Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wright S and Burton JL | Oral evening-primrose-seed oil improves atopic eczema. | 1982 | Lancet | pmid:6128449 |
Lovell CR et al. | Treatment of atopic eczema with evening primrose oil. | 1981 | Lancet | pmid:6109930 |
Monnier L | [Influence of metabolic and nutritional balance on platelet function in insulin-dependent diabetes]. | 1984 | Journ Annu Diabetol Hotel Dieu | pmid:6100381 |
Traitler H et al. | Characterization of gamma-linolenic acid in Ribes seed. | 1984 | Lipids | pmid:6098796 |
Leonard BE | Possible relationships between thiamine, carnitine, polyunsaturated fatty acids and the neurotoxicity of alcohol. | 1984 | Alcohol Alcohol. | pmid:6093831 |
Mertin J | Omega-6 and omega-3 polyunsaturates and the immune system. | 1984 | Br J Clin Pract Suppl | pmid:6091715 |
Horrobin DF | Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjogren's syndrome. | 1984 | Med. Hypotheses | pmid:6088955 |
Strong AM et al. | The effect of oral linoleic acid and gamma-linolenic acid (Efamol [G]). | 1985 Nov-Dec | Br J Clin Pract | pmid:4092010 |
Belch JJ et al. | Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. | 1985 | Thromb. Haemost. | pmid:4082084 |
Webb J and McCredie M | Primary Sjögren's syndrome treated with Efamol/efavit. A double-blind cross-over investigation. | 1985 | Rheumatol. Int. | pmid:4048763 |
Soma M et al. | The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. | 1985 | Can. J. Physiol. Pharmacol. | pmid:4005704 |
Kumar S et al. | Prediction of response to endocrine therapy in pronounced cyclical mastalgia using dynamic tests of prolactin release. | 1985 | Clin. Endocrinol. (Oxf) | pmid:3938354 |
Bamford JT et al. | Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids). | 1985 | J. Am. Acad. Dermatol. | pmid:3908514 |
Wright S | Atopic dermatitis and essential fatty acids: a biochemical basis for atopy? | 1985 | Acta Derm Venereol Suppl (Stockh) | pmid:3890448 |
Puolakka J et al. | Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors. | 1985 | J Reprod Med | pmid:3839018 |
Sugano M et al. | Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. | 1986 | Ann. Nutr. Metab. | pmid:3752928 |
Levy RJ and Lian JB | gamma-Carboxyglutamate excretion and warfarin therapy. | 1979 | Clin. Pharmacol. Ther. | pmid:373941 |
Das UN et al. | Beneficial effect of essential fatty acids in cirrhosis of the liver. | 1987 | J Assoc Physicians India | pmid:3693270 |
Singh NK et al. | Essential fatty acids and cancer with particular reference to Hodgkin's disease. | 1987 | J Assoc Physicians India | pmid:3693269 |
Ziboh VA and Chapkin RS | Biologic significance of polyunsaturated fatty acids in the skin. | 1987 | Arch Dermatol | pmid:3688908 |
Guenther L and Wexler D | Efamol in the treatment of atopic dermatitis. | 1987 | J. Am. Acad. Dermatol. | pmid:3680673 |
Papanikolaou N et al. | Effect of thromboxane A2-synthetase inhibitor OKY-046 and evening primrose oil (Efamol) on mercuric chloride induced autoimmune glomerulonephritis in Brown-Norway rats. | 1987 | Prog. Clin. Biol. Res. | pmid:3671393 |
Takahashi R et al. | Effect of different ratios of dietary N-6 and N-3 fatty acids on fatty acid composition, prostaglandin formation and platelet aggregation in the rat. | 1987 | Thromb. Res. | pmid:3660347 |
Chapkin RS et al. | Dietary influences of evening primrose and fish oil on the skin of essential fatty acid-deficient guinea pigs. | 1987 | J. Nutr. | pmid:3625311 |
Bordoni A et al. | [Treatment of premenstrual syndrome with essential fatty acids (evening primrose oil)]. | 1987 | G Clin Med | pmid:3609594 |
