gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alcoholism D000437 27 associated lipids
Arteriosclerosis D001161 86 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Back Pain D001416 5 associated lipids
Bacteriuria D001437 7 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Singer P et al. Blood pressure and serum lipids from SHR after diets supplemented with evening primrose, sunflowerseed or fish oil. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2399267
Huang YS et al. Stress modulates cholesterol-induced changes in plasma and liver fatty acid composition in rats fed n-6 fatty acid-rich oils. 1990 Proc. Soc. Exp. Biol. Med. pmid:2399256
Lopes C et al. Functional textiles for atopic dermatitis: a systematic review and meta-analysis. 2013 Pediatr Allergy Immunol pmid:23980847
Mayo TT et al. Comparative study on bruise reduction treatments after bruise induction using the pulsed dye laser. 2013 Dermatol Surg pmid:23899131
pmid:23884332
Watson J et al. Mechanism of action of polyunsaturated fatty acids in rheumatoid arthritis. 1990 Biochem. Soc. Trans. pmid:2379720
Kavanagh K et al. Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664597
Gateley CA and Mansel RE Management of cyclical breast pain. 1990 Br J Hosp Med pmid:2364227
Bamford JT et al. Oral evening primrose oil and borage oil for eczema. 2013 Cochrane Database Syst Rev pmid:23633319
Kmietowicz Z Evening primrose oil and borage oil do not help eczema symptoms, finds Cochrane review. 2013 BMJ pmid:23628953
Klempova T et al. Biosynthesis of gamma-linolenic acid and beta-carotene by Zygomycetes fungi. 2013 Biotechnol J pmid:23625863
Das UN n-3 fatty acids, γ-linolenic acid, and antioxidants in sepsis. 2013 Crit Care pmid:23597172
Čertík M et al. Simultaneous enrichment of cereals with polyunsaturated fatty acids and pigments by fungal solid state fermentations. 2013 J. Biotechnol. pmid:23583333
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952
Jubie S et al. Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line. 2013 Lipids Health Dis pmid:23537396
Gerhardt LC et al. Tribological investigation of a functional medical textile with lubricating drug-delivery finishing. 2013 Colloids Surf B Biointerfaces pmid:23524083
Tasset-Cuevas I et al. Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies. 2013 PLoS ONE pmid:23460824
Saha SS and Ghosh M Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. 2013 Nutrition pmid:23422533
Singer P et al. N-6 and N-3 PUFA in liver lipids, thromboxane formation and blood pressure from SHR during diets supplemented with evening primrose, sunflowerseed or fish oil. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2336450
Jacobs BR et al. Nutritional immunomodulation in critically ill children with acute lung injury: feasibility and impact on circulating biomarkers. 2013 Pediatr Crit Care Med pmid:23295853
Zikou E et al. Evaluating glucose and xylose as cosubstrates for lipid accumulation and γ-linolenic acid biosynthesis of Thamnidium elegans. 2013 J. Appl. Microbiol. pmid:23279437
Auberger J et al. Topical evening primrose oil for reduction of bortezomib-induced skin reactions. 2013 Ann. Hematol. pmid:23262668
Martínez-Augustin O et al. Bioactive anti-obesity food components. 2012 Int J Vitam Nutr Res pmid:23258394
Safarinejad MR et al. Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. 2013 Br. J. Nutr. pmid:23199523
Cohen DA et al. Impact of two pulmonary enteral formulations on nutritional indices and outcomes. 2013 J Hum Nutr Diet pmid:23189938
Schott CK and Huang DT ω-3 fatty acids, γ-linolenic acid, and antioxidants: immunomodulators or inert dietary supplements? 2012 Crit Care pmid:23176247
pmid:23075595
Yamanaka K et al. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. 2012 PLoS ONE pmid:23056190
Zhu Y and Zhang BB Molecular cloning and functional characterization of a Δ6-fatty acid desaturase gene from Rhizopus oryzae. 2013 J. Basic Microbiol. pmid:22961300
Mütze U et al. Metabolomics of dietary fatty acid restriction in patients with phenylketonuria. 2012 PLoS ONE pmid:22912778
Sharma N et al. Mastalgia cured! Randomized trial comparing centchroman to evening primrose oil. 2012 Breast J pmid:22892074
Fu J et al. Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits. 2012 J. Food Sci. pmid:22747885
Lopez HL Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. 2012 PM R pmid:22632694
Omran OM Histopathological study of evening primrose oil effects on experimental diabetic neuropathy. 2012 Ultrastruct Pathol pmid:22574767
