Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ziboh VA and Fletcher MP | Dose-response effects of dietary gamma-linolenic acid-enriched oils on human polymorphonuclear-neutrophil biosynthesis of leukotriene B4. | 1992 | Am. J. Clin. Nutr. | pmid:1309474 |
Mimouni V et al. | Evidence for insulin dependent hepatic microsomal gamma-linolenic acid chain elongation in spontaneously diabetic Wistar BB rats. | 1992 | Biochim. Biophys. Acta | pmid:1310052 |
St Louis C et al. | Antihypertensive effect of gamma-linolenic acid in spontaneously hypertensive rats. | 1992 | Hypertension | pmid:1310479 |
Lockett MJ and Tomlinson DR | The effects of dietary treatment with essential fatty acids on sciatic nerve conduction and activity of the Na+/K+ pump in streptozotocin-diabetic rats. | 1992 | Br. J. Pharmacol. | pmid:1313726 |
Van Biervliet JP et al. | Serum cholesterol, cholesteryl ester, and high-density lipoprotein development in newborn infants: response to formulas supplemented with cholesterol and gamma-linolenic acid. | 1992 | J. Pediatr. | pmid:1313864 |
Navarette R et al. | Dietary intake of concentrated gamma-linolenic acid (GLA)-enriched oil suppresses cutaneous level of dihomo-gamma-linolenic acid (DGLA): possible in vivo inhibition of microsomal elongation of GLA to DGLA. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1323857 |
Gateley CA et al. | Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. | 1992 | J R Soc Med | pmid:1548647 |
Gateley CA et al. | Plasma fatty acid profiles in benign breast disorders. | 1992 | Br J Surg | pmid:1596720 |
Nassar BA et al. | The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed N-6 and N-3 fatty acid-supplemented diets. | 1992 | Proc. Soc. Exp. Biol. Med. | pmid:1539039 |
Jenkins AP et al. | Effects of bolus doses of fat on small intestinal structure and on release of gastrin, cholecystokinin, peptide tyrosine-tyrosine, and enteroglucagon. | 1992 | Gut | pmid:1541417 |
Jenkins AP and Thompson RP | Effect of dietary fat on the distribution of mucosal mass and cell proliferation along the small intestine. | 1992 | Gut | pmid:1541418 |
Ergan F et al. | Lipase specificity against some fatty acids? | 1992 | Ann. N. Y. Acad. Sci. | pmid:1335712 |
Oon BB et al. | A diet enriched in essential fatty acids protects against the loss of lymphocytes which occurs in rats suffering from streptozotocin-induced diabetes. | 1992 | Exp. Physiol. | pmid:1543584 |
Furuse M et al. | Effect of gamma-linolenic acid on lipid metabolism in laying hens. | 1992 | Comp Biochem Physiol A Comp Physiol | pmid:1347726 |
Ormerod LD et al. | Eicosanoid modulation and epithelial wound healing kinetics of the alkali-burned cornea. | 1992 | J Ocul Pharmacol | pmid:1328428 |
Barre DE and Holub BJ | The effect of borage oil consumption on the composition of individual phospholipids in human platelets. | 1992 | Lipids | pmid:1328794 |
Gunstone FD | Gamma linolenic acid--occurrence and physical and chemical properties. | 1992 | Prog. Lipid Res. | pmid:1334265 |
Horrobin DF | Nutritional and medical importance of gamma-linolenic acid. | 1992 | Prog. Lipid Res. | pmid:1334266 |
Engler MM et al. | Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. | 1992 | J. Hypertens. | pmid:1335001 |
McFayden IJ et al. | Cyclical breast pain--some observations and the difficulties in treatment. | 1992 | Br J Clin Pract | pmid:1286012 |
Hayashi Y et al. | Anticancer effects of free polyunsaturated fatty acids in an oily lymphographic agent following intrahepatic arterial administration to a rabbit bearing VX-2 tumor. | 1992 | Cancer Res. | pmid:1309442 |
Dobbin SN | Evening primrose oil and epilepsy. | 1992 Dec 19-26 | Vet. Rec. | pmid:1287960 |
Takeda S et al. | Lipid peroxidation in human breast cancer cells in response to gamma-linolenic acid and iron. | 1992 Mar-Apr | Anticancer Res. | pmid:1316091 |
Söreide E et al. | Long-term use of gamma-linolenic acid-enriched fat emulsion (PFE 4501): case report. | 1992 May-Jun | Nutrition | pmid:1326350 |
Cantrill RC et al. | The effect of n-6 fatty acids on normal and v-Ki ras transformed NIH-3T3 cells. | 1992 Nov-Dec | Anticancer Res. | pmid:1338278 |
Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
Araya J and Cagalj A | [Exclusion of alpha-linolenic acid from diets for rats during several generations. I. Effect on reproduction and postnatal growth]. | 1993 | Arch Latinoam Nutr | pmid:7826185 |
Tollesson A and Frithz A | Transepidermal water loss and water content in the stratum corneum in infantile seborrhoeic dermatitis. | 1993 | Acta Derm. Venereol. | pmid:8095744 |
Berth-Jones J and Graham-Brown RA | Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8099640 |
