Int Midwife | pmid:15124319 |
| Karia C et al. | Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. | 2004 | Int J Pharm | pmid:15129999 |
| Menendez JA et al. | Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. | 2004 | Oncol. Rep. | pmid:15138562 |
| Menendez JA et al. | Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. | 2004 | Int. J. Oncol. | pmid:15138577 |
| Ziboh VA et al. | Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma. | 2004 | Clin. Dev. Immunol. | pmid:15154607 |
| Knorr R and Hamburger M | Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil. | 2004 | J. Agric. Food Chem. | pmid:15161190 |
| Remans PH et al. | Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. | 2004 | Eur J Clin Nutr | pmid:15164103 |
| Torres CF et al. | Lipase-catalyzed ethanolysis of borage oil: a kinetic study. | 2004 May-Jun | Biotechnol. Prog. | pmid:15176879 |
| Miles EA et al. | The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. | 2004 | Br. J. Nutr. | pmid:15182393 |
| Liu JW et al. | Effect of long-term dietary supplementation of high-gamma-linolenic canola oil versus borage oil on growth, hematology, serum biochemistry, and N-6 fatty acid metabolism in rats. | 2004 | J. Agric. Food Chem. | pmid:15186123 |
| Pham H et al. | Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. | 2004 | Int. J. Cancer | pmid:15197770 |
| Johnston GA et al. | The use of dietary manipulation by parents of children with atopic dermatitis. | 2004 | Br. J. Dermatol. | pmid:15214908 |