gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wright S and Burton JL | Oral evening-primrose-seed oil improves atopic eczema. | 1982 | Lancet | pmid:6128449 |
| Lovell CR et al. | Treatment of atopic eczema with evening primrose oil. | 1981 | Lancet | pmid:6109930 |
| Monnier L | [Influence of metabolic and nutritional balance on platelet function in insulin-dependent diabetes]. | 1984 | Journ Annu Diabetol Hotel Dieu | pmid:6100381 |
| Traitler H et al. | Characterization of gamma-linolenic acid in Ribes seed. | 1984 | Lipids | pmid:6098796 |
| Leonard BE | Possible relationships between thiamine, carnitine, polyunsaturated fatty acids and the neurotoxicity of alcohol. | 1984 | Alcohol Alcohol. | pmid:6093831 |
| Mertin J | Omega-6 and omega-3 polyunsaturates and the immune system. | 1984 | Br J Clin Pract Suppl | pmid:6091715 |
| Horrobin DF | Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjogren's syndrome. | 1984 | Med. Hypotheses | pmid:6088955 |
| Strong AM et al. | The effect of oral linoleic acid and gamma-linolenic acid (Efamol [G]). | 1985 Nov-Dec | Br J Clin Pract | pmid:4092010 |
| Belch JJ et al. | Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. | 1985 | Thromb. Haemost. | pmid:4082084 |
| Webb J and McCredie M | Primary Sjögren's syndrome treated with Efamol/efavit. A double-blind cross-over investigation. | 1985 | Rheumatol. Int. | pmid:4048763 |
| Soma M et al. | The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. | 1985 | Can. J. Physiol. Pharmacol. | pmid:4005704 |
| Kumar S et al. | Prediction of response to endocrine therapy in pronounced cyclical mastalgia using dynamic tests of prolactin release. | 1985 | Clin. Endocrinol. (Oxf) | pmid:3938354 |
| Bamford JT et al. | Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids). | 1985 | J. Am. Acad. Dermatol. | pmid:3908514 |
| Wright S | Atopic dermatitis and essential fatty acids: a biochemical basis for atopy? | 1985 | Acta Derm Venereol Suppl (Stockh) | pmid:3890448 |
| Puolakka J et al. | Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors. | 1985 | J Reprod Med | pmid:3839018 |
| Sugano M et al. | Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. | 1986 | Ann. Nutr. Metab. | pmid:3752928 |
| Levy RJ and Lian JB | gamma-Carboxyglutamate excretion and warfarin therapy. | 1979 | Clin. Pharmacol. Ther. | pmid:373941 |
| Das UN et al. | Beneficial effect of essential fatty acids in cirrhosis of the liver. | 1987 | J Assoc Physicians India | pmid:3693270 |
| Singh NK et al. | Essential fatty acids and cancer with particular reference to Hodgkin's disease. | 1987 | J Assoc Physicians India | pmid:3693269 |
| Ziboh VA and Chapkin RS | Biologic significance of polyunsaturated fatty acids in the skin. | 1987 | Arch Dermatol | pmid:3688908 |
| Guenther L and Wexler D | Efamol in the treatment of atopic dermatitis. | 1987 | J. Am. Acad. Dermatol. | pmid:3680673 |
| Papanikolaou N et al. | Effect of thromboxane A2-synthetase inhibitor OKY-046 and evening primrose oil (Efamol) on mercuric chloride induced autoimmune glomerulonephritis in Brown-Norway rats. | 1987 | Prog. Clin. Biol. Res. | pmid:3671393 |
| Takahashi R et al. | Effect of different ratios of dietary N-6 and N-3 fatty acids on fatty acid composition, prostaglandin formation and platelet aggregation in the rat. | 1987 | Thromb. Res. | pmid:3660347 |
| Chapkin RS et al. | Dietary influences of evening primrose and fish oil on the skin of essential fatty acid-deficient guinea pigs. | 1987 | J. Nutr. | pmid:3625311 |
| Bordoni A et al. | [Treatment of premenstrual syndrome with essential fatty acids (evening primrose oil)]. | 1987 | G Clin Med | pmid:3609594 |
| Glen I et al. | The role of essential fatty acids in alcohol dependence and tissue damage. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3551662 |
| Oxholm P et al. | Patients with primary Sjögren's syndrome treated for two months with evening primrose oil. | 1986 | Scand. J. Rheumatol. | pmid:3529370 |
| Ferrando J | [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions]. | 1986 | Med Cutan Ibero Lat Am | pmid:3528709 |
| Singer P et al. | Serum triglycerides and HDL cholesterol from SHR after evening primrose oil and other polyunsaturated fats. | 1986 | Prostaglandins Leukot Med | pmid:3523538 |
| Godfrey DG et al. | Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation. | 1986 | Ann. Rheum. Dis. | pmid:3492970 |
| Papanikolaou N | Alteration of mercuric chloride-induced autoimmune glomerulonephritis in brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor. | 1987 | Prostaglandins Leukot Med | pmid:3475724 |
