gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Urolithiasis D052878 1 associated lipids
Mucocele D009078 1 associated lipids
Fibrocystic Breast Disease D005348 1 associated lipids
Salivary Gland Diseases D012466 1 associated lipids
Tietze's Syndrome D013991 1 associated lipids
Fallopian Tube Neoplasms D005185 1 associated lipids
Scurvy D012614 2 associated lipids
Mastocytoma D034801 3 associated lipids
Ecchymosis D004438 3 associated lipids
Pityriasis D010915 3 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Arthritis, Psoriatic D015535 3 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Hand Dermatoses D006229 5 associated lipids
Back Pain D001416 5 associated lipids
Intermittent Claudication D007383 6 associated lipids
Xerostomia D014987 6 associated lipids
Kidney Calculi D007669 7 associated lipids
Raynaud Disease D011928 7 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Nausea D009325 7 associated lipids
Premenstrual Syndrome D011293 7 associated lipids
Bacteriuria D001437 7 associated lipids
Dysmenorrhea D004412 9 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Fatigue D005221 10 associated lipids
Critical Illness D016638 13 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Synovitis D013585 15 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Gastritis D005756 27 associated lipids
Alcoholism D000437 27 associated lipids
Dermatitis D003872 30 associated lipids
Acute Lung Injury D055371 33 associated lipids
Hyperplasia D006965 34 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Christie A et al. Effectiveness of nonpharmacological and nonsurgical interventions for patients with rheumatoid arthritis: an overview of systematic reviews. 2007 Phys Ther pmid:17906290
Vecera R et al. Antioxidant status, lipoprotein profile and liver lipids in rats fed on high-cholesterol diet containing currant oil rich in n-3 and n-6 polyunsaturated fatty acids. 2003 Physiol Res pmid:12678660
Guil-Guerrero JL et al. Occurrence and characterization of oils rich in gamma-linolenic acid part II: fatty acids and squalene from Macaronesian Echium leaves. 2000 Phytochemistry pmid:10939357
Guil-Guerrero JL et al. Occurrence and characterization of oils rich in gamma-linolenic acid Part I: Echium seeds from Macaronesia. 2000 Phytochemistry pmid:10731022
Řezanka T et al. Regioisomer separation and identification of triacylglycerols containing vaccenic and oleic acids, and α- and γ-linolenic acids, in thermophilic cyanobacteria Mastigocladus laminosus and Tolypothrix sp. 2012 Phytochemistry pmid:22445652
Guil-Guerrero JL et al. Occurrence and characterization of oils rich in gamma-linolenic acid (III): the taxonomical value of the fatty acids in Echium (Boraginaceae). 2001 Phytochemistry pmid:11524120
Lukivskaya OY et al. Reversal of experimental ethanol-induced liver steatosis by borage oil. 2012 Phytother Res pmid:22359349
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Hong H et al. High-level production of gamma-linolenic acid in Brassica juncea using a delta6 desaturase from Pythium irregulare. 2002 Plant Physiol. pmid:12011365
Nandakumar M and Tan MW Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. 2008 PLoS Genet. pmid:19023415
Mütze U et al. Metabolomics of dietary fatty acid restriction in patients with phenylketonuria. 2012 PLoS ONE pmid:22912778
Tasset-Cuevas I et al. Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies. 2013 PLoS ONE pmid:23460824
Yamanaka K et al. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. 2012 PLoS ONE pmid:23056190
Yabuki C et al. A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1. 2013 PLoS ONE pmid:24130766
Tang X et al. Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. 2015 PLoS ONE pmid:26046932
Gautam M et al. Importance of fatty acid compositions in patients with peripheral arterial disease. 2014 PLoS ONE pmid:25191963
Lopez HL Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. 2012 PM R pmid:22632694
Białek M and Rutkowska J [The importance of γ-linolenic acid in the prevention and treatment]. 2015 Postepy Hig Med Dosw (Online) pmid:26270516
Steinbrunn BS et al. Mastalgia. Tailoring treatment to type of breast pain. 1997 Postgrad Med pmid:9385340
