gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Das UN Re: Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2006 J. Natl. Cancer Inst. pmid:16705127
Kristofíková L et al. Selection of Rhizopus strains for L(+)-lactic acid and gamma-linolenic acid production. 1991 Folia Microbiol. (Praha) pmid:1668279
Gilani S et al. Chick embryonic development following exposure to ethanol, gamma-linolenic and linolenic acids. 1991 Anat Anz pmid:1666823
Melnik B and Plewig G Atopic dermatitis and disturbances of essential fatty acid and prostaglandin E metabolism. 1991 J. Am. Acad. Dermatol. pmid:1666398
Freeman MS et al. The effects of essential fatty acid supplementation on lithium absorption kinetics in guinea pig jejunum. 1991 Biochem. Soc. Trans. pmid:1665438
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
Julu PO and Mutamba A Comparison of short-term effects of insulin and essential fatty acids on the slowed nerve conduction of streptozotocin diabetes in rats. 1991 J. Neurol. Sci. pmid:1663993
Tocher DR et al. Effect of diets enriched in Delta6 desaturated fatty acids (18:3n-6 and 18:4n-3), on growth, fatty acid composition and highly unsaturated fatty acid synthesis in two populations of Arctic charr (Salvelinus alpinus L.). 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16630735
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Kitz R et al. Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. 2006 Pediatr Allergy Immunol pmid:16618360
Hongsthong A et al. Revealing the complementation of ferredoxin by cytochrome b (5) in the Spirulina- (6)-desaturation reaction by N-terminal fusion and co-expression of the fungal-cytochrome b (5) domain and Spirulina- (6)-acyl-lipid desaturase. 2006 Appl. Microbiol. Biotechnol. pmid:16575563
Beck SA et al. Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover. 1991 Cancer Res. pmid:1657378
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Pham H et al. Dietary gamma-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE(2) and 5S-HETE. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16567086
Chapkin RS and Coble KJ Utilization of gammalinolenic acid by mouse peritoneal macrophages. 1991 Biochim. Biophys. Acta pmid:1655039
Gasperino J and Kvetan V Acute lung injury and nutritional support. 2006 Crit. Care Med. pmid:16550085
Martin TA et al. Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. 2006 J. Cell. Biochem. pmid:16514648
Gardiner NS and Duncan JR Possible involvement of delta-6-desaturase in control of melanoma growth by gamma-linolenic acid. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1650000
Noli C et al. Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. 2007 Vet. J. pmid:16495095
Das UN and Rao KP Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16488586
Singer P et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. 2006 Crit. Care Med. pmid:16484911
Scott DW et al. Comparison of the clinical efficacy of two commercial fatty acid supplements (EfaVet and DVM Derm Caps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. 1992 Cornell Vet pmid:1643883
Yu Z et al. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. 2006 J. Pharmacol. Exp. Ther. pmid:16421287
Thurmond DC et al. Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. 1993 Obes. Res. pmid:16353349
Vahedi K et al. A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients. 2005 Br. J. Nutr. pmid:16351767
Aragona P et al. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients. 2005 Invest. Ophthalmol. Vis. Sci. pmid:16303936
Guil-Guerrero JL et al. Gamma-linolenic acid from Cape Verdian Boraginaceae. 2006 Nat. Prod. Res. pmid:16286301
Menendez JA et al. Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2005 J. Natl. Cancer Inst. pmid:16264182
Heard CM et al. Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. 2005 Int J Pharm pmid:16115741
Oikawa D et al. Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. 2005 Br. J. Nutr. pmid:16115363
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Verhoeven MO et al. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. 2005 Jul-Aug Menopause pmid:16037756
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Gateley CA et al. Plasma fatty acid profiles in benign breast disorders. 1992 Br J Surg pmid:1596720
Li MC et al. [Expression of Mortierella isabellina delta6-fatty acid desaturase gene in gamma-linolenic acid production in transgenic tobacco]. 2003 Sheng Wu Gong Cheng Xue Bao pmid:15966318
Cerolini S et al. Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels. 2005 Br. Poult. Sci. pmid:15957443
Seidel A et al. The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. 2005 J Vet Med A Physiol Pathol Clin Med pmid:15943605
Tahvonen RL et al. Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. 2005 J. Nutr. Biochem. pmid:15936647
Hao YL et al. Cloning of delta6-desaturase from Mucor circinelloides and its high expression in Saccharomyces cerevisiae. 2005 Yi Chuan Xue Bao pmid:15931792
Taweechaisupapong S et al. Evening primrose oil effects on osteoclasts during tooth movement. 2005 Angle Orthod pmid:15898373
Na-Ranong S et al. Substrate specificity and preference of Delta6-desaturase of Mucor rouxii. 2005 FEBS Lett. pmid:15862319
Vang K and Ziboh VA 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850718
Efstathopoulos N et al. N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850717
Patnayak S and Sree A Screening of bacterial associates of marine sponges for single cell oil and PUFA. 2005 Lett. Appl. Microbiol. pmid:15836739
Takeno S et al. Molecular evidence that the rate-limiting step for the biosynthesis of arachidonic acid in Mortierella alpina is at the level of an elongase. 2005 Lipids pmid:15825827
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15810447
Qureshi S and Sultan N Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. 2005 Surgeon pmid:15789786
Watkins G et al. Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15763439
Hrastinger A et al. Is there clinical evidence supporting the use of botanical dietary supplements in children? 2005 J. Pediatr. pmid:15756210
Goyal A and Mansel RE A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. 2005 Jan-Feb Breast J pmid:15647077