Shield MJ et al. | Essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8101623 |
Dines KC et al. | Contrasting effects of treatment with omega-3 and omega-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. | 1993 | Diabetologia | pmid:8270127 |
Szczesna M | [Therapeutic assessment of the evening primrose]. | 1993 | Rocz Panstw Zakl Hig | pmid:8016534 |
Laivuori H et al. | Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248275 |
Stevens EJ et al. | Prostacyclin release in experimental diabetes: effects of evening primrose oil. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248277 |
Leyton E | Disagreeing on how to treat CFS patients. | 1993 | Can Fam Physician | pmid:8347205 |
Leventhal LJ et al. | Treatment of rheumatoid arthritis with gammalinolenic acid. | 1993 | Ann. Intern. Med. | pmid:8214997 |
Karlstad MD et al. | Effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma n-6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats. | 1993 | Crit. Care Med. | pmid:8222692 |
Harvey RG | Effect of varying proportions of evening primrose oil and fish oil on cats with crusting dermatosis ('miliary dermatitis') | 1993 | Vet. Rec. | pmid:8280288 |
Engler MM | Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8259378 |
Harvey RG | A comparison of evening primrose oil and sunflower oil for the management of papulocrustous dermatitis in cats. | 1993 | Vet. Rec. | pmid:8303807 |
Stevens EJ et al. | Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. | 1993 | Diabetologia | pmid:8314443 |
Joe LA and Hart LL | Evening primrose oil in rheumatoid arthritis. | 1993 | Ann Pharmacother | pmid:8305783 |
Keen H et al. | Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. | 1993 | Diabetes Care | pmid:8380765 |
Horrobin DF | The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8380930 |
Hopewell JW et al. | The modulation of radiation-induced damage to pig skin by essential fatty acids. | 1993 | Br. J. Cancer | pmid:8391301 |
Cerin A et al. | Hormonal and biochemical profiles of premenstrual syndrome. Treatment with essential fatty acids. | 1993 | Acta Obstet Gynecol Scand | pmid:8392261 |
Galle AM et al. | Biosynthesis of gamma-linolenic acid in developing seeds of borage (Borago officinalis L.). | 1993 | Biochim. Biophys. Acta | pmid:8394742 |
Kinchington D et al. | Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. | 1993 | FEBS Lett. | pmid:8396048 |
Tollesson A and Frithz A | Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. | 1993 | Br. J. Dermatol. | pmid:8396411 |
Cameron NE et al. | The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. | 1993 | Br. J. Pharmacol. | pmid:8401950 |
Phinney SD et al. | Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration. | 1993 | Metab. Clin. Exp. | pmid:8412765 |
Collins A et al. | Essential fatty acids in the treatment of premenstrual syndrome. | 1993 | Obstet Gynecol | pmid:8416468 |
Plumb JA et al. | Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin. | 1993 | Br. J. Cancer | pmid:8385976 |
Miura Y et al. | Production of gamma-linolenic acid from the marine green alga Chlorella sp. NKG 042401. | 1993 | FEMS Microbiol. Lett. | pmid:8386122 |
Karmali RA et al. | Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8388566 |
Bala KV et al. | Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linolenic acid. | 1993 | Food Chem. Toxicol. | pmid:8390392 |
Oliwiecki S et al. | The effect of essential fatty acids on epidermal atrophy due to topical steroids. | 1993 | Clin. Exp. Dermatol. | pmid:8403467 |
Melnik B and Plewig G | [External treatment of atopic eczema with gamma-linolenic acid?]. | 1993 | Hautarzt | pmid:8407331 |
Beno DW et al. | Gamma-linolenic acid suppression of hepatic Ito cell mitogenesis: post-PDGF receptor prostaglandin-independent mechanism. | 1993 | Am. J. Physiol. | pmid:7694498 |
Cantrill RC et al. | Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture. | 1993 | Cancer Lett. | pmid:8402582 |
Thurmond DC et al. | Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. | 1993 | Obes. Res. | pmid:16353349 |
Poisson JP et al. | Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. | 1993 | Biochem. Med. Metab. Biol. | pmid:8382502 |
Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |
Takeda S et al. | Mechanism of lipid peroxidation in cancer cells in response to gamma-linolenic acid (GLA) analyzed by GC-MS(I): Conjugated dienes with peroxyl (or hydroperoxyl) groups and cell-killing effects. | 1993 Jan-Feb | Anticancer Res. | pmid:8386494 |
González CA et al. | Borage consumption as a possible gastric cancer protective factor. | 1993 Mar-Apr | Cancer Epidemiol. Biomarkers Prev. | pmid:8385521 |
Falconer JS et al. | Polyunsaturated fatty acids in the treatment of weight-losing patients with pancreatic cancer. | 1994 | World Rev Nutr Diet | pmid:7856240 |
