gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Urolithiasis D052878 1 associated lipids
Fallopian Tube Neoplasms D005185 1 associated lipids
Fibrocystic Breast Disease D005348 1 associated lipids
Mucocele D009078 1 associated lipids
Tietze's Syndrome D013991 1 associated lipids
Salivary Gland Diseases D012466 1 associated lipids
Scurvy D012614 2 associated lipids
Mastocytoma D034801 3 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Ecchymosis D004438 3 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Arthritis, Psoriatic D015535 3 associated lipids
Pityriasis D010915 3 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Back Pain D001416 5 associated lipids
Hand Dermatoses D006229 5 associated lipids
Xerostomia D014987 6 associated lipids
Intermittent Claudication D007383 6 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Nausea D009325 7 associated lipids
Premenstrual Syndrome D011293 7 associated lipids
Bacteriuria D001437 7 associated lipids
Raynaud Disease D011928 7 associated lipids
Kidney Calculi D007669 7 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Dysmenorrhea D004412 9 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Fatigue D005221 10 associated lipids
Critical Illness D016638 13 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Synovitis D013585 15 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Gastritis D005756 27 associated lipids
Alcoholism D000437 27 associated lipids
Dermatitis D003872 30 associated lipids
Acute Lung Injury D055371 33 associated lipids
Hyperplasia D006965 34 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Singer P et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. 2006 Crit. Care Med. pmid:16484911
Das UN and Rao KP Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16488586
Martin TA et al. Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. 2006 J. Cell. Biochem. pmid:16514648
Pacht ER Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come. 2006 Crit. Care Med. pmid:16921322
Arab K et al. Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. 2006 Br. J. Nutr. pmid:17092368
Puri BK Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). 2007 J. Clin. Pathol. pmid:16935966
Noli C et al. Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. 2007 Vet. J. pmid:16495095
Dasgupta S and Bhattacharyya DK Dietary effect of gamma-linolenic acid on the lipid profile of rat fed erucic acid rich oil. 2007 J Oleo Sci pmid:17938547
Sýkora J et al. High-performance liquid chromatography with nuclear magnetic resonance detection--A method for quantification of alpha- and gamma-linolenic acids in their mixtures with free fatty acids. 2007 J Chromatogr A pmid:17157864
Martin TA et al. Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid. 2007 J. Cell. Biochem. pmid:17243118
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Pitel S et al. At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. 2007 J. Nutr. pmid:17237313
Christie A et al. Effectiveness of nonpharmacological and nonsurgical interventions for patients with rheumatoid arthritis: an overview of systematic reviews. 2007 Phys Ther pmid:17906290
Dobryniewski J et al. [The gamma-linolenic acid (GLA)--the therapeutic value]. 2007 Prz. Lek. pmid:17892041
Theilla M et al. A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study. 2007 Clin Nutr pmid:17933438
Garaiova I et al. A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. 2007 Nutr J pmid:17254329
Das UN Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. 2007 Med. Sci. Monit. pmid:17599036
Schirmer MA and Phinney SD Gamma-linolenate reduces weight regain in formerly obese humans. 2007 J. Nutr. pmid:17513402
Curtis L High-quality enteral nutrition essential for reducing morbidity and mortality in acute care patients. 2007 Crit. Care Med. pmid:17421112
Ortiz-Leyba C and Garnacho-Montero J Saving lives in severe sepsis with the help of enteral nutrition. 2007 Crit. Care Med. pmid:17421113
Kanehara S et al. Clinical effects of undershirts coated with borage oil on children with atopic dermatitis: a double-blind, placebo-controlled clinical trial. 2007 J. Dermatol. pmid:18078406
Vrinten P et al. Production of polyunsaturated fatty acids in transgenic plants. 2007 Biotechnol. Genet. Eng. Rev. pmid:18059637
Villamor E et al. Long-chain n-6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding. 2007 Am. J. Clin. Nutr. pmid:17823433
