gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Saevik BK et al. A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. 2004 Vet. Dermatol. pmid:15214949
Hirawa N and Umemura S [Prostaglandin/bradykinin]. 2004 Nippon Rinsho pmid:15250292
Bruder ED et al. Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. 2004 Endocrinology pmid:15271879
Cheng Z et al. Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes. 2004 J. Endocrinol. pmid:15283685
Papanikolaou S et al. Single cell oil (SCO) production by Mortierella isabellina grown on high-sugar content media. 2004 Bioresour. Technol. pmid:15288271
Harrison RA et al. Who and how many people are taking herbal supplements? A survey of 21,923 adults. 2004 Int J Vitam Nutr Res pmid:15296076
Crowe DL and Chandraratna RA A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. 2004 Breast Cancer Res. pmid:15318936
Papanikolaou S et al. Repression of reserve lipid turnover in Cunninghamella echinulata and Mortierella isabellina cultivated in multiple-limited media. 2004 J. Appl. Microbiol. pmid:15357737
Nassar BA et al. The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed N-6 and N-3 fatty acid-supplemented diets. 1992 Proc. Soc. Exp. Biol. Med. pmid:1539039
Jenkins AP et al. Effects of bolus doses of fat on small intestinal structure and on release of gastrin, cholecystokinin, peptide tyrosine-tyrosine, and enteroglucagon. 1992 Gut pmid:1541417
Jenkins AP and Thompson RP Effect of dietary fat on the distribution of mucosal mass and cell proliferation along the small intestine. 1992 Gut pmid:1541418
Oon BB et al. A diet enriched in essential fatty acids protects against the loss of lymphocytes which occurs in rats suffering from streptozotocin-induced diabetes. 1992 Exp. Physiol. pmid:1543584
Gillis RC et al. Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells. 2004 Sep-Oct JPEN J Parenter Enteral Nutr pmid:15449569
Javadi M et al. The effect of six different C18 fatty acids on body fat and energy metabolism in mice. 2004 Br. J. Nutr. pmid:15469642
Li MC et al. [Heteologous expression of Mortierella isabellina delta6 -fatty acid desaturase gene in soybean]. 2004 Yi Chuan Xue Bao pmid:15481543
Gateley CA et al. Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. 1992 J R Soc Med pmid:1548647
Gueck T et al. Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. 2004 Vet. Dermatol. pmid:15500483
Ho S et al. In-vitro transcutaneous delivery of tamoxifen and gamma-linolenic acid from borage oil containing ethanol and 1,8-cineole. 2004 J. Pharm. Pharmacol. pmid:15525441
Cury-Boaventura MF and Curi R Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. 2005 Clin. Sci. pmid:15563273
Menendez JA et al. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. 2005 Med. Hypotheses pmid:15607568
Hirasawa A et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. 2005 Nat. Med. pmid:15619630
Goyal A and Mansel RE A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. 2005 Jan-Feb Breast J pmid:15647077
Hrastinger A et al. Is there clinical evidence supporting the use of botanical dietary supplements in children? 2005 J. Pediatr. pmid:15756210
Watkins G et al. Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15763439
Qureshi S and Sultan N Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. 2005 Surgeon pmid:15789786
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15810447
Takeno S et al. Molecular evidence that the rate-limiting step for the biosynthesis of arachidonic acid in Mortierella alpina is at the level of an elongase. 2005 Lipids pmid:15825827
Patnayak S and Sree A Screening of bacterial associates of marine sponges for single cell oil and PUFA. 2005 Lett. Appl. Microbiol. pmid:15836739
Efstathopoulos N et al. N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850717
Vang K and Ziboh VA 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850718
Na-Ranong S et al. Substrate specificity and preference of Delta6-desaturase of Mucor rouxii. 2005 FEBS Lett. pmid:15862319
Taweechaisupapong S et al. Evening primrose oil effects on osteoclasts during tooth movement. 2005 Angle Orthod pmid:15898373
Hao YL et al. Cloning of delta6-desaturase from Mucor circinelloides and its high expression in Saccharomyces cerevisiae. 2005 Yi Chuan Xue Bao pmid:15931792
Tahvonen RL et al. Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. 2005 J. Nutr. Biochem. pmid:15936647
