| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Matsuo N et al. | Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951990 |
| Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
| Dines KC et al. | Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931113 |
| Julu PO | Latency of neuroactivity and optimum period of treatment with evening primrose oil in diabetic rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925199 |
| Julu PO et al. | Endogenous cyclo-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925193 |
| Zurier RB et al. | gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. | 1996 | Arthritis Rheum. | pmid:8912502 |
| Redden PR et al. | Comparison of the grignard deacylation TLC and HPLC methods and high resolution 13C-NMR for the sn-2 positional analysis of triacylglycerols containing gamma-linolenic acid. | 1996 | Chem. Phys. Lipids | pmid:8907238 |
| Deferne JL and Leeds AR | Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. | 1996 | J Hum Hypertens | pmid:8895037 |
| Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
| Sutton GC | 'Too tired to go to the support group': a health needs assessment of myalgic encephalomyelitis. | 1996 | J Public Health Med | pmid:8887847 |
| Whitaker DK et al. | Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. | 1996 | Dermatology (Basel) | pmid:8884146 |
| Cameron NE and Cotter MA | Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. | 1996 | Diabetologia | pmid:8877288 |
| Williams WV et al. | Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes. | 1996 | Pathobiology | pmid:8856792 |
| Jenkins AP et al. | Essential fatty acid supplementation in chronic hepatitis B. | 1996 | Aliment. Pharmacol. Ther. | pmid:8853774 |
| Wigmore SJ et al. | The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. | 1996 | Nutrition | pmid:8850216 |
| Cameron NE and Cotter MA | Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats. | 1996 | Am. J. Physiol. | pmid:8843740 |
| Ingram AJ et al. | Dietary alteration of dihomogamma-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. The Nutrition & Kidney Disease Research Group. | 1996 | J. Am. Soc. Nephrol. | pmid:8829117 |
| Leichsenring M et al. | (n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. | 1995 | Pediatr Allergy Immunol | pmid:8822394 |
| Koba K et al. | Distribution of plasma phosphatidylcholine molecular species in rabbits fed fish oil is modulated by dietary n-6 fatty acids. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8821127 |
| Fan YY et al. | Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro. | 1996 | J. Nutr. | pmid:8814195 |
| Wainwright PE et al. | Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior. | 1996 | Pharmacol. Biochem. Behav. | pmid:8801587 |
| Quoc KP and Pascaud M | Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. | 1996 | Ann. Nutr. Metab. | pmid:8773734 |
| Hrelia S et al. | gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid composition. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753781 |
| Meehan E et al. | Influence of an n-6 polyunsaturated fatty acid-enriched diet on the development of tolerance during chronic ethanol administration in rats. | 1995 | Alcohol. Clin. Exp. Res. | pmid:8749808 |
| Murai A et al. | Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. | 1995 | Br. Poult. Sci. | pmid:8746984 |
| Stainforth JM et al. | Clinical aspects of the use of gamma linolenic acid in systemic sclerosis. | 1996 | Acta Derm. Venereol. | pmid:8740271 |
| Grant D et al. | The antioxidant activity of heparins. | 1996 | Biochem. Soc. Trans. | pmid:8736852 |
| Sherrington EJ et al. | The effect of dietary lipid manipulation on the uptake of [3H]-triolein by tissues of the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736833 |
| Omawari N et al. | Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. | 1996 | Br. J. Pharmacol. | pmid:8733594 |
| de Bravo MG et al. | [Effect of dietary supplementation with gamma-linolenic acid on the growth of a human lung carcinoma implanted in nude mice]. | 1995 | Medicina (B Aires) | pmid:8731577 |
| Budeiri D et al. | Is evening primrose oil of value in the treatment of premenstrual syndrome? | 1996 | Control Clin Trials | pmid:8721802 |
| Each of the following has been shown to be effective for cyclical breast pain. | 1996 | Can Fam Physician | pmid:8704485 | |
