| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wainwright PE et al. | Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior. | 1996 | Pharmacol. Biochem. Behav. | pmid:8801587 |
| Fan YY et al. | Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro. | 1996 | J. Nutr. | pmid:8814195 |
| Koba K et al. | Distribution of plasma phosphatidylcholine molecular species in rabbits fed fish oil is modulated by dietary n-6 fatty acids. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8821127 |
| Leichsenring M et al. | (n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. | 1995 | Pediatr Allergy Immunol | pmid:8822394 |
| Ingram AJ et al. | Dietary alteration of dihomogamma-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. The Nutrition & Kidney Disease Research Group. | 1996 | J. Am. Soc. Nephrol. | pmid:8829117 |
| Cameron NE and Cotter MA | Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats. | 1996 | Am. J. Physiol. | pmid:8843740 |
| Wigmore SJ et al. | The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. | 1996 | Nutrition | pmid:8850216 |
| Jenkins AP et al. | Essential fatty acid supplementation in chronic hepatitis B. | 1996 | Aliment. Pharmacol. Ther. | pmid:8853774 |
| Williams WV et al. | Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes. | 1996 | Pathobiology | pmid:8856792 |
| Cameron NE and Cotter MA | Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. | 1996 | Diabetologia | pmid:8877288 |
| Whitaker DK et al. | Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. | 1996 | Dermatology (Basel) | pmid:8884146 |
| Sutton GC | 'Too tired to go to the support group': a health needs assessment of myalgic encephalomyelitis. | 1996 | J Public Health Med | pmid:8887847 |
| Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
| Deferne JL and Leeds AR | Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. | 1996 | J Hum Hypertens | pmid:8895037 |
| Redden PR et al. | Comparison of the grignard deacylation TLC and HPLC methods and high resolution 13C-NMR for the sn-2 positional analysis of triacylglycerols containing gamma-linolenic acid. | 1996 | Chem. Phys. Lipids | pmid:8907238 |
| Zurier RB et al. | gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. | 1996 | Arthritis Rheum. | pmid:8912502 |
| Julu PO et al. | Endogenous cyclo-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925193 |
| Julu PO | Latency of neuroactivity and optimum period of treatment with evening primrose oil in diabetic rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925199 |
| Dines KC et al. | Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931113 |
| Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
| Matsuo N et al. | Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951990 |
| Papanikolaou N et al. | Effects of OKY-046 and nifedipine in cyclosporine-induced renal dysfunction in rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951993 |
| de Kock M et al. | The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014218 |
| Hederos CA and Berg A | Epogam evening primrose oil treatment in atopic dermatitis and asthma. | 1996 | Arch. Dis. Child. | pmid:9014601 |
| Fang C et al. | Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051726 |
| Sasaki S et al. | Effects of gamma-linolenic and eicosapentaenoic acids on blood pressure in SHR. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072404 |
| Vartak S et al. | Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. | 1997 | Lipids | pmid:9076665 |
| Leaver HA et al. | Arachidonic acid activation of monocyte and neutrophil reactive oxygen in lung cancer patients undergoing pulmonary resection. | 1996 | Biologicals | pmid:9088546 |
| Murray MJ and Zhang T | The incorporation of dietary n-3 polyunsaturated fatty acids into porcine platelet phospholipids and their effects on platelet thromboxane A2 release. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089803 |
| Bard JM et al. | A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. | 1997 | Fundam Clin Pharmacol | pmid:9107561 |
| Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
| Biernat J and Grajeta H | Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 1. Blood serum and liver lipids. | 1997 | Nahrung | pmid:9113670 |
| Grajeta H and Biernat J | Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 2. Blood serum and liver fatty acids. | 1997 | Nahrung | pmid:9113671 |