Seidel A et al. The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. 2005 J Vet Med A Physiol Pathol Clin Med pmid:15943605
Cerolini S et al. Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels. 2005 Br. Poult. Sci. pmid:15957443
Li MC et al. [Expression of Mortierella isabellina delta6-fatty acid desaturase gene in gamma-linolenic acid production in transgenic tobacco]. 2003 Sheng Wu Gong Cheng Xue Bao pmid:15966318
Gateley CA et al. Plasma fatty acid profiles in benign breast disorders. 1992 Br J Surg pmid:1596720
Zhang Q et al. [Progress on molecular biology of delta6-fatty acid desaturases]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:15971598
Verhoeven MO et al. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. 2005 Jul-Aug Menopause pmid:16037756
Li MC et al. [Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:16108486
Oikawa D et al. Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. 2005 Br. J. Nutr. pmid:16115363
Heard CM et al. Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. 2005 Int J Pharm pmid:16115741
Menendez JA et al. Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2005 J. Natl. Cancer Inst. pmid:16264182
Guil-Guerrero JL et al. Gamma-linolenic acid from Cape Verdian Boraginaceae. 2006 Nat. Prod. Res. pmid:16286301
Aragona P et al. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients. 2005 Invest. Ophthalmol. Vis. Sci. pmid:16303936
Vahedi K et al. A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients. 2005 Br. J. Nutr. pmid:16351767
Thurmond DC et al. Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. 1993 Obes. Res. pmid:16353349
Yu Z et al. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. 2006 J. Pharmacol. Exp. Ther. pmid:16421287
Scott DW et al. Comparison of the clinical efficacy of two commercial fatty acid supplements (EfaVet and DVM Derm Caps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. 1992 Cornell Vet pmid:1643883
Singer P et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. 2006 Crit. Care Med. pmid:16484911
Das UN and Rao KP Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16488586
Noli C et al. Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. 2007 Vet. J. pmid:16495095
Gardiner NS and Duncan JR Possible involvement of delta-6-desaturase in control of melanoma growth by gamma-linolenic acid. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1650000
Martin TA et al. Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. 2006 J. Cell. Biochem. pmid:16514648
Gasperino J and Kvetan V Acute lung injury and nutritional support. 2006 Crit. Care Med. pmid:16550085
Chapkin RS and Coble KJ Utilization of gammalinolenic acid by mouse peritoneal macrophages. 1991 Biochim. Biophys. Acta pmid:1655039
Pham H et al. Dietary gamma-linolenate attenuates tumor growth in a rodent model of prostatic adenocarcinoma via suppression of elevated generation of PGE(2) and 5S-HETE. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16567086
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Beck SA et al. Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover. 1991 Cancer Res. pmid:1657378
Hongsthong A et al. Revealing the complementation of ferredoxin by cytochrome b (5) in the Spirulina- (6)-desaturation reaction by N-terminal fusion and co-expression of the fungal-cytochrome b (5) domain and Spirulina- (6)-acyl-lipid desaturase. 2006 Appl. Microbiol. Biotechnol. pmid:16575563
Kitz R et al. Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. 2006 Pediatr Allergy Immunol pmid:16618360
Izumi T et al. Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. 1991 Eur. J. Biochem. pmid:1662607
Tocher DR et al. Effect of diets enriched in Delta6 desaturated fatty acids (18:3n-6 and 18:4n-3), on growth, fatty acid composition and highly unsaturated fatty acid synthesis in two populations of Arctic charr (Salvelinus alpinus L.). 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16630735
Julu PO and Mutamba A Comparison of short-term effects of insulin and essential fatty acids on the slowed nerve conduction of streptozotocin diabetes in rats. 1991 J. Neurol. Sci. pmid:1663993
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
Freeman MS et al. The effects of essential fatty acid supplementation on lithium absorption kinetics in guinea pig jejunum. 1991 Biochem. Soc. Trans. pmid:1665438