| McCarty MF | Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. | 1996 | Med. Hypotheses | pmid:8692033 |
| Goonaratna C | Good morning, evening primrose oil. | 1995 | Ceylon Med J | pmid:8689697 |
| Sadi AM et al. | Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. | 1996 | Exp. Anim. | pmid:8689581 |
| Jiang WG et al. | Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. | 1996 | Br J Surg | pmid:8689213 |
| Fearon KC et al. | An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. | 1996 Mar-Apr | Anticancer Res. | pmid:8687143 |
| Schöpf E et al. | [Gamma-linolenic acid in atopic patients?]. | 1996 | Med Monatsschr Pharm | pmid:8684312 |
| Cameron NE et al. | Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. | 1996 | Diabetologia | pmid:8635669 |
| Cantrill RC et al. | Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. | 1996 | Cancer Lett. | pmid:8620439 |
| Huang Z et al. | Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. | 1996 | Biochemistry | pmid:8619991 |
| Chilton SA | Cognitive behaviour therapy for the chronic fatigue syndrome. Evening primrose oil and magnesium have been shown to be effective. | 1996 | BMJ | pmid:8616424 |
| Chilton-Lopez ME et al. | Metabolism of gammalinolenic acid in human neutrophils. | 1996 | J. Immunol. | pmid:8609415 |
| Murray MJ et al. | Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. | 1995 | Am. J. Physiol. | pmid:8594921 |
| Rothman D et al. | Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. | 1995 | Semin. Arthritis Rheum. | pmid:8578315 |
| Bell JG et al. | Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577782 |
| Palombo JD et al. | Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. | 1996 | Am. J. Clin. Nutr. | pmid:8561062 |
| Luthria DL and Sprecher H | Metabolism of deuterium-labeled linoleic, 6,9,12-octadecatrienoic, 8,11,14-eicosatrienoic, and arachidonic acids in the rat. | 1995 | J. Lipid Res. | pmid:8558078 |
| Ells GW et al. | Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. | 1996 | Cancer Lett. | pmid:8556710 |
| Sture GH and Lloyd DH | Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. | 1995 | Vet. Rec. | pmid:8553525 |
| Harbige LS et al. | Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. | 1995 | Br. J. Nutr. | pmid:8541276 |
| Burgess NA et al. | Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. | 1995 | Urol. Res. | pmid:8533210 |
| Giamarellos-Bourboulis EJ et al. | In-vitro inhibitory activity of gamma-linolenic acid on Escherichia coli strains and its influence on their susceptibilities to various antimicrobial agents. | 1995 | J. Antimicrob. Chemother. | pmid:8522462 |
| Dines CD et al. | Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin. | 1995 | Eur. J. Pharmacol. | pmid:8521914 |
| Collins A et al. | Essential fatty acids in the treatment of premenstrual syndrome. | 1993 | Obstet Gynecol | pmid:8416468 |
| Phinney SD et al. | Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration. | 1993 | Metab. Clin. Exp. | pmid:8412765 |
| Melnik B and Plewig G | [External treatment of atopic eczema with gamma-linolenic acid?]. | 1993 | Hautarzt | pmid:8407331 |
| Oliwiecki S et al. | The effect of essential fatty acids on epidermal atrophy due to topical steroids. | 1993 | Clin. Exp. Dermatol. | pmid:8403467 |
| Cantrill RC et al. | Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture. | 1993 | Cancer Lett. | pmid:8402582 |
| Cameron NE et al. | The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. | 1993 | Br. J. Pharmacol. | pmid:8401950 |
| Tollesson A and Frithz A | Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. | 1993 | Br. J. Dermatol. | pmid:8396411 |
| Kinchington D et al. | Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. | 1993 | FEBS Lett. | pmid:8396048 |
| Galle AM et al. | Biosynthesis of gamma-linolenic acid in developing seeds of borage (Borago officinalis L.). | 1993 | Biochim. Biophys. Acta | pmid:8394742 |
| Cerin A et al. | Hormonal and biochemical profiles of premenstrual syndrome. Treatment with essential fatty acids. | 1993 | Acta Obstet Gynecol Scand | pmid:8392261 |
| Hopewell JW et al. | The modulation of radiation-induced damage to pig skin by essential fatty acids. | 1993 | Br. J. Cancer | pmid:8391301 |