| Utsunomiya T | Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. | 1997 | Br J Surg | pmid:9117334 |
| Mancuso P et al. | Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. | 1997 | Crit. Care Med. | pmid:9118672 |
| Wagner W and Nootbaar-Wagner U | Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. | 1997 | Cephalalgia | pmid:9137851 |
| Jiang WG et al. | Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150377 |
| Palombo JD et al. | Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168366 |
| Küpper C | [Premenstrual syndrome: does gamma-linolenic acid help?]. | 1997 | Fortschr. Med. | pmid:9173016 |
| Vassilopoulos D et al. | Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. | 1997 | Clin. Immunol. Immunopathol. | pmid:9175912 |
| Kokura S et al. | Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. | 1997 | Cancer Res. | pmid:9187121 |
| Harbige LS et al. | Protective mechanisms by omega-6 lipids in experimental autoimmune encephalomyelitis (EAE) are associated with cytokines and eicosanoids. | 1997 | Biochem. Soc. Trans. | pmid:9191387 |
| Fisher BA and Harbige LS | Effect of omega-6 lipid-rich borage oil feeding on immune function in healthy volunteers. | 1997 | Biochem. Soc. Trans. | pmid:9191388 |
| de Antueno R et al. | In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas. | 1997 | Br. J. Cancer | pmid:9192987 |
| Magnusson G et al. | Plasma and tissue levels of lipids, fatty acids and plasma carnitine in neonates receiving a new fat emulsion. | 1997 | Acta Paediatr. | pmid:9202801 |
| Garland HO et al. | Dietary essential fatty acid supplementation, urinary calcium excretion and reproductive performance in the diabetic pregnant rat. | 1997 | J. Endocrinol. | pmid:9203989 |
| Quoc KP and Dubacq JP | Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. | 1997 | Biochim. Biophys. Acta | pmid:9219908 |
| Mancuso P et al. | Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats. | 1997 | Crit. Care Med. | pmid:9233748 |
| Johnson MM et al. | Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. | 1997 | J. Nutr. | pmid:9237935 |
| Liang T and Liao S | Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase. | 1997 | J. Invest. Dermatol. | pmid:9242500 |
| Borrek S et al. | [Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study]. | 1997 May-Jun | Klin Padiatr | pmid:9244815 |
| Ziboh VA et al. | gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. | 1997 | Lipids | pmid:9252965 |
| De La Cruz JP et al. | Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. | 1997 | Thromb. Res. | pmid:9253809 |
| Manninen P and Laakso P | Capillary supercritical fluid chromatography--atmospheric pressure chemical ionization mass spectrometry of gamma- and alpha-linolenic acid containing triacylglycerols in berry oils. | 1997 | Lipids | pmid:9270973 |
| Fan YY et al. | Dietary gamma-linolenic acid enhances mouse macrophage-derived prostaglandin E1 which inhibits vascular smooth muscle cell proliferation. | 1997 | J. Nutr. | pmid:9278557 |
| Horrobin DF | Essential fatty acids in the management of impaired nerve function in diabetes. | 1997 | Diabetes | pmid:9285506 |
| Jiang WG et al. | Gamma linolenic acid regulates expression of maspin and the motility of cancer cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299418 |
| McGahon B et al. | The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. | 1997 | Neuroscience | pmid:9300396 |
| BÃró K et al. | Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. | 1997 | Brain Res. Bull. | pmid:9323440 |
| Rossetti RG et al. | Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. | 1997 | J. Leukoc. Biol. | pmid:9335312 |
| Jiang WG et al. | Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids. | 1997 | Clin. Exp. Metastasis | pmid:9344043 |
| Campbell EM et al. | Premenstrual symptoms in general practice patients. Prevalence and treatment. | 1997 | J Reprod Med | pmid:9350019 |
| al-Shabanah OA | Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. | 1997 | Food Chem. Toxicol. | pmid:9350221 |
| Andreassi M et al. | Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. | 1997 Sep-Oct | J. Int. Med. Res. | pmid:9364289 |
| Bordoni A et al. | Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. | 1997 | Biochim. Biophys. Acta | pmid:9366250 |
| Larsen LN et al. | Polyunsaturated thia- and oxa-fatty acids: incorporation into cell-lipids and their effects on arachidonic acid- and eicosanoid synthesis. | 1997 | Biochim. Biophys. Acta | pmid:9366251 |
