gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Carpal Tunnel Syndrome D002349 3 associated lipids
Back Pain D001416 5 associated lipids
Urolithiasis D052878 1 associated lipids
Mastocytoma D034801 3 associated lipids
Ecchymosis D004438 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Yoshimoto-Furuie K et al. Effects of oral supplementation with evening primrose oil for six weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients. 1999 Nephron pmid:9933750
Kruger MC et al. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. 1998 Aging (Milano) pmid:9932142
Reilly JD et al. Effect of a supplementary dietary evening primrose oil mixture on hoof growth, hoof growth rate and hoof lipid fractions in horses: a controlled and blinded trial. 1998 Equine Vet J Suppl pmid:9932095
Brouwer DA et al. Gamma-linolenic acid does not augment long-chain polyunsaturated fatty acid omega-3 status. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888208
Seegers JC et al. Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849656
Dirks J et al. Cytokine levels affected by gamma-linolenic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849654
Kuruvilla R et al. Evening primrose oil treatment corrects reduced conduction velocity but not depletion of arachidonic acid in nerve from streptozotocin-induced diabetic rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9844993
Ramesh G and Das UN Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9844986
Gu JY et al. Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. 1998 Biosci. Biotechnol. Biochem. pmid:9836427
Solomon LZ et al. Intravesical chemotherapy with gamma linolenic acid becomes a realistic prospect in serum-free applications: in vitro cytotoxicity and systemic absorption studies. 1998 J. Urol. pmid:9817384
Schellhammer PF Intravesical chemotherapy with gamma linolenic acid becomes a reality. 1998 J. Urol. pmid:9817299
Villalobos MA et al. Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. 1998 Thromb. Haemost. pmid:9798993
van Rooyen J et al. Diet can manipulate the metabolism of EPA and GLA in erythrocyte membrane and plasma. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758205
Engler MM and Engler MB Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758202
Ravichandran D et al. Effect of lithium gamma-linolenate on the growth of experimental human pancreatic carcinoma. 1998 Br J Surg pmid:9752859
de Vries JE [Painful breasts]. 1998 Ned Tijdschr Geneeskd pmid:9749309
Tanaka T et al. Methylene-interrupted double bond in polyunsaturated fatty acid is an essential structure for metabolism by the fatty acid chain elongation system of rat liver. 1998 Biochim. Biophys. Acta pmid:9748638
Fan YY and Chapkin RS Importance of dietary gamma-linolenic acid in human health and nutrition. 1998 J. Nutr. pmid:9732298
Martens-Lobenhoffer J and Meyer FP Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). 1998 Int J Clin Pharmacol Ther pmid:9707349
Solomon LZ et al. Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? 1998 Br J Urol pmid:9698674
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Kumamoto T and Ide T Comparative effects of alpha- and gamma-linolenic acids on rat liver fatty acid oxidation. 1998 Lipids pmid:9688166
Hounsom L et al. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. 1998 Diabetologia pmid:9686927
Jiang WG et al. gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. 1998 Int. J. Oncol. pmid:9683802
Frati-Munari AC and Ariza-Andraca CR [Treatment of diabetic neuropathy]. 1998 Jan-Feb Gac Med Mex pmid:9658700
Kahler CP and Du Plooy WJ Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654407
Giamarellos-Bourboulis EJ et al. In vitro activity of polyunsaturated fatty acids on Pseudomonas aeruginosa: relationship to lipid peroxidation. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654401
Engler MM et al. Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. 1998 Proc. Soc. Exp. Biol. Med. pmid:9648942
Johnson SR Premenstrual syndrome therapy. 1998 Clin Obstet Gynecol pmid:9646973
McGahon B et al. Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study. 1998 Exp. Gerontol. pmid:9639170
Vartak S et al. Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. 1998 Br. J. Cancer pmid:9635836
Reddy AS and Thomas TL Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid production in transgenic plants. 1996 Nat. Biotechnol. pmid:9630958
Sanderson P and Calder PC Dietary fish oil appears to prevent the activation of phospholipase C-gamma in lymphocytes. 1998 Biochim. Biophys. Acta pmid:9630688
Ravichandran D et al. Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. 1998 Eur. J. Cancer pmid:9624256
Anderson KM et al. Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. 1998 Mar-Apr Anticancer Res. pmid:9615721
Marra F et al. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. 1998 J. Hepatol. pmid:9566835
Willemaers V et al. [Atopic dermatitis]. 1998 Rev Med Liege pmid:9564223
Cameron NE et al. Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. 1998 Diabetologia pmid:9562342
Burnard SL et al. Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat. 1998 Mar-Apr J. Diabetes Complicat. pmid:9559483
Hørby Jørgensen M et al. Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. 1998 J. Pediatr. Gastroenterol. Nutr. pmid:9552137
Kis M et al. Light-induced expression of fatty acid desaturase genes. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9539715
Solomon LZ et al. Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. 1998 Urol. Res. pmid:9537690
Jiang WG et al. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. 1998 Biochem. Biophys. Res. Commun. pmid:9514943
Jiang WG et al. The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. 1998 Br. J. Cancer pmid:9514051
Morris GM et al. Modulation of the cell kinetics of pig skin by the topical application of evening primrose oil or Lioxasol. 1997 Aug-Sep Cell Prolif. pmid:9501921
Ramesh G and Das UN Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. 1998 Cancer Lett. pmid:9489490
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Chen Q et al. Analysis of the acyl-CoAs that accumulate during the peroxisomal beta-oxidation of arachidonic acid and 6,9,12-octadecatrienoic acid. 1998 Arch. Biochem. Biophys. pmid:9448727
Tocher DR et al. Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. 1997 Lipids pmid:9438233
Kairemo KJ et al. The effect of lithium gamma-linolenate therapy of pancreatic cancer on perfusion in liver and pancreatic tissues. 1998 Pancreas pmid:9436871