BeLieu RM | Mastodynia. | 1994 | Obstet. Gynecol. Clin. North Am. | pmid:7816407 |
Berth-Jones J and Graham-Brown RA | Evening primrose oil. Does not show promise in atopic dermatitis. | 1994 | BMJ | pmid:7819863 |
Rubin M et al. | Effect of three intravenously administered fat emulsions containing different concentrations of fatty acids on the plasma fatty acid composition of premature infants. | 1994 | J. Pediatr. | pmid:7931881 |
Miller MA and Morgan RJ | Eicosanoids, erections and erectile dysfunction. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938091 |
Tulloch I et al. | Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. | 1994 | Urol. Res. | pmid:7871634 |
Purasiri P et al. | Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. | 1994 | Clin. Sci. | pmid:7874864 |
Stillwell W et al. | Cholesterol condensation of alpha-linolenic and gamma-linolenic acid-containing phosphatidylcholine monolayers and bilayers. | 1994 | Biochim. Biophys. Acta | pmid:7918592 |
Veale DJ et al. | A double-blind placebo controlled trial of Efamol Marine on skin and joint symptoms of psoriatic arthritis. | 1994 | Br. J. Rheumatol. | pmid:7921757 |
Darlington LG and Ramsey NW | Review of dietary therapy for rheumatoid arthritis. | 1994 | Compr Ther | pmid:7805365 |
Guivernau M et al. | Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846101 |
Hopewell JW et al. | Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. | 1994 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:7961020 |
McCaul JA and Lamey PJ | Multiple oral mucoceles treated with gamma-linolenic acid: report of a case. | 1994 | Br J Oral Maxillofac Surg | pmid:7849001 |
Christophe A et al. | Effect of administration of gamma-linolenic acid on the fatty acid composition of serum phospholipids and cholesteryl esters in patients with cystic fibrosis. | 1994 | Ann. Nutr. Metab. | pmid:8185286 |
du Toit PJ et al. | Pyelonephritis: renal urokinase activity in rats on essential fatty acid diets. | 1994 | Urol. Res. | pmid:7992455 |
de Kock M et al. | Differential cytotoxic effects of gamma-linolenic acid on MG-63 and HeLa cells. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972263 |
du Toit PJ et al. | The effect of gamma-linolenic acid and eicosapentaenoic acid on urokinase activity. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972265 |
Milner LS et al. | Synergistic effects of fish oil diet and dimethylthiourea in acute adriamycin nephrosis. | 1994 | Am. J. Med. Sci. | pmid:7977444 |
Bond R and Lloyd DH | Combined treatment with concentrated essential fatty acids and prednisolone in the management of canine atopy. | 1994 | Vet. Rec. | pmid:8135003 |
Phinney S | Potential risk of prolonged gamma-linolenic acid use. | 1994 | Ann. Intern. Med. | pmid:8135457 |
Chenoy R et al. | Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. | 1994 | BMJ | pmid:8136666 |
Leventhal LJ et al. | Treatment of rheumatoid arthritis with blackcurrant seed oil. | 1994 | Br. J. Rheumatol. | pmid:8081671 |
Takada R et al. | Dietary gamma-linolenic acid-enriched oil reduces body fat content and induces liver enzyme activities relating to fatty acid beta-oxidation in rats. | 1994 | J. Nutr. | pmid:8145067 |
Morphake P et al. | Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146206 |
Devi MA and Das NP | Antiproliferative effect of polyunsaturated fatty acids and interleukin-2 on normal and abnormal human lymphocytes. | 1994 | Experientia | pmid:8194587 |
Jamal GA | The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. | 1994 | Diabet. Med. | pmid:8200197 |
Ramanathan R et al. | Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. | 1994 | Free Radic. Biol. Med. | pmid:8299995 |
Maaswinkel-Mooij PD et al. | Unsuccessful dietary treatment of Sjögren-Larsson syndrome. | 1994 | J. Pediatr. | pmid:8176565 |
Wetzig NR | Mastalgia: a 3 year Australian study. | 1994 | Aust N Z J Surg | pmid:8179529 |
Tate GA and Zurier RB | Suppression of monosodium urate crystal-induced inflammation by black currant seed oil. | 1994 | Agents Actions | pmid:7741038 |
Goldfien A | Premenstrual syndrome. | 1994 | Curr Ther Endocrinol Metab | pmid:7704719 |
Biagi PL et al. | The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. | 1994 | Drugs Exp Clin Res | pmid:7924900 |
Cameron NE and Cotter MA | Effects of evening primrose oil treatment on sciatic nerve blood flow and endoneurial oxygen tension in streptozotocin-diabetic rats. | 1994 | Acta Diabetol | pmid:7888693 |
Oliwiecki S and Burton JL | Evening primrose oil and marine oil in the treatment of psoriasis. | 1994 | Clin. Exp. Dermatol. | pmid:8050140 |
Kleijnen J | Evening primrose oil. | 1994 | BMJ | pmid:7950599 |