Watkins BA Levels of dihomo-gamma-linolenate are depressed in heart phosphatidylcholine and phosphatidylethanolamine in the biotin-deficient chick. 1989 Poult. Sci. pmid:2547210
Funtikova NS et al. [Synthesis of biologically active lipids by fungus Mucor lusitanicus 306D grown on media with various composition]. 2002 Nov-Dec Prikl. Biokhim. Mikrobiol. pmid:12449793
Funtikova NS and Mysiakina IS [Effects of conditions for obtaining sporangiospores of the inoculum on the morphology and productivity of the fungus Mucor circinelloides var. lusitanicus 12 M, a producer of gamma-linolenic acid]. 2008 Jul-Aug Prikl. Biokhim. Mikrobiol. pmid:18924414
Calder PC Rationale and use of n-3 fatty acids in artificial nutrition. 2010 Proc Nutr Soc pmid:20441676
Parker-Barnes JM et al. Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10899997
Kis M et al. Light-induced expression of fatty acid desaturase genes. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9539715
Huang YS et al. Stress modulates cholesterol-induced changes in plasma and liver fatty acid composition in rats fed n-6 fatty acid-rich oils. 1990 Proc. Soc. Exp. Biol. Med. pmid:2399256
Engler MM et al. Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. 1998 Proc. Soc. Exp. Biol. Med. pmid:9648942
Nassar BA et al. The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed N-6 and N-3 fatty acid-supplemented diets. 1992 Proc. Soc. Exp. Biol. Med. pmid:1539039
Huang YS et al. Effect of dietary alpha- and gamma-linolenic acid on tissue fatty acids in guinea pigs. 1985 Proc. Soc. Exp. Biol. Med. pmid:2857052
Huang YS and Horrobin DF Sex differences in n-3 and n-6 fatty acid metabolism in EFA-depleted rats. 1987 Proc. Soc. Exp. Biol. Med. pmid:3037555
Mills DE and Ward R Attenuation of psychosocial stress-induced hypertension by gamma-linolenic acid (GLA) administration in rats. 1984 Proc. Soc. Exp. Biol. Med. pmid:6324224
Papanikolaou N et al. Partial protection against acute renal failure by Efamol. 1989 Prog. Clin. Biol. Res. pmid:2798451
Papanikolaou N et al. Effect of thromboxane A2-synthetase inhibitor OKY-046 and evening primrose oil (Efamol) on mercuric chloride induced autoimmune glomerulonephritis in Brown-Norway rats. 1987 Prog. Clin. Biol. Res. pmid:3671393
Costall B et al. Dihomo-gamma-linolenic acid, prostaglandins and dyskinesias. 1986 Prog. Lipid Res. pmid:2827191
Karmali RA et al. Prostaglandins and essential fatty acids in regulation of autoimmunity and development of antibodies to DNA in NZB x NZW F1 mice. 1981 Prog. Lipid Res. pmid:7342118
Kunkel SL et al. Suppression of chronic inflammation by evening primrose oil. 1981 Prog. Lipid Res. pmid:7342138
Gunstone FD Gamma linolenic acid--occurrence and physical and chemical properties. 1992 Prog. Lipid Res. pmid:1334265
Horrobin DF Nutritional and medical importance of gamma-linolenic acid. 1992 Prog. Lipid Res. pmid:1334266
Das UN et al. Prostaglandins and their precursors can modify genetic damage-induced by gamma-radiation and benzo(a)pyrene. 1985 Prostaglandins pmid:2994175
Bonacossa A et al. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. 1982 Prostaglandins pmid:6278538
Chaud M et al. Gamma-linolenic acid improves the constancy of contractions in uteri from sprayed rats and is metabolized to prostaglandin E1 but not to bisenoic prostanoids. 1988 Prostaglandins pmid:2836889
Bégin ME et al. Selective killing of human cancer cells by polyunsaturated fatty acids. 1985 Prostaglandins Leukot Med pmid:2864701
Segarnick DJ et al. Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver. 1985 Prostaglandins Leukot Med pmid:2986177
Botha JH et al. The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis. 1985 Prostaglandins Leukot Med pmid:2994114
Varma PK and Persaud TV Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. 1982 Prostaglandins Leukot Med pmid:6287501
Nassar BA et al. The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature. 1987 Prostaglandins Leukot Med pmid:3033691
Hoffman P and Förster W Effects of sunflowerseed oil, linseed oil, evening primrose oil and hydrogenated palm kernel oil on hypertension development in spontaneously hypertensive rats. 1983 Prostaglandins Leukot Med pmid:6348801
Fujiwara F et al. Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells. 1986 Prostaglandins Leukot Med pmid:3020590