| Morrison CS | Leg ulcers and Efamol. | 1986 | N. Z. Med. J. | pmid:3468432 |
| Simpson LO | Leg ulceration and Efamol. | 1986 | N. Z. Med. J. | pmid:3466083 |
| Morrison CS | Leg ulceration and Efamol. | 1986 | N. Z. Med. J. | pmid:3463912 |
| Novak E | Maintaining remission of Crohn's disease. | 1988 | CMAJ | pmid:3383034 |
| Greaves MW and Corbett MF | Treatment of atopic eczema with evening primrose oil. | 1988 | Br. J. Dermatol. | pmid:3355786 |
| Schalin-Karrila M et al. | Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. | 1987 | Br. J. Dermatol. | pmid:3307886 |
| Horrobin DF | Essential fatty acid and prostaglandin metabolism in Sjögren's syndrome, systemic sclerosis and rheumatoid arthritis. | 1986 | Scand. J. Rheumatol. Suppl. | pmid:3296151 |
| Manthorpe R and Prause JU | Treatment of Sjögren's syndrome: an overview. | 1986 | Scand. J. Rheumatol. Suppl. | pmid:3296150 |
| Darlington LG | Do diets rich in polyunsaturated fatty acids affect disease activity in rheumatoid arthritis? | 1988 | Ann. Rheum. Dis. | pmid:3281607 |
| Barcelli UO et al. | A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats. | 1988 | Lipids | pmid:3237005 |
| Wade AE et al. | Effect of 7,12-dimethylbenz(a)anthracene administration on hepatic drug metabolizing enzymes in female rats fed corn, primrose, and menhaden oils. | 1988 | Drug Nutr Interact | pmid:3149238 |
| Abou-el-Ela SH et al. | Eicosanoid synthesis in 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats fed primrose oil, menhaden oil or corn oil diet. | 1988 | Lipids | pmid:3143882 |
| el-Ela SH et al. | Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12-dimethylbenz(a)anthracene. | 1987 | Lipids | pmid:3131611 |
| Simpson LO | Pinch skin grafting or porcine dermis in venous ulcers. | 1987 | Br Med J (Clin Res Ed) | pmid:3109651 |
| van Doormaal JJ et al. | Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, alpha-tocopherol levels, and erythropoiesis in normal and type 1 (insulin-dependent) diabetic men. | 1988 | Diabetologia | pmid:3065111 |
| Bordoni A et al. | Evening primrose oil (Efamol) in the treatment of children with atopic eczema. | 1988 | Drugs Exp Clin Res | pmid:3048953 |
| Biagi PL et al. | A long-term study on the use of evening primrose oil (Efamol) in atopic children. | 1988 | Drugs Exp Clin Res | pmid:3048952 |
| Huang YS and Horrobin DF | Sex differences in n-3 and n-6 fatty acid metabolism in EFA-depleted rats. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3037555 |
| McIllmurray MB and Turkie W | Controlled trial of gamma linolenic acid in Duke's C colorectal cancer. | 1987 | Br Med J (Clin Res Ed) | pmid:3036291 |
| Nassar BA et al. | The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature. | 1987 | Prostaglandins Leukot Med | pmid:3033691 |
| Cunnane SC | Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032013 |
| Horrobin DF | Essential fatty acids, prostaglandins, and alcoholism: an overview. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032012 |
| Huang YS et al. | Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats. | 1987 | Digestion | pmid:3030865 |
| Bursztyn PG and King MH | Fat induced hypertension in rabbits: the effects of dietary linoleic and linolenic acid. | 1986 | J. Hypertens. | pmid:3029216 |
| Viikari J and Lehtonen A | Effect of primrose oil on serum lipids and blood pressure in hyperlipidemic subjects. | 1986 | Int J Clin Pharmacol Ther Toxicol | pmid:3028968 |
| Stymne S and Stobart AK | Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). | 1986 | Biochem. J. | pmid:3028375 |
| Dib A and Carreau JP | Effects of gamma-linolenic acid supplementation on lipogenesis regulation in pregnant zinc-deficient rat and fetus. | 1986 | Int. J. Biochem. | pmid:3026865 |
| Fujiwara F et al. | Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells. | 1986 | Prostaglandins Leukot Med | pmid:3020590 |
| Bégin ME and Das UN | A deficiency in dietary gamma-linolenic and/or eicosapentaenoic acids may determine individual susceptibility to AIDS. | 1986 | Med. Hypotheses | pmid:3014282 |
| Skogh M | Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids) | 1986 | J. Am. Acad. Dermatol. | pmid:3013957 |
| Wolkin A et al. | Essential fatty acid supplementation in tardive dyskinesia. | 1986 | Am J Psychiatry | pmid:3013033 |
| Robinson KM and Botha JH | Effects of gamma-linolenic acid, dihomo-gamma-linolenic acid and ethanol on cultured human mammary carcinoma cells. | 1985 | Prostaglandins Leukot Med | pmid:2999828 |