Norris S et al. FPIN's Clinical Inquiries. Complementary and alternative therapies for atopic dermatitis. 2012 Am Fam Physician pmid:22534392
Szachowicz-Petelska B et al. Protective effect of blackcurrant on liver cell membrane of rats intoxicated with ethanol. 2012 J. Membr. Biol. pmid:22527605
Manosroi A et al. Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction. 2012 Eur J Pharm Biopharm pmid:22490981
Řezanka T et al. Regioisomer separation and identification of triacylglycerols containing vaccenic and oleic acids, and α- and γ-linolenic acids, in thermophilic cyanobacteria Mastigocladus laminosus and Tolypothrix sp. 2012 Phytochemistry pmid:22445652
Ramandi NF et al. Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. 2011 Nov-Dec J. Food Sci. pmid:22416687
Vaquerizo Alonso C et al. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus SEMICYUC-SENPE: hyperglycemia and diabetes mellitus. 2011 Nutr Hosp pmid:22411519
Machado FR et al. INTERSEPT study: we still need more clarity. 2012 Crit Care pmid:22410246
Lukivskaya OY et al. Reversal of experimental ethanol-induced liver steatosis by borage oil. 2012 Phytother Res pmid:22359349
Horrobin DF Evening primrose oil and premenstrual syndrome. 1990 Med. J. Aust. pmid:2233440
Qin F et al. Composition of transgenic soybean seeds with higher γ-linolenic acid content is equivalent to that of conventional control. 2012 J. Agric. Food Chem. pmid:22324875
Tso P et al. Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days. 2012 Food Chem. Toxicol. pmid:22265940
Trevizan L et al. Maintenance of arachidonic acid and evidence of Δ5 desaturation in cats fed γ-linolenic and linoleic acid enriched diets. 2012 Lipids pmid:22249937
Gateley CA et al. Mastalgia refractory to drug treatment. 1990 Br J Surg pmid:2224458
König K et al. Supplementation in acute lung injury. 2012 JAMA pmid:22235080
Bistrian BR Supplementation in acute lung injury. 2012 JAMA pmid:22235079
Felbinger TW et al. Supplementation in acute lung injury. 2012 JAMA pmid:22235078
Kim SH et al. Isolation and functional characterization of polyunsaturated fatty acid elongase (AsELOVL5) gene from black seabream (Acanthopagrus schlegelii). 2012 Biotechnol. Lett. pmid:22198347
Hennessy AA et al. The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. 2012 Lipids pmid:22160449
Kawamura A et al. Dietary supplementation of gamma-linolenic acid improves skin parameters in subjects with dry skin and mild atopic dermatitis. 2011 J Oleo Sci pmid:22123240
Machado FR Fish oil and sepsis: we still need more trials. 2011 Crit Care pmid:22112369
Teichert SA and Akoh CC Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. 2011 J. Agric. Food Chem. pmid:22097918
Khoo SK et al. Evening primrose oil and treatment of premenstrual syndrome. 1990 Med. J. Aust. pmid:2201888
Rice TW et al. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. 2011 JAMA pmid:21976613
Cook DJ and Heyland DK Pharmaconutrition in acute lung injury. 2011 JAMA pmid:21976612
Faragó N et al. MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes. 2011 Lipids Health Dis pmid:21961478
Mansel RE et al. A randomized trial of dietary intervention with essential fatty acids in patients with categorized cysts. 1990 Ann. N. Y. Acad. Sci. pmid:2192634
Viau S et al. Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells. 2012 Graefes Arch. Clin. Exp. Ophthalmol. pmid:21894532
Dodge JA et al. Paradoxical effects of essential fatty acid supplementation on lipid profiles and sweat electrolytes in cystic fibrosis. 1990 Br. J. Nutr. pmid:2185826
Nykiforuk CL et al. High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds. 2012 Transgenic Res. pmid:21853296
Dawczynski C et al. Incorporation of n-3 PUFA and γ-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis--a randomized controlled human intervention trial. 2011 Lipids Health Dis pmid:21816071
Sircar S et al. Transformation renders MDR cells more sensitive to polyunsaturated fatty acids. 1990 Nov-Dec Anticancer Res. pmid:2178327
Huang YS et al. The effects of dietary protein and cholesterol on tissue cholesterol contents and N-6 fatty acid compositions in rats and mice fed a gamma-linolenate-rich diet. 1990 Monogr Atheroscler pmid:2178226
Bunce OR and Abou-El-Ela SH Eicosanoid synthesis and ornithine decarboxylase activity in mammary tumors of rats fed varying levels and types of N-3 and/or N-6 fatty acids. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2177199
Ranchordas MK et al. A-z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 23. 2011 Br J Sports Med pmid:21743106
