Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Oguogho A et al. | Prostaglandin synthesis in human lymphatics from precursor fatty acids. | 2000 | Lymphology | pmid:10897472 |
Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
Ferrando J | [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions]. | 1986 | Med Cutan Ibero Lat Am | pmid:3528709 |
Ring J and Kleinheinz A | [Evening primrose oil in neurodermatitis?]. | 1991 | Med Monatsschr Pharm | pmid:1943974 |
Schöpf E et al. | [Gamma-linolenic acid in atopic patients?]. | 1996 | Med Monatsschr Pharm | pmid:8684312 |
Menendez JA et al. | Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. | 2005 | Med. Hypotheses | pmid:15607568 |
Schrek R | An animal model for intractable chronic lymphocytic leukemia. | 1990 | Med. Hypotheses | pmid:1963468 |
Horrobin DF | A biochemical basis for alcoholism and alcohol-induced damage including the fetal alcohol syndrome and cirrhosis: interference with essential fatty acid and prostaglandin metabolism. | 1980 | Med. Hypotheses | pmid:6253773 |
Horrobin DF | Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjogren's syndrome. | 1984 | Med. Hypotheses | pmid:6088955 |
Puri BK | The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparations. | 2004 | Med. Hypotheses | pmid:14729014 |
McCarty MF | Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. | 1996 | Med. Hypotheses | pmid:8692033 |
Booyens J et al. | The use of drugs for the inhibition of prostaglandin or leukotriene synthesis from arachidonic acid is theoretically hazardous. | 1985 | Med. Hypotheses | pmid:2995775 |
Bégin ME and Das UN | A deficiency in dietary gamma-linolenic and/or eicosapentaenoic acids may determine individual susceptibility to AIDS. | 1986 | Med. Hypotheses | pmid:3014282 |
Nwankwo JO | Repression of cellular anaplerosis as the hypothesized mechanism of gamma-linolenic acid-induced toxicity to tumor cells. | 2001 | Med. Hypotheses | pmid:11388772 |
Booyens J and Katzeff IE | Cancer: a simple metabolic disease? | 1983 | Med. Hypotheses | pmid:6321917 |
McCarty MF and Rubin EJ | Rationales for micronutrient supplementation in diabetes. | 1984 | Med. Hypotheses | pmid:6325854 |
Khoo SK et al. | Evening primrose oil and treatment of premenstrual syndrome. | 1990 | Med. J. Aust. | pmid:2201888 |
Horrobin DF | Evening primrose oil and premenstrual syndrome. | 1990 | Med. J. Aust. | pmid:2233440 |
Barar J et al. | Barrier functionality and transport machineries of human ECV304 cells. | 2010 | Med. Sci. Monit. | pmid:20037486 |
Das UN | Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. | 2007 | Med. Sci. Monit. | pmid:17599036 |
de Bravo MG et al. | [Effect of dietary supplementation with gamma-linolenic acid on the growth of a human lung carcinoma implanted in nude mice]. | 1995 | Medicina (B Aires) | pmid:8731577 |
Verhoeven MO et al. | Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. | 2005 Jul-Aug | Menopause | pmid:16037756 |
Phinney SD et al. | Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration. | 1993 | Metab. Clin. Exp. | pmid:8412765 |
de La Puerta Vázquez R et al. | Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. | 2004 | Metab. Clin. Exp. | pmid:14681843 |
Ford I et al. | The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. | 2001 | Metab. Clin. Exp. | pmid:11474472 |
Gallagher S | Omega 3 oils and pregnancy. | 2004 | Midwifery Today Int Midwife | pmid:15124319 |
Mysiakina IS and Funtikova NS | [Activity of NAD-dependent isocitrate dehydrogenase, isocitrate lyase, and malate dehydrogenase in Mucor circinelloides var. lusitanicus INMI under different modes of nitrogen supply]. | 2008 Jul-Aug | Mikrobiologiia | pmid:18825970 |
Mysiakina IS and Funtikova NS | [Metabolic characteristics and lipid composition of yeastlike cells and mycelium of Mucor circinelloides var. lusitanicus INMI grown at a high glucose content in the medium]. | 2008 Jul-Aug | Mikrobiologiia | pmid:18825971 |
Siliprandi N | [Significance of evening primrose oil in the problem of the nutritional value of poly-unsaturated fatty acids]. | 1989 Jan-Mar | Minerva Dietol Gastroenterol | pmid:2657494 |
Lu H et al. | Identification and characterization of a novel delta6-fatty acid desaturase gene from Rhizopus nigricans. | 2009 | Mol. Biol. Rep. | pmid:19152021 |