Melnik B and Plewig G Atopic dermatitis and disturbances of essential fatty acid and prostaglandin E metabolism. 1991 J. Am. Acad. Dermatol. pmid:1666398
Gilani S et al. Chick embryonic development following exposure to ethanol, gamma-linolenic and linolenic acids. 1991 Anat Anz pmid:1666823
Kristofíková L et al. Selection of Rhizopus strains for L(+)-lactic acid and gamma-linolenic acid production. 1991 Folia Microbiol. (Praha) pmid:1668279
Das UN Re: Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. 2006 J. Natl. Cancer Inst. pmid:16705127
Biagi PL et al. Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. 1991 Biochim. Biophys. Acta pmid:1674661
Chen YC et al. Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. 2006 Am. J. Kidney Dis. pmid:16797388
Miles EA et al. Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820286
Pontes-Arruda A et al. Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. 2006 Crit. Care Med. pmid:16850002
Fakas S et al. Lipids of Cunninghamella echinulata with emphasis to gamma-linolenic acid distribution among lipid classes. 2006 Appl. Microbiol. Biotechnol. pmid:16850299
Kong X et al. Induction of apoptosis in K562/ADM cells by gamma-linolenic acid involves lipid peroxidation and activation of caspase-3. 2006 Chem. Biol. Interact. pmid:16857180
Pacht ER Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come. 2006 Crit. Care Med. pmid:16921322
Puri BK Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). 2007 J. Clin. Pathol. pmid:16935966
Umeda-Sawada R et al. Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats. 2006 Biosci. Biotechnol. Biochem. pmid:16960355
Kim J et al. Comparative effect of gromwell (Lithospermum erythrorhizon) extract and borage oil on reversing epidermal hyperproliferation in guinea pigs. 2006 Biosci. Biotechnol. Biochem. pmid:16960390
Hatanaka E et al. Systematic study on ROS production induced by oleic, linoleic, and gamma-linolenic acids in human and rat neutrophils. 2006 Free Radic. Biol. Med. pmid:16962937
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Arab K et al. Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. 2006 Br. J. Nutr. pmid:17092368
Kim JJ et al. Properties of cholesterol-reduced butter made with beta-cyclodextrin and added evening primrose oil and phytosterols. 2006 J. Dairy Sci. pmid:17106080
DeMichele SJ et al. A nutritional strategy to improve oxygenation and decrease morbidity in patients who have acute respiratory distress syndrome. 2006 Respir Care Clin N Am pmid:17150431
Sýkora J et al. High-performance liquid chromatography with nuclear magnetic resonance detection--A method for quantification of alpha- and gamma-linolenic acids in their mixtures with free fatty acids. 2007 J Chromatogr A pmid:17157864
Das UN Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives. 2006 Curr Pharm Biotechnol pmid:17168663
Morse NL and Clough PM A meta-analysis of randomized, placebo-controlled clinical trials of Efamol evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries? 2006 Curr Pharm Biotechnol pmid:17168667
Kapoor R and Huang YS Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. 2006 Curr Pharm Biotechnol pmid:17168669
Pitel S et al. At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. 2007 J. Nutr. pmid:17237313
Martin TA et al. Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid. 2007 J. Cell. Biochem. pmid:17243118
Garaiova I et al. A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. 2007 Nutr J pmid:17254329
Pinna A et al. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. 2007 Cornea pmid:17413949
Curtis L High-quality enteral nutrition essential for reducing morbidity and mortality in acute care patients. 2007 Crit. Care Med. pmid:17421112
Ortiz-Leyba C and Garnacho-Montero J Saving lives in severe sepsis with the help of enteral nutrition. 2007 Crit. Care Med. pmid:17421113
Lu H et al. [Cloning and expression of a delta6-fatty acid desaturase gene from Rhizopus stolonifer in Saccharomyces cervisiae]. 2007 Wei Sheng Wu Xue Bao pmid:17436625
Schirmer MA and Phinney SD Gamma-linolenate reduces weight regain in formerly obese humans. 2007 J. Nutr. pmid:17513402
Das UN Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. 2007 Med. Sci. Monit. pmid:17599036
Kanehara S et al. Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children. 2007 Sep-Oct Eur J Dermatol pmid:17673396