| Steinbrunn BS et al. | Mastalgia. Tailoring treatment to type of breast pain. | 1997 | Postgrad Med | pmid:9385340 |
| Pohl CH et al. | The production of gamma-linolenic acid by selected members of the Dikaryomycota grown on different carbon sources. | 1997 | Antonie Van Leeuwenhoek | pmid:9403104 |
| Purasiri P et al. | Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. | 1997 | Immunology | pmid:9415022 |
| Kairemo KJ et al. | Effects of lithium gammalinolenate on the perfusion of liver and pancreatic tissues in pancreatic cancer. | 1997 Sep-Oct | Anticancer Res. | pmid:9427770 |
| Tollesson A et al. | Malassezia furfur in infantile seborrheic dermatitis. | 1997 Nov-Dec | Pediatr Dermatol | pmid:9436835 |
| Kairemo KJ et al. | The effect of lithium gamma-linolenate therapy of pancreatic cancer on perfusion in liver and pancreatic tissues. | 1998 | Pancreas | pmid:9436871 |
| Tocher DR et al. | Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. | 1997 | Lipids | pmid:9438233 |
| Chen Q et al. | Analysis of the acyl-CoAs that accumulate during the peroxisomal beta-oxidation of arachidonic acid and 6,9,12-octadecatrienoic acid. | 1998 | Arch. Biochem. Biophys. | pmid:9448727 |
| Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
| Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
| Morris GM et al. | Modulation of the cell kinetics of pig skin by the topical application of evening primrose oil or Lioxasol. | 1997 Aug-Sep | Cell Prolif. | pmid:9501921 |
| Jiang WG et al. | The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. | 1998 | Br. J. Cancer | pmid:9514051 |
| Jiang WG et al. | Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514943 |
| Solomon LZ et al. | Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. | 1998 | Urol. Res. | pmid:9537690 |
| Kis M et al. | Light-induced expression of fatty acid desaturase genes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539715 |
| Hørby Jørgensen M et al. | Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9552137 |
| Burnard SL et al. | Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat. | 1998 Mar-Apr | J. Diabetes Complicat. | pmid:9559483 |
| Cameron NE et al. | Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. | 1998 | Diabetologia | pmid:9562342 |
| Willemaers V et al. | [Atopic dermatitis]. | 1998 | Rev Med Liege | pmid:9564223 |
| Marra F et al. | Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. | 1998 | J. Hepatol. | pmid:9566835 |
| Anderson KM et al. | Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid. | 1998 Mar-Apr | Anticancer Res. | pmid:9615721 |
| Ravichandran D et al. | Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. | 1998 | Eur. J. Cancer | pmid:9624256 |
| Sanderson P and Calder PC | Dietary fish oil appears to prevent the activation of phospholipase C-gamma in lymphocytes. | 1998 | Biochim. Biophys. Acta | pmid:9630688 |
| Reddy AS and Thomas TL | Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid production in transgenic plants. | 1996 | Nat. Biotechnol. | pmid:9630958 |
| Vartak S et al. | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. | 1998 | Br. J. Cancer | pmid:9635836 |
| McGahon B et al. | Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study. | 1998 | Exp. Gerontol. | pmid:9639170 |
| Johnson SR | Premenstrual syndrome therapy. | 1998 | Clin Obstet Gynecol | pmid:9646973 |
| Engler MM et al. | Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. | 1998 | Proc. Soc. Exp. Biol. Med. | pmid:9648942 |
| Giamarellos-Bourboulis EJ et al. | In vitro activity of polyunsaturated fatty acids on Pseudomonas aeruginosa: relationship to lipid peroxidation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654401 |
| Kahler CP and Du Plooy WJ | Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654407 |
| Frati-Munari AC and Ariza-Andraca CR | [Treatment of diabetic neuropathy]. | 1998 Jan-Feb | Gac Med Mex | pmid:9658700 |
| Jiang WG et al. | gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. | 1998 | Int. J. Oncol. | pmid:9683802 |
| Hounsom L et al. | A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. | 1998 | Diabetologia | pmid:9686927 |
| Kumamoto T and Ide T | Comparative effects of alpha- and gamma-linolenic acids on rat liver fatty acid oxidation. | 1998 | Lipids | pmid:9688166 |