Cook D et al. | Modification of fatty acid composition in tomato (Lycopersicon esculentum) by expression of a borage delta6-desaturase. | 2002 | Mol. Biotechnol. | pmid:12059112 |
Stahl A et al. | Identification of the major intestinal fatty acid transport protein. | 1999 | Mol. Cell | pmid:10518211 |
Colquhoun A and Schumacher RI | Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid. | 2001 | Mol. Cell. Biochem. | pmid:11330827 |
Melnik BC | [A chance for the prevention of atopic diseases]. | 1990 | Monatsschr Kinderheilkd | pmid:2162007 |
Huang YS et al. | The effects of dietary protein and cholesterol on tissue cholesterol contents and N-6 fatty acid compositions in rats and mice fed a gamma-linolenate-rich diet. | 1990 | Monogr Atheroscler | pmid:2178226 |
Patel J and Tomlinson DR | Nerve conduction impairment in experimental diabetes-proximodistal gradient of severity. | 1999 | Muscle Nerve | pmid:10487907 |
Chuang LT et al. | Co-expression of heterologous desaturase genes in Yarrowia lipolytica. | 2010 | N Biotechnol | pmid:20188875 |
Simpson LO | Melanoma and fatty acids. | 1990 | N. Z. Med. J. | pmid:2173823 |
Simpson LO | Melanoma and fatty acids. | 1991 | N. Z. Med. J. | pmid:1996191 |
Holborow P | Melanoma and polyunsaturated fat. | 1991 | N. Z. Med. J. | pmid:2006066 |
Holborow P | Melanoma and fatty acids. | 1991 | N. Z. Med. J. | pmid:2008253 |
Morrison CS | Leg ulceration and Efamol. | 1986 | N. Z. Med. J. | pmid:3463912 |
Simpson LO | Leg ulceration and Efamol. | 1986 | N. Z. Med. J. | pmid:3466083 |
Morrison CS | Leg ulcers and Efamol. | 1986 | N. Z. Med. J. | pmid:3468432 |
Phillips JS | Oil of the evening primrose. | 1984 | N. Z. Med. J. | pmid:6589527 |
Biernat J and Grajeta H | Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 1. Blood serum and liver lipids. | 1997 | Nahrung | pmid:9113670 |
Grajeta H and Biernat J | Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 2. Blood serum and liver fatty acids. | 1997 | Nahrung | pmid:9113671 |
Reddy AS and Thomas TL | Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid production in transgenic plants. | 1996 | Nat. Biotechnol. | pmid:9630958 |
Hirasawa A et al. | Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | 2005 | Nat. Med. | pmid:15619630 |
Guil-Guerrero JL et al. | Gamma-linolenic acid from Cape Verdian Boraginaceae. | 2006 | Nat. Prod. Res. | pmid:16286301 |
de Vries JE | [Painful breasts]. | 1998 | Ned Tijdschr Geneeskd | pmid:9749309 |
Iijima S et al. | Oral supplementation with gamma-linolenic acid extracted from Mucor circinelloides improves the deformability of red blood cells in hemodialysis patients. | 2000 | Nephron | pmid:11014980 |
Tamimi NA et al. | Role of gamma-linolenic acid in uraemic pruritus. | 1999 | Nephron | pmid:10516500 |
Yoshimoto-Furuie K et al. | Effects of oral supplementation with evening primrose oil for six weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients. | 1999 | Nephron | pmid:9933750 |
Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
McGahon B et al. | The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. | 1997 | Neuroscience | pmid:9300396 |
Hirawa N and Umemura S | [Prostaglandin/bradykinin]. | 2004 | Nippon Rinsho | pmid:15250292 |
Yogo Y and Fujishima S | [Nutritional support for ARDS]. | 2001 | Nippon Rinsho | pmid:11439576 |
Uesaka Y | [Prevention and treatment of diabetic neuropathy]. | 2002 | Nippon Rinsho | pmid:12430238 |
Say B | A panacea for all ills? | 1991 Apr 10-16 | Nurs Times | pmid:2020583 |
Banni S et al. | Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | 2001 | Nutr Cancer | pmid:12094634 |
Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
Hamilton LA and Trobaugh KA | Acute respiratory distress syndrome: use of specialized nutrients in pediatric patients and infants. | 2011 | Nutr Clin Pract | pmid:21266694 |
Vaquerizo Alonso C et al. | Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus SEMICYUC-SENPE: hyperglycemia and diabetes mellitus. | 2011 | Nutr Hosp | pmid:22411519 |
Garaiova I et al. | A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. | 2007 | Nutr J | pmid:17254329 |
Veselinovic M et al. | Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. | 2017 | Nutrients | pmid:28346333 |
Li C et al. | Enteral Immunomodulatory Diet (Omega-3 Fatty Acid, γ-Linolenic Acid and Antioxidant Supplementation) for Acute Lung Injury and Acute Respiratory Distress Syndrome: An Updated Systematic Review and Meta-Analysis. | 2015 | Nutrients | pmid:26184293 |
