| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Karikó K et al. | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. | 1995 | FEBS Lett. | pmid:7890029 |
| Morris GM et al. | Trophic effects of essential fatty acids on pig skin. | 1995 | Cell Prolif. | pmid:7893841 |
| Fiocchi A et al. | The efficacy and safety of gamma-linolenic acid in the treatment of infantile atopic dermatitis. | 1994 Jan-Feb | J. Int. Med. Res. | pmid:7910570 |
| Stillwell W et al. | Cholesterol condensation of alpha-linolenic and gamma-linolenic acid-containing phosphatidylcholine monolayers and bilayers. | 1994 | Biochim. Biophys. Acta | pmid:7918592 |
| Veale DJ et al. | A double-blind placebo controlled trial of Efamol Marine on skin and joint symptoms of psoriatic arthritis. | 1994 | Br. J. Rheumatol. | pmid:7921757 |
| Biagi PL et al. | The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. | 1994 | Drugs Exp Clin Res | pmid:7924900 |
| Rubin M et al. | Effect of three intravenously administered fat emulsions containing different concentrations of fatty acids on the plasma fatty acid composition of premature infants. | 1994 | J. Pediatr. | pmid:7931881 |
| Miller MA and Morgan RJ | Eicosanoids, erections and erectile dysfunction. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938091 |
| Kleijnen J | Evening primrose oil. | 1994 | BMJ | pmid:7950599 |
| Hopewell JW et al. | Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. | 1994 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:7961020 |
| de Kock M et al. | Differential cytotoxic effects of gamma-linolenic acid on MG-63 and HeLa cells. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972263 |
| du Toit PJ et al. | The effect of gamma-linolenic acid and eicosapentaenoic acid on urokinase activity. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972265 |
| Milner LS et al. | Synergistic effects of fish oil diet and dimethylthiourea in acute adriamycin nephrosis. | 1994 | Am. J. Med. Sci. | pmid:7977444 |
| du Toit PJ et al. | Pyelonephritis: renal urokinase activity in rats on essential fatty acid diets. | 1994 | Urol. Res. | pmid:7992455 |
| Szczesna M | [Therapeutic assessment of the evening primrose]. | 1993 | Rocz Panstw Zakl Hig | pmid:8016534 |
| Schoemaker JH | Pharmacological treatment of diabetic peripheral neuropathy: challenges and possibilities. | 1994 Mar-Apr | Br J Clin Pract | pmid:8024999 |
| Oliwiecki S and Burton JL | Evening primrose oil and marine oil in the treatment of psoriasis. | 1994 | Clin. Exp. Dermatol. | pmid:8050140 |
| Giamarellos-Bourboulis EJ et al. | Do Escherichia coli susceptibilities to various antibiotics decrease in the presence of polyunsaturated fatty acids? A preliminary report. | 1994 | J Chemother | pmid:8071677 |
| Kirchgessner M et al. | The effects of dietary oils on the fatty acid composition and osmotic fragility of rat erythrocytes. | 1994 | Z Ernahrungswiss | pmid:8079509 |
| Leventhal LJ et al. | Treatment of rheumatoid arthritis with blackcurrant seed oil. | 1994 | Br. J. Rheumatol. | pmid:8081671 |
| Tollesson A and Frithz A | Transepidermal water loss and water content in the stratum corneum in infantile seborrhoeic dermatitis. | 1993 | Acta Derm. Venereol. | pmid:8095744 |
| Berth-Jones J and Graham-Brown RA | Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8099640 |
| Shield MJ et al. | Essential fatty acid supplementation in atopic dermatitis. | 1993 | Lancet | pmid:8101623 |
| Bond R and Lloyd DH | Combined treatment with concentrated essential fatty acids and prednisolone in the management of canine atopy. | 1994 | Vet. Rec. | pmid:8135003 |
| Phinney S | Potential risk of prolonged gamma-linolenic acid use. | 1994 | Ann. Intern. Med. | pmid:8135457 |
| Chenoy R et al. | Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. | 1994 | BMJ | pmid:8136666 |
| Takada R et al. | Dietary gamma-linolenic acid-enriched oil reduces body fat content and induces liver enzyme activities relating to fatty acid beta-oxidation in rats. | 1994 | J. Nutr. | pmid:8145067 |
| Morphake P et al. | Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146206 |
| Maaswinkel-Mooij PD et al. | Unsuccessful dietary treatment of Sjögren-Larsson syndrome. | 1994 | J. Pediatr. | pmid:8176565 |
| Wetzig NR | Mastalgia: a 3 year Australian study. | 1994 | Aust N Z J Surg | pmid:8179529 |