Glen I et al. | The role of essential fatty acids in alcohol dependence and tissue damage. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3551662 |
Oxholm P et al. | Patients with primary Sjögren's syndrome treated for two months with evening primrose oil. | 1986 | Scand. J. Rheumatol. | pmid:3529370 |
Ferrando J | [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions]. | 1986 | Med Cutan Ibero Lat Am | pmid:3528709 |
Singer P et al. | Serum triglycerides and HDL cholesterol from SHR after evening primrose oil and other polyunsaturated fats. | 1986 | Prostaglandins Leukot Med | pmid:3523538 |
Godfrey DG et al. | Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation. | 1986 | Ann. Rheum. Dis. | pmid:3492970 |
Papanikolaou N | Alteration of mercuric chloride-induced autoimmune glomerulonephritis in brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor. | 1987 | Prostaglandins Leukot Med | pmid:3475724 |
Morrison CS | Leg ulcers and Efamol. | 1986 | N. Z. Med. J. | pmid:3468432 |
Simpson LO | Leg ulceration and Efamol. | 1986 | N. Z. Med. J. | pmid:3466083 |
Morrison CS | Leg ulceration and Efamol. | 1986 | N. Z. Med. J. | pmid:3463912 |
Novak E | Maintaining remission of Crohn's disease. | 1988 | CMAJ | pmid:3383034 |
Greaves MW and Corbett MF | Treatment of atopic eczema with evening primrose oil. | 1988 | Br. J. Dermatol. | pmid:3355786 |
Schalin-Karrila M et al. | Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. | 1987 | Br. J. Dermatol. | pmid:3307886 |
Horrobin DF | Essential fatty acid and prostaglandin metabolism in Sjögren's syndrome, systemic sclerosis and rheumatoid arthritis. | 1986 | Scand. J. Rheumatol. Suppl. | pmid:3296151 |
Manthorpe R and Prause JU | Treatment of Sjögren's syndrome: an overview. | 1986 | Scand. J. Rheumatol. Suppl. | pmid:3296150 |
Darlington LG | Do diets rich in polyunsaturated fatty acids affect disease activity in rheumatoid arthritis? | 1988 | Ann. Rheum. Dis. | pmid:3281607 |
Barcelli UO et al. | A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats. | 1988 | Lipids | pmid:3237005 |
Wade AE et al. | Effect of 7,12-dimethylbenz(a)anthracene administration on hepatic drug metabolizing enzymes in female rats fed corn, primrose, and menhaden oils. | 1988 | Drug Nutr Interact | pmid:3149238 |
Abou-el-Ela SH et al. | Eicosanoid synthesis in 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats fed primrose oil, menhaden oil or corn oil diet. | 1988 | Lipids | pmid:3143882 |
el-Ela SH et al. | Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12-dimethylbenz(a)anthracene. | 1987 | Lipids | pmid:3131611 |
Simpson LO | Pinch skin grafting or porcine dermis in venous ulcers. | 1987 | Br Med J (Clin Res Ed) | pmid:3109651 |
van Doormaal JJ et al. | Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, alpha-tocopherol levels, and erythropoiesis in normal and type 1 (insulin-dependent) diabetic men. | 1988 | Diabetologia | pmid:3065111 |
Bordoni A et al. | Evening primrose oil (Efamol) in the treatment of children with atopic eczema. | 1988 | Drugs Exp Clin Res | pmid:3048953 |
Biagi PL et al. | A long-term study on the use of evening primrose oil (Efamol) in atopic children. | 1988 | Drugs Exp Clin Res | pmid:3048952 |
Huang YS and Horrobin DF | Sex differences in n-3 and n-6 fatty acid metabolism in EFA-depleted rats. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3037555 |
McIllmurray MB and Turkie W | Controlled trial of gamma linolenic acid in Duke's C colorectal cancer. | 1987 | Br Med J (Clin Res Ed) | pmid:3036291 |