Nakanishi T et al. | Gamma-linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice. | 2004 | Nutrition | pmid:15043857 |
Wigmore SJ et al. | The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. | 1996 | Nutrition | pmid:8850216 |
Saha SS and Ghosh M | Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. | 2013 | Nutrition | pmid:23422533 |
Muñoz SE et al. | Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. | 1999 | Nutrition | pmid:10198915 |
Meyer BJ and Kolanu N | Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health. | 2011 Nov-Dec | Nutrition | pmid:21658909 |
Foster RH et al. | Borage oil in the treatment of atopic dermatitis. | 2010 Jul-Aug | Nutrition | pmid:20579590 |
Das UN | Polyunsaturated fatty acids and atopic dermatitis. | 2010 Jul-Aug | Nutrition | pmid:20579591 |
Das UN | Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. | 2002 Jul-Aug | Nutrition | pmid:12093450 |
Söreide E et al. | Long-term use of gamma-linolenic acid-enriched fat emulsion (PFE 4501): case report. | 1992 May-Jun | Nutrition | pmid:1326350 |
Usami M et al. | Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation. | 2003 | Nutrition | pmid:12591548 |
Das UN | Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. | 2002 | Nutrition | pmid:12297217 |
Thurmond DC et al. | Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. | 1993 | Obes. Res. | pmid:16353349 |
Collins A et al. | Essential fatty acids in the treatment of premenstrual syndrome. | 1993 | Obstet Gynecol | pmid:8416468 |
BeLieu RM | Mastodynia. | 1994 | Obstet. Gynecol. Clin. North Am. | pmid:7816407 |
Menendez JA et al. | Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. | 2004 | Oncol. Rep. | pmid:15138562 |
Schnebelen C et al. | Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation. | 2009 | Ophthalmic Res. | pmid:19451735 |
Riaz A et al. | Assessment of anticoagulant effect of evening primrose oil. | 2009 | Pak J Pharm Sci | pmid:19783511 |
Beaudoin AR et al. | Type of dietary lipids exerts a major influence on the secretory activity of the exocrine pancreas: medium-term studies. | 1989 | Pancreas | pmid:2762271 |
Kairemo KJ et al. | The effect of lithium gamma-linolenate therapy of pancreatic cancer on perfusion in liver and pancreatic tissues. | 1998 | Pancreas | pmid:9436871 |
Whitehouse PA et al. | Synergistic activity of gamma-linolenic acid and cytotoxic drugs against pancreatic adenocarcinoma cell lines. | 2003 | Pancreatology | pmid:14526145 |
Williams WV et al. | Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes. | 1996 | Pathobiology | pmid:8856792 |
Bodak A et al. | [Comparative study of light and electron microscopic aspects of myocardial lesions induced in the rat by oils with several amounts of gamma-linolenic acid (author's transl)]. | 1982 | Pathol. Biol. | pmid:6278382 |
Kitz R et al. | Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. | 2006 | Pediatr Allergy Immunol | pmid:16618360 |
Lopes C et al. | Functional textiles for atopic dermatitis: a systematic review and meta-analysis. | 2013 | Pediatr Allergy Immunol | pmid:23980847 |
Leichsenring M et al. | (n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. | 1995 | Pediatr Allergy Immunol | pmid:8822394 |
Plowman PN | Re: Packer RJ. Effects of radiotherapy on the brain. Med Pediatr Oncol 2003;41:448-449. | 2004 | Pediatr Blood Cancer | pmid:15049029 |
Jacobs BR et al. | Nutritional immunomodulation in critically ill children with acute lung injury: feasibility and impact on circulating biomarkers. | 2013 | Pediatr Crit Care Med | pmid:23295853 |
Rasmussen JE | Advances in nondietary management of children with atopic dermatitis. | 1989 | Pediatr Dermatol | pmid:2552424 |
Tollesson A et al. | Malassezia furfur in infantile seborrheic dermatitis. | 1997 Nov-Dec | Pediatr Dermatol | pmid:9436835 |
Ernst E | Ayurvedic medicines. | 2002 | Pharmacoepidemiol Drug Saf | pmid:12426929 |
Wainwright PE et al. | Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior. | 1996 | Pharmacol. Biochem. Behav. | pmid:8801587 |
Segarnick DJ et al. | Prostanoid modulation (mediation?) of certain behavioral effects of ethanol. | 1985 | Pharmacol. Biochem. Behav. | pmid:2994122 |
Cho HS et al. | Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation. | 2007 | Photodermatol Photoimmunol Photomed | pmid:17803593 |