| Wainwright P et al. | gamma-Linolenic acid fails to prevent the effects of prenatal ethanol exposure on brain and behavioral development in B6D2F2 mice. | 1985 Jul-Aug | Alcohol. Clin. Exp. Res. | pmid:2996378 |
| Booyens J et al. | The use of drugs for the inhibition of prostaglandin or leukotriene synthesis from arachidonic acid is theoretically hazardous. | 1985 | Med. Hypotheses | pmid:2995775 |
| Mills DE et al. | Gamma linolenic acid attenuates cardiovascular responses to stress in borderline hypertensive rats. | 1985 | Lipids | pmid:2995750 |
| de Bravo MM et al. | Metabolism of gammalinolenic acid by human blood platelet microsomes. | 1985 | Biochem. Int. | pmid:2994669 |
| Das UN et al. | Prostaglandins and their precursors can modify genetic damage-induced by gamma-radiation and benzo(a)pyrene. | 1985 | Prostaglandins | pmid:2994175 |
| Segarnick DJ et al. | Prostanoid modulation (mediation?) of certain behavioral effects of ethanol. | 1985 | Pharmacol. Biochem. Behav. | pmid:2994122 |
| Botha JH et al. | The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis. | 1985 | Prostaglandins Leukot Med | pmid:2994114 |
| Segarnick DJ et al. | Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver. | 1985 | Prostaglandins Leukot Med | pmid:2986177 |
| O'Brien PM et al. | The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension? | 1985 | Br J Clin Pharmacol | pmid:2985102 |
| Pascaud M and Strouve-Vallet C | Desaturation of 14C linoleic acid by the rat fetus. | 1985 | Ann. Nutr. Metab. | pmid:2983600 |
| Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
| Meigel W et al. | [Additional oral therapy of atopic dermatitis with unsaturated fatty acids]. | 1987 | Z. Hautkr. | pmid:2894730 |
| Jamal GA et al. | Gamma-linolenic acid in diabetic neuropathy. | 1986 | Lancet | pmid:2871365 |
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| Bégin ME et al. | Selective killing of human cancer cells by polyunsaturated fatty acids. | 1985 | Prostaglandins Leukot Med | pmid:2864701 |
| pmid:28646265 | ||||
| Khattab HAH et al. | EFFICIENCY OF BORAGE SEEDS OIL AGAINST GAMMA IRRADIATION-INDUCED HEPATOTOXICITY IN MALE RATS: POSSIBLE ANTIOXIDANT ACTIVITY. | 2017 | Afr J Tradit Complement Altern Med | pmid:28638880 |
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| pmid:28637506 | ||||
| Pye JK et al. | Clinical experience of drug treatments for mastalgia. | 1985 | Lancet | pmid:2862523 |
| Huang YS et al. | Effect of dietary alpha- and gamma-linolenic acid on tissue fatty acids in guinea pigs. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:2857052 |
| pmid:28557429 | ||||
| pmid:28545346 | ||||
| Julu PO | Essential fatty acids prevent slowed nerve conduction in streptozotocin diabetic rats. | 1988 Oct-Dec | J Diabet Complications | pmid:2853165 |
| pmid:28528342 | ||||
| pmid:28526097 | ||||
| Williams JH | The use of gamma linolenic acid, linoleic acid and natural vitamin E for the treatment of multicentric lymphoma in two dogs. | 1988 | J S Afr Vet Assoc | pmid:2848946 |
| Tate GA et al. | Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. | 1988 | Arthritis Rheum. | pmid:2848532 |
| Cronholm T et al. | Influence of dietary fats on pancreatic phospholipids of chronically ethanol-treated rats. | 1988 | Lipids | pmid:2846981 |
| Miller CC and Ziboh VA | Gammalinolenic acid-enriched diet alters cutaneous eicosanoids. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2841938 |
| Daneshmand R et al. | Associations of estimated Δ-5-desaturase and Δ-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2017 | Br. J. Nutr. | pmid:28382895 |
| Van der Merwe CF et al. | Oral gamma-linolenic acid in 21 patients with untreatable malignancy. An ongoing pilot open clinical trial. | 1987 | Br J Clin Pract | pmid:2837264 |
| Chaud M et al. | Gamma-linolenic acid improves the constancy of contractions in uteri from sprayed rats and is metabolized to prostaglandin E1 but not to bisenoic prostanoids. | 1988 | Prostaglandins | pmid:2836889 |
| Veselinovic M et al. | Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. | 2017 | Nutrients | pmid:28346333 |
| pmid:28336102 | ||||
| Belch JJ et al. | Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. | 1988 | Ann. Rheum. Dis. | pmid:2833184 |
| Fujiwara F et al. | Fatty acid modification of cultured neuroblastoma cells by gamma linolenic acid relevant to its antitumor effect. | 1987 | Prostaglandins Leukot Med | pmid:2829239 |