| Christophe A et al. | Effect of administration of gamma-linolenic acid on the fatty acid composition of serum phospholipids and cholesteryl esters in patients with cystic fibrosis. | 1994 | Ann. Nutr. Metab. | pmid:8185286 |
| Devi MA and Das NP | Antiproliferative effect of polyunsaturated fatty acids and interleukin-2 on normal and abnormal human lymphocytes. | 1994 | Experientia | pmid:8194587 |
| Jamal GA | The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. | 1994 | Diabet. Med. | pmid:8200197 |
| Leventhal LJ et al. | Treatment of rheumatoid arthritis with gammalinolenic acid. | 1993 | Ann. Intern. Med. | pmid:8214997 |
| Karlstad MD et al. | Effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma n-6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats. | 1993 | Crit. Care Med. | pmid:8222692 |
| Laivuori H et al. | Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248275 |
| Stevens EJ et al. | Prostacyclin release in experimental diabetes: effects of evening primrose oil. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248277 |
| Engler MM | Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8259378 |
| Dines KC et al. | Contrasting effects of treatment with omega-3 and omega-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. | 1993 | Diabetologia | pmid:8270127 |
| Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
| Harvey RG | Effect of varying proportions of evening primrose oil and fish oil on cats with crusting dermatosis ('miliary dermatitis') | 1993 | Vet. Rec. | pmid:8280288 |
| Ramanathan R et al. | Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. | 1994 | Free Radic. Biol. Med. | pmid:8299995 |
| Harvey RG | A comparison of evening primrose oil and sunflower oil for the management of papulocrustous dermatitis in cats. | 1993 | Vet. Rec. | pmid:8303807 |
| Joe LA and Hart LL | Evening primrose oil in rheumatoid arthritis. | 1993 | Ann Pharmacother | pmid:8305783 |
| Stevens EJ et al. | Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus. | 1993 | Diabetologia | pmid:8314443 |
| Leyton E | Disagreeing on how to treat CFS patients. | 1993 | Can Fam Physician | pmid:8347205 |
| Keen H et al. | Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. | 1993 | Diabetes Care | pmid:8380765 |
| Horrobin DF | The effects of gamma-linolenic acid on breast pain and diabetic neuropathy: possible non-eicosanoid mechanisms. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8380930 |
| Poisson JP et al. | Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. | 1993 | Biochem. Med. Metab. Biol. | pmid:8382502 |
| González CA et al. | Borage consumption as a possible gastric cancer protective factor. | 1993 Mar-Apr | Cancer Epidemiol. Biomarkers Prev. | pmid:8385521 |
| Plumb JA et al. | Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin. | 1993 | Br. J. Cancer | pmid:8385976 |
| Miura Y et al. | Production of gamma-linolenic acid from the marine green alga Chlorella sp. NKG 042401. | 1993 | FEMS Microbiol. Lett. | pmid:8386122 |
| Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |
| Takeda S et al. | Mechanism of lipid peroxidation in cancer cells in response to gamma-linolenic acid (GLA) analyzed by GC-MS(I): Conjugated dienes with peroxyl (or hydroperoxyl) groups and cell-killing effects. | 1993 Jan-Feb | Anticancer Res. | pmid:8386494 |
| Karmali RA et al. | Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8388566 |
| Bala KV et al. | Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linolenic acid. | 1993 | Food Chem. Toxicol. | pmid:8390392 |
| Hopewell JW et al. | The modulation of radiation-induced damage to pig skin by essential fatty acids. | 1993 | Br. J. Cancer | pmid:8391301 |
| Cerin A et al. | Hormonal and biochemical profiles of premenstrual syndrome. Treatment with essential fatty acids. | 1993 | Acta Obstet Gynecol Scand | pmid:8392261 |
| Galle AM et al. | Biosynthesis of gamma-linolenic acid in developing seeds of borage (Borago officinalis L.). | 1993 | Biochim. Biophys. Acta | pmid:8394742 |
| Kinchington D et al. | Lithium gamma-linolenate-induced cytotoxicity against cells chronically infected with HIV-1. | 1993 | FEBS Lett. | pmid:8396048 |
| Tollesson A and Frithz A | Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. | 1993 | Br. J. Dermatol. | pmid:8396411 |
| Cameron NE et al. | The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen. | 1993 | Br. J. Pharmacol. | pmid:8401950 |
| Cantrill RC et al. | Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture. | 1993 | Cancer Lett. | pmid:8402582 |
