gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Gastritis D005756 27 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Kidney Calculi D007669 7 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hyperplasia D006965 34 associated lipids
Arteriosclerosis D001161 86 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Psoriasis D011565 47 associated lipids
Alcoholism D000437 27 associated lipids
Bacteriuria D001437 7 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Dermatitis D003872 30 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Hyperlipidemias D006949 73 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Premenstrual Syndrome D011293 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Willemaers V et al. [Atopic dermatitis]. 1998 Rev Med Liege pmid:9564223
Hørby Jørgensen M et al. Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. 1998 J. Pediatr. Gastroenterol. Nutr. pmid:9552137
Solomon LZ et al. Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. 1998 Urol. Res. pmid:9537690
Kis M et al. Light-induced expression of fatty acid desaturase genes. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9539715
Cameron NE et al. Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. 1998 Diabetologia pmid:9562342
Villalobos MA et al. Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. 1998 Thromb. Haemost. pmid:9798993
Eynard AR et al. Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin and desmoglein in human squamous cell carcinoma in vitro. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:10102382
Tanaka T et al. Methylene-interrupted double bond in polyunsaturated fatty acid is an essential structure for metabolism by the fatty acid chain elongation system of rat liver. 1998 Biochim. Biophys. Acta pmid:9748638
Brouwer DA et al. Gamma-linolenic acid does not augment long-chain polyunsaturated fatty acid omega-3 status. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888208
Seegers JC et al. Comparative anti-mitotic effects of lithium gamma-linolenate, gamma-linolenic acid and arachidonic acid, on transformed and embryonic cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849656
Leng GC et al. Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. 1998 Clin Nutr pmid:10205349
Hounsom L et al. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. 1998 Diabetologia pmid:9686927
Kumamoto T and Ide T Comparative effects of alpha- and gamma-linolenic acids on rat liver fatty acid oxidation. 1998 Lipids pmid:9688166
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Ravichandran D et al. Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. 1998 Eur. J. Cancer pmid:9624256
Sanderson P and Calder PC Dietary fish oil appears to prevent the activation of phospholipase C-gamma in lymphocytes. 1998 Biochim. Biophys. Acta pmid:9630688
Martens-Lobenhoffer J and Meyer FP Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). 1998 Int J Clin Pharmacol Ther pmid:9707349
Johnson SR Premenstrual syndrome therapy. 1998 Clin Obstet Gynecol pmid:9646973
Engler MM et al. Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. 1998 Proc. Soc. Exp. Biol. Med. pmid:9648942
Giamarellos-Bourboulis EJ et al. In vitro activity of polyunsaturated fatty acids on Pseudomonas aeruginosa: relationship to lipid peroxidation. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654401
Kahler CP and Du Plooy WJ Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654407
Solomon LZ et al. Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? 1998 Br J Urol pmid:9698674
Vartak S et al. Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. 1998 Br. J. Cancer pmid:9635836
Reilly JD et al. Effect of a supplementary dietary evening primrose oil mixture on hoof growth, hoof growth rate and hoof lipid fractions in horses: a controlled and blinded trial. 1998 Equine Vet J Suppl pmid:9932095
Kruger MC et al. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. 1998 Aging (Milano) pmid:9932142
Ramesh G and Das UN Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9844986
Kuruvilla R et al. Evening primrose oil treatment corrects reduced conduction velocity but not depletion of arachidonic acid in nerve from streptozotocin-induced diabetic rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9844993
Schellhammer PF Intravesical chemotherapy with gamma linolenic acid becomes a reality. 1998 J. Urol. pmid:9817299
Solomon LZ et al. Intravesical chemotherapy with gamma linolenic acid becomes a realistic prospect in serum-free applications: in vitro cytotoxicity and systemic absorption studies. 1998 J. Urol. pmid:9817384
Marra F et al. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. 1998 J. Hepatol. pmid:9566835
Jiang WG et al. The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. 1998 Br. J. Cancer pmid:9514051
Frati-Munari AC and Ariza-Andraca CR [Treatment of diabetic neuropathy]. 1998 Jan-Feb Gac Med Mex pmid:9658700
Oakley OR et al. The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro. 1998 Jan-Jun Rom J Physiol pmid:11000861
Burnard SL et al. Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat. 1998 Mar-Apr J. Diabetes Complicat. pmid:9559483
Anderson KM et al. Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. 1998 Mar-Apr Anticancer Res. pmid:9615721
Stahl A et al. Identification of the major intestinal fatty acid transport protein. 1999 Mol. Cell pmid:10518211
Cai J et al. Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10319914
Ihara-Watanabe M et al. Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. 1999 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:10327618
Giamarellos-Bourboulis EJ et al. In vitro interactions of gamma-linolenic acid and arachidonic acid with ceftazidime on multiresistant Pseudomonas aeruginosa. 1999 Lipids pmid:10419130
Hrelia S et al. Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10397404
Pakala R et al. Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10397410
Warren G et al. The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. 1999 Acta Neurol. Scand. pmid:10071170
Muñoz SE et al. Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. 1999 Nutrition pmid:10198915
Tamimi NA et al. Role of gamma-linolenic acid in uraemic pruritus. 1999 Nephron pmid:10516500
Wu D et al. Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. 1999 Am. J. Clin. Nutr. pmid:10500023
Peterson LD et al. Dose-dependent effects of dietary gamma-linolenic acid on rat spleen lymphocyte functions. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10477037
Haag M et al. Polyunsaturated fatty acids inhibit Mg2+ -ATPase in basolateral membranes from rat enterocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10477038
Huang YS et al. Cloning of delta12- and delta6-desaturases from Mortierella alpina and recombinant production of gamma-linolenic acid in Saccharomyces cerevisiae. 1999 Lipids pmid:10478922
Gadek JE et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. 1999 Crit. Care Med. pmid:10470743
Khamaisi M et al. Metabolic effects of gamma-linolenic acid-alpha-lipoic acid conjugate in streptozotocin diabetic rats. 1999 Antioxid. Redox Signal. pmid:11233149