| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Kidney Calculi | D007669 | 7 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kavanagh T et al. | Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041032 |
| Howie A et al. | The influence of dietary essential fatty acids on uterine C20 and C22 fatty acid composition. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1502249 |
| Navarette R et al. | Dietary intake of concentrated gamma-linolenic acid (GLA)-enriched oil suppresses cutaneous level of dihomo-gamma-linolenic acid (DGLA): possible in vivo inhibition of microsomal elongation of GLA to DGLA. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1323857 |
| Matsuo N et al. | Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951990 |
| Pham H et al. | Dietary gamma-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE(2) and 5S-HETE. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16567086 |
| Das UN and Rao KP | Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16488586 |
| Arisaka M et al. | Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1871184 |
| Hrelia S et al. | Kinetic analysis of delta-6-desaturation in liver microsomes: influence of gamma-linoleic acid dietary supplementation to young and old rats. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808628 |
| Gardiner NS and Duncan JR | Possible involvement of delta-6-desaturase in control of melanoma growth by gamma-linolenic acid. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1650000 |
| Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
| Brouwer DA et al. | Gamma-linolenic acid does not augment long-chain polyunsaturated fatty acid omega-3 status. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9888208 |
| Horrobin DF | The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8380930 |
| Moodley J and Norman RJ | Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2608693 |
| Koba K et al. | Distribution of plasma phosphatidylcholine molecular species in rabbits fed fish oil is modulated by dietary n-6 fatty acids. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8821127 |
| Bunce OR and Abou-El-Ela SH | Eicosanoid synthesis and ornithine decarboxylase activity in mammary tumors of rats fed varying levels and types of N-3 and/or N-6 fatty acids. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2177199 |
| Kaku S et al. | Dietary gamma-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728173 |
| Nwankwo JO and Robbins ME | Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418018 |
| Bégin ME et al. | Selective killing of human cancer cells by polyunsaturated fatty acids. | 1985 | Prostaglandins Leukot Med | pmid:2864701 |
| Segarnick DJ et al. | Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver. | 1985 | Prostaglandins Leukot Med | pmid:2986177 |
| Botha JH et al. | The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis. | 1985 | Prostaglandins Leukot Med | pmid:2994114 |
| Fujiwara F et al. | Fatty acid modification of cultured neuroblastoma cells by gamma linolenic acid relevant to its antitumor effect. | 1987 | Prostaglandins Leukot Med | pmid:2829239 |
| Varma PK and Persaud TV | Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. | 1982 | Prostaglandins Leukot Med | pmid:6287501 |
| Nassar BA et al. | The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature. | 1987 | Prostaglandins Leukot Med | pmid:3033691 |
| Hoffman P and Förster W | Effects of sunflowerseed oil, linseed oil, evening primrose oil and hydrogenated palm kernel oil on hypertension development in spontaneously hypertensive rats. | 1983 | Prostaglandins Leukot Med | pmid:6348801 |
| Papanikolaou N | Alteration of mercuric chloride-induced autoimmune glomerulonephritis in brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor. | 1987 | Prostaglandins Leukot Med | pmid:3475724 |
| Robinson KM and Botha JH | Effects of gamma-linolenic acid, dihomo-gamma-linolenic acid and ethanol on cultured human mammary carcinoma cells. | 1985 | Prostaglandins Leukot Med | pmid:2999828 |
| Singer P et al. | Serum triglycerides and HDL cholesterol from SHR after evening primrose oil and other polyunsaturated fats. | 1986 | Prostaglandins Leukot Med | pmid:3523538 |
| Fujiwara F et al. | Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells. | 1986 | Prostaglandins Leukot Med | pmid:3020590 |
| Das UN et al. | Prostaglandins and their precursors can modify genetic damage-induced by gamma-radiation and benzo(a)pyrene. | 1985 | Prostaglandins | pmid:2994175 |
| Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
| Chaud M et al. | Gamma-linolenic acid improves the constancy of contractions in uteri from sprayed rats and is metabolized to prostaglandin E1 but not to bisenoic prostanoids. | 1988 | Prostaglandins | pmid:2836889 |
| Costall B et al. | Dihomo-gamma-linolenic acid, prostaglandins and dyskinesias. | 1986 | Prog. Lipid Res. | pmid:2827191 |
| Karmali RA et al. | Prostaglandins and essential fatty acids in regulation of autoimmunity and development of antibodies to DNA in NZB x NZW F1 mice. | 1981 | Prog. Lipid Res. | pmid:7342118 |
| Kunkel SL et al. | Suppression of chronic inflammation by evening primrose oil. | 1981 | Prog. Lipid Res. | pmid:7342138 |
| Gunstone FD | Gamma linolenic acid--occurrence and physical and chemical properties. | 1992 | Prog. Lipid Res. | pmid:1334265 |
| Horrobin DF | Nutritional and medical importance of gamma-linolenic acid. | 1992 | Prog. Lipid Res. | pmid:1334266 |
| Papanikolaou N et al. | Partial protection against acute renal failure by Efamol. | 1989 | Prog. Clin. Biol. Res. | pmid:2798451 |
| Papanikolaou N et al. | Effect of thromboxane A2-synthetase inhibitor OKY-046 and evening primrose oil (Efamol) on mercuric chloride induced autoimmune glomerulonephritis in Brown-Norway rats. | 1987 | Prog. Clin. Biol. Res. | pmid:3671393 |
| Huang YS et al. | Stress modulates cholesterol-induced changes in plasma and liver fatty acid composition in rats fed n-6 fatty acid-rich oils. | 1990 | Proc. Soc. Exp. Biol. Med. | pmid:2399256 |
| Engler MM et al. | Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. | 1998 | Proc. Soc. Exp. Biol. Med. | pmid:9648942 |
| Nassar BA et al. | The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed N-6 and N-3 fatty acid-supplemented diets. | 1992 | Proc. Soc. Exp. Biol. Med. | pmid:1539039 |
| Huang YS et al. | Effect of dietary alpha- and gamma-linolenic acid on tissue fatty acids in guinea pigs. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:2857052 |
| Huang YS and Horrobin DF | Sex differences in n-3 and n-6 fatty acid metabolism in EFA-depleted rats. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3037555 |
| Mills DE and Ward R | Attenuation of psychosocial stress-induced hypertension by gamma-linolenic acid (GLA) administration in rats. | 1984 | Proc. Soc. Exp. Biol. Med. | pmid:6324224 |
| Parker-Barnes JM et al. | Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10899997 |
| Kis M et al. | Light-induced expression of fatty acid desaturase genes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539715 |
| Calder PC | Rationale and use of n-3 fatty acids in artificial nutrition. | 2010 | Proc Nutr Soc | pmid:20441676 |
| Funtikova NS et al. | [Synthesis of biologically active lipids by fungus Mucor lusitanicus 306D grown on media with various composition]. | 2002 Nov-Dec | Prikl. Biokhim. Mikrobiol. | pmid:12449793 |
| Funtikova NS and Mysiakina IS | [Effects of conditions for obtaining sporangiospores of the inoculum on the morphology and productivity of the fungus Mucor circinelloides var. lusitanicus 12 M, a producer of gamma-linolenic acid]. | 2008 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:18924414 |
| Watkins BA | Levels of dihomo-gamma-linolenate are depressed in heart phosphatidylcholine and phosphatidylethanolamine in the biotin-deficient chick. | 1989 | Poult. Sci. | pmid:2547210 |