| Oliwiecki S et al. | The effect of essential fatty acids on epidermal atrophy due to topical steroids. | 1993 | Clin. Exp. Dermatol. | pmid:8403467 |
| Melnik B and Plewig G | [External treatment of atopic eczema with gamma-linolenic acid?]. | 1993 | Hautarzt | pmid:8407331 |
| Phinney SD et al. | Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration. | 1993 | Metab. Clin. Exp. | pmid:8412765 |
| Collins A et al. | Essential fatty acids in the treatment of premenstrual syndrome. | 1993 | Obstet Gynecol | pmid:8416468 |
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| Giamarellos-Bourboulis EJ et al. | In-vitro inhibitory activity of gamma-linolenic acid on Escherichia coli strains and its influence on their susceptibilities to various antimicrobial agents. | 1995 | J. Antimicrob. Chemother. | pmid:8522462 |
| Burgess NA et al. | Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. | 1995 | Urol. Res. | pmid:8533210 |
| Harbige LS et al. | Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. | 1995 | Br. J. Nutr. | pmid:8541276 |
| Sture GH and Lloyd DH | Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. | 1995 | Vet. Rec. | pmid:8553525 |
| Ells GW et al. | Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. | 1996 | Cancer Lett. | pmid:8556710 |
| Luthria DL and Sprecher H | Metabolism of deuterium-labeled linoleic, 6,9,12-octadecatrienoic, 8,11,14-eicosatrienoic, and arachidonic acids in the rat. | 1995 | J. Lipid Res. | pmid:8558078 |
| Palombo JD et al. | Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. | 1996 | Am. J. Clin. Nutr. | pmid:8561062 |
| Bell JG et al. | Diets rich in eicosapentaenoic acid and gamma-linolenic acid affect phospholipid fatty acid composition and production of prostaglandins E1, E2 and E3 in turbot (Scophthalmus maximus), a species deficient in delta 5 fatty acid desaturase. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577782 |
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| Chilton SA | Cognitive behaviour therapy for the chronic fatigue syndrome. Evening primrose oil and magnesium have been shown to be effective. | 1996 | BMJ | pmid:8616424 |
| Huang Z et al. | Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. | 1996 | Biochemistry | pmid:8619991 |
| Cantrill RC et al. | Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. | 1996 | Cancer Lett. | pmid:8620439 |
| Cameron NE et al. | Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. | 1996 | Diabetologia | pmid:8635669 |
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| Fearon KC et al. | An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. | 1996 Mar-Apr | Anticancer Res. | pmid:8687143 |
| Jiang WG et al. | Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. | 1996 | Br J Surg | pmid:8689213 |
| Sadi AM et al. | Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. | 1996 | Exp. Anim. | pmid:8689581 |
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| McCarty MF | Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. | 1996 | Med. Hypotheses | pmid:8692033 |
| Each of the following has been shown to be effective for cyclical breast pain. | 1996 | Can Fam Physician | pmid:8704485 | |
| Budeiri D et al. | Is evening primrose oil of value in the treatment of premenstrual syndrome? | 1996 | Control Clin Trials | pmid:8721802 |
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| Omawari N et al. | Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. | 1996 | Br. J. Pharmacol. | pmid:8733594 |
| Sherrington EJ et al. | The effect of dietary lipid manipulation on the uptake of [3H]-triolein by tissues of the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736833 |
| Grant D et al. | The antioxidant activity of heparins. | 1996 | Biochem. Soc. Trans. | pmid:8736852 |
| Stainforth JM et al. | Clinical aspects of the use of gamma linolenic acid in systemic sclerosis. | 1996 | Acta Derm. Venereol. | pmid:8740271 |
| Murai A et al. | Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. | 1995 | Br. Poult. Sci. | pmid:8746984 |
| Meehan E et al. | Influence of an n-6 polyunsaturated fatty acid-enriched diet on the development of tolerance during chronic ethanol administration in rats. | 1995 | Alcohol. Clin. Exp. Res. | pmid:8749808 |
| Hrelia S et al. | gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid composition. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753781 |
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