| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Engler MM et al. | Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. | 1992 | J. Hypertens. | pmid:1335001 |
| Santoli D and Zurier RB | Prostaglandin E precursor fatty acids inhibit human IL-2 production by a prostaglandin E-independent mechanism. | 1989 | J. Immunol. | pmid:2545787 |
| Chilton-Lopez ME et al. | Metabolism of gammalinolenic acid in human neutrophils. | 1996 | J. Immunol. | pmid:8609415 |
| Furse RK et al. | Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes. | 2001 | J. Immunol. | pmid:11418687 |
| Fiocchi A et al. | The efficacy and safety of gamma-linolenic acid in the treatment of infantile atopic dermatitis. | 1994 Jan-Feb | J. Int. Med. Res. | pmid:7910570 |
| Andreassi M et al. | Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. | 1997 Sep-Oct | J. Int. Med. Res. | pmid:9364289 |
| Liang T and Liao S | Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase. | 1997 | J. Invest. Dermatol. | pmid:9242500 |
| DeLuca P et al. | Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo. | 1999 | J. Investig. Med. | pmid:10361385 |
| Rossetti RG et al. | Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. | 1997 | J. Leukoc. Biol. | pmid:9335312 |
| Song C et al. | Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. | 2003 | J. Lipid Res. | pmid:12837849 |
| Luthria DL and Sprecher H | Metabolism of deuterium-labeled linoleic, 6,9,12-octadecatrienoic, 8,11,14-eicosatrienoic, and arachidonic acids in the rat. | 1995 | J. Lipid Res. | pmid:8558078 |
| Shewale SV et al. | Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver. | 2015 | J. Lipid Res. | pmid:25921305 |
| Szachowicz-Petelska B et al. | Protective effect of blackcurrant on liver cell membrane of rats intoxicated with ethanol. | 2012 | J. Membr. Biol. | pmid:22527605 |
| Kim SH et al. | Isolation and functional characterization of a delta 6-desaturase gene from the pike eel (Muraenesox cinereus). | 2013 | J. Microbiol. | pmid:24097133 |
| Wan X et al. | Molecular cloning and expression analysis of a delta 6-fatty acid desaturase gene from Rhizopus stolonifer strain YF6 which can accumulate high levels of gamma-linolenic acid. | 2011 | J. Microbiol. | pmid:21369993 |
| Khongto B et al. | Fermentation process development of recombinant Hansenula polymorpha for gamma-linolenic acid production. | 2010 | J. Microbiol. Biotechnol. | pmid:21124062 |
| Wan X et al. | Production of gamma-linolenic acid in Pichia pastoris by Expression of a delta-6 desaturase gene from Cunninghamella echinulata. | 2009 | J. Microbiol. Biotechnol. | pmid:19884765 |
| Choi GG et al. | Enhanced biomass and gamma-linolenic acid production of mutant strain Arthrospira platensis. | 2008 | J. Microbiol. Biotechnol. | pmid:18388474 |
| Cunnane SC et al. | NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478372 |
| Menendez JA et al. | Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. | 2005 | J. Natl. Cancer Inst. | pmid:16264182 |
| Das UN | Re: Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. | 2006 | J. Natl. Cancer Inst. | pmid:16705127 |
| Likhodii SS and Cunnane SC | Uptake of 13C-tracer arachidonate and gamma-linolenate by the brain and liver of the suckling rat observed using 13C-NMR. | 1999 | J. Neurochem. | pmid:10349866 |
| Biessels GJ et al. | The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats. | 2001 | J. Neurol. Sci. | pmid:11137514 |
| Julu PO and Mutamba A | Comparison of short-term effects of insulin and essential fatty acids on the slowed nerve conduction of streptozotocin diabetes in rats. | 1991 | J. Neurol. Sci. | pmid:1663993 |
| Bell HS et al. | Effects of N-6 essential fatty acids on glioma invasion and growth: experimental studies with glioma spheroids in collagen gels. | 1999 | J. Neurosurg. | pmid:10584845 |
| Fan YY et al. | Dietary gamma-linolenic acid enhances mouse macrophage-derived prostaglandin E1 which inhibits vascular smooth muscle cell proliferation. | 1997 | J. Nutr. | pmid:9278557 |
| Fan YY and Chapkin RS | Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid. | 1992 | J. Nutr. | pmid:1322453 |
| Johnson MM et al. | Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. | 1997 | J. Nutr. | pmid:9237935 |
| Chapkin RS and Carmichael SL | Effect of dietary blackcurrant seed oil on mouse macrophage subclasses of choline and ethanolamine glycerophospholipids. | 1990 | J. Nutr. | pmid:1974284 |
| Barham JB et al. | Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. | 2000 | J. Nutr. | pmid:10917903 |
| Fan YY and Chapkin RS | Importance of dietary gamma-linolenic acid in human health and nutrition. | 1998 | J. Nutr. | pmid:9732298 |
| Takada R et al. | Dietary gamma-linolenic acid-enriched oil reduces body fat content and induces liver enzyme activities relating to fatty acid beta-oxidation in rats. | 1994 | J. Nutr. | pmid:8145067 |
| Fan YY et al. | Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro. | 1996 | J. Nutr. | pmid:8814195 |
| Tso P et al. | Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. | 2002 | J. Nutr. | pmid:11823581 |
| Tsimaratos M et al. | Gamma-linolenic acid restores renal medullary thick ascending limb Na(+),K(+)-ATPase activity in diabetic rats. | 2001 | J. Nutr. | pmid:11739860 |
| Fan YY et al. | Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. | 2001 | J. Nutr. | pmid:11385052 |
| Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
| Pitel S et al. | At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. | 2007 | J. Nutr. | pmid:17237313 |
| Frenoux JM et al. | A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. | 2001 | J. Nutr. | pmid:11208936 |
| Schirmer MA and Phinney SD | Gamma-linolenate reduces weight regain in formerly obese humans. | 2007 | J. Nutr. | pmid:17513402 |
| Petrik MB et al. | Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. | 2000 | J. Nutr. | pmid:11015469 |
| Chapkin RS et al. | Dietary influences of evening primrose and fish oil on the skin of essential fatty acid-deficient guinea pigs. | 1987 | J. Nutr. | pmid:3625311 |
| Chung S et al. | Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. | 2002 | J. Nutr. | pmid:12368400 |
| Song C et al. | Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. | 2008 | J. Nutr. | pmid:18424607 |
| Tahvonen RL et al. | Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. | 2005 | J. Nutr. Biochem. | pmid:15936647 |
| Fauconnot L and Buist PH | Gamma-linolenic acid biosynthesis: cryptoregiochemistry of delta6 desaturation. | 2001 | J. Org. Chem. | pmid:11312950 |
| Van Biervliet JP et al. | Serum cholesterol, cholesteryl ester, and high-density lipoprotein development in newborn infants: response to formulas supplemented with cholesterol and gamma-linolenic acid. | 1992 | J. Pediatr. | pmid:1313864 |
| Rubin M et al. | Effect of three intravenously administered fat emulsions containing different concentrations of fatty acids on the plasma fatty acid composition of premature infants. | 1994 | J. Pediatr. | pmid:7931881 |
| Maaswinkel-Mooij PD et al. | Unsuccessful dietary treatment of Sjögren-Larsson syndrome. | 1994 | J. Pediatr. | pmid:8176565 |
| Hrastinger A et al. | Is there clinical evidence supporting the use of botanical dietary supplements in children? | 2005 | J. Pediatr. | pmid:15756210 |