gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Bordoni A et al. Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. 1997 Biochim. Biophys. Acta pmid:9366250
Larsen LN et al. Polyunsaturated thia- and oxa-fatty acids: incorporation into cell-lipids and their effects on arachidonic acid- and eicosanoid synthesis. 1997 Biochim. Biophys. Acta pmid:9366251
Fan YY et al. Dietary gamma-linolenic acid enhances mouse macrophage-derived prostaglandin E1 which inhibits vascular smooth muscle cell proliferation. 1997 J. Nutr. pmid:9278557
Jiang WG et al. Gamma linolenic acid regulates expression of maspin and the motility of cancer cells. 1997 Biochem. Biophys. Res. Commun. pmid:9299418
Mancuso P et al. Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats. 1997 Crit. Care Med. pmid:9233748
Johnson MM et al. Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. 1997 J. Nutr. pmid:9237935
Harbige LS et al. Protective mechanisms by omega-6 lipids in experimental autoimmune encephalomyelitis (EAE) are associated with cytokines and eicosanoids. 1997 Biochem. Soc. Trans. pmid:9191387
Fisher BA and Harbige LS Effect of omega-6 lipid-rich borage oil feeding on immune function in healthy volunteers. 1997 Biochem. Soc. Trans. pmid:9191388
Kokura S et al. Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. 1997 Cancer Res. pmid:9187121
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Garland HO et al. Dietary essential fatty acid supplementation, urinary calcium excretion and reproductive performance in the diabetic pregnant rat. 1997 J. Endocrinol. pmid:9203989
Murray MJ and Zhang T The incorporation of dietary n-3 polyunsaturated fatty acids into porcine platelet phospholipids and their effects on platelet thromboxane A2 release. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089803
Wagner W and Nootbaar-Wagner U Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. 1997 Cephalalgia pmid:9137851
Jiang WG et al. Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150377
Biernat J and Grajeta H Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 1. Blood serum and liver lipids. 1997 Nahrung pmid:9113670
Grajeta H and Biernat J Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 2. Blood serum and liver fatty acids. 1997 Nahrung pmid:9113671
Utsunomiya T Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1997 Br J Surg pmid:9117334
Mancuso P et al. Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. 1997 Crit. Care Med. pmid:9118672
Vartak S et al. Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. 1997 Lipids pmid:9076665
Bard JM et al. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. 1997 Fundam Clin Pharmacol pmid:9107561
Fang C et al. Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9051726
Liang T and Liao S Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase. 1997 J. Invest. Dermatol. pmid:9242500
Rossetti RG et al. Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. 1997 J. Leukoc. Biol. pmid:9335312
Horrobin DF Essential fatty acids in the management of impaired nerve function in diabetes. 1997 Diabetes pmid:9285506
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Mpanju O et al. Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. 1997 Antivir. Ther. (Lond.) pmid:11322262
Pohl CH et al. The production of gamma-linolenic acid by selected members of the Dikaryomycota grown on different carbon sources. 1997 Antonie Van Leeuwenhoek pmid:9403104
Jiang WG et al. Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids. 1997 Clin. Exp. Metastasis pmid:9344043
Campbell EM et al. Premenstrual symptoms in general practice patients. Prevalence and treatment. 1997 J Reprod Med pmid:9350019
al-Shabanah OA Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. 1997 Food Chem. Toxicol. pmid:9350221
Bíró K et al. Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. 1997 Brain Res. Bull. pmid:9323440
Steinbrunn BS et al. Mastalgia. Tailoring treatment to type of breast pain. 1997 Postgrad Med pmid:9385340
Tocher DR et al. Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. 1997 Lipids pmid:9438233
Fearon KC et al. An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. 1996 Mar-Apr Anticancer Res. pmid:8687143
Sutton GC 'Too tired to go to the support group': a health needs assessment of myalgic encephalomyelitis. 1996 J Public Health Med pmid:8887847
Cameron NE and Cotter MA Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats. 1996 Am. J. Physiol. pmid:8843740
Williams WV et al. Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes. 1996 Pathobiology pmid:8856792
Deferne JL and Leeds AR Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. 1996 J Hum Hypertens pmid:8895037
Papanikolaou N et al. Effects of OKY-046 and nifedipine in cyclosporine-induced renal dysfunction in rats. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8951993
Matsuo N et al. Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8951990
Wigmore SJ et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. 1996 Nutrition pmid:8850216
Jenkins AP et al. Essential fatty acid supplementation in chronic hepatitis B. 1996 Aliment. Pharmacol. Ther. pmid:8853774
de Kock M et al. The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014218
Hederos CA and Berg A Epogam evening primrose oil treatment in atopic dermatitis and asthma. 1996 Arch. Dis. Child. pmid:9014601
Ingram AJ et al. Dietary alteration of dihomogamma-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. The Nutrition & Kidney Disease Research Group. 1996 J. Am. Soc. Nephrol. pmid:8829117
Glen AI et al. Membrane fatty acids, niacin flushing and clinical parameters. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888117
Awad AB et al. The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. 1996 Cancer Lett. pmid:8950205
Leaver HA et al. Arachidonic acid activation of monocyte and neutrophil reactive oxygen in lung cancer patients undergoing pulmonary resection. 1996 Biologicals pmid:9088546
Ells GW et al. Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. 1996 Cancer Lett. pmid:8556710
Palombo JD et al. Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. 1996 Am. J. Clin. Nutr. pmid:8561062