| Bala KV et al. | Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linolenic acid. | 1993 | Food Chem. Toxicol. | pmid:8390392 |
| Karmali RA et al. | Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8388566 |
| Takeda S et al. | Mechanism of lipid peroxidation in cancer cells in response to gamma-linolenic acid (GLA) analyzed by GC-MS(I): Conjugated dienes with peroxyl (or hydroperoxyl) groups and cell-killing effects. | 1993 Jan-Feb | Anticancer Res. | pmid:8386494 |
| Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |
| Miura Y et al. | Production of gamma-linolenic acid from the marine green alga Chlorella sp. NKG 042401. | 1993 | FEMS Microbiol. Lett. | pmid:8386122 |
| Plumb JA et al. | Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin. | 1993 | Br. J. Cancer | pmid:8385976 |
| González CA et al. | Borage consumption as a possible gastric cancer protective factor. | 1993 Mar-Apr | Cancer Epidemiol. Biomarkers Prev. | pmid:8385521 |
| Poisson JP et al. | Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. | 1993 | Biochem. Med. Metab. Biol. | pmid:8382502 |
| Horrobin DF | The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8380930 |
| Keen H et al. | Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. | 1993 | Diabetes Care | pmid:8380765 |
| Leyton E | Disagreeing on how to treat CFS patients. | 1993 | Can Fam Physician | pmid:8347205 |
| Stevens EJ et al. | Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. | 1993 | Diabetologia | pmid:8314443 |
| Joe LA and Hart LL | Evening primrose oil in rheumatoid arthritis. | 1993 | Ann Pharmacother | pmid:8305783 |
| Harvey RG | A comparison of evening primrose oil and sunflower oil for the management of papulocrustous dermatitis in cats. | 1993 | Vet. Rec. | pmid:8303807 |
| Ramanathan R et al. | Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. | 1994 | Free Radic. Biol. Med. | pmid:8299995 |
| Harvey RG | Effect of varying proportions of evening primrose oil and fish oil on cats with crusting dermatosis ('miliary dermatitis') | 1993 | Vet. Rec. | pmid:8280288 |
| Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
| Dines KC et al. | Contrasting effects of treatment with omega-3 and omega-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. | 1993 | Diabetologia | pmid:8270127 |
| Engler MM | Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8259378 |
| Stevens EJ et al. | Prostacyclin release in experimental diabetes: effects of evening primrose oil. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248277 |
| Laivuori H et al. | Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248275 |
| Karlstad MD et al. | Effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma n-6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats. | 1993 | Crit. Care Med. | pmid:8222692 |
| Leventhal LJ et al. | Treatment of rheumatoid arthritis with gammalinolenic acid. | 1993 | Ann. Intern. Med. | pmid:8214997 |
| Jamal GA | The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. | 1994 | Diabet. Med. | pmid:8200197 |
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| Christophe A et al. | Effect of administration of gamma-linolenic acid on the fatty acid composition of serum phospholipids and cholesteryl esters in patients with cystic fibrosis. | 1994 | Ann. Nutr. Metab. | pmid:8185286 |
| Wetzig NR | Mastalgia: a 3 year Australian study. | 1994 | Aust N Z J Surg | pmid:8179529 |
| Maaswinkel-Mooij PD et al. | Unsuccessful dietary treatment of Sjögren-Larsson syndrome. | 1994 | J. Pediatr. | pmid:8176565 |
| Morphake P et al. | Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146206 |
| Takada R et al. | Dietary gamma-linolenic acid-enriched oil reduces body fat content and induces liver enzyme activities relating to fatty acid beta-oxidation in rats. | 1994 | J. Nutr. | pmid:8145067 |
| Chenoy R et al. | Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. | 1994 | BMJ | pmid:8136666 |
| Phinney S | Potential risk of prolonged gamma-linolenic acid use. | 1994 | Ann. Intern. Med. | pmid:8135457 |
| Bond R and Lloyd DH | Combined treatment with concentrated essential fatty acids and prednisolone in the management of canine atopy. | 1994 | Vet. Rec. | pmid:8135003 |
| Shield MJ et al. | Essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8101623 |
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