gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Mastocytoma D034801 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Urolithiasis D052878 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Leaver HA et al. Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12445487
Vaddadi KS Use of gamma-linolenic acid in the treatment of schizophrenia and tardive dyskinesia. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1321448
Horrobin DF The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1321449
Mengeaud V et al. Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1337209
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
Dines KC et al. Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8931113
Fang C et al. Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9051726
de Kock M et al. The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014218
Cleland LG et al. The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2169063
van der Merwe CF et al. The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2169638
Miller MA and Morgan RJ Eicosanoids, erections and erectile dysfunction. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7938091
Miles EA et al. Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820286
Horrobin DF et al. The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: choice of an appropriate placebo for clinical studies on primrose oil. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1871175
Arisaka M et al. Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1871184
Hrelia S et al. Kinetic analysis of delta-6-desaturation in liver microsomes: influence of gamma-linoleic acid dietary supplementation to young and old rats. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1808628
Engler MM and Engler MB Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758202
van Rooyen J et al. Diet can manipulate the metabolism of EPA and GLA in erythrocyte membrane and plasma. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758205
Dirks J et al. Cytokine levels affected by gamma-linolenic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849654
Seegers JC et al. Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849656
Cai J et al. Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10319914
Hrelia S et al. Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10397404
Pakala R et al. Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10397410
Engler MM Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8259378
Botha JH et al. The role of prostaglandins in the inhibition of cultured carcinoma cell growth produced by gamma-linolenic acid. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2541450
Kavanagh K et al. Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664597
Leaver HA et al. Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15062847
Miles EA et al. The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120716
Peterson LD et al. Dose-dependent effects of dietary gamma-linolenic acid on rat spleen lymphocyte functions. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10477037
Haag M et al. Polyunsaturated fatty acids inhibit Mg2+ -ATPase in basolateral membranes from rat enterocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10477038
Ebden P et al. A study of evening primrose seed oil in atopic asthma. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2717651
Huang YS et al. The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2717652
Bell JG et al. Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:8577782
Sangeetha P et al. Free radical generation in human leukocytes by CIS-unsaturated fatty acids is a calmodulin dependent process. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2160083
Bunce OR and Abou-El-Ela SH Eicosanoid synthesis and ornithine decarboxylase activity in mammary tumors of rats fed varying levels and types of N-3 and/or N-6 fatty acids. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2177199
Agostoni C et al. Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11237478
Hrelia S et al. Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11334548
Leaver HA et al. Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12051954
Watkins G et al. Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15763439
Griffiths G et al. Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. 1997 Prostate pmid:9108883
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Vaddadi KS et al. A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. 1989 Psychiatry Res pmid:2565585
Hindo J et al. Evidence of the formation of different hydroperoxides in irradiated gamma-linolenate solutions: effect of micelle formation. 2000 Radiat. Res. pmid:10629620
Castellanos P et al. Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. 2010 Reprod. Toxicol. pmid:20096347
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