gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Carpal Tunnel Syndrome D002349 3 associated lipids
Back Pain D001416 5 associated lipids
Urolithiasis D052878 1 associated lipids
Mastocytoma D034801 3 associated lipids
Ecchymosis D004438 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Plumb JA et al. Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin. 1993 Br. J. Cancer pmid:8385976
Miura Y et al. Production of gamma-linolenic acid from the marine green alga Chlorella sp. NKG 042401. 1993 FEMS Microbiol. Lett. pmid:8386122
Horrobin DF Fatty acid metabolism in health and disease: the role of delta-6-desaturase. 1993 Am. J. Clin. Nutr. pmid:8386433
Takeda S et al. Mechanism of lipid peroxidation in cancer cells in response to gamma-linolenic acid (GLA) analyzed by GC-MS(I): Conjugated dienes with peroxyl (or hydroperoxyl) groups and cell-killing effects. 1993 Jan-Feb Anticancer Res. pmid:8386494
Karmali RA et al. Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8388566
Bala KV et al. Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linolenic acid. 1993 Food Chem. Toxicol. pmid:8390392
Hopewell JW et al. The modulation of radiation-induced damage to pig skin by essential fatty acids. 1993 Br. J. Cancer pmid:8391301
Cerin A et al. Hormonal and biochemical profiles of premenstrual syndrome. Treatment with essential fatty acids. 1993 Acta Obstet Gynecol Scand pmid:8392261
Galle AM et al. Biosynthesis of gamma-linolenic acid in developing seeds of borage (Borago officinalis L.). 1993 Biochim. Biophys. Acta pmid:8394742
Kinchington D et al. Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. 1993 FEBS Lett. pmid:8396048
Tollesson A and Frithz A Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. 1993 Br. J. Dermatol. pmid:8396411
Cameron NE et al. The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. 1993 Br. J. Pharmacol. pmid:8401950
Cantrill RC et al. Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture. 1993 Cancer Lett. pmid:8402582
Oliwiecki S et al. The effect of essential fatty acids on epidermal atrophy due to topical steroids. 1993 Clin. Exp. Dermatol. pmid:8403467
Melnik B and Plewig G [External treatment of atopic eczema with gamma-linolenic acid?]. 1993 Hautarzt pmid:8407331
Phinney SD et al. Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration. 1993 Metab. Clin. Exp. pmid:8412765
Collins A et al. Essential fatty acids in the treatment of premenstrual syndrome. 1993 Obstet Gynecol pmid:8416468
Dines CD et al. Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin. 1995 Eur. J. Pharmacol. pmid:8521914
Giamarellos-Bourboulis EJ et al. In-vitro inhibitory activity of gamma-linolenic acid on Escherichia coli strains and its influence on their susceptibilities to various antimicrobial agents. 1995 J. Antimicrob. Chemother. pmid:8522462
Burgess NA et al. Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. 1995 Urol. Res. pmid:8533210
Harbige LS et al. Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. 1995 Br. J. Nutr. pmid:8541276
Sture GH and Lloyd DH Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. 1995 Vet. Rec. pmid:8553525
Ells GW et al. Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. 1996 Cancer Lett. pmid:8556710
Luthria DL and Sprecher H Metabolism of deuterium-labeled linoleic, 6,9,12-octadecatrienoic, 8,11,14-eicosatrienoic, and arachidonic acids in the rat. 1995 J. Lipid Res. pmid:8558078
Palombo JD et al. Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. 1996 Am. J. Clin. Nutr. pmid:8561062
Bell JG et al. Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:8577782
Rothman D et al. Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. 1995 Semin. Arthritis Rheum. pmid:8578315
Murray MJ et al. Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. 1995 Am. J. Physiol. pmid:8594921
Chilton-Lopez ME et al. Metabolism of gammalinolenic acid in human neutrophils. 1996 J. Immunol. pmid:8609415
Chilton SA Cognitive behaviour therapy for the chronic fatigue syndrome. Evening primrose oil and magnesium have been shown to be effective. 1996 BMJ pmid:8616424
Huang Z et al. Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. 1996 Biochemistry pmid:8619991
Cantrill RC et al. Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. 1996 Cancer Lett. pmid:8620439
Cameron NE et al. Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. 1996 Diabetologia pmid:8635669
Schöpf E et al. [Gamma-linolenic acid in atopic patients?]. 1996 Med Monatsschr Pharm pmid:8684312
Fearon KC et al. An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. 1996 Mar-Apr Anticancer Res. pmid:8687143
Jiang WG et al. Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1996 Br J Surg pmid:8689213
Sadi AM et al. Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. 1996 Exp. Anim. pmid:8689581
Goonaratna C Good morning, evening primrose oil. 1995 Ceylon Med J pmid:8689697
McCarty MF Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. 1996 Med. Hypotheses pmid:8692033
Each of the following has been shown to be effective for cyclical breast pain. 1996 Can Fam Physician pmid:8704485
Budeiri D et al. Is evening primrose oil of value in the treatment of premenstrual syndrome? 1996 Control Clin Trials pmid:8721802
de Bravo MG et al. [Effect of dietary supplementation with gamma-linolenic acid on the growth of a human lung carcinoma implanted in nude mice]. 1995 Medicina (B Aires) pmid:8731577
Omawari N et al. Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. 1996 Br. J. Pharmacol. pmid:8733594
Sherrington EJ et al. The effect of dietary lipid manipulation on the uptake of [3H]-triolein by tissues of the rat. 1996 Biochem. Soc. Trans. pmid:8736833
Grant D et al. The antioxidant activity of heparins. 1996 Biochem. Soc. Trans. pmid:8736852
Stainforth JM et al. Clinical aspects of the use of gamma linolenic acid in systemic sclerosis. 1996 Acta Derm. Venereol. pmid:8740271
Murai A et al. Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. 1995 Br. Poult. Sci. pmid:8746984
Meehan E et al. Influence of an n-6 polyunsaturated fatty acid-enriched diet on the development of tolerance during chronic ethanol administration in rats. 1995 Alcohol. Clin. Exp. Res. pmid:8749808
Hrelia S et al. gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid composition. 1996 Biochem. Biophys. Res. Commun. pmid:8753781
Quoc KP and Pascaud M Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. 1996 Ann. Nutr. Metab. pmid:8773734