gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Dasgupta S and Bhattacharyya DK Dietary effect of gamma-linolenic acid on the lipid profile of rat fed erucic acid rich oil. 2007 J Oleo Sci pmid:17938547
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Martin TA et al. Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid. 2007 J. Cell. Biochem. pmid:17243118
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Pitel S et al. At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. 2007 J. Nutr. pmid:17237313
Christie A et al. Effectiveness of nonpharmacological and nonsurgical interventions for patients with rheumatoid arthritis: an overview of systematic reviews. 2007 Phys Ther pmid:17906290
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Theilla M et al. A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study. 2007 Clin Nutr pmid:17933438
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Villamor E et al. Long-chain n-6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding. 2007 Am. J. Clin. Nutr. pmid:17823433
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Puri BK The safety of evening primrose oil in epilepsy. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17764919
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Cho HS et al. Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation. 2007 Photodermatol Photoimmunol Photomed pmid:17803593
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Kim J et al. Comparative effect of gromwell (Lithospermum erythrorhizon) extract and borage oil on reversing epidermal hyperproliferation in guinea pigs. 2006 Biosci. Biotechnol. Biochem. pmid:16960390
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Kong X et al. Induction of apoptosis in K562/ADM cells by gamma-linolenic acid involves lipid peroxidation and activation of caspase-3. 2006 Chem. Biol. Interact. pmid:16857180
Pham H et al. Dietary gamma-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE(2) and 5S-HETE. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16567086
Singer P et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. 2006 Crit. Care Med. pmid:16484911
Das UN and Rao KP Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16488586
Martin TA et al. Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. 2006 J. Cell. Biochem. pmid:16514648
Pacht ER Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come. 2006 Crit. Care Med. pmid:16921322
Arab K et al. Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. 2006 Br. J. Nutr. pmid:17092368
Das UN Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives. 2006 Curr Pharm Biotechnol pmid:17168663
Morse NL and Clough PM A meta-analysis of randomized, placebo-controlled clinical trials of Efamol evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries? 2006 Curr Pharm Biotechnol pmid:17168667
Kapoor R and Huang YS Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. 2006 Curr Pharm Biotechnol pmid:17168669
DeMichele SJ et al. A nutritional strategy to improve oxygenation and decrease morbidity in patients who have acute respiratory distress syndrome. 2006 Respir Care Clin N Am pmid:17150431
Kim JJ et al. Properties of cholesterol-reduced butter made with beta-cyclodextrin and added evening primrose oil and phytosterols. 2006 J. Dairy Sci. pmid:17106080
Gasperino J and Kvetan V Acute lung injury and nutritional support. 2006 Crit. Care Med. pmid:16550085
Yu Z et al. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. 2006 J. Pharmacol. Exp. Ther. pmid:16421287
Tocher DR et al. Effect of diets enriched in Delta6 desaturated fatty acids (18:3n-6 and 18:4n-3), on growth, fatty acid composition and highly unsaturated fatty acid synthesis in two populations of Arctic charr (Salvelinus alpinus L.). 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16630735
Kitz R et al. Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. 2006 Pediatr Allergy Immunol pmid:16618360
Chen YC et al. Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. 2006 Am. J. Kidney Dis. pmid:16797388
Miles EA et al. Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820286
Hongsthong A et al. Revealing the complementation of ferredoxin by cytochrome b (5) in the Spirulina- (6)-desaturation reaction by N-terminal fusion and co-expression of the fungal-cytochrome b (5) domain and Spirulina- (6)-acyl-lipid desaturase. 2006 Appl. Microbiol. Biotechnol. pmid:16575563
Das UN Re: Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2006 J. Natl. Cancer Inst. pmid:16705127
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
Verhoeven MO et al. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. 2005 Jul-Aug Menopause pmid:16037756
Goyal A and Mansel RE A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. 2005 Jan-Feb Breast J pmid:15647077
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15810447
Menendez JA et al. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. 2005 Med. Hypotheses pmid:15607568
Vahedi K et al. A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients. 2005 Br. J. Nutr. pmid:16351767
Menendez JA et al. Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2005 J. Natl. Cancer Inst. pmid:16264182
Heard CM et al. Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. 2005 Int J Pharm pmid:16115741
Efstathopoulos N et al. N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850717
Oikawa D et al. Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. 2005 Br. J. Nutr. pmid:16115363
Vang K and Ziboh VA 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850718
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Hao YL et al. Cloning of delta6-desaturase from Mucor circinelloides and its high expression in Saccharomyces cerevisiae. 2005 Yi Chuan Xue Bao pmid:15931792
Tahvonen RL et al. Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. 2005 J. Nutr. Biochem. pmid:15936647
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Menendez JA et al. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. 2004 Int. J. Cancer pmid:15027132
Nakanishi T et al. Gamma-linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice. 2004 Nutrition pmid:15043857
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Gamma-linolenic acid (GLA). Monograph. 2004 Altern Med Rev pmid:15005646
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Knorr R and Hamburger M Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil. 2004 J. Agric. Food Chem. pmid:15161190
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Javadi M et al. The effect of six different C18 fatty acids on body fat and energy metabolism in mice. 2004 Br. J. Nutr. pmid:15469642
Miles EA et al. The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. 2004 Br. J. Nutr. pmid:15182393
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Das UN Occlusion of infusion vessels on gamma-linolenic acid infusion. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643176
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Crowe DL and Chandraratna RA A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. 2004 Breast Cancer Res. pmid:15318936
Leaver HA et al. Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15062847
Miles EA et al. The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120716
Das UN From bench to the clinic: gamma-linolenic acid therapy of human gliomas. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120717
Gallagher S Omega 3 oils and pregnancy. 2004 Midwifery Today Int Midwife pmid:15124319
Karia C et al. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. 2004 Int J Pharm pmid:15129999
Menendez JA et al. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. 2004 Int. J. Oncol. pmid:15138577
Shotton HR et al. Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil. 2004 Auton Neurosci pmid:15109939
Fewtrell MS et al. Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. 2004 J. Pediatr. pmid:15069395
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