Stolyhwo A and Mol J Changes in the content of gamma-linolenic C18:3 (n-6) and stearidonic C18:4 (n-3) acids in developing seeds of viper's bugloss Echium vulgare L. 2007 Acta Biochim. Pol. pmid:18066400
Saied GM et al. Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females. 2007 Tanzan Health Res Bull pmid:18087899
Poulsen RC et al. Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. 2007 Calcif. Tissue Int. pmid:18008020
Lindmark L and Clough P A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia. 2007 J Med Food pmid:18158838
Guo SX et al. [Influence of methyl esterification on the ultraviolet absorption of gamma-linolenic acid]. 2007 Zhong Yao Cai pmid:18236761
Puri BK The safety of evening primrose oil in epilepsy. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17764919
Pinna A et al. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. 2007 Cornea pmid:17413949
Lu H et al. [Cloning and expression of a delta6-fatty acid desaturase gene from Rhizopus stolonifer in Saccharomyces cervisiae]. 2007 Wei Sheng Wu Xue Bao pmid:17436625
Cho HS et al. Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation. 2007 Photodermatol Photoimmunol Photomed pmid:17803593
Kanehara S et al. Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children. 2007 Sep-Oct Eur J Dermatol pmid:17673396
Yen CH et al. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. 2008 Ann. Allergy Asthma Immunol. pmid:18254485
Clément M et al. Purification and identification of bovine cheese whey fatty acids exhibiting in vitro antifungal activity. 2008 J. Dairy Sci. pmid:18565910
Leskinen H et al. Regioisomeric structure determination of alpha- and gamma-linolenoyldilinoleoylglycerol in blackcurrant seed oil by silver ion high-performance liquid chromatography and mass spectrometry. 2008 Anal. Chem. pmid:18578547
Guo JP and Xue H [Prepared evening primrose oil microspheres by spray drying]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18589773
Fakas S et al. Gamma-linolenic acid production by Cunninghamella echinulata growing on complex organic nitrogen sources. 2008 Bioresour. Technol. pmid:18609766
Yu Q et al. LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenase-catalysed peroxidation of gamma-linolenic acid. 2008 Free Radic. Res. pmid:18484409
Thumfart J et al. Magnesium stimulates renal phosphate reabsorption. 2008 Am. J. Physiol. Renal Physiol. pmid:18701629
Bloom P Atopic dermatitis: the quest for the silver bullet. 2008 Vet. J. pmid:18554562
Adam O [Ankylosing Spondylitis and convenient nutrition]. 2008 Wien Med Wochenschr pmid:18560957
Wedig KE and Whitsett JA Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. 2008 J. Pediatr. pmid:18154917
Nasrollahzadeh J et al. The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. 2008 Lipids Health Dis pmid:19014610
Shi LM et al. [Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19260318
Nandakumar M and Tan MW Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. 2008 PLoS Genet. pmid:19023415
Won J et al. Stability analysis of zinc oxide-nanoencapsulated conjugated linoleic acid and gamma-linolenic acid. 2008 J. Food Sci. pmid:19019122
Geppert J et al. Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. 2008 Br. J. Nutr. pmid:17678567
Rühl R et al. Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. 2008 Br. J. Nutr. pmid:18005485
Chilton FH et al. Mechanisms by which botanical lipids affect inflammatory disorders. 2008 Am. J. Clin. Nutr. pmid:18258646
Surette ME et al. The impact of a medical food containing gammalinolenic and eicosapentaenoic acids on asthma management and the quality of life of adult asthma patients. 2008 Curr Med Res Opin pmid:18194593
Cui PH et al. Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. 2008 Chem. Phys. Lipids pmid:18339314
Wu CC et al. Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. 2008 Asia Pac J Clin Nutr pmid:18296341
Jeennor S et al. Evaluation of inoculum performance for enhancing gamma-linolenic acid production from Mucor rouxii. 2008 Lett. Appl. Microbiol. pmid:18298455
Puch F et al. Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. 2008 Exp. Dermatol. pmid:18318715
Vinggaard AM et al. Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. 2008 Chem. Res. Toxicol. pmid:18324785
Song C et al. Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. 2008 J. Nutr. pmid:18424607
