gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

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Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Authors Title Published Journal PubMed Link
Bordoni A et al. Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. 1997 Biochim. Biophys. Acta pmid:9366250
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Ziboh VA et al. gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. 1997 Lipids pmid:9252965
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Manninen P and Laakso P Capillary supercritical fluid chromatography--atmospheric pressure chemical ionization mass spectrometry of gamma- and alpha-linolenic acid containing triacylglycerols in berry oils. 1997 Lipids pmid:9270973
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Wagner W and Nootbaar-Wagner U Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. 1997 Cephalalgia pmid:9137851
Jiang WG et al. Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150377
Biernat J and Grajeta H Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 1. Blood serum and liver lipids. 1997 Nahrung pmid:9113670
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Utsunomiya T Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1997 Br J Surg pmid:9117334
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Bard JM et al. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. 1997 Fundam Clin Pharmacol pmid:9107561
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Liang T and Liao S Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase. 1997 J. Invest. Dermatol. pmid:9242500
McGahon B et al. The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. 1997 Neuroscience pmid:9300396
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Horrobin DF Essential fatty acids in the management of impaired nerve function in diabetes. 1997 Diabetes pmid:9285506
Quoc KP and Dubacq JP Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. 1997 Biochim. Biophys. Acta pmid:9219908
Purasiri P et al. Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. 1997 Immunology pmid:9415022
de Antueno R et al. In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas. 1997 Br. J. Cancer pmid:9192987
Mpanju O et al. Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. 1997 Antivir. Ther. (Lond.) pmid:11322262
Griffiths G et al. Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. 1997 Prostate pmid:9108883
Steinbrunn BS et al. Mastalgia. Tailoring treatment to type of breast pain. 1997 Postgrad Med pmid:9385340
Tocher DR et al. Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. 1997 Lipids pmid:9438233
Fearon KC et al. An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. 1996 Mar-Apr Anticancer Res. pmid:8687143
Whitaker DK et al. Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. 1996 Dermatology (Basel) pmid:8884146
Sutton GC 'Too tired to go to the support group': a health needs assessment of myalgic encephalomyelitis. 1996 J Public Health Med pmid:8887847
Cameron NE and Cotter MA Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats. 1996 Am. J. Physiol. pmid:8843740
Williams WV et al. Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes. 1996 Pathobiology pmid:8856792
Deferne JL and Leeds AR Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. 1996 J Hum Hypertens pmid:8895037
Papanikolaou N et al. Effects of OKY-046 and nifedipine in cyclosporine-induced renal dysfunction in rats. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8951993
Dines KC et al. Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8931113
Matsuo N et al. Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8951990
Zurier RB et al. gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. 1996 Arthritis Rheum. pmid:8912502
Wigmore SJ et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. 1996 Nutrition pmid:8850216
Jenkins AP et al. Essential fatty acid supplementation in chronic hepatitis B. 1996 Aliment. Pharmacol. Ther. pmid:8853774
de Kock M et al. The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014218
Hederos CA and Berg A Epogam evening primrose oil treatment in atopic dermatitis and asthma. 1996 Arch. Dis. Child. pmid:9014601
Ingram AJ et al. Dietary alteration of dihomogamma-linolenic acid/arachidonic acid ratio in a rat 5/6-renal-ablation model. The Nutrition & Kidney Disease Research Group. 1996 J. Am. Soc. Nephrol. pmid:8829117
Glen AI et al. Membrane fatty acids, niacin flushing and clinical parameters. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888117
Cameron NE and Cotter MA Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. 1996 Diabetologia pmid:8877288
Awad AB et al. The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. 1996 Cancer Lett. pmid:8950205
Reddy AS and Thomas TL Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid production in transgenic plants. 1996 Nat. Biotechnol. pmid:9630958
Sadi AM et al. Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. 1996 Exp. Anim. pmid:8689581
Huang Z et al. Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. 1996 Biochemistry pmid:8619991
