gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Mastocytoma D034801 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Urolithiasis D052878 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Simán CM et al. Failure of short-term gamma-linolenic acid treatment to reduce urinary calcium loss of diabetic rats. 2000 Urol. Res. pmid:10850637
Preuss M et al. Role of antioxidant enzyme expression in the selective cytotoxic response of glioma cells to gamma-linolenic acid supplementation. 2000 Free Radic. Biol. Med. pmid:10832077
Decsi T et al. Effect of type of early infant feeding on fatty acid composition of plasma lipid classes in full-term infants during the second 6 months of life. 2000 J. Pediatr. Gastroenterol. Nutr. pmid:10817286
Charnock JS Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780878
Jiang WG et al. Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780877
Leonard AE et al. cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid. 2000 Biochem. J. pmid:10769175
Mohan IK and Das UN Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765977
Guil-Guerrero JL et al. Occurrence and characterization of oils rich in gamma-linolenic acid Part I: Echium seeds from Macaronesia. 2000 Phytochemistry pmid:10731022
Thijs C et al. Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation. 2000 Eur J Clin Nutr pmid:10713746
Ravichandran D et al. Effect of 1-(gamma)linolenyl-3-eicosapentaenoyl propane diol on the growth of human pancreatic carcinoma in vitro and in vivo. 2000 Eur. J. Cancer pmid:10708945
Kenny FS et al. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. 2000 Int. J. Cancer pmid:10699943
Davies CL et al. Effect of gamma-linolenic acid on cellular uptake of structurally related anthracyclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines. 1999 Eur. J. Cancer pmid:10673983
Motaung E et al. Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10670696
Ramrath S et al. Stimulation of cardiac glucose transport by thioctic acid and insulin. 1999 Horm. Metab. Res. pmid:10668913
Harris JE et al. Five-lipoxygenase inhibitors reduce Panc-1 survival: synergism of MK886 with gamma linolenic acid. 1999 Adv. Exp. Med. Biol. pmid:10667375
Robbins M et al. gamma-linolenic acid (GLA)-mediated cytotoxicity in human prostate cancer cells. 1999 Adv. Exp. Med. Biol. pmid:10667374
Vartak S et al. The selective cytotoxicity of gamma-linolenic acid (GLA) is associated with increased oxidative stress. 1999 Adv. Exp. Med. Biol. pmid:10667373
Fan YY et al. Modulation of atherogenesis by dietary gamma-linolenic acid. 1999 Adv. Exp. Med. Biol. pmid:10667372
Peth JA et al. Effects of a unique conjugate of alpha-lipoic acid and gamma-linolenic acid on insulin action in obese Zucker rats. 2000 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:10666147
Hornych A et al. Effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandins in old subjects. 1999 Br J Clin Pharmacol pmid:10651470
Srinivas CV et al. Safflower petals: a source of gamma linolenic acid. 1999 Plant Foods Hum Nutr pmid:10646633
Burke A et al. Specific analysis in plasma and urine of 2,3-dinor-5, 6-dihydro-isoprostane F(2alpha)-III, a metabolite of isoprostane F(2alpha)-III and an oxidation product of gamma-linolenic acid. 2000 J. Biol. Chem. pmid:10644705
Hindo J et al. Evidence of the formation of different hydroperoxides in irradiated gamma-linolenate solutions: effect of micelle formation. 2000 Radiat. Res. pmid:10629620
Schwartz J Role of polyunsaturated fatty acids in lung disease. 2000 Am. J. Clin. Nutr. pmid:10618003
Head RJ et al. Prevention of nerve conduction deficit in diabetic rats by polyunsaturated fatty acids. 2000 Am. J. Clin. Nutr. pmid:10618002
Horrobin DF Essential fatty acid metabolism and its modification in atopic eczema. 2000 Am. J. Clin. Nutr. pmid:10617999
Belch JJ and Hill A Evening primrose oil and borage oil in rheumatologic conditions. 2000 Am. J. Clin. Nutr. pmid:10617996
Pirich C et al. Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. 1999 Thromb. Res. pmid:10588465
Bell HS et al. Effects of N-6 essential fatty acids on glioma invasion and growth: experimental studies with glioma spheroids in collagen gels. 1999 J. Neurosurg. pmid:10584845
Joubert AM et al. Comparative study of the effects of polyunsaturated fatty acids and their metabolites on cell growth and tyrosine kinase activity in oesophageal carcinoma cells. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10582657
Ward GR et al. Effects of gamma-linolenic acid and docosahexaenoic acid in formulae on brain fatty acid composition in artificially reared rats. 1999 Lipids pmid:10580333
Pakala R et al. Eicosapentaenoic acid and docosahexaenoic acid selectively attenuate U46619-induced smooth muscle cell proliferation. 1999 Lipids pmid:10574655
Senanayake SP and Shahidi F Enzyme-assisted acidolysis of borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils: incorporation of omega-3 polyunsaturated fatty acids. 1999 J. Agric. Food Chem. pmid:10552616
Stahl A et al. Identification of the major intestinal fatty acid transport protein. 1999 Mol. Cell pmid:10518211
Tamimi NA et al. Role of gamma-linolenic acid in uraemic pruritus. 1999 Nephron pmid:10516500
Palombo JD et al. Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats. 1999 Crit. Care Med. pmid:10507617
Wu D et al. Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. 1999 Am. J. Clin. Nutr. pmid:10500023
Patel J and Tomlinson DR Nerve conduction impairment in experimental diabetes-proximodistal gradient of severity. 1999 Muscle Nerve pmid:10487907
Passorn S et al. Heterologous expression of Mucor rouxii delta(12)-desaturase gene in Saccharomyces cerevisiae. 1999 Biochem. Biophys. Res. Commun. pmid:10486251
Huang YS et al. Cloning of delta12- and delta6-desaturases from Mortierella alpina and recombinant production of gamma-linolenic acid in Saccharomyces cerevisiae. 1999 Lipids pmid:10478922
Haag M et al. Polyunsaturated fatty acids inhibit Mg2+ -ATPase in basolateral membranes from rat enterocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10477038
Peterson LD et al. Dose-dependent effects of dietary gamma-linolenic acid on rat spleen lymphocyte functions. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10477037
Zurier RB et al. Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor: effects of unsaturated fatty acids. 1999 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:10471124
Gadek JE et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. 1999 Crit. Care Med. pmid:10470743
De Antueno R et al. Tissue distribution and metabolism of gamma-linolenoyl-3-eicosapentaenoyl propane diol enterally or intravenously administered to mice bearing human pancreatic carcinomas. 1999 May-Jun Anticancer Res. pmid:10470146
De La Cruz JP et al. Antioxidant potential of evening primrose oil administration in hyperlipemic rabbits. 1999 Life Sci. pmid:10462081
Cheung KL Management of cyclical mastalgia in oriental women: pioneer experience of using gamolenic acid (Efamast) in Asia. 1999 Aust N Z J Surg pmid:10442919
Gehring W et al. Effect of topically applied evening primrose oil on epidermal barrier function in atopic dermatitis as a function of vehicle. 1999 Arzneimittelforschung pmid:10442214
Giamarellos-Bourboulis EJ et al. In vitro interactions of gamma-linolenic acid and arachidonic acid with ceftazidime on multiresistant Pseudomonas aeruginosa. 1999 Lipids pmid:10419130
Murakami K et al. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. 1999 Biochem. Biophys. Res. Commun. pmid:10403814