Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ziboh VA and Fletcher MP | Dose-response effects of dietary gamma-linolenic acid-enriched oils on human polymorphonuclear-neutrophil biosynthesis of leukotriene B4. | 1992 | Am. J. Clin. Nutr. | pmid:1309474 |
Mimouni V et al. | Evidence for insulin dependent hepatic microsomal gamma-linolenic acid chain elongation in spontaneously diabetic Wistar BB rats. | 1992 | Biochim. Biophys. Acta | pmid:1310052 |
St Louis C et al. | Antihypertensive effect of gamma-linolenic acid in spontaneously hypertensive rats. | 1992 | Hypertension | pmid:1310479 |
Lockett MJ and Tomlinson DR | The effects of dietary treatment with essential fatty acids on sciatic nerve conduction and activity of the Na+/K+ pump in streptozotocin-diabetic rats. | 1992 | Br. J. Pharmacol. | pmid:1313726 |
Van Biervliet JP et al. | Serum cholesterol, cholesteryl ester, and high-density lipoprotein development in newborn infants: response to formulas supplemented with cholesterol and gamma-linolenic acid. | 1992 | J. Pediatr. | pmid:1313864 |
de Kock M et al. | Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells. | 1992 | S. Afr. Med. J. | pmid:1315459 |
Bégin ME and Ells G | Levels of thiobarbituric acid reactive substances and the cytocidal potential of gammalinolenic and docosahexaenoic acids on ZR-75-1 and CV-1 cells. | 1992 | Lipids | pmid:1315901 |
Duffy O et al. | Effects of an oil enriched in gamma linolenic acid on locomotor activity and behaviour in the Morris Maze, following in utero ethanol exposure in rats. | 1992 | Drug Alcohol Depend | pmid:1317288 |
Kerscher MJ and Korting HC | Treatment of atopic eczema with evening primrose oil: rationale and clinical results. | 1992 | Clin Investig | pmid:1318129 |
Gibson RA et al. | Gamma linolenic acid (GLA) content of encapsulated evening primrose oil products. | 1992 | Lipids | pmid:1318991 |
Vaddadi KS | Use of gamma-linolenic acid in the treatment of schizophrenia and tardive dyskinesia. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1321448 |
Horrobin DF | The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1321449 |
Navarette R et al. | Dietary intake of concentrated gamma-linolenic acid (GLA)-enriched oil suppresses cutaneous level of dihomo-gamma-linolenic acid (DGLA): possible in vivo inhibition of microsomal elongation of GLA to DGLA. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1323857 |
Scott DW et al. | Comparison of the clinical efficacy of two commercial fatty acid supplements (EfaVet and DVM Derm Caps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. | 1992 | Cornell Vet | pmid:1643883 |
Gateley CA et al. | Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. | 1992 | J R Soc Med | pmid:1548647 |
Hamberg M | Metabolism of 6,9,12-octadecatrienoic acid in the red alga Lithothamnion corallioides: mechanism of formation of a conjugated tetraene fatty acid. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1332713 |
Gunstone FD | Gamma linolenic acid--occurrence and physical and chemical properties. | 1992 | Prog. Lipid Res. | pmid:1334265 |
Horrobin DF | Nutritional and medical importance of gamma-linolenic acid. | 1992 | Prog. Lipid Res. | pmid:1334266 |
Engler MM et al. | Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. | 1992 | J. Hypertens. | pmid:1335001 |
McFayden IJ et al. | Cyclical breast pain--some observations and the difficulties in treatment. | 1992 | Br J Clin Pract | pmid:1286012 |
Hayashi Y et al. | Anticancer effects of free polyunsaturated fatty acids in an oily lymphographic agent following intrahepatic arterial administration to a rabbit bearing VX-2 tumor. | 1992 | Cancer Res. | pmid:1309442 |
Dobbin SN | Evening primrose oil and epilepsy. | 1992 Dec 19-26 | Vet. Rec. | pmid:1287960 |
Takeda S et al. | Lipid peroxidation in human breast cancer cells in response to gamma-linolenic acid and iron. | 1992 Mar-Apr | Anticancer Res. | pmid:1316091 |
Söreide E et al. | Long-term use of gamma-linolenic acid-enriched fat emulsion (PFE 4501): case report. | 1992 May-Jun | Nutrition | pmid:1326350 |
Cantrill RC et al. | The effect of n-6 fatty acids on normal and v-Ki ras transformed NIH-3T3 cells. | 1992 Nov-Dec | Anticancer Res. | pmid:1338278 |
Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
Araya J and Cagalj A | [Exclusion of alpha-linolenic acid from diets for rats during several generations. I. Effect on reproduction and postnatal growth]. | 1993 | Arch Latinoam Nutr | pmid:7826185 |
Tollesson A and Frithz A | Transepidermal water loss and water content in the stratum corneum in infantile seborrhoeic dermatitis. | 1993 | Acta Derm. Venereol. | pmid:8095744 |
Berth-Jones J and Graham-Brown RA | Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8099640 |
Shield MJ et al. | Essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8101623 |
Dines KC et al. | Contrasting effects of treatment with omega-3 and omega-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. | 1993 | Diabetologia | pmid:8270127 |
Szczesna M | [Therapeutic assessment of the evening primrose]. | 1993 | Rocz Panstw Zakl Hig | pmid:8016534 |
Laivuori H et al. | Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248275 |
Stevens EJ et al. | Prostacyclin release in experimental diabetes: effects of evening primrose oil. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248277 |
Leyton E | Disagreeing on how to treat CFS patients. | 1993 | Can Fam Physician | pmid:8347205 |
Engler MM | Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8259378 |
Harvey RG | A comparison of evening primrose oil and sunflower oil for the management of papulocrustous dermatitis in cats. | 1993 | Vet. Rec. | pmid:8303807 |
Stevens EJ et al. | Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. | 1993 | Diabetologia | pmid:8314443 |
Joe LA and Hart LL | Evening primrose oil in rheumatoid arthritis. | 1993 | Ann Pharmacother | pmid:8305783 |
Keen H et al. | Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. | 1993 | Diabetes Care | pmid:8380765 |
Horrobin DF | The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8380930 |
Hopewell JW et al. | The modulation of radiation-induced damage to pig skin by essential fatty acids. | 1993 | Br. J. Cancer | pmid:8391301 |
Cerin A et al. | Hormonal and biochemical profiles of premenstrual syndrome. Treatment with essential fatty acids. | 1993 | Acta Obstet Gynecol Scand | pmid:8392261 |
Galle AM et al. | Biosynthesis of gamma-linolenic acid in developing seeds of borage (Borago officinalis L.). | 1993 | Biochim. Biophys. Acta | pmid:8394742 |
Kinchington D et al. | Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. | 1993 | FEBS Lett. | pmid:8396048 |
Tollesson A and Frithz A | Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. | 1993 | Br. J. Dermatol. | pmid:8396411 |
Cameron NE et al. | The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. | 1993 | Br. J. Pharmacol. | pmid:8401950 |
Phinney SD et al. | Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration. | 1993 | Metab. Clin. Exp. | pmid:8412765 |
Poisson JP et al. | Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. | 1993 | Biochem. Med. Metab. Biol. | pmid:8382502 |
Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |