Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Liu FX et al. | [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15810447 |
Guo JP and Xue H | [Prepared evening primrose oil microspheres by spray drying]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18589773 |
Shi LM et al. | [Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260318 |
Wang H et al. | [Separation of gamma linolenic acid from evening primrose oil with urea inclusion--orthogonal experiment of optimizing technological parameters and observation of urea inclusion compound I]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20707192 |
Guo SX et al. | [Influence of methyl esterification on the ultraviolet absorption of gamma-linolenic acid]. | 2007 | Zhong Yao Cai | pmid:18236761 |
Li J et al. | Feeding stimulant in Cinnamomum camphora for the common bluebottle, Graphium sarpedon nipponum (Lepidoptera: Papilionidae). | 2010 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:21138058 |
Meigel W et al. | [Additional oral therapy of atopic dermatitis with unsaturated fatty acids]. | 1987 | Z. Hautkr. | pmid:2894730 |
Keysser G | [Are there effective dietary recommendations for patients with rheumatoid arthritis?]. | 2001 | Z Rheumatol | pmid:11263011 |
Kirchgessner M et al. | The effects of dietary oils on the fatty acid composition and osmotic fragility of rat erythrocytes. | 1994 | Z Ernahrungswiss | pmid:8079509 |
Li MC et al. | [Heteologous expression of Mortierella isabellina delta6 -fatty acid desaturase gene in soybean]. | 2004 | Yi Chuan Xue Bao | pmid:15481543 |
Hao YL et al. | Cloning of delta6-desaturase from Mucor circinelloides and its high expression in Saccharomyces cerevisiae. | 2005 | Yi Chuan Xue Bao | pmid:15931792 |
Falconer JS et al. | Polyunsaturated fatty acids in the treatment of weight-losing patients with pancreatic cancer. | 1994 | World Rev Nutr Diet | pmid:7856240 |
Adam O | [Ankylosing Spondylitis and convenient nutrition]. | 2008 | Wien Med Wochenschr | pmid:18560957 |
Lu H et al. | [Cloning and expression of a delta6-fatty acid desaturase gene from Rhizopus stolonifer in Saccharomyces cervisiae]. | 2007 | Wei Sheng Wu Xue Bao | pmid:17436625 |
Arundel BL | Evening primrose oil and epilepsy. | 1992 | Vet. Rec. | pmid:1475904 |
Bond R and Lloyd DH | A double-blind comparison of olive oil and a combination of evening primrose oil and fish oil in the management of canine atopy. | 1992 | Vet. Rec. | pmid:1481346 |
Bond R and Lloyd DH | Combined treatment with concentrated essential fatty acids and prednisolone in the management of canine atopy. | 1994 | Vet. Rec. | pmid:8135003 |
Harvey RG | Effect of varying proportions of evening primrose oil and fish oil on cats with crusting dermatosis ('miliary dermatitis') | 1993 | Vet. Rec. | pmid:8280288 |
Harvey RG | A comparison of evening primrose oil and sunflower oil for the management of papulocrustous dermatitis in cats. | 1993 | Vet. Rec. | pmid:8303807 |
Sture GH and Lloyd DH | Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. | 1995 | Vet. Rec. | pmid:8553525 |
Dobbin SN | Evening primrose oil and epilepsy. | 1992 Dec 19-26 | Vet. Rec. | pmid:1287960 |
Noli C et al. | Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. | 2007 | Vet. J. | pmid:16495095 |
Bloom P | Atopic dermatitis: the quest for the silver bullet. | 2008 | Vet. J. | pmid:18554562 |
Gueck T et al. | Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. | 2004 | Vet. Dermatol. | pmid:15500483 |
Saevik BK et al. | A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. | 2004 | Vet. Dermatol. | pmid:15214949 |
Solomon LZ et al. | Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. | 1998 | Urol. Res. | pmid:9537690 |
Simán CM et al. | Failure of short-term gamma-linolenic acid treatment to reduce urinary calcium loss of diabetic rats. | 2000 | Urol. Res. | pmid:10850637 |
Tulloch I et al. | Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. | 1994 | Urol. Res. | pmid:7871634 |
du Toit PJ et al. | Pyelonephritis: renal urokinase activity in rats on essential fatty acid diets. | 1994 | Urol. Res. | pmid:7992455 |
Burgess NA et al. | Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. | 1995 | Urol. Res. | pmid:8533210 |
Crook TJ et al. | The effects of meglumine gamma linolenic acid (MeGLA) on an organ culture model of superficial bladder cancer. | 2002 | Urol. Res. | pmid:11942327 |
Schumacher MC et al. | A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens. | 2013 | Urol. Oncol. | pmid:21414816 |
Omran OM | Histopathological study of evening primrose oil effects on experimental diabetic neuropathy. | 2012 | Ultrastruct Pathol | pmid:22574767 |
Lindskov R and Petersen CS | [Oral gamma-linoleic acid (Epogam) in the treatment of atopic dermatitis]. | 1995 | Ugeskr. Laeg. | pmid:7483071 |
Nykiforuk CL et al. | High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds. | 2012 | Transgenic Res. | pmid:21853296 |
Kong X et al. | Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. | 2009 | Toxicol In Vitro | pmid:19268700 |
Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |
Kietzmann M | [Pharmacotherapeutic use of antipruritic drugs in skin diseases]. | 1995 | Tierarztl Prax | pmid:7545832 |
De La Cruz JP et al. | Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. | 1997 | Thromb. Res. | pmid:9253809 |
Nakahara T et al. | Inhibitory effects of mold oil including gamma-linolenate on platelet thrombus formation in mesenteric microvessels of the rat. | 1990 | Thromb. Res. | pmid:2156348 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Takahashi R et al. | Effect of different ratios of dietary N-6 and N-3 fatty acids on fatty acid composition, prostaglandin formation and platelet aggregation in the rat. | 1987 | Thromb. Res. | pmid:3660347 |
Akahane N et al. | Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature. | 1995 | Thromb. Res. | pmid:7660360 |
Villalobos MA et al. | Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. | 1998 | Thromb. Haemost. | pmid:9798993 |
Belch JJ et al. | Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. | 1985 | Thromb. Haemost. | pmid:4082084 |
Paccalin J et al. | [Changes in the higher derivatives of linoleic acid in cirrhotics treated with gamma-linolenic acid]. | 1983 May-Jun | Therapie | pmid:6310813 |
Saied GM et al. | Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females. | 2007 | Tanzan Health Res Bull | pmid:18087899 |
Qureshi S and Sultan N | Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. | 2005 | Surgeon | pmid:15789786 |
Mohajeri S and Newman SA | Review of evidence for dietary influences on atopic dermatitis. | 2014 Jul-Aug | Skin Therapy Lett. | pmid:25188523 |
Yoon S et al. | The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. | 2002 Jan-Feb | Skin Pharmacol. Appl. Skin Physiol. | pmid:11803254 |
Larsson-Backström C et al. | Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. | 1995 | Shock | pmid:7552772 |
Li MC et al. | [Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]. | 2004 | Sheng Wu Gong Cheng Xue Bao | pmid:16108486 |
Zhang Q et al. | [Progress on molecular biology of delta6-fatty acid desaturases]. | 2004 | Sheng Wu Gong Cheng Xue Bao | pmid:15971598 |
Li MC et al. | [Expression of Mortierella isabellina delta6-fatty acid desaturase gene in gamma-linolenic acid production in transgenic tobacco]. | 2003 | Sheng Wu Gong Cheng Xue Bao | pmid:15966318 |
Rothman D et al. | Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. | 1995 | Semin. Arthritis Rheum. | pmid:8578315 |
Saad N et al. | Optimization of aeration and agitation rate for lipid and gamma linolenic acid production by Cunninghamella bainieri 2A1 in submerged fermentation using response surface methodology. | 2014 | ScientificWorldJournal | pmid:25610901 |
Simmons DA et al. | Significance of tissue myo-inositol concentrations in metabolic regulation in nerve. | 1982 | Science | pmid:6285474 |
Manthorpe R and Prause JU | Treatment of Sjögren's syndrome: an overview. | 1986 | Scand. J. Rheumatol. Suppl. | pmid:3296150 |
Horrobin DF | Essential fatty acid and prostaglandin metabolism in Sjögren's syndrome, systemic sclerosis and rheumatoid arthritis. | 1986 | Scand. J. Rheumatol. Suppl. | pmid:3296151 |
Hansen TM et al. | Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. | 1983 | Scand. J. Rheumatol. | pmid:6304871 |
Theander E et al. | Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome. | 2002 | Scand. J. Rheumatol. | pmid:12109650 |
Oxholm P et al. | Patients with primary Sjögren's syndrome treated for two months with evening primrose oil. | 1986 | Scand. J. Rheumatol. | pmid:3529370 |
de Kock M et al. | Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells. | 1992 | S. Afr. Med. J. | pmid:1315459 |
Leary WP et al. | Some effects of gamma-linolenic acid on cultured human oesophageal carcinoma cells. | 1982 | S. Afr. Med. J. | pmid:6291175 |
Dippenaar N et al. | The reversibility of cancer: evidence that malignancy in human hepatoma cells is gamma-linolenic acid deficiency-dependent. | 1982 | S. Afr. Med. J. | pmid:6291176 |
van der Merwe CF | The reversibility of cancer. | 1983 | S. Afr. Med. J. | pmid:6298954 |
Botha JH et al. | Parenteral gamma-linolenic acid administration in nude mice bearing a range of human tumour xenografts. | 1983 | S. Afr. Med. J. | pmid:6304925 |
Van der Merwe CF | The reversibility of cancer. | 1984 | S. Afr. Med. J. | pmid:6320476 |
Booyens J and Koenig L | The effect of dietary supplementation with gamma-linolenic acid on the growth of induced tumours in rats. | 1984 | S. Afr. Med. J. | pmid:6324397 |
van der Merwe CF | The reversibility of cancer. | 1984 | S. Afr. Med. J. | pmid:6326340 |
Oakley OR et al. | The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro. | 1998 Jan-Jun | Rom J Physiol | pmid:11000861 |
Szczesna M | [Therapeutic assessment of the evening primrose]. | 1993 | Rocz Panstw Zakl Hig | pmid:8016534 |
Macfarlane GJ et al. | Evidence for the efficacy of complementary and alternative medicines in the management of rheumatoid arthritis: a systematic review. | 2011 | Rheumatology (Oxford) | pmid:21652584 |
Soeken KL et al. | Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. | 2003 | Rheumatology (Oxford) | pmid:12709541 |
Manthorpe R et al. | Primary Sjögren's syndrome treated with Efamol/Efavit. A double-blind cross-over investigation. | 1984 | Rheumatol. Int. | pmid:6385206 |
Webb J and McCredie M | Primary Sjögren's syndrome treated with Efamol/efavit. A double-blind cross-over investigation. | 1985 | Rheumatol. Int. | pmid:4048763 |
Willemaers V et al. | [Atopic dermatitis]. | 1998 | Rev Med Liege | pmid:9564223 |
DeMichele SJ et al. | A nutritional strategy to improve oxygenation and decrease morbidity in patients who have acute respiratory distress syndrome. | 2006 | Respir Care Clin N Am | pmid:17150431 |
Castellanos P et al. | Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. | 2010 | Reprod. Toxicol. | pmid:20096347 |
Hindo J et al. | Evidence of the formation of different hydroperoxides in irradiated gamma-linolenate solutions: effect of micelle formation. | 2000 | Radiat. Res. | pmid:10629620 |
Vaddadi KS et al. | A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. | 1989 | Psychiatry Res | pmid:2565585 |
Dobryniewski J et al. | [The gamma-linolenic acid (GLA)--the therapeutic value]. | 2007 | Prz. Lek. | pmid:17892041 |
Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
Joubert AM et al. | Comparative study of the effects of polyunsaturated fatty acids and their metabolites on cell growth and tyrosine kinase activity in oesophageal carcinoma cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582657 |
Mengeaud V et al. | Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1337209 |
Das UN and Rao KP | Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16488586 |
Cleland LG et al. | The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2169063 |
van der Merwe CF et al. | The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2169638 |
Miller MA and Morgan RJ | Eicosanoids, erections and erectile dysfunction. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938091 |
Guivernau M et al. | Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846101 |
Das UN | Occlusion of infusion vessels on gamma-linolenic acid infusion. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643176 |
Horrobin DF | The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8380930 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
Ebden P et al. | A study of evening primrose seed oil in atopic asthma. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2717651 |
Huang YS et al. | The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2717652 |
Bell JG et al. | Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577782 |
Koba K et al. | Distribution of plasma phosphatidylcholine molecular species in rabbits fed fish oil is modulated by dietary n-6 fatty acids. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8821127 |
Kaku S et al. | Dietary gamma-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728173 |
Nwankwo JO and Robbins ME | Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418018 |
Puri BK | The safety of evening primrose oil in epilepsy. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17764919 |