Cameron NE et al. Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. 1996 Diabetologia pmid:8635669
Leaver HA et al. Arachidonic acid activation of monocyte and neutrophil reactive oxygen in lung cancer patients undergoing pulmonary resection. 1996 Biologicals pmid:9088546
Chilton SA Cognitive behaviour therapy for the chronic fatigue syndrome. Evening primrose oil and magnesium have been shown to be effective. 1996 BMJ pmid:8616424
Cantrill RC et al. Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. 1996 Cancer Lett. pmid:8620439
Wainwright PE et al. Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior. 1996 Pharmacol. Biochem. Behav. pmid:8801587
Quoc KP and Pascaud M Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. 1996 Ann. Nutr. Metab. pmid:8773734
Hrelia S et al. gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid composition. 1996 Biochem. Biophys. Res. Commun. pmid:8753781
Fan YY et al. Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro. 1996 J. Nutr. pmid:8814195
Omawari N et al. Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. 1996 Br. J. Pharmacol. pmid:8733594
Sherrington EJ et al. The effect of dietary lipid manipulation on the uptake of [3H]-triolein by tissues of the rat. 1996 Biochem. Soc. Trans. pmid:8736833
Grant D et al. The antioxidant activity of heparins. 1996 Biochem. Soc. Trans. pmid:8736852
Stainforth JM et al. Clinical aspects of the use of gamma linolenic acid in systemic sclerosis. 1996 Acta Derm. Venereol. pmid:8740271
Budeiri D et al. Is evening primrose oil of value in the treatment of premenstrual syndrome? 1996 Control Clin Trials pmid:8721802
Each of the following has been shown to be effective for cyclical breast pain. 1996 Can Fam Physician pmid:8704485
Schöpf E et al. [Gamma-linolenic acid in atopic patients?]. 1996 Med Monatsschr Pharm pmid:8684312
Jiang WG et al. Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1996 Br J Surg pmid:8689213
McCarty MF Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. 1996 Med. Hypotheses pmid:8692033
Ells GW et al. Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. 1996 Cancer Lett. pmid:8556710
Palombo JD et al. Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. 1996 Am. J. Clin. Nutr. pmid:8561062
Chilton-Lopez ME et al. Metabolism of gammalinolenic acid in human neutrophils. 1996 J. Immunol. pmid:8609415
Redden PR et al. Comparison of the grignard deacylation TLC and HPLC methods and high resolution 13C-NMR for the sn-2 positional analysis of triacylglycerols containing gamma-linolenic acid. 1996 Chem. Phys. Lipids pmid:8907238
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Scholey JW and Mills DE Dietary fatty acids and the glomerular hemodynamic response to cyclosporine in borderline hypertensive rats. 1995 Kidney Int. pmid:7723248
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Fan YY et al. Dietary gamma-linolenic acid modulates macrophage-vascular smooth muscle cell interactions. Evidence for a macrophage-derived soluble factor that downregulates DNA synthesis in smooth muscle cells. 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7670954
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Dines CD et al. Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin. 1995 Eur. J. Pharmacol. pmid:8521914
Koba K et al. Distribution of plasma phosphatidylcholine molecular species in rabbits fed fish oil is modulated by dietary n-6 fatty acids. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:8821127
Leichsenring M et al. (n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. 1995 Pediatr Allergy Immunol pmid:8822394
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Goonaratna C Good morning, evening primrose oil. 1995 Ceylon Med J pmid:8689697
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Giamarellos-Bourboulis EJ et al. In-vitro inhibitory activity of gamma-linolenic acid on Escherichia coli strains and its influence on their susceptibilities to various antimicrobial agents. 1995 J. Antimicrob. Chemother. pmid:8522462
Burgess NA et al. Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. 1995 Urol. Res. pmid:8533210
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Rossetti RG et al. Differential regulation of human T lymphocyte protein kinase C activity by unsaturated fatty acids. 1995 Clin. Immunol. Immunopathol. pmid:7554442
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Hrelia S et al. Essential fatty acid metabolism in cultured rat cardiomyocytes in response to either N-6 or N-3 fatty acid supplementation. 1995 Biochem. Biophys. Res. Commun. pmid:7488075
Chajès V et al. Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E. 1995 Breast Cancer Res. Treat. pmid:7579484
Akahane N et al. Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature. 1995 Thromb. Res. pmid:7660360
Jiang WG et al. Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. 1995 Br. J. Cancer pmid:7710939
Jiang WG et al. Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). 1995 Cancer Res. pmid:7585549