Choi GG et al. Enhanced biomass and gamma-linolenic acid production of mutant strain Arthrospira platensis. 2008 J. Microbiol. Biotechnol. pmid:18388474
Prociuk MA et al. Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. 2008 Can. J. Physiol. Pharmacol. pmid:18418423
Funtikova NS and Mysiakina IS [Effects of conditions for obtaining sporangiospores of the inoculum on the morphology and productivity of the fungus Mucor circinelloides var. lusitanicus 12 M, a producer of gamma-linolenic acid]. 2008 Jul-Aug Prikl. Biokhim. Mikrobiol. pmid:18924414
Mysiakina IS and Funtikova NS [Activity of NAD-dependent isocitrate dehydrogenase, isocitrate lyase, and malate dehydrogenase in Mucor circinelloides var. lusitanicus INMI under different modes of nitrogen supply]. 2008 Jul-Aug Mikrobiologiia pmid:18825970
Mysiakina IS and Funtikova NS [Metabolic characteristics and lipid composition of yeastlike cells and mycelium of Mucor circinelloides var. lusitanicus INMI grown at a high glucose content in the medium]. 2008 Jul-Aug Mikrobiologiia pmid:18825971
Pontes-Arruda A et al. The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. 2008 Nov-Dec JPEN J Parenter Enteral Nutr pmid:18974237
Preiser JC Nutrition therapy for acute respiratory distress syndrome. 2008 Nov-Dec JPEN J Parenter Enteral Nutr pmid:18974251
Dickerson RN Modified EN support for patients with acute respiratory distress syndrome. 2008 Nov-Dec JPEN J Parenter Enteral Nutr pmid:18974252
Senapati S et al. Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. 2008 Sep-Oct Indian J Dermatol Venereol Leprol pmid:19052401
Ahmed SU et al. Application of response surface method for studying the role of dissolved oxygen and agitation speed on gamma-linolenic acid production. 2009 Appl. Biochem. Biotechnol. pmid:18480973
De Spirt S et al. Intervention with flaxseed and borage oil supplements modulates skin condition in women. 2009 Br. J. Nutr. pmid:18761778
Kong X et al. Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. 2009 Toxicol In Vitro pmid:19268700
Schnebelen C et al. Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. 2009 Lipids pmid:19242743
Miyake JA et al. Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. 2009 Lipids Health Dis pmid:19292920
Ge H et al. Gamma-linolenic acid induces apoptosis and lipid peroxidation in human chronic myelogenous leukemia K562 cells. 2009 Cell Biol. Int. pmid:19356705
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Zaniewska A et al. The activity of lysosomal exoglycosidases in serum of alcohol-dependent men supplemented with borage oil enriched with vitamin E. 2009 J Med Food pmid:19735195
Lu H et al. Identification and characterization of a novel delta6-fatty acid desaturase gene from Rhizopus nigricans. 2009 Mol. Biol. Rep. pmid:19152021
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Wan X et al. Production of gamma-linolenic acid in Pichia pastoris by Expression of a delta-6 desaturase gene from Cunninghamella echinulata. 2009 J. Microbiol. Biotechnol. pmid:19884765
Lísa M et al. Comparison of various types of stationary phases in non-aqueous reversed-phase high-performance liquid chromatography-mass spectrometry of glycerolipids in blackcurrant oil and its enzymatic hydrolysis mixture. 2009 J Chromatogr A pmid:19837411
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Rodgers A et al. Evening primrose oil supplementation increases citraturia and decreases other urinary risk factors for calcium oxalate urolithiasis. 2009 J. Urol. pmid:19846138
Scheim DE Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. 2009 Lipids Health Dis pmid:20003514
Lindemann J et al. Clinical study of the effects on asthma-related QOL and asthma management of a medical food in adult asthma patients. 2009 Curr Med Res Opin pmid:19811112
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Labruzzo BA et al. Which complementary therapies can help patients with PMS? 2009 J Fam Pract pmid:19874736
Ranieri M et al. The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. 2009 Jul-Sep Int J Immunopathol Pharmacol pmid:19887043
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Khongto B et al. Fermentation process development of recombinant Hansenula polymorpha for gamma-linolenic acid production. 2010 J. Microbiol. Biotechnol. pmid:21124062
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