gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Insulin Resistance D007333 99 associated lipids
Fatigue D005221 10 associated lipids
Nausea D009325 7 associated lipids
Critical Illness D016638 13 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Acute Lung Injury D055371 33 associated lipids
Intermittent Claudication D007383 6 associated lipids
Fibrocystic Breast Disease D005348 1 associated lipids
Tietze's Syndrome D013991 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Ziboh VA and Fletcher MP Dose-response effects of dietary gamma-linolenic acid-enriched oils on human polymorphonuclear-neutrophil biosynthesis of leukotriene B4. 1992 Am. J. Clin. Nutr. pmid:1309474
Mimouni V et al. Evidence for insulin dependent hepatic microsomal gamma-linolenic acid chain elongation in spontaneously diabetic Wistar BB rats. 1992 Biochim. Biophys. Acta pmid:1310052
St Louis C et al. Antihypertensive effect of gamma-linolenic acid in spontaneously hypertensive rats. 1992 Hypertension pmid:1310479
Lockett MJ and Tomlinson DR The effects of dietary treatment with essential fatty acids on sciatic nerve conduction and activity of the Na+/K+ pump in streptozotocin-diabetic rats. 1992 Br. J. Pharmacol. pmid:1313726
Van Biervliet JP et al. Serum cholesterol, cholesteryl ester, and high-density lipoprotein development in newborn infants: response to formulas supplemented with cholesterol and gamma-linolenic acid. 1992 J. Pediatr. pmid:1313864
de Kock M et al. Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells. 1992 S. Afr. Med. J. pmid:1315459
Bégin ME and Ells G Levels of thiobarbituric acid reactive substances and the cytocidal potential of gammalinolenic and docosahexaenoic acids on ZR-75-1 and CV-1 cells. 1992 Lipids pmid:1315901
Bond R and Lloyd DH A double-blind comparison of olive oil and a combination of evening primrose oil and fish oil in the management of canine atopy. 1992 Vet. Rec. pmid:1481346
Howie A et al. The influence of dietary essential fatty acids on uterine C20 and C22 fatty acid composition. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1502249
Navarette R et al. Dietary intake of concentrated gamma-linolenic acid (GLA)-enriched oil suppresses cutaneous level of dihomo-gamma-linolenic acid (DGLA): possible in vivo inhibition of microsomal elongation of GLA to DGLA. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1323857
Scott DW et al. Comparison of the clinical efficacy of two commercial fatty acid supplements (EfaVet and DVM Derm Caps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. 1992 Cornell Vet pmid:1643883
Gateley CA et al. Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. 1992 J R Soc Med pmid:1548647
Gateley CA et al. Plasma fatty acid profiles in benign breast disorders. 1992 Br J Surg pmid:1596720
Ergan F et al. Lipase specificity against some fatty acids? 1992 Ann. N. Y. Acad. Sci. pmid:1335712
Duffy O et al. Attenuation of the effects of chronic ethanol administration in the brain lipid content of the developing rat by an oil enriched in gamma linolenic acid. 1992 Drug Alcohol Depend pmid:1330473
Hamberg M Metabolism of 6,9,12-octadecatrienoic acid in the red alga Lithothamnion corallioides: mechanism of formation of a conjugated tetraene fatty acid. 1992 Biochem. Biophys. Res. Commun. pmid:1332713
Gunstone FD Gamma linolenic acid--occurrence and physical and chemical properties. 1992 Prog. Lipid Res. pmid:1334265
Horrobin DF Nutritional and medical importance of gamma-linolenic acid. 1992 Prog. Lipid Res. pmid:1334266
Engler MM et al. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. 1992 J. Hypertens. pmid:1335001
McFayden IJ et al. Cyclical breast pain--some observations and the difficulties in treatment. 1992 Br J Clin Pract pmid:1286012
Hayashi Y et al. Anticancer effects of free polyunsaturated fatty acids in an oily lymphographic agent following intrahepatic arterial administration to a rabbit bearing VX-2 tumor. 1992 Cancer Res. pmid:1309442
Dobbin SN Evening primrose oil and epilepsy. 1992 Dec 19-26 Vet. Rec. pmid:1287960
Takeda S et al. Lipid peroxidation in human breast cancer cells in response to gamma-linolenic acid and iron. 1992 Mar-Apr Anticancer Res. pmid:1316091
Söreide E et al. Long-term use of gamma-linolenic acid-enriched fat emulsion (PFE 4501): case report. 1992 May-Jun Nutrition pmid:1326350
Cantrill RC et al. The effect of n-6 fatty acids on normal and v-Ki ras transformed NIH-3T3 cells. 1992 Nov-Dec Anticancer Res. pmid:1338278
Dehaut F et al. n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. 1993 Neurosci. Lett. pmid:8272254
Tollesson A and Frithz A Transepidermal water loss and water content in the stratum corneum in infantile seborrhoeic dermatitis. 1993 Acta Derm. Venereol. pmid:8095744
Berth-Jones J and Graham-Brown RA Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. 1993 Lancet pmid:8099640
Shield MJ et al. Essential fatty acid supplementation in atopic dermatitis. 1993 Lancet pmid:8101623
Szczesna M [Therapeutic assessment of the evening primrose]. 1993 Rocz Panstw Zakl Hig pmid:8016534
Leventhal LJ et al. Treatment of rheumatoid arthritis with gammalinolenic acid. 1993 Ann. Intern. Med. pmid:8214997
Karlstad MD et al. Effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma n-6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats. 1993 Crit. Care Med. pmid:8222692
Harvey RG Effect of varying proportions of evening primrose oil and fish oil on cats with crusting dermatosis ('miliary dermatitis') 1993 Vet. Rec. pmid:8280288
Engler MM Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8259378
Harvey RG A comparison of evening primrose oil and sunflower oil for the management of papulocrustous dermatitis in cats. 1993 Vet. Rec. pmid:8303807
Stevens EJ et al. Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. 1993 Diabetologia pmid:8314443
Joe LA and Hart LL Evening primrose oil in rheumatoid arthritis. 1993 Ann Pharmacother pmid:8305783
Keen H et al. Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. 1993 Diabetes Care pmid:8380765
Horrobin DF The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8380930
Hopewell JW et al. The modulation of radiation-induced damage to pig skin by essential fatty acids. 1993 Br. J. Cancer pmid:8391301
Cerin A et al. Hormonal and biochemical profiles of premenstrual syndrome. Treatment with essential fatty acids. 1993 Acta Obstet Gynecol Scand pmid:8392261
Galle AM et al. Biosynthesis of gamma-linolenic acid in developing seeds of borage (Borago officinalis L.). 1993 Biochim. Biophys. Acta pmid:8394742
Kinchington D et al. Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. 1993 FEBS Lett. pmid:8396048
Tollesson A and Frithz A Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. 1993 Br. J. Dermatol. pmid:8396411
Cameron NE et al. The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. 1993 Br. J. Pharmacol. pmid:8401950
Phinney SD et al. Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration. 1993 Metab. Clin. Exp. pmid:8412765
Collins A et al. Essential fatty acids in the treatment of premenstrual syndrome. 1993 Obstet Gynecol pmid:8416468
Beno DW et al. Gamma-linolenic acid suppression of hepatic Ito cell mitogenesis: post-PDGF receptor prostaglandin-independent mechanism. 1993 Am. J. Physiol. pmid:7694498
Thurmond DC et al. Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. 1993 Obes. Res. pmid:16353349
Horrobin DF Fatty acid metabolism in health and disease: the role of delta-6-desaturase. 1993 Am. J. Clin. Nutr. pmid:8386433