Simpson LO Melanoma and fatty acids. 1990 N. Z. Med. J. pmid:2173823
Hirschberg Y et al. The response to endotoxin in guinea pigs after intravenous black currant seed oil. 1990 Lipids pmid:2170795
Ribeiro P et al. Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. 2012 Int J Food Sci Nutr pmid:21707451
Alhazzaa R et al. Up-regulated desaturase and elongase gene expression promoted accumulation of polyunsaturated fatty acid (PUFA) but not long-chain PUFA in Lates calcarifer, a tropical euryhaline fish, fed a stearidonic acid- and γ-linoleic acid-enriched diet. 2011 J. Agric. Food Chem. pmid:21707030
van der Merwe CF et al. The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2169638
Liu J et al. Δ6-Desaturase from Mortierella alpina: cDNA cloning, expression, and phylogenetic analysis. 2011 Biotechnol. Lett. pmid:21691840
Cleland LG et al. The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2169063
Wiedemann HP Fish oil is not the fix for acute lung injury. 2011 Crit. Care Med. pmid:21685749
Wang P et al. Production of γ-linolenic acid using a novel heterologous expression system in the oleaginous yeast Lipomyces kononenkoae. 2011 Biotechnol. Lett. pmid:21681556
Chen Q et al. Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells. 2011 Biochem. Biophys. Res. Commun. pmid:21679695
Laho T et al. Effects of prefermented cereal-derived substrates (ground barley and rye bran) enriched with fungal γ-linolenic acid on rumen fermentation parameters and lipid metabolism in vitro. 2011 J. Appl. Microbiol. pmid:21672096
Roemen TH et al. Quantitative assessment of gamma-linolenic acid in human blood and plasma with capillary gas chromatography. 1990 J. Chromatogr. pmid:2166745
Ikushima S et al. Gamma linolenic acid alters the cytotoxic activity of anticancer drugs on cultured human neuroblastoma cells. 1990 Jul-Aug Anticancer Res. pmid:2166461
Meyer BJ and Kolanu N Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health. 2011 Nov-Dec Nutrition pmid:21658909
Pontes-Arruda A et al. Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study. 2011 Crit Care pmid:21658240
Macfarlane GJ et al. Evidence for the efficacy of complementary and alternative medicines in the management of rheumatoid arthritis: a systematic review. 2011 Rheumatology (Oxford) pmid:21652584
Hoppu U et al. Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines. 2012 Eur J Nutr pmid:21626296
Melnik BC [A chance for the prevention of atopic diseases]. 1990 Monatsschr Kinderheilkd pmid:2162007
Kawashima Y et al. Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. 1990 J. Biol. Chem. pmid:2160962
Sangeetha P et al. Free radical generation in human leukocytes by CIS-unsaturated fatty acids is a calmodulin dependent process. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2160083
Kanbur M et al. The effects of evening primrose oil on lipid peroxidation induced by subacute aflatoxin exposure in mice. 2011 Food Chem. Toxicol. pmid:21600263
Jamal GA and Carmichael H The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. 1990 Diabet. Med. pmid:2159860
Bordoni A [Significance and motivation of the clinical use of essential fatty acid derivatives, especially gamma-linolenic acid]. 1990 Clin Ter pmid:2158408
Nakahara T et al. Inhibitory effects of mold oil including gamma-linolenate on platelet thrombus formation in mesenteric microvessels of the rat. 1990 Thromb. Res. pmid:2156348
Zaitone SA et al. Effect of evening primrose oil and ω-3 polyunsaturated fatty acids on the cardiovascular risk of celecoxib in rats. 2011 J. Cardiovasc. Pharmacol. pmid:21499116
Grau-Carmona T et al. Effect of an enteral diet enriched with eicosapentaenoic acid, gamma-linolenic acid and anti-oxidants on the outcome of mechanically ventilated, critically ill, septic patients. 2011 Clin Nutr pmid:21474219
Schumacher MC et al. A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens. 2013 Urol. Oncol. pmid:21414816
Al-Khamees WA et al. Status epilepticus associated with borage oil ingestion. 2011 J Med Toxicol pmid:21387119
Wan X et al. Molecular cloning and expression analysis of a delta 6-fatty acid desaturase gene from Rhizopus stolonifer strain YF6 which can accumulate high levels of gamma-linolenic acid. 2011 J. Microbiol. pmid:21369993
Cameron M et al. Herbal therapy for treating rheumatoid arthritis. 2011 Cochrane Database Syst Rev pmid:21328257
Gamolenic acid in atopic eczema: Epogam. 1990 Drug Ther Bull pmid:2131219
Enzenbach C et al. Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men. 2011 Eur J Nutr pmid:21301856